The DOI matches its Crossref record; 12 of the 13 references it cites were found in a registry or an index.
Interleukin-10 (cytokine synthesis inhibitory factor) acts in the central nervous system of rats to reduce sleep
Abstract
Interleukin-10 (IL-10), originally designated a cytokine synthesis inhibitory factor, inhibits the synthesis of the pro-inflammatory cytokines IL-1 and tumor necrosis factor by stimulated human and mouse monocytes/macrophages; these cytokines are involved in the regulation of sleep. To determine if IL-10 reduces spontaneous sleep, we injected murine recombinant IL-10 intracerebroventricularly into rats prior to light onset. Non-rapid eye movements sleep was reduced. The behavioral responses to IL-10 were abolished by heat-inactivation of this cytokine. We believe these to be the first observations of central nervous system actions for this cytokine. These results further support the hypothesis that cytokines are involved in the regulation of sleep, and suggest an additional mechanism whereby sleep may be altered in response to an activated immune system.
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“IL‐10 inhibits synthesis of TNF‐α (212).”
From Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020) · cites this paper as [212]
Citations
Cites
IL-10 inhibits cytokine production by activated macrophages
Fiorentino, D. F., Zlotnik, A., Mosmann, T. R., Howard, M., & O’Garra, A. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.147.11.3815 · Cited by 2,888
Fiorentino, D. F., Bond, M. W., & Mosmann, T. R. (1989) · The Journal of Experimental Medicine · doi:10.1084/jem.170.6.2081 · Cited by 2,733
Interleukin-1 and interleukin-1 antagonism
Dinarello, C. A. (1991) · Blood · doi:10.1182/blood.v77.8.1627.1627 · Cited by 2,292
Moore, K. W., O’Garra, A., Malefyt, R. D. W., Vieira, P., & Mosmann, T. R. (1993) · Annual Review of Immunology · doi:10.1146/annurev.iy.11.040193.001121 · Cited by 1,883
Recombinant tumor necrosis factor and interleukin 1 enhance slow-wave sleep
Shoham, S., Davenne, D., Cady, A. B., Dinarello, C. A., & Krueger, J. M. (1987) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1987.253.1.r142 · Cited by 290
Sleep Disorders in Patients with Chronic Fatigue
Buchwald, D., Pascualy, R. A., Bombardier, C. H., & Kith, P. (1994) · Clinical Infectious Diseases · doi:10.1093/clinids/18.supplement_1.s68 · Cited by 116
Sleep, sleep deprivation and infectious disease: Studies in animals
Toth, L. A. (1995) · Advances in Neuroimmunology · doi:10.1016/0960-5428(94)00045-p · Cited by 93
Interferon alpha-2 enhances slow-wave sleep in rabbits
Krueger, J. M., Dinarello, C. A., Shoham, S., Davenne, D., Walter, J., & Kubillus, S. L. (1987) · International Journal of Immunopharmacology · doi:10.1016/0192-0561(87)90107-x · Cited by 93
Cytokine Involvement in the Regulation of Sleep
Opp, M. R., Kapás, L., & Toth, L. A. (1992) · Experimental Biology and Medicine · doi:10.3181/00379727-201-43474 · Cited by 88
Self-citationTumor necrosis factor-beta induces sleep, fever, and anorexia
Kapás, L., & Krueger, J. M. (1992) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1992.263.3.r703 · Cited by 70
Research works printed but not linked: 2
- Obál, 1990, Interleukin la and an interleukin 1β fragment are somnogenic, Am. J. Physiol., 259, R439
- Opp, 1994, Anti-interleukin-lβ reduces sleep and sleep rebound after sleep deprivation in rats, Am. J. Physiol., 266, R688
Cited by
Sorted by citations
Muscle–Organ Crosstalk: The Emerging Roles of Myokines
Severinsen, M. C. K., & Pedersen, B. K. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa016 · Cited by 1,226
“Moreover, it was shown that IL‐6‐deficient knockout mice have elevated levels of TNF‐α (214).”
InfluentialAnti-inflammatory effects of exercise: role in diabetes and cardiovascular disease
Pedersen, B. K. (2017) · European Journal of Clinical Investigation · doi:10.1111/eci.12781 · Cited by 617
Sick and tired: does sleep have a vital role in the immune system?
Bryant, P. A., Trinder, J., & Curtis, N. (2004) · Nature Reviews Immunology · doi:10.1038/nri1369 · Cited by 551
Shearer, W. T., Reuben, J. M., Mullington, J. M., Price, N. J., Lee, B.-N., Smith, E. O., Szuba, M. P., Van Dongen, H. P. A., & Dinges, D. F. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.112270 · Cited by 455
Self-citationOpp, M. R. (2005) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2005.01.002 · Cited by 393
Self-citation
Metadata
- Authors
- Opp, M. R., Smith, E. M., & Hughes, T. K.
- Affiliations
- The University of Texas Medical Branch at Galveston (US)
- Corresponding author
- Opp, M.R.
- ORCID
- Venue
- Journal of Neuroimmunology
- Publisher
- Elsevier BV
- Published
- 1995-07
- Volume
- 60
- Issue
- 1-2
- Pages
- 165-168
- ISSN
- 0165-5728 (ISSN-L)
- OpenAlex
- W2092703130
- Cited by
- 145
- References
- 13
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 2 · 2023: 2 · 2022: 9 · 2021: 11 · 2020: 9 · 2019: 11 · 2018: 8 · 2017: 3 · 2016: 7 · 2015: 1 · 2014: 2 · 2013: 5 · 2012: 3
- FWCI
- 3.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroimmunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01dk041034-06, 5r01da008354-03)
- National Institute on Drug Abuse (DA-08354)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK41034)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- IL-10, sleep regulation, NREM sleep, cytokines, central nervous system, intracerebroventricular administration, inflammatory cytokines, TNF-α, interleukin-1
- MeSH terms
- Animals, Brain, Injections, Intraventricular, Male, Recombinant Proteins, Sleep, Sleep Stages, Interleukin-10, Rats, Sprague-Dawley, Rats
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