Association study of eight circadian genes with bipolar I disorder, schizoaffective disorder and schizophrenia
Open accessAbstract
We hypothesize that circadian dysfunction could underlie, at least partially, the liability for bipolar 1 disorder (BD1). Our hypothesis motivated tests for the association between the polymorphisms of genes that mediate circadian function and liability for BD1. The US Caucasian patients with BD1 (DSM‐IV criteria) and available parents were recruited from Pittsburgh and surrounding areas (n = 138 cases, 196 parents) and also selected from the NIMH Genetics Collaborative Initiative (n = 96 cases, 192 parents). We assayed 44 informative single‐nucleotide polymorphisms (SNPs) from eight circadian genes in the BD1 samples. A population‐based sample, specifically cord blood samples from local live births, served as community‐based controls (n = 180). It was used as a contrast for genotype and haplotype distributions with those of patients. US patients with schizophrenia/schizoaffective disorder (SZ/SZA, n = 331) and available parents from Pittsburgh (n = 344) were assayed for a smaller set of SNPs based on the results from the BD1 samples. Modest associations with SNPs at ARNTL (BmaL1) and TIMELESS genes were observed in the BD1 samples. The associations were detected using family‐based and case–control analyses, albeit with different SNPs. Associations with TIMELESS and PERIOD3 were also detected in the Pittsburgh SZ/SZA group. Thus far, evidence for association between specific SNPs at the circadian gene loci and BD1 is tentative. Additional studies using larger samples are required to evaluate the associations reported here.
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An earlier and smaller study identified modest associations for PERIOD3 and TIMELESS in patients with schizophrenia.
“An earlier and smaller study also identified modest associations for PERIOD3 and TIMELESS in patients with SZ163.”
From Circadian rhythm disruption and mental health (2020) · cites this paper as [163]
Other studies that examined SNPs throughout the sequence of some central members of the circadian clock have found no associations with these genes and any psychiatric disorders.
“other studies that have examined SNPs throughout the sequence of some of the central members of the circadian clock have found no associations with these genes and any psychiatric disorders (Shiino et al., 2003; Nievergelt et al., 2005; Mansour et al., 2006; Nievergelt et al., 2006).”
From Circadian genes, rhythms and the biology of mood disorders (2007) · cites this paper as Mansour et al., 2006
A SNP in BMAL1 associates with bipolar disorder.
“a SNP in BMAL1 and a SNP in the Timeless gene have also been identified that associate with BPD (Mansour et al., 2006).”
From Circadian genes, rhythms and the biology of mood disorders (2007) · cites this paper as Mansour et al., 2006
A SNP in the Timeless gene associates with bipolar disorder.
“a SNP in BMAL1 and a SNP in the Timeless gene have also been identified that associate with BPD (Mansour et al., 2006).”
From Circadian genes, rhythms and the biology of mood disorders (2007) · cites this paper as Mansour et al., 2006
Additional studies have found associations between members of the molecular clock and other psychiatric disorders such as schizophrenia and alcoholism.
