Circadian rhythms and mood regulation: insights from pre-clinical models

McClung, Colleen A.

doi:10.1016/j.euroneuro.2011.07.008

Cited by 169Circadian rhythm and melatoninSleep and Wakefulness ResearchNeurotransmitter Receptor Influence on Behavior

Circadian rhythms and mood regulation: insights from pre-clinical models

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McClung, Colleen A.·2011·European Neuropsychopharmacology

DOI 10.1016/j.euroneuro.2011.07.008PMC PMC3179573

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Abstract

Affective disorders such as major depression, bipolar disorder, and seasonal affective disorder are associated with major disruptions in circadian rhythms. Indeed, altered sleep/wake cycles are a critical feature for diagnosis in the DSM IV and several of the therapies used to treat these disorders have profound effects on rhythm length and stabilization in human populations. Furthermore, multiple human genetic studies have identified polymorphisms in specific circadian genes associated with these disorders. Thus, there appears to be a strong association between the circadian system and mood regulation, although the mechanisms that underlie this association are unclear. Recently, a number of studies in animal models have begun to shed light on the complex interactions between circadian genes and mood-related neurotransmitter systems, the effects of light manipulation on brain circuitry, the impact of chronic stress on rhythms, and the ways in which antidepressant and mood-stabilizing drugs alter the clock. This review will focus on the recent advances that have been gleaned from the use of pre-clinical models to further our understanding of how the circadian system regulates mood.

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Recent work on circadian factors influencing risk of affective disorders has revealed extensive interactions between key emotion regulatory neurotransmitters such as dopamine and the genes controlling the molecular circadian clock.
“Recent work on circadian factors influencing risk of affective disorders have revealed extensive interactions between key emotion regulatory neurotransmitters such as dopamine and the genes controlling the molecular circadian clock (McClung, 2007(McClung, , 2011(McClung, , 2013)).”
From Physiological feelings (2019) · cites this paper as McClung, 2011
A major component of many mood, anxiety and psychotic disorders is a disrupted sleep-wake cycle.
“A major component of many mood, anxiety and psychotic disorders is a disrupted sleep–wake cycle183–188”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [187]

