Cited by 275Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsTreatment of Major Depression

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The impact of postsynaptic calcium on synaptic transmission — its role in long-term potentiation

Malenka, R.C., Kauer, J.A., Perkel, D.J., Nicoll, R.A.·1989·Trends in Neurosciences

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Abstract

Recent studies have gone a long way to explain the steps involved in generating long-term potentiation (LTP). This review focuses on the triggering role of postsynaptic calcium, the sequence of events which might be initiated by calcium, and where the persistent change may ultimately occur during LTP.

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Long‐lasting potentiation of synaptic transmission in the dentate area of the unanaesthetized rabbit following stimulation of the perforant path
Bliss, T. V. P., & Gardner-Medwin, A. R. (1973) · The Journal of Physiology · doi:10.1113/jphysiol.1973.sp010274 · Cited by 7,424
Magnesium gates glutamate-activated channels in mouse central neurones
Nowak, L. M., Bregestovski, P. D., Ascher, P., Herbet, A., & Prochiantz, A. (1984) · Nature · doi:10.1038/307462a0 · Cited by 4,116
Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones
Mayer, M. L., Westbrook, G. L., & Guthrie, P. B. (1984) · Nature · doi:10.1038/309261a0 · Cited by 2,941
Excitatory Amino Acid Transmitters
Watkins, J. C., & Evans, R. H. (1981) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.21.040181.001121 · Cited by 2,497
Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus
Collingridge, G. L., Kehl, S. J., & McLennan, H. (1983) · The Journal of Physiology · doi:10.1113/jphysiol.1983.sp014478 · Cited by 2,413
Quinoxalinediones: Potent Competitive Non-NMDA Glutamate Receptor Antagonists
Honoré, T., Davies, S. N., Drejer, J., Fletcher, E. J., Jacobsen, P., Lodge, D., & Nielsen, F. (1988) · Science · doi:10.1126/science.2899909 · Cited by 1,191
NMDA receptors - their role in long-term potentiation
Collingridge, G. L., & Bliss, T. (1987) · Trends in Neurosciences · doi:10.1016/0166-2236(87)90175-5 · Cited by 1,178
Intracellular injections of EGTA block induction of hippocampal long-term potentiation
Lynch, G., Larson, J., Kelso, S., Barrionuevo, G., & Schottler, F. (1983) · Nature · doi:10.1038/305719a0 · Cited by 1,116
An essential role for postsynaptic calmodulin and protein kinase activity in long-term potentiation
Malenka, R. C., Kauer, J. A., Perkel, D. J., Mauk, M. D., Kelly, P. T., Nicoll, R. A., & Waxham, M. N. (1989) · Nature · doi:10.1038/340554a0 · Cited by 1,025
Self-citation
Permeation and block of N‐methyl‐D‐aspartic acid receptor channels by divalent cations in mouse cultured central neurones.
Mayer, M. L., & Westbrook, G. L. (1987) · The Journal of Physiology · doi:10.1113/jphysiol.1987.sp016883 · Cited by 943

Show all 69 references

Research works printed but not linked: 12

Lømo, 1966, Acta Physiol. Scand., 68, 128
Bliss, 1973, J. Physiol. (London), 232, 331, 10.1113/jphysiol.1973.sp010273 · DOI · Paper page
Kelso, 1986, 83, 5326
Sah, 1989, Biophys. J., 55, 64a
Muller, 1988, 85, 9346
Murphy, 1988, 85, 8737
Muller, 1988, 85, 6997
Kennedy, 1983, 80, 7357
Kelly, 1984, 81, 945
Ouiment, 1984, 81, 5604
Lisman, 1985, 82, 3055
Kelly, 1988, 85, 4991

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References
(1997) · Advances in psychology · doi:10.1016/s0166-4115(97)80114-8
Basic Neurosciences
Rayport, S. (1990) · Journal of Neuropsychiatry · doi:10.1176/jnp.2.3.343
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Long-Term Potentiation as a Model
Daw, N. W. (1995) · Springer eBooks · doi:10.1007/978-1-4757-6940-1_11
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Gall, C. M., Le, A. A., & LYNCH, G. S. (2026) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2026.1855059
Untitled work
Mattson, M. (1999) · doi:10.1002/(sici)1097-4547(19991001)58:1
Untitled work
(1999) · doi:10.1002/(sici)1097-4547(19990715)57:2

Authors: Malenka, R. C., Kauer, J. A., Perkel, D. J., & Nicoll, R. A.
Affiliations: University of California, San Francisco (US)
Stanford University (US)
Corresponding author: Nicoll, R.A.
ORCID: Malenka, R.C.
Kauer, J.A.
Perkel, D.J.
Nicoll, R.A.
Venue: Trends in Neurosciences
Publisher: Elsevier BV
Published: 1989-01
Volume: 12
Issue: 11
Pages: 444-450
ISSN: 0166-2236 (ISSN-L)
DOI: 10.1016/0166-2236(89)90094-5
OpenAlex: W2072731296
Cited by: 275
References: 69
Citations by year: 2026: 1 · 2025: 1 · 2024: 4 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 4 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 3 · 2014: 1 · 2013: 4 · 2012: 5
FWCI: 3.53
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Neurosciences (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
U.S. Public Health Service (N524205)
National Institute of Mental Health (MH00437)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords: postsynaptic calcium, synaptic transmission, long-term potentiation, synaptic plasticity
MeSH terms: Animals, Calcium, Synaptic Transmission, Synapses, Synaptic Membranes, Time Factors, Receptors, N-Methyl-D-Aspartate, Receptors, Neurotransmitter

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The impact of postsynaptic calcium on synaptic transmission — its role in long-term potentiation

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