“additional studies have found associations between members of the molecular clock and other psychiatric disorders such as schizophrenia and alcoholism”
From Circadian genes, rhythms and the biology of mood disorders (2007) · cites this paper as Mansour et al., 2006
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Cites
Kessler, R. C. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950010008002 · Cited by 12,370 · see citing works
A self-assessment questionnaire to determine morningness- eveningness in human circadian rhythms
Home, J. K. (1976) · Medical Entomology and Zoology · Cited by 4,783 · see citing works
(1976) · PubMed · Cited by 3,979 · see citing works
Spielman, R. S., McGinnis, R. E., & Ewens, W. J. (1993) · PubMed · Cited by 3,679 · see citing works
Diagnostic Interview for Genetic Studies
Nürnberger, J. I. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950110009002 · Cited by 2,066 · see citing works
PedCheck: A Program for Identification of Genotype Incompatibilities in Linkage Analysis
O'Connell, J. R., & Weeks, D. E. (1998) · The American Journal of Human Genetics · doi:10.1086/301904 · Cited by 2,063 · see citing works
An h <i>Per2</i> Phosphorylation Site Mutation in Familial Advanced Sleep Phase Syndrome
Toh, K. L., Jones, C. R., He, Y., Eide, E. J., Hinz, W. A., Virshup, D. M., Ptáček, L. J., & Fu, Y.-H. (2001) · Science · doi:10.1126/science.1057499 · Cited by 1,460 · see citing works
Prospects for whole-genome linkage disequilibrium mapping of common disease genes
Kruglyak, L. (1999) · Nature Genetics · doi:10.1038/9642 · Cited by 1,416 · see citing works
Smith, C. S., Reilly, C., & Midkiff, K. (1989) · Journal of Applied Psychology · doi:10.1037/0021-9010.74.5.728 · Cited by 1,106 · see citing works
Archer, S. N., Robilliard, D. L., Skene, D. J., Smits, M. G., Williams, A., Arendt, J., & von Schantz, M. (2003) · SLEEP · doi:10.1093/sleep/26.4.413 · Cited by 734 · see citing works
A Generalization of the Transmission/Disequilibrium Test for Uncertain-Haplotype Transmission
Clayton, D. G. (1999) · The American Journal of Human Genetics · doi:10.1086/302577 · Cited by 634 · see citing works
A CLOCK Polymorphism Associated with Human Diurnal Preference
Katzenberg, D. R., Young, T. B., Finn, L. A., Lin, L., King, D. P., Takahashi, J. S., & Mignot, E. J.-M. (1998) · SLEEP · doi:10.1093/sleep/21.6.569 · Cited by 587 · see citing works
The transmission/disequilibrium test: history, subdivision, and admixture.
Ewens, W. J., & Spielman, R. S. (1995) · PubMed Central · Cited by 546 · see citing works
Baehr, E. K., Revelle, W., & Eastman, C. I. (2000) · Journal of Sleep Research · doi:10.1046/j.1365-2869.2000.00196.x · Cited by 530 · see citing works
Association of structural polymorphisms in the human period3 gene with delayed sleep phase syndrome
Ebisawa, T., Uchiyama, M., Kajimura, N., Mishima, K., Kamei, Y., Katoh, M., Watanabe, T., Sekimoto, M., Shibui, K., Kim, K., et al. (2001) · EMBO Reports · doi:10.1093/embo-reports/kve070 · Cited by 517 · see citing works
Genomic Control, a New Approach to Genetic-Based Association Studies
Devlin, B., Roeder, K., & Wasserman, L. (2001) · Theoretical Population Biology · doi:10.1006/tpbi.2001.1542 · Cited by 511 · see citing works
Self-citationFallin, M. D., Cohen, A., Essioux, L., Chumakov, I. M., BLUMENFELD, M. L., Cohen, D., & Schork, N. J. (2001) · Genome Research · doi:10.1101/gr.148401 · Cited by 417 · see citing works
Association and linkage analyses of RGS4 polymorphisms in schizophrenia
Chowdari, K. V. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.12.1373 · Cited by 368 · see citing works
Self-citation(1978) · PubMed · Cited by 355 · see citing works
Johansson, C., Willeit, M., Smedh, C., Ekholm, J., Paunio, T., Kieseppä, T., Lichtermann, D., Praschak-Rieder, N., Neumeister, A., Nilsson, L.-G., et al. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300121 · Cited by 341 · see citing works
Bacanu, S.-A., Devlin, B., & Roeder, K. (2000) · The American Journal of Human Genetics · doi:10.1086/302929 · Cited by 340 · see citing works
Self-citationBenedetti, F., Serretti, A., Colombo, C., Barbini, B., Lorenzi, C., Campori, E., & Smeraldi, E. (2003) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20038 · Cited by 324 · see citing works
Are schizophrenic and bipolar disorders related? A review of family and molecular studies
Berrettini, W. H. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00883-0 · Cited by 272 · see citing works
GENETIC ANALYSIS OF MORNINGNESS AND EVENINGNESS
Vink, J. M., Vink, J. M., Groot, A. S., KERKHOF, G. A., & Boomsma, D. I. (2001) · Chronobiology International · doi:10.1081/cbi-100107516 · Cited by 272 · see citing works
PBAT: tools for family-based association studies.