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Coordination of circadian timing in mammals
Reppert, S. M., & Weaver, D. R. (2002) · Nature · doi:10.1038/nature00965 · Cited by 4,379 · see citing works
Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice
Turek, F. W., Joshu, C., Kohsaka, A., Lin, E., Ivanova, G., McDearmon, E., Laposky, A., Losee-Olson, S., Easton, A., Jensen, D. R., et al. (2005) · Science · doi:10.1126/science.1108750 · Cited by 2,485 · see citing works
Molecular Adaptations Underlying Susceptibility and Resistance to Social Defeat in Brain Reward Regions
Krishnan, V., Han, M.-H., Graham, D. L., Berton, O., Renthal, W., Russo, S. J., LaPlant, Q., Graham, A., Lutter, M., Lagace, D. C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.09.018 · Cited by 2,307 · cited 2× · see citing works
“Only the susceptible, but not the resilient mice, show altered body temperature rhythms, suggesting that they are involved in the development of depression-related behavior (Krishnan et al. 2007).”
Background
The Orphan Nuclear Receptor REV-ERBα Controls Circadian Transcription within the Positive Limb of the Mammalian Circadian Oscillator
Preitner, N., Damiola, F., Luis-Lopez-Molina, Zakany, J., Duboule, D., Albrecht, U., & Schibler, U. (2002) · Cell · doi:10.1016/s0092-8674(02)00825-5 · Cited by 2,198 · see citing works
Circadian integration of metabolism and energetics
Bass, J., & Takahashi, J. S. (2010) · Science · doi:10.1126/science.1195027 · Cited by 1,910 · see citing works
Molecular components of the mammalian circadian clock
Ko, C. H., & Takahashi, J. S. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl207 · Cited by 1,657 · see citing works
Mutagenesis and Mapping of a Mouse Gene, Clock , Essential for Circadian Behavior
Vitaterna, M. H., King, D. P., Chang, A.-M., Kornhauser, J. M., Lowrey, P. L., McDonald, J. D., Dove, W. F., Pinto, L. H., Turek, F. W., & Takahashi, J. S. (1994) · Science · doi:10.1126/science.8171325 · Cited by 1,632 · see citing works
High-Fat Diet Disrupts Behavioral and Molecular Circadian Rhythms in Mice
Kohsaka, A., Laposky, A. D., Ramsey, K. M., Estrada, C., Joshu, C., Kobayashi, Y., Turek, F. W., & Bass, J. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.09.006 · Cited by 1,528 · see citing works
The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control
Nakahata, Y., Kaluzova, M., Grimaldi, B., Sahar, S., Hirayama, J., Chen, D., Guarente, L. P., & Sassone-Corsi, P. (2008) · Cell · doi:10.1016/j.cell.2008.07.002 · Cited by 1,427 · see citing works
Is there a common molecular pathway for addiction?
Nestler, E. J. (2005) · Nature Neuroscience · doi:10.1038/nn1578 · Cited by 1,388 · see citing works
Positional Cloning of the Mouse Circadian Gene
King, D. P., Zhao, Y., Sangoram, A. M., Wilsbacher, L. D., Tanaka, M., Antoch, M. P., Steeves, T. D. L., Vitaterna, M. H., Kornhauser, J. M., Lowrey, P. L., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80245-7 · Cited by 1,382 · see citing works
SIRT1 regulates circadian clock gene expression through PER2 deacetylation
Asher, G., Gatfield, D., Stratmann, M., Reinke, H., Dibner, C., Kreppel, F., Mostoslavsky, R., Alt, F. W., & Schibler, U. (2008) · Cell · doi:10.1016/j.cell.2008.06.050 · Cited by 1,376 · see citing works
A Functional Genomics Strategy Reveals Rora as a Component of the Mammalian Circadian Clock
Sato, T. K., Panda, S., Miraglia, L. J., Reyes, T. M., Rudic, R. D., McNamara, P., Naik, K. A., FitzGerald, G. A., Kay, S. A., & Hogenesch, J. B. (2004) · Neuron · doi:10.1016/j.neuron.2004.07.018 · Cited by 1,115 · see citing works
Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite
Abizaid, A., Liu, Z.-W., Andrews, Z. B., Shanabrough, M., Borok, E., Elsworth, J. D., Roth, R. H., Sleeman, M. W., Picciotto, M. R., Tschöp, M. H., et al. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29867 · Cited by 984 · see citing works
Leptin Receptor Signaling in Midbrain Dopamine Neurons Regulates Feeding
Hommel, J. D., Trinko, R., Sears, R. M., Georgescu, D., Liu, Z.-W., Gao, X.-B., Thurmon, J. J., Marinelli, M., & DiLeone, R. J. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.023 · Cited by 902 · see citing works
Circadian Regulator CLOCK Is a Histone Acetyltransferase
Doi, M., Hirayama, J., & Sassone‐Corsi, P. (2006) · Cell · doi:10.1016/j.cell.2006.03.033 · Cited by 890 · see citing works
Positional Syntenic Cloning and Functional Characterization of the Mammalian Circadian Mutation tau
Lowrey, P. L., Shimomura, K., Antoch, M. P., Yamazaki, S., Zemenides, P. D., Ralph, M. R., Menaker, M., & Takahashi, J. S. (2000) · Science · doi:10.1126/science.288.5465.483 · Cited by 860 · see citing works
Mania-like behavior induced by disruption of CLOCK
Roybal, K., Theobold, D., Graham, A., DiNieri, J. A., Russo, S. J., Krishnan, V., Chakravarty, S., Peevey, J., Oehrlein, N., Birnbaum, S., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609625104 · Cited by 803 · see citing works
Self-citation
Physiological effects of melatonin: Role of melatonin receptors and signal transduction pathways
Pandi-Perumal, S. R., Trakht, I. N., SRINIVASAN, V., SPENCE, D., Maestroni, G. J. M., Zisapel, N., & Cardinali, D. P. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.04.001 · Cited by 799 · see citing works
Social Zeitgebers and Biological Rhythms: A Unified Approach to Understanding the Etiology of Depression
Ehlers, C. L. (1988) · Archives of General Psychiatry · doi:10.1001/archpsyc.1988.01800340076012 · Cited by 707 · cited 1× · see citing works
“The social zeitgeber theory of depression put forth by Ehlers, Frank, and Kupfer in 1988 suggests that life events (usually stressful ones) disrupt the circadian cycle and in turn derail the internal circadian clock leading to depressive episodes in vulnerable individuals (Ehlers et al. 1988).”
Background
The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress
Lutter, M., Sakata, I., Osborne-Lawrence, S., Rovinsky, S. A., Anderson, J. G., Jung, S., Birnbaum, S., Yanagisawa, M., Elmquist, J. K., Nestler, E. J., et al. (2008) · Nature Neuroscience · doi:10.1038/nn.2139 · Cited by 644 · see citing works
The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption
Spanagel, R., Pendyala, G., Abarca, C., Zghoul, T., Sanchis-Segura, C., Magnone, M. C., Lascorz, J., Depner, M., Holzberg, D., Soyka, M., et al. (2005) · Nature Medicine · doi:10.1038/nm1163 · Cited by 594 · see citing works
Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions
Ripperger, J. A., & Schibler, U. (2006) · Nature Genetics · doi:10.1038/ng1738 · Cited by 593 · see citing works
NPAS2: an analog of clock operative in the mammalian forebrain
Reick, M., Garcia, J. A., Dudley, C., & McKnight, S. L. (2001) · Science · doi:10.1126/science.1060699 · Cited by 572 · see citing works
Nuclear Receptor Rev-erbα Is a Critical Lithium-Sensitive Component of the Circadian Clock
Yin, L., Wang, J., Klein, P. S., & Lazar, M. A. (2006) · Science · doi:10.1126/science.1121613 · Cited by 556 · see citing works
Molecular Genetics of Circadian Rhythms in Mammals
King, D. P., & Takahashi, J. S. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.713 · Cited by 551 · see citing works
CLOCK-mediated acetylation of BMAL1 controls circadian function
Hirayama, J., Sahar, S., Grimaldi, B., Tamaru, T., Takamatsu, K., Nakahata, Y., & Sassone‐Corsi, P. (2007) · Nature · doi:10.1038/nature06394 · Cited by 525 · see citing works
Interpersonal and social rhythm therapy: managing the chaos of bipolar disorder
Frank, E., Swartz, H. A., & Kupfer, D. J. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00969-0 · Cited by 521 · cited 1× · see citing works
“Interpersonal and social rhythm therapy has been developed to help control the sleep/wake, work, and social schedules of individuals with bipolar disorder and this helps to stabilize their mood (Frank et al. 2000).”
Background
The Suprachiasmatic Nucleus: A 25-Year Retrospective
Weaver, D. R. (1998) · Journal of Biological Rhythms · doi:10.1177/074873098128999952 · Cited by 508 · see citing works
Regulation of dopaminergic transmission and cocaine reward by the Clock gene
McClung, C. A., Sidiropoulou, K., Vitaterna, M., Takahashi, J. S., White, F. J., Cooper, D. C., & Nestler, E. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503584102 · Cited by 493 · see citing works
Self-citation
CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock
DeBruyne, J. P., Weaver, D. R., & Reppert, S. M. (2007) · Nature Neuroscience · doi:10.1038/nn1884 · Cited by 484 · see citing works
Cocaine sensitization and reward are under the influence of circadian genes and rhythm
Abarca, C., Albrecht, U., & Spanagel, R. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.142039099 · Cited by 472 · see citing works
The circadian basis of winter depression
Lewy, A. J., Lefler, B. J., Emens, J. S., & Bauer, V. K. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602425103 · Cited by 451 · see citing works
Melanopsin: an exciting photopigment
