Effects of Chronic Stress on Structure and Cell Function in Rat Hippocampus and Hypothalamus
Open accessAbstract
It has become increasingly clear that the increase in corticosteroid levels, e.g. after a brief stressor induce molecular and cellular changes in brain, including the hippocampal formation. These effects eventually result in behavioral adaptation. Prolonged exposure to stress, though, may lead to mal-adaptation and even be a risk factor for diseases like major depression in genetically predisposed individuals. We conducted a series of experiments where changes in brain function were examined after 3 weeks of unpredictable stress. After unpredictable stress, inhibitory input to neurons involved in the hypothalamus-pituitary-adrenal (HPA) axis regulation was suppressed, which may dysregulate the axis and lead to overexposure of the brain to glucocorticoids. Furthermore, glutamate transmission in the dentate gyrus (DG) was enhanced, possibly through transcriptional regulation of receptor subunits. Combined with enhanced calcium channel expression this could increase vulnerability to cell death. Neurogenesis and apoptosis in the dentate were diminished. Synaptic plasticity was suppressed both in the dentate and CA1 area. Collectively, these effects may give rise to deficits in memory formation. Finally, we observed reduced responses to serotonin in the CA1 area, which could contribute to the onset of symptoms of depression in predisposed individuals. All of these endpoints provide potential targets for novel treatment strategies of stress-related brain disorders.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Chronic stress and exogenous corticosteroids impair generation of new dentate gyrus neurons from stem cells.
“Preclinical studies have shown that the genesis of new neurons in the dentate gyrus from stem cells is impaired after chronic stress and exogenous corticosteroid administration [90][91][92].”
From Plasticity of synapses and reward circuit function in the genesis and treatment of depression (2023) · cites this paper as [92]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., et al. (2003) · Science · doi:10.1126/science.1083328 · Cited by 4,321 · see citing works
Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus
Malberg, J. E., Eisch, A. J., Nestler, E. J., & Duman, R. S. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-24-09104.2000 · Cited by 3,111 · see citing works
Brain corticosteroid receptor balance in health and disease
de Kloet, E. R., Vreugdenhil, E., Oitzl, M. S., & Joëls, M. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.3.0331 · Cited by 2,614 · see citing works
Two receptor systems for corticosterone in rat brain: Microdistribution and differential occupation
REUL, J. M. H. M., & KLOET, E. R. D. (1985) · Endocrinology · doi:10.1210/endo-117-6-2505 · Cited by 2,580 · see citing works
Neurocircuitry of stress: central control of the hypothalamo–pituitary–adrenocortical axis
Herman, J. P., & Cullinan, W. E. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10069-2 · Cited by 2,270 · see citing works
STRESS AND HIPPOCAMPAL PLASTICITY
McEwen, B. S. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.105 · Cited by 2,087 · see citing works
Glucocorticoids and Hippocampal Atrophy in Neuropsychiatric Disorders
Sapolsky, R. M. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.10.925 · Cited by 2,016 · see citing works
Gould, E., Tanapat, P., McEwen, B. S., Flügge, G., & Fuchs, E. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.6.3168 · Cited by 1,395 · see citing works
Gold, P. W., & Chrousos, G. P. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001032 · Cited by 1,274 · see citing works
Stress and cognition: are corticosteroids good or bad guys?
de Kloet, E. R., Oitzl, M. S., & Joëls, M. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01438-1 · Cited by 1,258 · see citing works
Self-citationCzéh, B., Michaelis, T., Watanabe, T., Frahm, J., de Biurrun, G., van Kampen, M., Bartolomucci, A., & Fuchs, E. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211427898 · Cited by 1,090 · see citing works
Lemaire, V., Koehl, M., Le Moal, M., & Abrous, D. N. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.20.11032 · Cited by 1,044 · cited 1× · see citing works
“These effects are more profound when applied early in life (Lemaire et al., 2000).”