Lange, C., DeMeo, D., Silverman, E. K., Weiss, S. T., & Laird, N. M. (2004) · The American Journal of Human Genetics · doi:10.1086/381563 · Cited by 268 · see citing works
Serretti, A., Benedetti, F., Mandelli, L., Lorenzi, C., Pirovano, A., Colombo, C., & Smeraldi, E. (2003) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20053 · Cited by 264 · see citing works
Dominant inheritance in two families with familial Mediterranean fever (FMF).
Yuval, Y., Hemo-Zisser, M., Zemer, D., Sohar, E., & Pras, M. (1995) · American journal of medical genetics · doi:10.1002/ajmg.1320570319 · Cited by 264 · see citing works
Localization of Psoriasis-Susceptibility Locus PSORS1 to a 60-kb Interval Telomeric to HLA-C
Nair, R. P., Stuart, P. E., Henseler, T., Jenisch, S., Chia, N. V. C., Westphal, E., Schork, N. J., Kim, J. P., Lim, H. W., Christophers, E., et al. (2000) · The American Journal of Human Genetics · doi:10.1086/302932 · Cited by 259 · see citing works
Are Schizophrenic and Bipolar Disorders Related? A Review of Family and Molecular Studies
Berrettini, W. H. (2019) · Routledge eBooks · doi:10.4324/9781315054308-5 · Cited by 245 · see citing works
Circadian Phase Variation in Bipolar I Disorder
Mansour, H. A., Wood, J., Chowdari, K. V., Dayal, M., Thase, M. E., Kupfer, D. J., Monk, T. H., Devlin, B., & Nimgaonkar, V. L. (2005) · Chronobiology International · doi:10.1081/cbi-200062413 · Cited by 204 · see citing works
Self-citationRobilliard, D. L., Archer, S. N., Arendt, J., Lockley, S. W., Hack, L. M., English, J., Léger, D., Smits, M. G., Williams, A., Skene, D. J., et al. (2002) · Journal of Sleep Research · doi:10.1046/j.1365-2869.2002.00320.x · Cited by 203 · see citing works
Lithium lengthens the circadian period of individual suprachiasmatic nucleus neurons
Abe, M., Herzog, E. D., & Block, G. D. (2000) · Neuroreport · doi:10.1097/00001756-200009280-00042 · Cited by 169 · see citing works
Bipolar disorder: leads from the molecular and cellular mechanisms of action of mood stabilisers
Manji, H. K., Moore, G. J., & Chen, G. (2001) · The British Journal of Psychiatry · doi:10.1192/bjp.178.41.s107 · Cited by 138 · see citing works
Kennedy, S. H., Kutcher, S., Ralevski, E., & Brown, G. M. (1996) · Psychiatry Research · doi:10.1016/0165-1781(96)02910-1 · Cited by 133 · see citing works
A molecular perspective of human circadian rhythm disorders
Cermakian, N., & Boivin, D. B. (2003) · Brain Research Reviews · doi:10.1016/s0165-0173(03)00171-1 · Cited by 130 · see citing works
Healy, D. (1987) · Psychopharmacology · doi:10.1007/bf00187243 · Cited by 123 · see citing works
Monk, T. H., Reynolds, C. F., Buysse, D. J., Hoch, C. C., Jarrett, D. B., Jennings, J. R., & Kupfer, D. J. (1991) · Journal of Gerontology · doi:10.1093/geronj/46.5.m171 · Cited by 88 · see citing works
Self-citationThe Circadian Clock: A Manager of Biochemical Processes Within the Organism
Holzberg, D., & Albrecht, U. (2003) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2003.00992.x · Cited by 64 · see citing works
Psychiatric aspects of jet lag: review and hypothesis
Katz, G., Durst, R., Zislin, Y., Barel, Y., & Knobler, H. Y. (2001) · Medical Hypotheses · doi:10.1054/mehy.2000.1094 · Cited by 64 · see citing works