Hankins, M. W., Peirson, S. N., & Foster, R. G. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2007.11.002 · Cited by 426 · see citing works
Regulation of Monoamine Oxidase A by Circadian-Clock Components Implies Clock Influence on Mood
Hampp, G., Ripperger, J. A., Houben, T., Schmutz, I., Blex, C., Perreau‐Lenz, S., Brunk, I., Spanagel, R., Ahnert‐Hilger, G., Meijer, J. H., et al. (2008) · Current Biology · doi:10.1016/j.cub.2008.04.012 · Cited by 419 · see citing works
Epigenetic programming of the stress response in male and female rats by prenatal restraint stress
Darnaudéry, M., & Maccari, S. (2008) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.11.004 · Cited by 412 · see citing works
Constant light desynchronizes mammalian clock neurons
Ohta, H., Yamazaki, S., & McMahon, D. G. (2005) · Nature Neuroscience · doi:10.1038/nn1395 · Cited by 405 · see citing works
The social zeitgeber theory, circadian rhythms, and mood disorders: Review and evaluation
Sylvia, L. G., Alloy, L. B., & Abramson, L. Y. (2006) · Clinical Psychology Review · doi:10.1016/j.cpr.2006.07.001 · Cited by 404 · see citing works
Mesolimbic dopamine neurons in the brain reward circuit mediate susceptibility to social defeat and antidepressant action
Cao, J.-L., Covington, H. E., Friedman, A. K., Wilkinson, M. B., Walsh, J. J., Cooper, D. C., Nestler, E. J., & Han, M.-H. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.3177-10.2010 · Cited by 402 · see citing works
Lateral hypothalamic orexin/hypocretin neurons: A role in reward-seeking and addiction
Aston‐Jones, G., Smith, R. J., Sartor, G. C., Moorman, D. E., Massi, L., Tahsili‐Fahadan, P., & Richardson, K. A. (2009) · Brain Research · doi:10.1016/j.brainres.2009.09.106 · Cited by 386 · see citing works
Glycogen Synthase Kinase-3: a Putative Molecular Target for Lithium Mimetic Drugs
Gould, T. D., & Manji, H. K. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300731 · Cited by 377 · see citing works
The Flinders Sensitive Line rat: A selectively bred putative animal model of depression
Overstreet, D. H., Friedman, E. M., Mathé, A. A., & Yadid, G. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.015 · Cited by 375 · see citing works
A Role for Glycogen Synthase Kinase-3β in the Mammalian Circadian Clock
Iitaka, C., Miyazaki, K., Akaike, T., & Ishida, N. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503526200 · Cited by 373 · see citing works
The CircadianClockMutation Alters Sleep Homeostasis in the Mouse
Naylor, E., Bergmann, B. M., Krauski, K., Zee, P. C., Takahashi, J. S., Vitaterna, M. H., & Turek, F. W. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-21-08138.2000 · Cited by 367 · see citing works
Untitled work
(1978) · PubMed · Cited by 355 · see citing works
Differential Association of Circadian Genes with Mood Disorders: CRY1 and NPAS2 are Associated with Unipolar Major Depression and CLOCK and VIP with Bipolar Disorder
Soria, V., Martínez‐Amorós, È., Escaramís, G., Valero, J., Pérez‐Egea, R., García, C. B., Gutiérrez‐Zotes, A., Puigdemont, D., Bayés, M., Crespo, J. M., et al. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.230 · Cited by 352 · see citing works
Transgenic Mice Overexpressing Glycogen Synthase Kinase 3β: A Putative Model of Hyperactivity and Mania
Prickaerts, J., Moechars, D., Cryns, K., Lenaerts, I., van Craenendonck, H., Goris, I., Daneels, G., Bouwknecht, J. A., & Steckler, T. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.5216-05.2006 · Cited by 341 · see citing works
Circadian clock-related polymorphisms in seasonal affective disorder and their relevance to diurnal preference
Johansson, C., Willeit, M., Smedh, C., Ekholm, J., Paunio, T., Kieseppä, T., Lichtermann, D., Praschak-Rieder, N., Neumeister, A., Nilsson, L.-G., et al. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300121 · Cited by 341 · see citing works
Circadian Clock Control by SUMOylation of BMAL1
Cardone, L., Hirayama, J., Giordano, F., Tamaru, T., Palvimo, J. J., & Sassone‐Corsi, P. (2005) · Science · doi:10.1126/science.1110689 · Cited by 329 · see citing works
Influence of CLOCK gene polymorphism on circadian mood fluctuation and illness recurrence in bipolar depression
Benedetti, F., Serretti, A., Colombo, C., Barbini, B., Lorenzi, C., Campori, E., & Smeraldi, E. (2003) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20038 · Cited by 324 · see citing works
Association study of eight circadian genes with bipolar I disorder, schizoaffective disorder and schizophrenia
Mansour, H. A., Wood, J., Logue, T., Chowdari, K. V., Dayal, M., Kupfer, D. J., Monk, T. H., Devlin, B., & Nimgaonkar, V. L. (2006) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2005.00147.x · Cited by 293 · see citing works
Melatonin in mood disorders
Srinivasan, V., Smits, M., Spence, W., Lowe, A. D., Kayumov, L., Pandi-Perumal, S. R., Parry, B., & Cardinali, D. P. (2006) · The World Journal of Biological Psychiatry · doi:10.1080/15622970600571822 · Cited by 292 · see citing works
The histone methyltransferase MLL1 permits the oscillation of circadian gene expression
Katada, S., & Sassone‐Corsi, P. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1961 · Cited by 291 · see citing works
A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3β
Hirota, T., Lewis, W. G., Liu, A. C., Lee, J. W., Schultz, P. G., & Kay, S. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811410106 · Cited by 283 · see citing works
Three circadian clock genes Per2, Arntl, and Npas2 contribute to winter depression
Partonen, T., Treutlein, J., Alpman, A., Frank, J., Johansson, C. H., Depner, M., Aron, L., Rietschel, M., Wellek, S., Soronen, P., et al. (2007) · Annals of Medicine · doi:10.1080/07853890701278795 · Cited by 264 · see citing works
Rapid and Sustained Antidepressant Response with Sleep Deprivation and Chronotherapy in Bipolar Disorder
Wu, J. C., Kelsoe, J. R., Schachat, C., Bunney, B. G., DeModena, A., Golshan, S., Gillin, J. C., Potkin, S. G., & Bunney, W. E. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.02.018 · Cited by 263 · see citing works
Circadian misalignment in major depressive disorder
Emens, J., Lewy, A., Kinzie, J. M., Arntz, D., & Rough, J. (2009) · Psychiatry Research · doi:10.1016/j.psychres.2009.04.009 · Cited by 253 · see citing works
Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes
Meng, Q., Maywood, E. S., Bechtold, D. A., Lu, W., Li, J., Gibbs, J. E., Dupré, S. M., Chesham, J. E., Rajamohan, F., Knafels, J. D., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005101107 · Cited by 253 · see citing works
Knockdown of Clock in the Ventral Tegmental Area Through RNA Interference Results in a Mixed State of Mania and Depression-Like Behavior
Mukherjee, S., Coque, L., Cao, J., Kumar, J., Chakravarty, S., Asaithamby, A., Graham, A., Gordon, E., Enwright, J. F., Dileone, R., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.04.031 · Cited by 249 · see citing works
Self-citation
Endogenous Dopamine Regulates the Rhythm of Expression of the Clock Protein PER2 in the Rat Dorsal Striatum via Daily Activation of D2Dopamine Receptors
Hood, S., Cassidy, P., Cossette, M.-P., Weigl, Y., Verwey, M., Robinson, B., Stewart, J., & Amir, S. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.2128-10.2010 · Cited by 246 · see citing works
Diurnal modulation of pacemaker potentials and calcium current in the mammalian circadian clock
Pennartz, C. M. A., de Jeu, M. T. G., Bos, N. P. A., Schaap, J., & Geurtsen, A. M. S. (2002) · Nature · doi:10.1038/nature728 · Cited by 234 · see citing works
Circadian polymorphisms associated with affective disorders
Kripke, D. F., Nievergelt, C. M., Joo, E., Shekhtman, T., & Kelsoe, J. R. (2009) · Journal of Circadian Rhythms · doi:10.1186/1740-3391-7-2 · Cited by 225 · see citing works
The mouse Clock mutation reduces circadian pacemaker amplitude and enhances efficacy of resetting stimuli and phase–response curve amplitude
Vitaterna, M. H., Ko, C. H., Chang, A., Buhr, E. D., Fruechte, E. M., Schook, A. C., Antoch, M. P., Turek, F. W., & Takahashi, J. S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603601103 · Cited by 222 · see citing works
Influence of light at night on murine anxiety- and depressive-like responses
Fonken, L. K., Finy, M. S., Walton, J. C., Weil, Z. M., Workman, J. L., Ross, J., & Nelson, R. J. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.07.001 · Cited by 209 · see citing works
Genetic variation of melatonin productivity in laboratory mice under domestication
Kasahara, T., Abe, K., Mekada, K., Yoshiki, A., & Kato, T. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914399107 · Cited by 206 · see citing works
Signaling mediated by the dopamine D2 receptor potentiates circadian regulation by CLOCK:BMAL1
Yujnovsky, I., Hirayama, J., Doi, M., Borrelli, E., & Sassone‐Corsi, P. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510691103 · Cited by 199 · see citing works
Light deprivation damages monoamine neurons and produces a depressive behavioral phenotype in rats
