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The involvement of nucleus accumbens dopamine in appetitive and aversive motivation
Abstract
In recent years, considerable emphasis has been placed upon the putative role of nucleus accumbens dopamine systems in appetitive motivation and positive reinforcement. However, considerable evidence indicates that brain dopamine in general, and nucleus accumbens dopamine in particular, is involved in aspects of aversive motivation. Administration of dopamine antagonists or localized interference with nucleus accumbens dopamine systems has been shown to disrupt active avoidance behavior. In addition, accumbens dopamine release and metabolism is activated by a wide variety of stressful conditions. A review of the literature indicates that there are substantial similarities between the characteristics of dopaminergic involvement in appetitive and aversive motivation. There is conflicting evidence about the role of dopamine in emotion, and little evidence to suggest that the profound and consistent changes in instrumental behavior produced by interference with DA systems are due to direct dopaminergic mediation of positive affective responses such as hedonia. It is suggested that nucleus accumbens dopamine is involved in aspects of sensorimotor functions that are involved in both appetitive and aversive motivation.
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“The meso-limbic dopamine system has been implicated in motivated behavior triggered by aversive stimuli (Salamone, 1994; Ikemoto and Panksepp, 1999; Pezze and Feldon, 2004).”
From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Salamone, 1994
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Metadata
- Authors
- Salamone, J. D.
- Affiliations
- University of Connecticut (US)
- Corresponding author
- Salamone, John D.
- ORCID
- Salamone, John D.
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 1994-04
- Volume
- 61
- Issue
- 2
- Pages
- 117-133
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W2079322728
- Cited by
- 584
- References
- 238
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 12 · 2023: 9 · 2022: 16 · 2021: 6 · 2020: 7 · 2019: 12 · 2018: 15 · 2017: 15 · 2016: 24 · 2015: 28 · 2014: 22 · 2013: 32 · 2012: 18
- FWCI
- 1.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- nucleus accumbens, dopamine, appetitive motivation, aversive motivation, avoidance behavior, positive reinforcement, stress, dopamine antagonists, hedonia, instrumental behavior, sensorimotor function
- MeSH terms
- Animals, Appetitive Behavior, Arousal, Avoidance Learning, Dopamine, Motivation, Nucleus Accumbens, Receptors, Dopamine, Reinforcement, Psychology
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