NEBEL, L. E., Howell, R. H., Krantz, D. S., Falconer, J. J., Gottdiener, J. S., & Gabbay, F. H. (1996) · Psychophysiology · doi:10.1111/j.1469-8986.1996.tb00424.x · Cited by 62 · see citing works
Lithium delays circadian phase of temperature and REM sleep in a bipolar depressive: a case report
Campbell, S. S., Gillin, J. C., Kripke, D. F., Janowsky, D. S., & Risch, S. C. (1989) · Psychiatry Research · doi:10.1016/0165-1781(89)90005-x · Cited by 59 · see citing works
Mellerup, E. T., Lauritsen, B. J., Dam, H., & Rafaelsen, O. J. (1976) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1976.tb00084.x · Cited by 56 · see citing works
Baştürk, M., Karaaslan, F., Eşel, E., Sofuoǧlu, S., Tutuş, A., & Yabanoğlu, İ. (2001) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(00)00165-2 · Cited by 55 · see citing works
Leibenluft, E., Feldman‐Naim, S., Turner, E. H., Schwartz, P. J., & Wehr, T. A. (1996) · Biological Psychiatry · doi:10.1016/0006-3223(95)00488-2 · Cited by 51 · see citing works
Mitterauer, B. (2000) · Medical Hypotheses · doi:10.1054/mehy.1999.1039 · Cited by 41 · see citing works
Linkage and association between serotonin 2A receptor gene polymorphisms and bipolar I disorder
Ranade, S., Mansour, H., Wood, J. A., Chowdari, K. V., Brar, L. K., Kupfer, D. J., & Nimgaonkar, V. L. (2003) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20070 · Cited by 41 · see citing works
Self-citationBlunted ACTH and cortisol response to afternoon tryptophan infusion in euthymic bipolar patients
Nürnberger, J. I., Berrettini, W. H., Simmons-Alling, S., Lawrence, D., & Brittain, H. (1990) · Psychiatry Research · doi:10.1016/0165-1781(90)90109-i · Cited by 28 · see citing works
Genetic Control of 24-Hour Growth Hormone Secretion in Man: A Twin Study1
Mendlewicz, J., Linkowski, P., Kerkhofs, M., Leproult, R., Copinschi, G., & Cauter, E. V. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.3.5525 · Cited by 26 · see citing works
THE LEVEL AND DIURNAL RHYTHM OF SERUM SEROTONIN IN MANIC-DEPPESSIVE PATIENTS
Sarai, K., & Kayano, M. (1968) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.1968.tb01425.x · Cited by 25 · see citing works
Genetic Control of 24-Hour Growth Hormone Secretion in Man: A Twin Study
Mendlewicz, J. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.3.856 · Cited by 25 · see citing works
Matsumoto, M., Kamata, S., Naoe, H., et al. (1996) · PubMed · Cited by 18 · see citing works
Schreiner, R., Mirisch, S., Veselý, Z., & Wiegand, M. H. (2001) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s004060170064 · Cited by 15 · see citing works
Circadian variation of serum TSH in unipolar and bipolar depression
Mendlewicz, J., & KIRKEGAARD, C. (1982) · Psychiatry Research · doi:10.1016/0165-1781(82)90076-2 · Cited by 9 · see citing works
Donnelly, S. L., Wolpert, C. M., Menold, M. M., Bass, M. P., Gilbert, J. R., Cuccaro, M. L., Delong, G. R., & Pericak-Vance, M. A. (2000) · American Journal of Medical Genetics · doi:10.1002/1096-8628(20000612)96:3
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Walker, W. H., Walton, J. C., DeVries, A. C., & Nelson, R. J. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0694-0 · Cited by 1,030 · see citing works