González, M. M. C., & Aston‐Jones, G. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703615105 · Cited by 196 · see citing works
Selective Inhibition of Casein Kinase 1ϵ Minimally Alters Circadian Clock Period
Walton, K. M., Fisher, K., Rubitski, D., Marconi, M., Meng, Q.-J., Sládek, M., Adams, J., Bass, M., Chandrasekaran, R., Butler, T., et al. (2009) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.151415 · Cited by 184 · see citing works
Phase relationships between core body temperature, melatonin, and sleep are associated with depression severity: Further evidence for circadian misalignment in non-seasonal depression
Hasler, B. P., Buysse, D. J., Kupfer, D. J., & Germain, A. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2010.04.027 · Cited by 177 · see citing works
Clock genes outside the suprachiasmatic nucleus involved in manifestation of locomotor activity rhythm in rats
Masubuchi, S., Honma, S., Abe, H., Ishizaki, K., Namihira, M., Ikeda, M., & Honma, K. (2000) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2000.01313.x · Cited by 177 · see citing works
The Mouse Clock Mutation Behaves as an Antimorph and Maps Within the W19H Deletion, Distal of Kit
King, D. P., Vitaterna, M. H., Chang, A., Dove, W. F., Pinto, L. H., Turek, F. W., & Takahashi, J. S. (1997) · Genetics · doi:10.1093/genetics/146.3.1049 · Cited by 162 · see citing works
Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia
Mansour, H. A., Talkowski, M. E., Wood, J., Chowdari, K. V., McClain, L., Prasad, K., Montrose, D., Fagiolini, A., Friedman, E. S., Allen, M. H., et al. (2009) · Bipolar Disorders · doi:10.1111/j.1399-5618.2009.00756.x · Cited by 161 · see citing works
CRY2 Is Associated with Depression
Lavebratt, C., Sjöholm, L. K., Soronen, P., Paunio, T., Vawter, M. P., Bunney, W. E., Adolfsson, R., Forsell, Y., Wu, J. C., Kelsoe, J. R., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009407 · Cited by 155 · see citing works
Mitogen-activated Protein Kinase Phosphorylates and Negatively Regulates Basic Helix-Loop-Helix-PAS Transcription Factor BMAL1
Sanada, K., Okano, T., & Fukada, Y. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m107850200 · Cited by 151 · see citing works
A length polymorphism in the circadian clock gene Per3 influences age at onset of bipolar disorder
Benedetti, F., Dallaspezia, S., Colombo, C., Pirovano, A., Marino, E., & Smeraldi, E. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.09.002 · Cited by 149 · see citing works
Social Stress in Tree Shrews as an Animal Model of Depression: An Example of a Behavioral Model of a CNS Disorder
Fuchs, E. (2005) · CNS Spectrums · doi:10.1017/s1092852900010038 · Cited by 145 · see citing works
A serine cluster mediates BMAL1-dependent CLOCK phosphorylation and degradation
Spengler, M. L., Kuropatwinski, K. K., Schumer, M. E., & Antoch, M. P. (2009) · Cell Cycle · doi:10.4161/cc.8.24.10273 · Cited by 145 · see citing works
Mutagenesis and mapping of a mouse gene, Clock, essential for circadian …
Vitaterna, M. H. (1994) · Science · Cited by 144 · see citing works
In VivoResetting of the Hamster Circadian Clock by 5-HT7Receptors in the Suprachiasmatic Nucleus
Ehlen, J. C., Grossman, G. H., & Glass, J. D. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-14-05351.2001 · Cited by 139 · see citing works
Ghrelin's Roles in Stress, Mood, and Anxiety Regulation
Chuang, J.-C., & Zigman, J. M. (2010) · International Journal of Peptides · doi:10.1155/2010/460549 · Cited by 135 · see citing works
Circadian Regulation of Arousal: Role of the Noradrenergic Locus Coeruleus System and Light Exposure
González, M. M. C., & Aston‐Jones, G. (2006) · SLEEP · doi:10.1093/sleep/29.10.1327 · Cited by 134 · see citing works
Rhythms and the pharmacology of lithium
Klemfuss, H. (1992) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(92)90037-z · Cited by 134 · see citing works
DYRK1A and Glycogen Synthase Kinase 3β, a Dual-Kinase Mechanism Directing Proteasomal Degradation of CRY2 for Circadian Timekeeping
Kurabayashi, N., Hirota, T., Sakai, M., Sanada, K., & Fukada, Y. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.01047-09 · Cited by 134 · see citing works
CK2α phosphorylates BMAL1 to regulate the mammalian clock
Tamaru, T., Hirayama, J., Isojima, Y., Nagai, K., Norioka, S., Takamatsu, K., & Sassone‐Corsi, P. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1578 · Cited by 131 · see citing works
Shiftwork as a Risk Factor for Depression: A Pilot Study.
Scott, Monk, T., & Brink, L. (1997) · PubMed · Cited by 129 · see citing works
Orexin/Hypocretin Modulates Response of Ventral Tegmental Dopamine Neurons to Prefrontal Activation: Diurnal Influences
Moorman, D. E., & Aston‐Jones, G. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2871-10.2010 · Cited by 127 · see citing works
Anxiety and increased 5-HT1A receptor response in NCAM null mutant mice
Stork, O., Welzl, H., Wotjak, C. T., Hoyer, D., Delling, M., Cremer, H., & Schachner, M. (1999) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(19990905)40:3 · Cited by 127 · see citing works
Exposure to chronic constant light impairs spatial memory and influences long-term depression in rats
Ma, W., Cao, J., Tian, M., Cui, M., Han, H., Yang, Y., & Xu, L. (2007) · Neuroscience Research · doi:10.1016/j.neures.2007.06.1474 · Cited by 125 · see citing works
The phase shift hypothesis for the circadian component of winter depression
Lewy, A. J., Rough, J. N., Songer, J. B., Mishra, N., Yuhas, K., & Emens, J. S. (2007) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2007.9.3/alewy · Cited by 125 · see citing works
Methamphetamine‐induced, suprachiasmatic nucleus‐independent circadian rhythms of activity and mPer gene expression in the striatum of the mouse
Iijima, M., Nikaido, T., Akiyama, M., Moriya, T., & Shibata, S. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02140.x · Cited by 122 · see citing works
Fluoxetine Modulates the Circadian Biological Clock via Phase Advances of Suprachiasmatic Nucleus Neuronal Firing
Sprouse, J., Braselton, J., & Reynolds, L. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.003 · Cited by 122 · see citing works
Melatonin analogues as agonists and antagonists in the circadian system and other brain areas
Ying, S.-W., Rusak, B., Delagrange, P., Mocaër, E., Renard, P., & Guardiola-Lemaître, B. (1996) · European Journal of Pharmacology · doi:10.1016/0014-2999(95)00684-2 · Cited by 114 · see citing works
The Effects of Social Defeat and Other Stressors on the Expression of Circadian Rhythms
Meerlo, P., Sgoifo, A., & Turek, F. W. (2002) · Stress · doi:10.1080/102538902900012323 · Cited by 111 · see citing works
Sand rats see the light: Short photoperiod induces a depression-like response in a diurnal rodent
Einat, H., Kronfeld‐Schor, N., & Eilam, D. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.06.006 · Cited by 108 · see citing works
The circadian Clock mutation increases exploratory activity and escape-seeking behavior
Easton, A., Arbuzova, J., & Turek, F. W. (2003) · Genes, Brain and Behavior · doi:10.1034/j.1601-183x.2003.00002.x · Cited by 107 · see citing works
A Hierarchical Phosphorylation Cascade That Regulates the Timing of PERIOD Nuclear Entry Reveals Novel Roles for Proline-Directed Kinases and GSK-3β/SGG in Circadian Clocks
Ko, H. W., Kim, E. Y., Chiu, J. C., Vanselow, J. T., Kramer, A., & Edery, I. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1586-10.2010 · Cited by 107 · see citing works
Effect of lithium on the circadian rhythms of locomotor activity and glycogen synthase kinase-3 protein expression in the mouse suprachiasmatic nuclei
Iwahana, E., Akiyama, M., Miyakawa, K., Uchida, A., Kasahara, J., Fukunaga, K., Hamada, T., & Shibata, S. (2004) · European Journal of Neuroscience · doi:10.1111/j.0953-816x.2004.03322.x · Cited by 103 · see citing works
Prenatal stress induces a phase advance of circadian corticosterone rhythm in adult rats which is prevented by postnatal stress
Koehl, M., Barbazanges, A., Moal, M. L., & Maccari, S. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00394-6 · Cited by 100 · see citing works
Affective responses to changes in day length in Siberian hamsters (Phodopus sungorus)
Prendergast, B. J., & Nelson, R. J. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2004.08.008 · Cited by 100 · see citing works
Circadian Rhythms, the Mesolimbic Dopaminergic Circuit, and Drug Addiction
McClung, C. A. (2007) · The Scientific World JOURNAL · doi:10.1100/tsw.2007.213 · Cited by 99 · see citing works
Self-citation
Lithium- and Valproate-Induced Alterations in Circadian Locomotor Behavior in Drosophila
Dokucu, M. E., Yu, L., & Taghert, P. H. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300764 · Cited by 96 · see citing works
Comparing Clockworks: Mouse versus Fly
Reppert, S. M., & Weaver, D. R. (2000) · Journal of Biological Rhythms · doi:10.1177/074873000129001459 · Cited by 95 · see citing works
Reversible Protein Phosphorylation Regulates Circadian RhythmsPreprint
