A Role for Phasic Dopamine Release within the Nucleus Accumbens in Encoding Aversion: A Review of the Neurochemical Literature

Wenzel, Jennifer M.; Rauscher, Noah A.; Cheer, Joseph F.; Oleson, Erik B.

doi:10.1021/cn500255p

Cited by 131Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesMemory and Neural Mechanisms

A Role for Phasic Dopamine Release within the Nucleus Accumbens in Encoding Aversion: A Review of the Neurochemical Literature

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Wenzel, Jennifer M., Rauscher, Noah A., Cheer, Joseph F., Oleson, Erik B.·2015·ACS Chemical Neuroscience

DOI 10.1021/cn500255pPMC PMC5820768

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Abstract

Survival is dictated by an organism's fitness in approaching positive stimuli and avoiding harm. While a rich literature outlines a role for mesolimbic dopamine in reward and appetitive behaviors, dopamine's involvement in aversion and avoidance behaviors remains controversial. Debate surrounding dopamine's function in the processing of negative stimuli likely stems from conflicting results reported by single-unit electrophysiological studies. Indeed, a number of studies suggest that midbrain dopaminergic cells are inhibited by the presentation of negative or fearful stimuli, while others report no change, or even an increase, in their activity. These disparate results may be due to population heterogeneity. Recent evidence demonstrates that midbrain dopamine neurons are heterogeneous in their projection targets, responses to environmental stimuli, pharmacology, and influences on motivated behavior. Thus, in order to assemble an accurate account of dopamine function during aversive stimulus experience and related behavior, it is necessary to examine the functional output of dopamine neural activity at mesolimbic terminal regions. This Review presents a growing body of evidence that dopamine release in the nucleus accumbens encodes not only reward, but also aversion. For example, our laboratory recently utilized fast-scan cyclic voltammetry to show that real-time changes in accumbal dopamine release are detected when animals are presented with predictors of aversion and its avoidance. These data, along with other reports, support a considerably more nuanced view of dopamine neuron function, wherein accumbal dopamine release is differentially modulated by positive and negative affective stimuli to promote adaptive behaviors.

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Animal research indicates that dopaminergic neurons are strongly excited by acute stress and aversive stimuli during adulthood.
“Animal research indicates that dopaminergic neurons are strongly excited by acute stress and aversive stimuli during adulthood (Brischoux et al., 2009; Cohen et al., 2012; Wenzel et al., 2015; Zweifel et al., 2011).”
From The effects of psychosocial stress on dopaminergic function and the acute stress response (2019) · cites this paper as Wenzel et al., 2015

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The Functions of Dopamine in Operant Conditioned Reflexes
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Authors: Wenzel, J. M., Rauscher, N. A., Cheer, J. F., & Oleson, E. B.
Affiliations: University of Maryland, Baltimore (US)
University of Colorado Denver (US)
Corresponding author: Oleson, Erik B.
ORCID: Wenzel, Jennifer M.
Cheer, Joseph F.
Oleson, Erik B.
Venue: ACS Chemical Neuroscience
Publisher: American Chemical Society (ACS)
Published: 2014-12-24
Volume: 6
Issue: 1
Pages: 16-26
ISSN: 1948-7193 (ISSN-L)
DOI: 10.1021/cn500255p
PMC: PMC5820768
OpenAlex: W2047260216
Cited by: 131
References: 118
Citations by year: 2026: 5 · 2025: 6 · 2024: 14 · 2023: 10 · 2022: 7 · 2021: 16 · 2020: 14 · 2019: 14 · 2018: 10 · 2017: 16 · 2016: 10 · 2015: 9
FWCI: 1.33
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: ACS Chemical Neuroscience (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Drug Abuse (R21DA033926, R01DA022340)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: phasic dopamine release, nucleus accumbens, aversion, avoidance behavior, mesolimbic dopamine system, midbrain dopaminergic neurons, reward encoding, fast-scan cyclic voltammetry, motivated behavior
MeSH terms: Action Potentials, Animals, Dopamine, Escape Reaction, Humans, Motivation, Neurochemistry, Neurons, Nucleus Accumbens, Databases, Factual

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A Role for Phasic Dopamine Release within the Nucleus Accumbens in Encoding Aversion: A Review of the Neurochemical Literature

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