Circadian Phase Variation in Bipolar I Disorder
Abstract
Abnormalities in circadian rhythms are prominent features of bipolar I disorder (BD1). To investigate circadian variation in BD1, we evaluated morningness-eveningness (M/E), a stable trait reflecting circadian phase, using the composite scale (CS) among BD1 patients (DSM IV criteria; n = 75), unscreened controls (n = 349), and patients with schizophrenia (SZ) or schizoaffective disorder (SZA) (n = 81). Our analyses showed that CS scores correlated significantly with age but did not differ by gender among the controls. BD1 patients differed significantly from controls and from SZ/SZA patients when age was considered. CS scores were distributed bi-modally among BD1 cases. There are several possible reasons for the observed heterogeneity. Younger BD1 patients, and those with rapid mood swings, were significantly more likely to have lower CS scores (i.e., to score in the 'evening' range and to have later circadian phase). CS scores were also positively correlated with the age at onset and the duration of the most severe depressive episodes. These relationships were not observed among the SZ/SZA groups. Thus, distinct patterns of M/E were noted among BD1 patients and among BD1 subgroups. The impact of medication, mood state, and chronicity on CS scores needs to be considered.
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A major component of many mood, anxiety and psychotic disorders is a disrupted sleep-wake cycle.
“A major component of many mood, anxiety and psychotic disorders is a disrupted sleep–wake cycle183–188”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [185]
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Self-citation
- Authors
- Mansour, H. A., Wood, J., Chowdari, K. V., Dayal, M., Thase, M. E., Kupfer, D. J., Monk, T. H., Devlin, B., & Nimgaonkar, V. L.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Nimgaonkar, Vishwajit L.
- Venue
- Chronobiology International
- Publisher
- Informa UK Limited
- Published
- 2005-01
- Volume
- 22
- Issue
- 3
- Pages
- 571-584
- ISSN
- 0742-0528 (ISSN-L)
- 1525-6073
- OpenAlex
- W2139393158
- Cited by
- 204
- References
- 52
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 3 · 2023: 9 · 2022: 4 · 2021: 11 · 2020: 5 · 2019: 9 · 2018: 11 · 2017: 12 · 2016: 16 · 2015: 13 · 2014: 21 · 2013: 11 · 2012: 13
- FWCI
- 4.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Chronobiology International (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG 020677, R01AG013396, AG13396, P01AG020677)
- National Institute of Mental Health (MH 57881, MH56242, MH 66263, R01MH063420, R01MH066263, R01MH057881, MH63420, MH30915)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- bipolar I disorder, circadian rhythm, circadian phase, chronotype, composite scale, schizophrenia, schizoaffective disorder, age of onset, depressive episode duration
- MeSH terms
- Age Factors, Animals, Bipolar Disorder, Circadian Rhythm, Humans, Personality Tests, Psychotic Disorders, Surveys and Questionnaires, Schizophrenia, Statistics as Topic
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