Virshup, D. M., Eide, E. J., Forger, D. B., Gallego, M., & Vielhaber, E. L. (2007) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2007.72.048 · Cited by 93 · see citing works
Enduring effects of photoperiod on affective behaviors in Siberian hamsters (Phodopus sungorus).
Pyter, L. M., & Nelson, R. J. (2006) · Behavioral Neuroscience · doi:10.1037/0735-7044.120.1.125 · Cited by 88 · see citing works
Association study of clock gene (CLOCK) and schizophrenia and mood disorders in the Japanese population
Kishi, T., Kitajima, T., Ikeda, M., Yamanouchi, Y., Kinoshita, Y., Kawashima, K., Okochi, T., Okumura, T., Tsunoka, T., Inada, T., et al. (2009) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-009-0869-4 · Cited by 87 · see citing works
Lithium Ameliorates Nucleus Accumbens Phase-Signaling Dysfunction in a Genetic Mouse Model of Mania
Dzirasa, K., Coque, L., Sidor, M. M., Kumar, S., Dancy, E. A., Takahashi, J. S., McClung, C. A., & Nicolelis, M. A. L. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4289-10.2010 · Cited by 85 · see citing works
Self-citation
We are in the dark here: induction of depression- and anxiety-like behaviours in the diurnal fat sand rat, by short daylight or melatonin injections
Ashkenazy, T., Einat, H., & Kronfeld-Schor, N. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708009115 · Cited by 81 · see citing works
CRY2 Is Associated with Rapid Cycling in Bipolar Disorder Patients
Sjöholm, L. K., Backlund, L., Cheteh, E. H., Ek, I. R., Frisén, L., Schalling, M., Ösby, U., Lavebratt, C., & Nikamo, P. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012632 · Cited by 80 · see citing works
Bidirectional interactions between the circadian and reward systems: is restricted food access a unique zeitgeber?
Webb, I. C., Baltazar, R. M., Lehman, M. N., & Coolen, L. M. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06966.x · Cited by 79 · see citing works
Does gene deletion of AMPA GluA1 phenocopy features of schizoaffective disorder?
Fitzgerald, P. J., Barkus, C., Feyder, M. J., Wiedholz, L. M., Chen, Y.-C., Karlsson, R., Machado‐Vieira, R., Graybeal, C., Sharp, T., Zarate, C. A., et al. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.08.005 · Cited by 79 · see citing works
Rhythmicity in mice selected for extremes in stress reactivity: behavioural, endocrine and sleep changes resembling endophenotypes of major depression
Touma, C., Fenzl, T., Ruschel, J., Palme, R., Holsboer, F., Kimura, M., & Landgraf, R. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004325 · Cited by 77 · see citing works
In Vivo Assessment of the Midbrain Raphe Nuclear Regulation of Serotonin Release in the Hamster Suprachiasmatic Nucleus
Dudley, T. E., DiNardo, L. A., & Glass, J. D. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.81.4.1469 · Cited by 72 · see citing works
It is darkness and not light: Depression-like behaviors of diurnal unstriped Nile grass rats maintained under a short photoperiod schedule
Ashkenazy-Frolinger, T., Kronfeld‐Schor, N., Juetten, J., & Einat, H. (2009) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2009.11.013 · Cited by 70 · see citing works
Effects of bright light treatment on depression- and anxiety-like behaviors of diurnal rodents maintained on a short daylight schedule
Ashkenazy-Frolinger, T., Einat, H., & Kronfeld‐Schor, N. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.03.005 · Cited by 69 · see citing works
Effect of lesioning the suprachiasmatic nuclei on behavioral despair in rats
Tataroğlu, Ö., Aksoy, A., Yılmaz, A., & Canbeyli, R. (2004) · Brain Research · doi:10.1016/j.brainres.2003.11.063 · Cited by 69 · see citing works
Importance of early lighting conditions in maternal care by dam as well as anxiety and memory later in life of offspring
Toki, S., Morinobu, S., Imanaka, A., Yamamoto, S., Yamawaki, S., & Honma, K. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05288.x · Cited by 69 · see citing works
Entrainment of Rat Circadian Rhythms by the Melatonin Agonist S-20098 Requires Intact Suprachiasmatic Nuclei But Not the Pineal
Redman, J. R., & Francis, A. J. P. (1998) · Journal of Biological Rhythms · doi:10.1177/074873098128999907 · Cited by 65 · see citing works
Comparative effects of a melatonin agonist on the circadian system in mice and Syrian hamsters
Reeth, O. V., Olivares, E., Zhang, Y., Zee, P. C., Mocaër, E., Defrance, R., & Turek, F. W. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00382-x · Cited by 64 · see citing works
Period lengthening of human circadian rhythms by lithium carbonate, a prophylactic for depressive disorders.
Johnsson, A., Engelmann, W., Pflug, B., & Klemke, W. (1983) · PubMed · Cited by 64 · see citing works
Molecular control of circadian rhythms
Rosbash, M. (1995) · Current Opinion in Genetics & Development · doi:10.1016/0959-437x(95)80037-9 · Cited by 61 · see citing works
Ethanol self-administration and reinstatement of ethanol-seeking behavior in Per1 Brdm1 mutant mice
Zghoul, T., Abarca, C., Sanchis‐Segura, C., Albrecht, U., Schumann, G., & Spanagel, R. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0592-z · Cited by 60 · see citing works
Anxiolytic-like action of the antidepressant agomelatine (S 20098) after a social defeat requires the integrity of the SCN
Tuma, J., Strubbe, J. H., Mocaër, E., & Koolhaas, J. M. (2005) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2005.02.004 · Cited by 60 · see citing works
Autorhythmometry in manic-depressives.
Atkinson, M., Kripke, D. F., & Wolf, S. R. (1976) · PubMed · Cited by 60 · see citing works
The role of microRNAs (miRNA) in circadian rhythmicity
Pegoraro, M., & Tauber, E. (2008) · Journal of Genetics · doi:10.1007/s12041-008-0073-8 · Cited by 51 · see citing works
Spotlight on post-transcriptional control in the circadian system
Staiger, D., & Köster, T. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0513-5 · Cited by 50 · see citing works
Affective and Adrenocorticotrophic Responses to Photoperiod in Wistar Rats
Prendergast, B. J., & Kay, L. M. (2007) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2007.01633.x · Cited by 48 · see citing works
The Use of Animal Models in Psychiatric Research and Treatment
Krishnan, V., Berton, O., & Nestler, E. J. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.08071076 · Cited by 44 · see citing works
Posttranscriptional Regulation of Mammalian Circadian Clock OutputPreprint
Garbarino‐Pico, E., & Green, C. B. (2007) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2007.72.022 · Cited by 41 · see citing works
Psychiatric aspects of shiftwork.
Cole, R. J., Loving, R. T., & Kripke, D. F. (1990) · PubMed · Cited by 39 · see citing works
Inhibition of casein kinase I ε/δ produces phase shifts in the circadian rhythms of Cynomolgus monkeys
Sprouse, J. S., Reynolds, L. S., Swanson, T. A., & Engwall, M. J. A. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1503-x · Cited by 31 · see citing works
Circadian Rhythm Phase Advance with Dawn Simulation Treatment for Winter Depression
Terman, M., & Terman, J. S. (2010) · Journal of Biological Rhythms · doi:10.1177/0748730410374000 · Cited by 31 · see citing works
Chronic treatment with a selective inhibitor of casein kinase I δ/ε yields cumulative phase delays in circadian rhythms
Sprouse, J. S., Reynolds, L. S., Kleiman, R. J., Tate, B. A., Swanson, T. A., & Pickard, G. E. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1860-5 · Cited by 30 · see citing works
An Overview of Seasonal Affective Disorder and its Treatment Options
Howland, R. H. (2009) · The Physician and Sportsmedicine · doi:10.3810/psm.2009.12.1748 · Cited by 28 · see citing works
Managing Weight Gain in Patients With Severe Mental Illness
McIntyre, R. S. (2009) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.7075cc4c · Cited by 12 · see citing works
P.2.d.005 Comparison of agomelatine and melatonin for effects in chronically stressed tree shrews, an animal model of depression
Corbach, S., Schmelting, B., Fuchs, E., et al. (2007) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(07)70534-5 · Cited by 9 · see citing works
Monitoring of Circadian Rhythms of Heart Rate, Locomotor Activity, and Temperature for Diagnosis and Evaluation of Response to Treatment in an Animal Model of Depression
Friedman, A., Shaldubina, A., Flaumenhaft, Y., Weizman, A., & Yadid, G. (2010) · Journal of Molecular Neuroscience · doi:10.1007/s12031-010-9441-y · Cited by 8 · see citing works
Stress and disease
Birley, J. L. T. (1972) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(72)90004-9 · Cited by 6 · see citing works
The role of the hypothalamic neuropeptides hypocretin/orexin in the sleep-wake cycle.
Salín-Pascual, R. J. (2001) · PubMed · Cited by 5 · see citing works
[The effect of damage to the hypothalamic suprachiasmatic nuclei in rats on the dynamic short-period fluctuations of their normal and abnormal behaviors].
Arushanian, E. B., & Popov, A. V. (1994) · PubMed · Cited by 3 · see citing works

