Psychological stress repeatedly blocks hippocampal primed burst potentiation in behaving rats
Abstract
Primed burst (PB) potentiation is a long-term increase in CA1 population spike amplitude produced by brief physiologically patterned electrical stimulation of the hippocampal commissure. Exposure of rats to a novel environment resulted in a blockade of short-term (Post-tetanic potentiation, PTP) and long-term (PB potentiation) plasticity in all cases (n = 6). When the animals had extensive exposure to the environment (14 consecutive days), PTP and PB potentiation occurred. With placement of the rats in a second novel environment, once again, neither PTP nor PB potentiation was observed. Placement of rats in each of the two novel environments produced a significant increase in serum corticosterone levels, while placement in the familiar environment produced no increase in response. These findings support the hypothesis that hippocampal plasticity is repeatedly susceptible to modulation by the stress of forced exposure to a novel environment.
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When rats were acclimated to the environment, the blockade of PB potentiation was no longer present; when exposed to a second stress-provoking environment, PB potentiation was suppressed again.
“We also showed that when rats were explicitly acclimated to the environment, as indicated by a significant reduction in their levels of serum corticosterone, the blockade of PB potentiation was no longer present (Diamond et al. [131]). Importantly, when these same rats were then exposed to a second, stress-provoking (corticosterone-elevating) environment, once again, PB potentiation was suppressed”
From The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law (2007) · cites this paper as Diamond et al. [131]
The induction of primed burst (PB) potentiation was blocked in rats that were exposed to an unfamiliar environment.
“We found that the induction of PB potentiation was blocked in rats that were exposed to an unfamiliar environment (Diamond et al. [119]; Diamond et al. [131]).”
From The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law (2007) · cites this paper as Diamond et al. [131]
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“We also showed that when rats were explicitly acclimated to the environment, as indicated by a significant reduction in their levels of serum corticosterone, the blockade of PB potentiation was no longer present (Diamond et al. [131]).”
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Self-citation
- Authors
- Diamond, D. M., Fleshner, M., & Rose, G. M.
- Affiliations
- United States Department of Veterans Affairs (US)
- University of Colorado Boulder (US)
- Corresponding author
- Diamond, David M.
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 1994-05
- Volume
- 62
- Issue
- 1
- Pages
- 1-9
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W1975099325
- Cited by
- 182
- References
- 1
- Citations by year
- 2025: 1 · 2024: 1 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 4 · 2013: 3 · 2012: 15
- FWCI
- 5.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Digital Commons - University of South Florida (University of South Florida) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- psychological stress, hippocampal plasticity, post-tetanic potentiation, corticosterone, repeated stress
- MeSH terms
- Animals, Arousal, Corticosterone, Electric Stimulation, Evoked Potentials, Hippocampus, Neural Inhibition, Neuronal Plasticity, Neurons, Mental Recall, Social Environment, Stress, Psychological, Long-Term Potentiation, Rats
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