BackgroundParaventricular Nucleus:A Site for the Integration of Neuroendocrine and Autonomic Mechanisms
Swanson, L. W., & Sawchenko, P. E. (2008) · Neuroendocrinology · doi:10.1159/000123111 · Cited by 1,001 · see citing works
A G Protein Couples Serotonin and GABA B Receptors to the Same Channels in Hippocampus
Andrade, R., Malenka, R. C., & Nicoll, R. A. (1986) · Science · doi:10.1126/science.2430334 · Cited by 869 · see citing works
Magariños, A. M., McEwen, B. S., Flügge, G., & Fuchs, E. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-10-03534.1996 · Cited by 864 · see citing works
Magarin˜os, A. M., & McEwen, B. S. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00259-l · Cited by 863 · see citing works
Antidepressants and Hypothalamic-Pituitary-Adrenocortical Regulation
HOLSBOER, F., & Barden, N. (1996) · Endocrine Reviews · doi:10.1210/edrv-17-2-187 · Cited by 851 · see citing works
Stress and hippocampal neurogenesis
Gould, E., & Tanapat, P. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00247-4 · Cited by 805 · see citing works
Pham, K., Nacher, J., Hof, P. R., & McEwen, B. S. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02513.x · Cited by 657 · see citing works
GABA: A dominant neurotransmitter in the hypothalamus
Decavel, C., & van den Pol, A. N. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.903020423 · Cited by 571 · see citing works
Stress-induced atrophy of apical dendrites of hippocampal CA3c neurons: Comparison of stressors
Magarin˜os, A. M., & McEwen, B. S. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00256-i · Cited by 571 · see citing works
Nongenomic steroid action: controversies, questions, and answers
LÖSEL, R. M., FALKENSTEIN, E., FEURING, M., SCHULTZ, A., TILLMANN, H.-C., ROSSOL-HASEROTH, K., & WEHLING, M. (2003) · Physiological Reviews · doi:10.1152/physrev.00003.2003 · Cited by 561 · see citing works
Selective Loss of Hippocampal Granule Cells in the Mature Rat Brain After Adrenalectomy
Sloviter, R. S., Valiquette, G., Abrams, G., Ronk, E. C., Sollas, A. L., Paul, L. A., & Neubort, S. (1989) · Science · doi:10.1126/science.2911756 · Cited by 526 · see citing works
Bodnoff, S., Humphreys, A., Lehman, J., Diamond, D. M., Rose, G., & Meaney, M. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-01-00061.1995 · Cited by 522 · see citing works
Stress, memory, and the hippocampus: can't live with it, can't live without it
LUPIEN, S. J., & Lepage, M. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00361-8 · Cited by 509 · see citing works
Glucocorticoids, stress, and their adverse neurological effects: relevance to aging
Sapolsky, R. M. (1999) · Experimental Gerontology · doi:10.1016/s0531-5565(99)00047-9 · Cited by 507 · see citing works
Herman, J. P., Adams, D. J., & Prewitt, C. M. (2008) · Neuroendocrinology · doi:10.1159/000126839 · Cited by 458 · see citing works
Behavioral stress impairs long-term potentiation in rodent hippocampus
Foy, M. R., Stanton, M. E., Levine, S., & Thompson, R. F. (1987) · Behavioral and Neural Biology · doi:10.1016/s0163-1047(87)90664-9 · Cited by 436 · see citing works
Interaction of Steroid Hormone Receptors with the Transcription Initiation Complex
Beato, M., & Sánchez‐Pacheco, A. (1996) · Endocrine Reviews · doi:10.1210/edrv-17-6-587 · Cited by 402 · see citing works
An open label trial of C-1073 (mifepristone) for psychotic major depression*
Belanoff, J. K., Rothschild, A. J., Cassidy, F., DeBattista, C., Baulieu, E.-E., Schold, C., & Schatzberg, A. F. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01432-4 · Cited by 320 · see citing works
Heine, V. M., Maslam, S., Zareno, J., Joëls, M., & Lucassen, P. J. (2004) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.03100.x · Cited by 317 · see citing works
Self-citationEffects of chronic stress on hippocampal long‐term potentiation
Pavlides, C., Nivón, L. G., & McEwen, B. S. (2002) · Hippocampus · doi:10.1002/hipo.1116 · Cited by 316 · see citing works
Steroid Hormones and Excitability in the Mammalian Brain
Joëls, M. (1997) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1996.0144 · Cited by 280 · see citing works
Self-citationExposing Rats to a Predator Blocks Primed Burst Potentiation in the Hippocampus<i>In Vitro</i>
Mesches, M. H., Fleshner, M., Heman, K. L., Rose, G. M., & Diamond, D. M. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-14-j0004.1999 · Cited by 276 · see citing works