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Rhythms of life: circadian disruption and brain disorders across the lifespan
Logan, R. W., & McClung, C. A. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0088-y · Cited by 713 · see citing works
Self-citation
How might circadian rhythms control mood? Let me count the ways
McClung, C. A. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.02.019 · Cited by 507 · see citing works
Self-citation
The circadian clock and pathology of the ageing brain
Kondratova, A. A., & Kondratov, R. V. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3208 · Cited by 482 · see citing works
Lifestyle medicine for depression
Sarris, J., O’Neil, A., Coulson, C. E., Schweitzer, I., & Berk, M. (2014) · BMC Psychiatry · doi:10.1186/1471-244x-14-107 · Cited by 450 · see citing works
Efficacy of Bright Light Treatment, Fluoxetine, and the Combination in Patients With Nonseasonal Major Depressive Disorder: A Randomized Clinical Trial
Lam, R. W., Levitt, A. J., Levitan, R. D., Michalak, E. E., Cheung, A. H., Morehouse, R., Ramasubbu, R., Yatham, L. N., & Tam, E. M. (2016) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2015.2235 · Cited by 275 · see citing works
CHRONOTYPE ASSOCIATIONS WITH DEPRESSION AND ANXIETY DISORDERS IN A LARGE COHORT STUDY: Research Article: Chronotypes in Depression and Anxiety
Antypa, N., Vogelzangs, N., Meesters, Y., Schoevers, R., & Penninx, B. W. J. H. (2016) · Depression and Anxiety · doi:10.1002/da.22422 · Cited by 252 · see citing works
Physiological feelings
Pace-Schott, E. F., Amole, M. C., Aue, T., Balconi, M., Bylsma, L. M., Critchley, H., Demaree, H. A., Friedman, B. H., Gooding, A. E. K., Gosseries, O., et al. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.05.002 · Cited by 221 · see citing works
“Recent work on circadian factors influencing risk of affective disorders have revealed extensive interactions between key emotion regulatory neurotransmitters such as dopamine and the genes controlling the molecular circadian clock (McClung, 2007, 2011, 2013).”
The mammalian circadian clock and its entrainment by stress and exercise
Tahara, Y., Aoyama, S., & Shibata, S. (2017) · The Journal of Physiological Sciences · doi:10.1007/s12576-016-0450-7 · Cited by 198 · see citing works
A PERIOD3 variant causes a circadian phenotype and is associated with a seasonal mood trait
Zhang, L., Hirano, A., Hsu, P.-K., Jones, C. R., Sakai, N., Okuro, M., McMahon, T., Yamazaki, M., Xu, Y., Saigoh, N., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1600039113 · Cited by 169 · see citing works
Influence of the modern light environment on mood
Bedrosian, T. A., & Nelson, R. J. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.70 · Cited by 172 · see citing works
Links between circadian rhythms and psychiatric disease
Karatsoreos, I. N. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00162 · Cited by 146 · see citing works
Future Research Directions in Sleep and ADHD: Report of a Consensus Working Group
Owens, J., Gruber, R., Brown, T., Corkum, P., Cortese, S., O’Brien, L., Stein, M., & Weiss, M. (2013) · Journal of Attention Disorders · doi:10.1177/1087054712457992 · Cited by 143 · see citing works
Brains in the city: Neurobiological effects of urbanization
Lambert, K. G., Nelson, R. J., Jovanovic, T., & Cerdá, M. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.04.007 · Cited by 142 · see citing works
Circadian depression: A mood disorder phenotype
Carpenter, J. S., Crouse, J. J., Scott, E. M., Naismith, S. L., Wilson, C., Scott, J., Merikangas, K. R., & Hickie, I. B. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.02.045 · Cited by 114 · see citing works
Sleep- and circadian rhythm–associated pathways as therapeutic targets in bipolar disorder
Bellivier, F., Geoffroy, P.-A., Etain, B., & Scott, J. (2015) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2015.1018822 · Cited by 104 · see citing works
Motor-Activity Markers of Circadian Timekeeping Are Related to Ketamine’s Rapid Antidepressant Properties
Duncan, W. C., Slonena, E., Hejazi, N. S., Brutsche, N., Yu, K. C., Park, L., Ballard, E. D., & Zarate, C. A. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.03.011 · Cited by 93 · see citing works
Circadian Forced Desynchrony of the Master Clock Leads to Phenotypic Manifestation of Depression in Rats
Ben-Hamo, M., Larson, T. A., Duge, L. S., Sikkema, C., Wilkinson, C. W., de la Iglesia, H. O., & González, M. M. C. (2016) · eneuro · doi:10.1523/eneuro.0237-16.2016 · Cited by 57 · see citing works
NPAS2 Regulation of Anxiety-Like Behavior and GABAA Receptors
Ozburn, A. R., Kern, J., Parekh, P. K., Logan, R. W., Liu, Z., Falcon, E., Becker-Krail, D., Purohit, K., Edgar, N. M., Huang, Y., et al. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00360 · Cited by 49 · see citing works
“…are strongly associated with psychiatric diseases like seasonal affective disorder, bipolar disorder, major depression and drug addiction (Mukherjee et al., 2010; McClung, 2011; SalgadoDelgado et al., 2011; Hasler et al., 2012; McCarthy and Welsh, 2012; Li et al., 2013; McCarthy et al., 2013).”
BackgroundSelf-citation
Depressive Symptoms and Circadian Activity Rhythm Disturbances in Community-Dwelling Older Women
Maglione, J. E., Ancoli-Israel, S., Peters, K. W., Paudel, M. L., Yaffe, K., Ensrud, K. E., Tranah, G. J., & Stone, K. L. (2014) · The American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2012.09.003 · Cited by 49 · see citing works
Treatment of depression with low-strength transcranial pulsed electromagnetic fields: A mechanistic point of view
van Belkum, S. M., Bosker, F. J., Kortekaas, R., Beersma, D. G. M., & Schoevers, R. A. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.07.006 · Cited by 29 · see citing works
Are 24-hour motor activity patterns associated with continued rapid response to ketamine?
Duncan Jr, W. C., Slonena, E. E., Hejazi, N. S., Brutsche, N., Park, L. T., Henter, I. D., Ballard, E. D., & Zarate Jr, C. A. (2018) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s172089 · Cited by 17 · see citing works
Light therapy for bipolar disorders: Clinical recommendations from the international society for bipolar disorders (ISBD) Chronobiology and Chronotherapy Task Force
Geoffroy, P. A., Palagini, L., Henriksen, T. E. G., Bourgin, P., Garbazza, C., Gronfier, C., Esaki, Y., Fernandez, D. C., Lam, R. W., Lee, H.-J., et al. (2025) · Dialogues in Clinical Neuroscience · doi:10.1080/19585969.2025.2533806 · Cited by 10 · see citing works

