Cited by 130Autism Spectrum Disorder ResearchGenetic Associations and EpidemiologyGenetics and Neurodevelopmental Disorders

Strong association of the third hypervariable region of HLA-DRβ1 with autism

Warren, Reed P., Odell, J.Dennis, Warren, W.Louise, Burger, Roger A., Maciulis, Alma, Daniels, Wayne W., Torres, Anthony R.·1996·Journal of Neuroimmunology

Abstract

We reported that the major histocompatibility complex (MHC) including the null allele of the C4B gene and the extended haplotype B44-C30-DR4 is associated with autism. We report now that the third hypervariable region (HVR-3) of certain DR beta 1 alleles have very strong association with autism. The HVR-3 of DR beta 1* 0401 or the shared HVR-3 alleles DR beta 1* 0404 and DR beta 1* 0404 and DR *0101, was expressed on extended haplotypes in 23 of 50 (46%) autistic subjects as compared to only 6 of 79 (7.5%) normal subjects. Another HVR-3 sequence, the DR beta 1* 0701 allele, was carried on extended haplotypes in 16 (32.0%) of the autistic subjects as compared to 8 (10.1%) of the normal subjects.

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Crossref · 10.1016/0165-5728(96)00052-5

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23 of 23 references verified0 citation errors · 0 not checkable

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  • The hypervariable region 3 of DRB1*0401 is associated with increased relative risk for autism in children from Utah.

    “The hypervariable region 3 of DRB1*0401 has been associated with an increased relative risk for autism in children from Utah (Warren et al, 1996).”

    From The Role of the Immune System in Autism Spectrum Disorder (2017) · cites this paper as Warren et al, 1996

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Authors
Warren, R. P., Odell, J. D., Warren, W. L., Burger, R. A., Maciulis, A., Daniels, W. W., & Torres, A. R.
Affiliations
Utah State University (US)
Corresponding author
Warren, Reed P.
Venue
Journal of Neuroimmunology
Publisher
Elsevier BV
Published
1996-07
Volume
67
Issue
2
Pages
97-102
ISSN
0165-5728 (ISSN-L)
OpenAlex
W2070318406
Cited by
130
References
23
Citations by year
2025: 1 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 6 · 2016: 4 · 2015: 4 · 2014: 4 · 2013: 1 · 2012: 7
FWCI
3.54
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neuroimmunology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01mh042119-10)
  • National Institute of Mental Health (MH-42119)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords
autism spectrum disorder, HLA-DRB1, major histocompatibility complex, genetic association, extended haplotypes, HLA-DR4
MeSH terms
Alleles, Autistic Disorder, Chromosomes, Female, Haplotypes, Humans, Immunoglobulin Variable Region, Male, HLA-DR1 Antigen

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