Alfarez, D. N., Joëls, M., & Krugers, H. J. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02622.x · Cited by 258 · see citing works
Self-citationCole, R. L., & Sawchenko, P. E. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-03-00959.2002 · Cited by 253 · see citing works
Restraint stress reversibly enhances spatial memory performance
Luine, V. N., Martinez, C., Villegas, M., Magariños, A. M., & McEwen, B. S. (1996) · Physiology & Behavior · doi:10.1016/0031-9384(95)02016-0 · Cited by 249 · see citing works
Depression, Stress and the Adrenal axis
(2003) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2003.01058.x · Cited by 242 · see citing works
Miller, A. H., Pariante, C. M., & Pearce, B. D. (1999) · Advances in Experimental Medicine and Biology · doi:10.1007/978-0-585-37970-8_7 · Cited by 203 · see citing works
Lander, C., Kind, P., Maleski, M., & Hockfield, S. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-06-01928.1997 · Cited by 195 · see citing works
Psychological stress repeatedly blocks hippocampal primed burst potentiation in behaving rats
Diamond, D. M., Fleshner, M., & Rose, G. M. (1994) · Behavioural Brain Research · doi:10.1016/0166-4328(94)90032-9 · Cited by 182 · see citing works
Miklós, I. H., & Kovács, K. J. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00147-1 · Cited by 182 · see citing works
Kole, M. H. P., Swan, L., & Fuchs, E. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02136.x · Cited by 181 · see citing works
Mechanism of gene expression by the glucocorticoid receptor: Role of protein‐protein interactions
McEwan, I. J., Wright, A. P. H., & Gustafsson, J.-Α. (1997) · BioEssays · doi:10.1002/bies.950190210 · Cited by 179 · see citing works
Corticosteroid actions in hippocampus require DNA binding of glucocorticoid receptor homodimers
Karst, H., Karten, Y. J. G., Reichardt, H. M., de Kloet, E. R., Schütz, G., & Joëls, M. (2000) · Nature Neuroscience · doi:10.1038/79910 · Cited by 171 · see citing works
Self-citationJoëls, M., Hesen, W., & de Kloet, E. R. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-08-02288.1991 · Cited by 168 · see citing works
Self-citationGould, E., & McEwen, B. S. (1993) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(93)90138-o · Cited by 164 · see citing works
Verkuyl, J. M., Hemby, S. E., & Joëls, M. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03568.x · Cited by 164 · see citing works
Self-citationCryan, J. F., & Leonard, B. E. (2000) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/(sici)1099-1077(200003)15:2 · Cited by 164 · see citing works
Roozendaal, B., Phillips, R. G., Power, A. E., Brooke, S. M., Sapolsky, R. M., & McGaugh, J. L. (2001) · Nature Neuroscience · doi:10.1038/nn766 · Cited by 160 · see citing works
Gerges, N. Z., Stringer, J. L., & Alkadhi, K. A. (2001) · Brain Research · doi:10.1016/s0006-8993(01)03181-x · Cited by 155 · see citing works
Lucassen, P. J., Vollmann-Honsdorf, G. K., Gleisberg, M., Czéh, B., de Kloet, E. R., & Fuchs, E. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01629.x · Cited by 154 · see citing works
Self-citationKarten, Y. J. G., Nair, S. M., van Essen, L., Sibug, R. M., & Joëls, M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13456 · Cited by 150 · see citing works
Self-citationEffect of Chronic Stress on Synaptic Currents in Rat Hippocampal Dentate Gyrus Neurons
Karst, H., & Joëls, M. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00691.2002 · Cited by 111 · see citing works
Self-citationShors, T. J., & Dryver, E. T. (1994) · Brain Research · doi:10.1016/0006-8993(94)90777-3 · Cited by 111 · see citing works
Cullinan, W. E., & Wolfe, T. J. (2000) · Brain Research · doi:10.1016/s0006-8993(00)03000-6 · Cited by 102 · see citing works
Kapsimali, M., Vidal, B., González, A., Dufour, S., & Vernier, P. (2000) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(20000410)419:3 · Cited by 91 · see citing works
Hesen, W., & Joëls, M. (1996) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1996.04724.x · Cited by 75 · see citing works
Self-citationRiel, E. V., Meijer, O. C., Steenbergen, P. J., & Joëls, M. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00355-5 · Cited by 64 · see citing works
Self-citationBeck, S., Choi, K. C., List, T., Okuhara, D., & Birnstiel, S. (1996) · Neuropsychopharmacology · doi:10.1016/s0893-133x(96)80056-x · Cited by 60 · see citing works
