The dopamine augmenter L-DOPA does not affect positive mood in healthy human volunteers.
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Dopamine neurotransmission influences approach toward rewards and reward-related cues. The best cited interpretation of this effect proposes that dopamine mediates the pleasure that commonly accompanies reward. This hypothesis has received support in some animal models and a few studies in humans. However, direct assessments of the effect of transiently increasing dopamine neurotransmission have been largely limited to the use of psychostimulant drugs, which elevate brain levels of multiple neurotransmitters in addition to dopamine. In the present study we tested the effect of more selectively elevating dopamine neurotransmission, as produced by administration of the immediate dopamine precursor, L-DOPA (0, 100/25, 200/50 mg, Sinemet), in healthy human volunteers. Neither dose altered positive mood. The results suggest that dopamine neurotransmission does not directly influence positive mood in humans.
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Increases of human dopamine do not reliably cause enhancement of subjective ratings of pleasure.
“Similarly, it is now increasingly clear that increases of human dopamine do not reliably cause enhancement of subjective ratings of pleasure (although many rewards do induce dopamine release as a consequence and correlate, but not the cause, of pleasure) (Leyton et al., 2002; Evans et al., 2006; Liggins et al., 2012).”
From Evolving Concepts of Emotion and Motivation (2018) · cites this paper as Liggins et al., 2012
Many rewards induce dopamine release as a consequence and correlate, but not the cause, of pleasure.
“Similarly, it is now increasingly clear that increases of human dopamine do not reliably cause enhancement of subjective ratings of pleasure (although many rewards do induce dopamine release as a consequence and correlate, but not the cause, of pleasure) (Leyton et al., 2002; Evans et al., 2006; Liggins et al., 2012).”
From Evolving Concepts of Emotion and Motivation (2018) · cites this paper as Liggins et al., 2012
Giving ordinary people L-DOPA, which produces surges in brain dopamine levels, does not increase their subjective ratings of pleasure feelings.
“For example, giving ordinary people the medication L-DOPA, which produces surges in brain dopamine levels, does not increase their subjective ratings of pleasure feelings (Liggins et al., 2012).”
From Evolving Concepts of Emotion and Motivation (2018) · cites this paper as Liggins et al., 2012
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Research works printed but not linked: 1
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- Authors
- Liggins, J., Pihl, R. O., Benkelfat, C., & Leyton, M.
- Affiliations
- McGill University (CA)
- Corresponding author
- Leyton, Marco
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-01-04
- Volume
- 7
- Issue
- 1
- Pages
- e28370
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3251561
- OpenAlex
- W2074050833
- Cited by
- 58
- References
- 117
- Citations by year
- 2026: 2 · 2024: 1 · 2023: 16 · 2022: 3 · 2020: 4 · 2019: 3 · 2018: 5 · 2017: 2 · 2016: 4 · 2015: 7 · 2014: 4 · 2013: 5 · 2012: 2
- FWCI
- 2.37
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- McGill University
- Canadian Institutes of Health Research (36429, MOP–36429)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- L-DOPA, dopamine signaling, positive mood, reward, pleasure, psychostimulants, dopamine precursor, levodopa/carbidopa, human volunteers
- MeSH terms
- Adolescent, Adult, Affect, Dopamine, Double-Blind Method, Female, Health, Humans, Human Experimentation, Levodopa, Male, Synaptic Transmission, Up-Regulation, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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