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The involvement of nucleus accumbens dopamine in appetitive and aversive motivation

Salamone, John D.·1994·Behavioural Brain Research

DOI 10.1016/0166-4328(94)90153-8

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Abstract

In recent years, considerable emphasis has been placed upon the putative role of nucleus accumbens dopamine systems in appetitive motivation and positive reinforcement. However, considerable evidence indicates that brain dopamine in general, and nucleus accumbens dopamine in particular, is involved in aspects of aversive motivation. Administration of dopamine antagonists or localized interference with nucleus accumbens dopamine systems has been shown to disrupt active avoidance behavior. In addition, accumbens dopamine release and metabolism is activated by a wide variety of stressful conditions. A review of the literature indicates that there are substantial similarities between the characteristics of dopaminergic involvement in appetitive and aversive motivation. There is conflicting evidence about the role of dopamine in emotion, and little evidence to suggest that the profound and consistent changes in instrumental behavior produced by interference with DA systems are due to direct dopaminergic mediation of positive affective responses such as hedonia. It is suggested that nucleus accumbens dopamine is involved in aspects of sensorimotor functions that are involved in both appetitive and aversive motivation.

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Authors: Salamone, J. D.
Affiliations: University of Connecticut (US)
Corresponding author: Salamone, John D.
ORCID: Salamone, John D.
Venue: Behavioural Brain Research
Publisher: Elsevier BV
Published: 1994-04
Volume: 61
Issue: 2
Pages: 117-133
ISSN: 0166-4328 (ISSN-L)
DOI: 10.1016/0166-4328(94)90153-8
OpenAlex: W2079322728
Cited by: 584
References: 238
Citations by year: 2026: 4 · 2025: 7 · 2024: 12 · 2023: 9 · 2022: 16 · 2021: 6 · 2020: 7 · 2019: 12 · 2018: 15 · 2017: 15 · 2016: 24 · 2015: 28 · 2014: 22 · 2013: 32 · 2012: 18
FWCI: 1.98
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Behavioural Brain Research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: nucleus accumbens, dopamine, appetitive motivation, aversive motivation, avoidance behavior, positive reinforcement, stress, dopamine antagonists, hedonia, instrumental behavior, sensorimotor function
MeSH terms: Animals, Appetitive Behavior, Arousal, Avoidance Learning, Dopamine, Motivation, Nucleus Accumbens, Receptors, Dopamine, Reinforcement, Psychology

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The involvement of nucleus accumbens dopamine in appetitive and aversive motivation

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