11β‐Hydroxysteroid Dehydrogenases in the Brain
Holmes, M. C., Yau, J. L. W., Kotelevtsev, Y. V., Mullins, J. J., & Seckl, J. R. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1286.035 · Cited by 60 · see citing works
STEROIDS AND THE NERVOUS SYSTEM
Holmes, M. C., Yau, J. L. W., Kotelevtsev, Y. V., Mullins, J. J., & Seckl, J. R. (2003) · Cited by 57 · see citing works
Modell, S., Ising, M., Holsboer, F., & Lauer, C. J. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01398-7 · Cited by 56 · see citing works
Chronic unpredictable stress alters gene expression in rat single dentate granule cells
Qin, Y., Karst, H., & Joëls, M. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2003.02332.x · Cited by 48 · see citing works
Self-citationCorticosteroid Resistance and Disease
DeRijk, R. H., & Sternberg, E. M. (1997) · Annals of Medicine · doi:10.3109/07853899708998746 · Cited by 46 · see citing works
Goeders, N. E., Souza, E. B. D., & Kuhar, M. J. (1986) · European Journal of Pharmacology · doi:10.1016/0014-2999(86)90448-6 · Cited by 36 · see citing works
Verkuyl, J. M., & Joëls, M. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00401.2002 · Cited by 35 · see citing works
Self-citationCorticosterone alters G protein α-subunit levels in the rat hippocampus
Okuhara, D. Y., Beck, S. G., & Muma, N. A. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01142-0 · Cited by 30 · see citing works
Muma, N. A., & Beck, S. G. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01754-0 · Cited by 27 · see citing works
Birnstiel, S., & Beck, S. G. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)09576-x · Cited by 26 · see citing works
Corticosteroids Alter the 5-HT1A Receptor-Mediated Response in CA1 Hippocampal Pyramidal Cells
Mueller, N. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00134-2 · Cited by 22 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Karten, Y.J., Nair, S.M., van Essen, L., Sibug, R. and Joe ¨ls, M. (1999) Long-term corticosterone application decreases serotonin responses of CA1 neurons in the rat hippocampus, Proc. Natl Acad. Sci. USA 96, 13456-13461.
Cited by
Sorted by citations
Li, N., Liu, R.-J., Dwyer, J. M., Banasr, M., Lee, B., Son, H., Li, X.-Y., Aghajanian, G., & Duman, R. S. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.12.015 · Cited by 1,082 · see citing works
The stress system in the human brain in depression and neurodegeneration
Swaab, D. F., Bao, A.-M., & Lucassen, P. J. (2005) · Ageing Research Reviews · doi:10.1016/j.arr.2005.03.003 · Cited by 984 · see citing works
Self-citationChronic Stress-induced Hippocampal Vulnerability: The Glucocorticoid Vulnerability Hypothesis
Conrad, C. D. (2008) · Reviews in the Neurosciences · doi:10.1515/revneuro.2008.19.6.395 · Cited by 425 · see citing works
Ivy, A. S., Rex, C. S., Chen, Y., Dubé, C., Maras, P. M., Grigoriadis, D. E., Gall, C. M., Lynch, G., & Baram, T. Z. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1784-10.2010 · Cited by 402 · see citing works
Stressed Memories: How Acute Stress Affects Memory Formation in Humans
Henckens, M. J. A. G., Hermans, E. J., Pu, Z., Joëls, M., & Fernández, G. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.1184-09.2009 · Cited by 295 · see citing works
Self-citationMunhoz, C. D., Lepsch, L. B., Kawamoto, E. M., Malta, M. B., Lima, L. D. S., Werneck Avellar, M. C., Sapolsky, R. M., & Scavone, C. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4398-05.2006 · Cited by 274 · see citing works
Chen, Y., Rex, C. S., Rice, C. J., Dubé, C. M., Gall, C. M., Lynch, G., & Baram, T. Z. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003825107 · Cited by 256 · see citing works
Defeat stress in rodents: from behavior to molecules
Hammels, C., Pishva, E., De Vry, J., van den Hove, D. L. A., Prickaerts, J., van Winkel, R., Selten, J.-P., Lesch, K.-P., Daskalakis, N. P., Steinbusch, H. W. M., et al. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.10.006 · Cited by 230 · see citing works
Malykhin, N. V., Carter, R., Seres, P., & Coupland, N. J. (2010) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.100002 · Cited by 212 · see citing works
Huang, Y., Coupland, N. J., Lebel, R. M., Carter, R., Seres, P., Wilman, A. H., & Malykhin, N. V. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.01.005 · Cited by 179 · see citing works
Convergent Mechanisms Underlying Rapid Antidepressant Action
