Cited by 430Neuropeptides and Animal PhysiologyPain Mechanisms and TreatmentsNeurotransmitter Receptor Influence on Behavior

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Anatomy of the CNS opioid systems

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Khachaturian, Henry, Lewis, Michael E., Schäfer, Martin K.-H., Watson, Stanley J.·1985·Trends in Neurosciences

DOI 10.1016/0166-2236(85)90048-7

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The rat brain in stereotaxic coordinates
Palkovits, M. (1983) · Neuropeptides · doi:10.1016/0143-4179(83)90049-5 · Cited by 28,959
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
Handbook of Chemical Neuroanatomy
Stern, C. D. (1986) · Neurochemistry International · doi:10.1016/0197-0186(86)90021-5 · Cited by 4,160
Identification of two related pentapeptides from the brain with potent opiate agonist activity
Hughes, J., Smith, T. W., Kosterlitz, H. W., Fothergill, L. A., Morgan, B. A., & Morris, H. R. (1975) · Nature · doi:10.1038/258577a0 · Cited by 3,806
Handbook of Psychopharmacology
Iversen, L. L., Iversen, S. D., & Snyder, S. H. (1988) · Springer eBooks · doi:10.1007/978-1-4613-0933-8 · Cited by 2,756
Endogenous Opioids: Biology and Function
Akil, H., Watson, S. J., Young, E. A., Lewis, M. E., Khachaturian, H., & Walker, J. M. (1984) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.07.030184.001255 · Cited by 1,224
Self-citation
Immunohistochemical localization of enkephalin in rat brain and spinal cord
Sar, M., Stumpf, W. E., Miller, R. J., Chang, K., & Cuatrecasas, P. (1978) · The Journal of Comparative Neurology · doi:10.1002/cne.901820103 · Cited by 822
Immunohistochemical studies using antibodies to leucine-enkephalin: Initial observations on the nervous system of the rat
Elde, R., Hökfelt, T. G. M., Johansson, O., & Terenius, L. Y. (1976) · Neuroscience · doi:10.1016/0306-4522(76)90063-4 · Cited by 774
The distribution of enkephalin-immunoreactive cell bodies in the rat central nervous system
Hökfelt, T. G. M., Elde, R. P., Johansson, O., Terenius, L. Y., & Stein, L. (1977) · Neuroscience Letters · doi:10.1016/0304-3940(77)90160-4 · Cited by 693
Dynorphin1–8 and dynorphin1–9 are ligands for the κ-subtype of opiate receptor
Corbett, A. D., Paterson, S. J., McKnight, A. T., Magnan, J., & Kosterlitz, H. W. (1982) · Nature · doi:10.1038/299079a0 · Cited by 447

Show all 42 references

Research works printed but not linked: 7

Bloom, 1978, 75, 1591
Goldstein, 1979, 76, 6666
Watson, 1981, 78, 1260
Watson, 1983, 80, 891
Weber, 1983, 80, 1125
Lewis, M. E., Khachaturian, H. and Watson, S. J. Peptides (in press)
Herkenham, 1980, 77, 4469

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Self-citation
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Kowalski, C., Micheau, J., Corder, R., Gaillard, R. C., & Conte‐Devolx, B. (1992) · Brain Research · doi:10.1016/0006-8993(92)90314-y · Cited by 81
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Anderson, K. D., & Reiner, A. J. (1991) · The Journal of Comparative Neurology · doi:10.1002/cne.903030410 · Cited by 80
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Self-citation
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Presynaptic Versus Postsynaptic Localization of μ and δ Opioid Receptors in Dorsal and Ventral Striatopallidal Pathways
Olive, M. F., Antón, B., Micevych, P. E., Evans, C. J., & Maidment, N. T. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-19-07471.1997 · Cited by 89
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Alterations in regional concentrations of endogenous opioids following traumatic brain injury in the cat.
McIntosh, T. K., Head, V., & Faden, A. (1987) · Brain Research · doi:10.1016/0006-8993(87)90505-1 · Cited by 78
A group of cortical interneurons expressing μ-opioid receptor-like immunoreactivity: a double immunofluorescence study in the rat cerebral cortex
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c-fos expression in the rat brain following central administration of neuropeptide Y and effects of food consumption
Li, B.-H., Xu, B., Rowland, N. E., & Kalra, S. P. (1994) · Brain Research · doi:10.1016/0006-8993(94)91348-x · Cited by 74
Changes in Pro‐Opiomelanocortin and Pre‐proenkephalin mRNA Levels in the Ovine Brain during Pregnancy, Parturition and Lactation and in Response to Oestrogen and Progesterone
Broad, K. D., Kendrick, K. M., SIRINATHSINGHJI, D. J. S., & Keverne, E. B. (1993) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1993.tb00544.x · Cited by 73
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Gianoulakis, C., & de Waele, J. (1994) · Metabolic Brain Disease · doi:10.1007/bf01999765 · Cited by 70
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Tsou, K., Khachaturian, H., Akil, H., & Watson, S. J. (1986) · Brain Research · doi:10.1016/0006-8993(86)90283-0 · Cited by 70
Self-citation
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Gosnell, B. A. (1988) · Neuropharmacology · doi:10.1016/0028-3908(88)90050-0 · Cited by 69
Selective activation of opioid receptors differentially affects lordosis behavior in female rats
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Panksepp, J., & Sahley, T. L. (1987) · Springer eBooks · doi:10.1007/978-1-4899-1992-2_19 · Cited by 66
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Yakovleva, T., Marinova, Z., Kuzmin, A., Seidah, N. G., Haroutunian, V., Terenius, L. Y., & Bakalkin, G. Y. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.07.002 · Cited by 66
The Opioid Peptides
Evans, C. J., Hammond, D. L., & Frederickson, R. C. A. (1988) · Humana Press eBooks · doi:10.1007/978-1-60761-990-1_2 · Cited by 66
The opioid peptides. A role in hypertension?
FEUERSTEIN, G. Z., & Sirén, A. (1987) · Hypertension · doi:10.1161/01.hyp.9.6.561 · Cited by 64
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Pastor, R., & Aragón, C. M. G. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300928 · Cited by 61
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Veening, J., Gerrits, P., & Barendregt, H. (2012) · Fluids and Barriers of the CNS · doi:10.1186/2045-8118-9-16 · Cited by 61
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Sweep, F. C. G. J., Wiegant, V. M., Vry, J. D., & van Ree, J. M. (1989) · Life Sciences · doi:10.1016/0024-3205(89)90341-x · Cited by 61
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Olszewski, P. K., & Levine, A. S. (2004) · Endocrinology · doi:10.1210/en.2004-0016 · Cited by 59

Authors: Khachaturian, H., Lewis, M. E., Schäfer, M. K.-H., & Watson, S. J.
Affiliations: Universität Ulm (DE)
ORCID: Schäfer, Martin K.-H.
Watson, Stanley J.
Venue: Trends in Neurosciences
Publisher: Elsevier BV
Published: 1985-01
Volume: 8
Pages: 111-119
ISSN: 0166-2236 (ISSN-L)
DOI: 10.1016/0166-2236(85)90048-7
OpenAlex: W2053051844
Cited by: 428
References: 42
Citations by year: 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2018: 1 · 2016: 5 · 2014: 3 · 2013: 2 · 2012: 7
FWCI: 5.09
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Neurosciences (publishedVersion)
Deep Blue (University of Michigan) (submittedVersion)
Funders: National Institute of Mental Health
National Institute on Drug Abuse
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: endogenous opioids

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