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Hardeland, R., Cardinali, D. P., Srinivasan, V., Spence, D. W., Brown, G. M., & Pandi-Perumal, S. R. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.12.004 · Cited by 843 · see citing works
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Roybal, K., Theobold, D., Graham, A., DiNieri, J. A., Russo, S. J., Krishnan, V., Chakravarty, S., Peevey, J., Oehrlein, N., Birnbaum, S., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609625104 · Cited by 803 · see citing works
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McClung, C. A. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.02.003 · Cited by 666 · see citing works
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Harvey, A. G., Murray, G., Chandler, R. A., & Soehner, A. (2011) · Clinical Psychology Review · doi:10.1016/j.cpr.2010.04.003 · Cited by 609 · see citing works
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Barnett, J. H., & Smoller, J. W. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.03.080 · Cited by 407 · see citing works
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Foster, R. G., Peirson, S. N., Wulff, K., Winnebeck, E., Vetter, C., & Roenneberg, T. (2013) · Progress in Molecular Biology and Translational Science · doi:10.1016/b978-0-12-396971-2.00011-7 · Cited by 224 · see citing works
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McCarthy, M. J., & Welsh, D. K. (2012) · Journal of Biological Rhythms · doi:10.1177/0748730412456367 · Cited by 203 · see citing works
Le‐Niculescu, H., Patel, S. D., Bhat, M., Kuczenski, R., Faraone, S. V., Tsuang, M. T., McMahon, F. J., Schork, N. J., Nurnberger, J. I., & Niculescu, A. B. (2009) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30887 · Cited by 201 · see citing works
GROUP investigators, Børglum, A. D., Demontis, D., Grove, J., Pallesen, J., Hollegaard, M. V., Pedersen, C. B., Hedemand, A., Mattheisen, M., Uitterlinden, A., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.2 · Cited by 186 · see citing works
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Monteleone, P., & Maj, M. (2008) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2008.06.007 · Cited by 185 · see citing works
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McCarthy, M. J., Nievergelt, C. M., Kelsoe, J. R., & Welsh, D. K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032091 · Cited by 172 · see citing works
Saus, E., Soria, V., Escaramís, G., Vivarelli, F., Crespo, J. M., Kagerbauer, B., Menchón, J. M., Urretavizcaya, M., Gratacòs, M., & Estivill, X. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq316 · Cited by 163 · see citing works
Mansour, H. A., Talkowski, M. E., Wood, J., Chowdari, K. V., McClain, L., Prasad, K., Montrose, D., Fagiolini, A., Friedman, E. S., Allen, M. H., et al. (2009) · Bipolar Disorders · doi:10.1111/j.1399-5618.2009.00756.x · Cited by 161 · see citing works
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Monti, J. M., BaHammam, A. S., Pandi-Perumal, S. R., Bromundt, V., Spence, D. W., Cardinali, D. P., & Brown, G. M. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.12.021 · Cited by 157 · see citing works
Circadian rhythms and addiction: Mechanistic insights and future directions.
