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Interleukin-10 (cytokine synthesis inhibitory factor) acts in the central nervous system of rats to reduce sleep
Abstract
Interleukin-10 (IL-10), originally designated a cytokine synthesis inhibitory factor, inhibits the synthesis of the pro-inflammatory cytokines IL-1 and tumor necrosis factor by stimulated human and mouse monocytes/macrophages; these cytokines are involved in the regulation of sleep. To determine if IL-10 reduces spontaneous sleep, we injected murine recombinant IL-10 intracerebroventricularly into rats prior to light onset. Non-rapid eye movements sleep was reduced. The behavioral responses to IL-10 were abolished by heat-inactivation of this cytokine. We believe these to be the first observations of central nervous system actions for this cytokine. These results further support the hypothesis that cytokines are involved in the regulation of sleep, and suggest an additional mechanism whereby sleep may be altered in response to an activated immune system.
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“IL‐10 inhibits synthesis of TNF‐α (212).”
From Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020) · cites this paper as [212]
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Metadata
- Authors
- Opp, M. R., Smith, E. M., & Hughes, T. K.
- Affiliations
- The University of Texas Medical Branch at Galveston (US)
- Corresponding author
- Opp, M.R.
- ORCID
- Venue
- Journal of Neuroimmunology
- Publisher
- Elsevier BV
- Published
- 1995-07
- Volume
- 60
- Issue
- 1-2
- Pages
- 165-168
- ISSN
- 0165-5728 (ISSN-L)
- OpenAlex
- W2092703130
- Cited by
- 145
- References
- 13
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 2 · 2023: 2 · 2022: 9 · 2021: 11 · 2020: 9 · 2019: 11 · 2018: 8 · 2017: 3 · 2016: 7 · 2015: 1 · 2014: 2 · 2013: 5 · 2012: 3
- FWCI
- 3.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroimmunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01dk041034-06, 5r01da008354-03)
- National Institute on Drug Abuse (DA-08354)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK41034)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- IL-10, sleep regulation, NREM sleep, cytokines, central nervous system, intracerebroventricular administration, inflammatory cytokines, TNF-α, interleukin-1
- MeSH terms
- Animals, Brain, Injections, Intraventricular, Male, Recombinant Proteins, Sleep, Sleep Stages, Interleukin-10, Rats, Sprague-Dawley, Rats
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