Zanos, P., Thompson, S. M., Duman, R. S., Zarate, C. A., & Gould, T. D. (2018) · CNS Drugs · doi:10.1007/s40263-018-0492-x · Cited by 171 · see citing works
Denis, I., Potier, B., Vancassel, S., Heberden, C., & Lavialle, M. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.01.007 · Cited by 150 · see citing works
Alcaro, A., Panksepp, J., Witczak, J., Hayes, D. J., & Northoff, G. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.11.023 · Cited by 144 · see citing works
Filipović, D., Todorović, N., Bernardi, R. E., & Gass, P. (2017) · Brain Structure and Function · doi:10.1007/s00429-016-1218-9 · Cited by 138 · see citing works
Admon, R., Leykin, D., Lubin, G., Engert, V., Andrews, J., Pruessner, J., & Hendler, T. (2013) · Human Brain Mapping · doi:10.1002/hbm.22100 · Cited by 138 · see citing works
Mueller, S. G., Schuff, N., Raptentsetsang, S., Elman, J., & Weiner, M. W. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.04.174 · Cited by 116 · see citing works
The central corticotropin releasing factor system during development and adulthood
Korosi, A., & Baram, T. Z. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.11.066 · Cited by 102 · see citing works
Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation
Kato, T., Pothula, S., Liu, R.-J., Duman, C. H., Terwilliger, R., Vlasuk, G. P., Saiah, E., Hahm, S., & Duman, R. S. (2019) · Journal of Clinical Investigation · doi:10.1172/jci126859 · Cited by 88 · see citing works
Travis, S. G., Coupland, N. J., Hegadoren, K., Silverstone, P. H., Huang, Y., Carter, R., Fujiwara, E., Seres, P., & Malykhin, N. V. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.04.049 · Cited by 57 · see citing works
The dose makes the poison: From glutamate-mediated neurogenesis to neuronal atrophy and depression
Rubio-Casillas, A., & Fernández-Guasti, A. (2016) · Reviews in the Neurosciences · doi:10.1515/revneuro-2015-0066 · Cited by 49 · see citing works
Dhikav, V., & Anand, K. S. (2007) · Medical Hypotheses · doi:10.1016/j.mehy.2006.09.038 · Cited by 50 · see citing works
Plasticity of synapses and reward circuit function in the genesis and treatment of depression
Thompson, S. M. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-022-01422-1 · Cited by 40 · see citing works
Divergent Functional Effects of Sazetidine-A and Varenicline During Nicotine Withdrawal
Turner, J. R., Wilkinson, D. S., Poole, R. L., Gould, T. J., Carlson, G. C., & Blendy, J. A. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.105 · Cited by 29 · see citing works
Recent advances in psychoneuroimmunology: Inflammation in psychiatric disorders
Debnath, M., Doyle, K., Langan, C., McDonald, C., Leonard, B., & Cannon, D. (2011) · Translational Neuroscience · doi:10.2478/s13380-011-0019-0 · Cited by 28 · see citing works
Keller, B. N., Snyder, A. E., Coker, C. R., Aguilar, E. A., O’Brien, M. K., Bingaman, S. S., Arnold, A. C., Hajnal, A., & Silberman, Y. (2021) · doi:10.1101/2021.06.03.446790 · Cited by 4 · see citing works
- Authors
- Joëls, M., Karst, H., Alfarez, D., Heine, V. M., Qin, Y., Riel, E. V., Verkuyl, M., Lucassen, P. J., & Krugers, H. J.
- Affiliations
- University of Amsterdam (NL)
- Corresponding author
- Joëls, Marian
- Venue
- Stress
- Publisher
- Informa UK Limited
- Published
- 2004-12
- Volume
- 7
- Issue
- 4
- Pages
- 221-231
- ISSN
- 1025-3890 (ISSN-L)
- 1607-8888
- OpenAlex
- W2109694255
- Cited by
- 330
- References
- 72
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 10 · 2023: 7 · 2022: 14 · 2021: 19 · 2020: 12 · 2019: 15 · 2018: 20 · 2017: 21 · 2016: 13 · 2015: 16 · 2014: 18 · 2013: 15 · 2012: 23
- FWCI
- 5.11
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Stress (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- UvA-DARE (University of Amsterdam) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (900-95-312)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- chronic stress, unpredictable stress, hippocampus, hypothalamus, hypothalamic-pituitary-adrenal axis, glucocorticoids, dentate gyrus, CA1, glutamatergic neurotransmission, calcium channels, neurogenesis, apoptosis, synaptic plasticity, memory impairment, depression
- MeSH terms
- Animals, Chronic Disease, gamma-Aminobutyric Acid, Glutamates, Hippocampus, Hypothalamus, Neurons, Paraventricular Hypothalamic Nucleus, Stress, Psychological, Dentate Gyrus, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