Logan, R. W., Williams, W. P., & McClung, C. A. (2014) · Behavioral Neuroscience · doi:10.1037/a0036268 · Cited by 142 · see citing works
Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption
Kovanen, L., Saarikoski, S. T., Haukka, J., Pirkola, S., Aromaa, A., Lonnqvist, J., & Partonen, T. (2010) · Alcohol and Alcoholism · doi:10.1093/alcalc/agq035 · Cited by 138 · see citing works
McCarthy, M. J., Gottlieb, J. F., Gonzalez, R., McClung, C. A., Alloy, L. B., Cain, S., Dulcis, D., Etain, B., Frey, B. N., Garbazza, C., et al. (2022) · Bipolar Disorders · doi:10.1111/bdi.13165 · Cited by 136 · see citing works
Biological rhythms, higher brain function, and behavior: Gaps, opportunities, and challenges
Benca, R., Duncan, M. J., Frank, E., McClung, C., Nelson, R. J., & Vicentic, A. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.09.005 · Cited by 125 · see citing works
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Lu, G., Li, J., Zhang, H., Zhao, X., Yan, L.-J., & Yang, X. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/8596903 · Cited by 106 · see citing works
Assessment of circadian function in fibroblasts of patients with bipolar disorder
Yang, S., Van Dongen, H. P. A., Wang, K., Berrettini, W., & Bućan, M. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.10 · Cited by 113 · see citing works
Molecular aspects of circadian pharmacology and relevance for cancer chronotherapy
Ozturk, N., Ozturk, D., Kavakli, I. H., & Okyar, A. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18102168 · Cited by 106 · see citing works
Minutes, days and years: molecular interactions among different scales of biological timing
Golombek, D. A., Bussi, I. L., & Agostino, P. V. (2014) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2012.0465 · Cited by 80 · see citing works
Arey, R. N., Enwright, J. F., Spencer, S. M., Falcon, E., Ozburn, A. R., Ghose, S., Tamminga, C., & McClung, C. A. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.12 · Cited by 62 · see citing works
Role for the<i>Clock</i>Gene in Bipolar Disorder
McClung, C. A. (2007) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2007.72.031 · Cited by 57 · see citing works
Sun, H.-Q., Li, S.-X., Chen, F.-B., Zhang, Y., Li, P., Jin, M., Sun, Y., Wang, F., Mi, W.-F., Shi, L., et al. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.11.013 · Cited by 42 · see citing works
- Authors
- Mansour, H. A., Wood, J., Logue, T., Chowdari, K. V., Dayal, M., Kupfer, D. J., Monk, T. H., Devlin, B., & Nimgaonkar, V. L.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Nimgaonkar, V. L.
- Venue
- Genes, Brain and Behavior
- Publisher
- Wiley
- Published
- 2005-06-02
- Volume
- 5
- Issue
- 2
- Pages
- 150-157
- ISSN
- 1601-183X (ISSN-L)
- 1601-1848
- OpenAlex
- W2067945598
- Cited by
- 293
- References
- 54
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 9 · 2023: 6 · 2022: 9 · 2021: 14 · 2020: 9 · 2019: 7 · 2018: 13 · 2017: 16 · 2016: 21 · 2015: 19 · 2014: 23 · 2013: 15 · 2012: 17
- FWCI
- 8.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes Brain & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Aeronautics and Space Administration (NAG91234)
- University of Pittsburgh
- National Institutes of Health (MH56242, AG020677)
- National Institute on Aging (AG 020677, R01AG013396, AG13396, P01AG020677)
- National Institute of Mental Health (MH 57881, MH56242, MH 66263, R01MH063420, R01MH066263, R01MH057881, MH63420)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- circadian genes, bipolar I disorder, schizoaffective disorder, schizophrenia, single nucleotide polymorphisms, Bmal1, TIMELESS, circadian dysfunction, genetic association, family-based association, case-control association
- MeSH terms
- Biological Clocks, Bipolar Disorder, Brain Chemistry, Circadian Rhythm, DNA Mutational Analysis, Female, Gene Expression Regulation, Genetic Testing, Humans, Infant, Newborn, Male, Nerve Tissue Proteins, Nuclear Proteins, Psychotic Disorders, Schizophrenia, Transcription Factors, Genome, Human, Case-Control Studies, Cell Cycle Proteins, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Chronobiology Disorders, Intracellular Signaling Peptides and Proteins, Basic Helix-Loop-Helix Proteins, ARNTL Transcription Factors, Period Circadian Proteins
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