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The impact of postsynaptic calcium on synaptic transmission — its role in long-term potentiation

Malenka, R.C., Kauer, J.A., Perkel, D.J., Nicoll, R.A.·1989·Trends in Neurosciences

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Abstract

Recent studies have gone a long way to explain the steps involved in generating long-term potentiation (LTP). This review focuses on the triggering role of postsynaptic calcium, the sequence of events which might be initiated by calcium, and where the persistent change may ultimately occur during LTP.

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Authors: Malenka, R. C., Kauer, J. A., Perkel, D. J., & Nicoll, R. A.
Affiliations: University of California, San Francisco (US)
Stanford University (US)
Corresponding author: Nicoll, R.A.
ORCID: Malenka, R.C.
Kauer, J.A.
Perkel, D.J.
Nicoll, R.A.
Venue: Trends in Neurosciences
Publisher: Elsevier BV
Published: 1989-01
Volume: 12
Issue: 11
Pages: 444-450
ISSN: 0166-2236 (ISSN-L)
DOI: 10.1016/0166-2236(89)90094-5
OpenAlex: W2072731296
Cited by: 275
References: 69
Citations by year: 2026: 1 · 2025: 1 · 2024: 4 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 4 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 3 · 2014: 1 · 2013: 4 · 2012: 5
FWCI: 3.53
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Neurosciences (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
U.S. Public Health Service (N524205)
National Institute of Mental Health (MH00437)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords: postsynaptic calcium, synaptic transmission, long-term potentiation, synaptic plasticity
MeSH terms: Animals, Calcium, Synaptic Transmission, Synapses, Synaptic Membranes, Time Factors, Receptors, N-Methyl-D-Aspartate, Receptors, Neurotransmitter

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The impact of postsynaptic calcium on synaptic transmission — its role in long-term potentiation

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