CD4+ helper T cell depression in autism
Abstract
CD4+ (helper) T cells are a heterogenous population of lymphocytes including at least two distinct subpopulations. To investigate the possibility that immune abnormalities in some subjects with autism may involve abnormal distributions of CD4+ and/or CD8+ cells, (suppressor) T cells, peripheral blood lymphocytes of 25 autistic subjects were characterized with monoclonal antibodies and flow cytometry. The autistic subjects had a significantly lower percentage and number of CD4+ cells, a lower number of T cells (CD2+ cells) and B cells (CD20+ cells), and a lower percentage and number of total lymphocytes than siblings and normal subjects. The level of blood values for female subjects appeared lower than those for males as compared to normal subjects of the same sex. These results suggest that a decrease in CD4+ cells is associated with autism.
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A 1990 study suggested that CD4+ cell levels were decreased in autism.
“while a supporting 1990 study suggested CD4 + cell levels were decreased in autism (Yonk et al, 1990).”
From The Role of the Immune System in Autism Spectrum Disorder (2017) · cites this paper as Yonk et al, 1990
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Akintude, M. E., Heuer, L. S., & de Water, J. V. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-391924-3.00016-8 · Cited by 3 · see citing works
Autoimmunity in Autism Spectrum Disorders
Laila, Y. A. A. (2011) · InTech eBooks · doi:10.5772/17377 · Cited by 2 · see citing works
Мальцев, Д. В. (2022) · Immunology and Allergy Science and Practice · doi:10.37321/immunology.2021.4-01 · Cited by 2 · see citing works
Streptococcal infection-related autoimmunity and autism: crosstalk in protein functional networks
Huxley, M., Stead, J., & Vasieva, O. (2017) · Journal of Systems and Integrative Neuroscience · doi:10.15761/jsin.1000171 · Cited by 1 · see citing works
Immune Dysfunction in Autism Spectrum Disorder
Malkova, N. V., & Hsiao, E. Y. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800109-7.00005-4 · Cited by 1 · see citing works
The New Autism: One Family’s Perspective
Yazbak, K. (2002) · Clinical Child Psychology and Psychiatry · doi:10.1177/1359104502007004003 · Cited by 1 · see citing works
Bailey, A. R. (2012) · Digital Commons - University of South Florida (University of South Florida)
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- Authors
- Yonk, L. J., Warren, R. P., Burger, R. A., Cole, P., Odell, J. D., Warren, W. L., White, E., & Singh, V. K.
- Affiliations
- Utah State University (US)
- Corresponding author
- Warren, Reed P.
- ORCID
- Singh, Vijendra K.
- Venue
- Immunology Letters
- Publisher
- Elsevier BV
- Published
- 1990-09
- Volume
- 25
- Issue
- 4
- Pages
- 341-345
- ISSN
- 0165-2478 (ISSN-L)
- OpenAlex
- W2030658245
- Cited by
- 109
- References
- 11
- Citations by year
- 2026: 2 · 2024: 6 · 2023: 6 · 2022: 4 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 4 · 2015: 2 · 2014: 1 · 2013: 2 · 2012: 3
- FWCI
- 0.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Immunology Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01mh042119-10)
- National Institute of Mental Health (MH-42119)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- autism spectrum disorder, CD4+ T cells, T helper cells, CD8+ suppressor T cells, peripheral blood lymphocytes, immune abnormalities, CD2+ T cells, B cells, sex differences, lymphocyte count
- MeSH terms
- Adolescent, Adult, Autistic Disorder, Child, Child, Preschool, Family, Female, Flow Cytometry, Humans, Leukocyte Count, Male, CD4-Positive T-Lymphocytes, T-Lymphocyte Subsets
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