Circadian Rhythms in the CNS and Peripheral Clock Disorders: The Circadian Clock and Hyperlipidemia
Kudo, T., Horikawa, K., & Shibata, S. (2007) · Journal of Pharmacological Sciences · doi:10.1254/jphs.fmj06003x3 · Cited by 33 · see citing works
Circadian clock genes are differentially modulated during the daily cycles and chronological age in the social honeybee (Apis mellifera)
de Abreu, F. C. P., Freitas, F. C. D. P., & Simões, Z. L. P. (2018) · Apidologie · doi:10.1007/s13592-017-0558-7 · Cited by 8 · see citing works
Rat photoreceptor circadian oscillator strongly relies on lighting conditions
Sandu, C., Hicks, D., & Felder‐Schmittbuhl, M. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07772.x · Cited by 51 · see citing works
Potential Roles of Dec and Bmal1 Genes in Interconnecting Circadian Clock and Energy Metabolism
Sato, F., Kohsaka, A., BHAWAL, U. K., & Muragaki, Y. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030781 · Cited by 78 · see citing works
Insight Into the Circadian Clock Within Rat Colonic Epithelial Cells
Sládek, M., Rybová, M., Jindráková, Z., Zemanová, Z., Polidarová, L., Mrnka, L., O'Neill, J. S., Pácha, J., & Sumová, A. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.05.053 · Cited by 156 · see citing works

