Cited by 139Posttraumatic Stress Disorder ResearchStress Responses and CortisolMemory and Neural Mechanisms

Stress‐induced reduction in hippocampal volume and connectivity with the ventromedial prefrontal cortex are related to maladaptive responses to stressful military service

Open access
Admon, Roee, Leykin, Dmitry, Lubin, Gad, Engert, Veronika, Andrews, Julie, Pruessner, Jens, Hendler, Talma·2013·Human Brain Mapping

Abstract

Previous studies have shown that people who develop psychopathology such as posttraumatic stress disorder (PTSD) following stress exposure are characterized by reduced hippocampal (HC) volume and impaired HC functional connectivity with the ventromedial prefrontal cortex (vmPFC). Nevertheless, the exact interrelationship between reduced HC volume and HC‐vmPFC connectivity deficits in the context of stress has yet to be established. Furthermore, it is still not clear whether such neural abnormalities are stress induced or precursors for vulnerability. In this study, we combined measurements of MRI, functional MRI (fMRI), and diffusion tensor imaging (DTI) to prospectively study 33 a priori healthy Israeli soldiers both pre‐ and post‐exposure to stress during their military service. Thus, we were able to assess the contributions of structural and functional features of the HC and its connectivity to the onset and progression of maladaptive response to stress (i.e., increased PTSD symptoms post‐exposure). We found that soldiers with decreased HC volume following military service (i.e., post‐exposure) displayed more PTSD‐related symptoms post‐exposure as well as reduced HC‐vmPFC functional and structural connectivity post‐exposure, compared to soldiers with increased HC volume following military service. In contrast, initial smaller HC volume pre‐exposure did not have an effect on any of these factors. Our results therefore suggest that reduction in HC volume and connectivity with the vmPFC together mark a maladaptive response to stressful military service. As stress‐induced HC volume reductions were previously shown to be reversible, these localized biological markers may carry valuable therapeutic potential. Hum Brain Mapp 34:2808–2816, 2013. © 2012 Wiley Periodicals, Inc.

Integrity signals

Registry

Crossref · 10.1002/hbm.22100

Cites

49 of 49 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • In a prospective study of Israeli soldiers, soldiers with decreased hippocampal structural connectivity with the vmPFC had a more maladaptive response to stressful military service.

    “In a prospective study of Israeli soldiers, Admon et al. [148] used diffusion tensor imaging (DTI) pre- and post-military service, reporting that soldiers with decreased hippocampal structural connectivity with the vmPFC had a more maladaptive response to stressful military service.”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Admon, R., Leykin, D., Lubin, G., Engert, V., Andrews, J., Pruessner, J., & Hendler, T.
Affiliations
  • Tel Aviv University (IL)
  • Tel Aviv Sourasky Medical Center (IL)
  • Medical Corps Israeli Defense Forces Tel Aviv Israel
  • Douglas Mental Health University Institute (CA)
Venue
Human Brain Mapping
Publisher
Wiley
Published
2012-07-17
Volume
34
Issue
11
Pages
2808-2816
ISSN
  • 1065-9471 (ISSN-L)
  • 1097-0193
OpenAlex
W2124817492
Cited by
138
References
49
Citations by year
2026: 6 · 2025: 4 · 2024: 4 · 2023: 7 · 2022: 8 · 2021: 17 · 2020: 8 · 2019: 21 · 2018: 9 · 2017: 12 · 2016: 14 · 2015: 12 · 2014: 10 · 2013: 5 · 2012: 1
FWCI
10.18
Type
journal article
Language
en
Open access
Locations
  • Human Brain Mapping (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
hippocampal volume, ventromedial prefrontal cortex, post-traumatic stress disorder, military service, stress exposure, maladaptive stress response, structural connectivity, functional connectivity, biomarkers, military personnel
MeSH terms
Adaptation, Psychological, Adolescent, Female, Hippocampus, Humans, Image Processing, Computer-Assisted, Israel, Magnetic Resonance Imaging, Male, Neural Pathways, Neuropsychological Tests, Psychology, Military, Stress Disorders, Post-Traumatic, Stress, Psychological, Veterans, Biomarkers, Prefrontal Cortex, Young Adult, Diffusion Tensor Imaging

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review