Cited by 376Stress Responses and CortisolNeuropeptides and Animal PhysiologyAnimal Behavior and Welfare Studies

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Restraint stress in biomedical research: A review

Paré, William P., Glavin, Gary B.·1986·Neuroscience & Biobehavioral Reviews

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Abstract

The use of restraint or immobilization for investigations of animal physiology, pathology and pharmacology has an extensive history. The major use of this technique has been as a "stressor" for the induction of stress response syndromes in animals. Many such syndromes have been characterized from the behavioral level to the neurochemical concomitants of stress. As a consequence of this particular use of the restraint procedure, much information concerning drug effects on stress response syndromes has been obtained. Indeed, many researchers in the area of gastrointestinal drugs routinely screen their new compounds in a restraint model of gastric stress ulcer. The purpose of this review is to present for researchers, a summary of the methods for, the parameters of, and known drug effects on, restraint-induced pathology. In our experience, this technique has proven to be a very useful one for the examination of both central and peripheral mechanisms of stress-related disorders, as well as for studying drug effects upon these disorders.

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Authors: Paré, W. P., & Glavin, G. B.
Affiliations: United States Department of Veterans Affairs (US)
University of Manitoba (CA)
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 1986-09
Volume: 10
Issue: 3
Pages: 339-370
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/0149-7634(86)90017-5
OpenAlex: W1982596294
Cited by: 376
References: 327
Citations by year: 2026: 8 · 2025: 1 · 2024: 11 · 2023: 18 · 2022: 14 · 2021: 11 · 2020: 13 · 2019: 6 · 2018: 7 · 2017: 10 · 2016: 9 · 2015: 6 · 2014: 11 · 2013: 11 · 2012: 15
FWCI: 5.56
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Behavior and Welfare Studies
Keywords: restraint stress, immobilization, stress response syndromes, gastric stress ulcer, stress-related disorders, animal models of stress
MeSH terms: Animals, Haplorhini, Cricetinae, Restraint, Physical, Stress, Physiological, Mice, Rats

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Restraint stress in biomedical research: A review

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