Authors: McClung, C. A.
Affiliations: University of Pittsburgh (US)
Corresponding author: McClung, Colleen A.
ORCID: McClung, Colleen A.
Venue: European Neuropsychopharmacology
Publisher: Elsevier BV
Published: 2011-09
Volume: 21
Pages: S683-S693
ISSN: 0924-977X (ISSN-L)
DOI: 10.1016/j.euroneuro.2011.07.008
PMC: PMC3179573
OpenAlex: W2061359031
Cited by: 169
References: 139
Citations by year: 2026: 7 · 2025: 11 · 2024: 4 · 2023: 8 · 2022: 10 · 2021: 8 · 2020: 12 · 2019: 4 · 2018: 12 · 2017: 17 · 2016: 20 · 2015: 19 · 2014: 14 · 2013: 13 · 2012: 9
FWCI: 1.21
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: European Neuropsychopharmacology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (R01MH082876)
National Institute on Drug Abuse (R01DA023988)
National Institute of Neurological Disorders and Stroke (R21NS058339)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: circadian rhythm, mood regulation, circadian genes, major depressive disorder, bipolar disorder, seasonal affective disorder, sleep-wake cycle, circadian clock, light manipulation, chronic stress, antidepressants, mood stabilizers, neurotransmitter systems
MeSH terms: Affect, Animals, Circadian Rhythm, Drug Evaluation, Preclinical, Cricetinae, Humans, Stress, Psychological, Suprachiasmatic Nucleus, Mood Disorders, Models, Animal, Mice, Rats

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Circadian rhythms and mood regulation: insights from pre-clinical models

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