Idebenone in senile dementia of Alzheimer type: A multicentre study
Abstract
Idebenone is a new cerebro-active drug, effective in dementia disorders, particularly indicated in primary degenerative dementias, i.e. Alzheimer's disease. This new molecule acts as an electron trapper and a free radical scavenger protecting mitochondrial membranes from lipid peroxidation. A multicentric, double-blind trial of idebenone (45 mg twice daily orally) vs. placebo was carried out on 102 elderly patients affected by Alzheimer-type dementia of mild or moderate severity. Idebenone was administered for 4 consecutive months, 45 mg twice daily. Clinical evaluations were performed at the time of enrollment (t0) and monthly thereafter (t30, t60, t90 and t120) and at follow-up (t150 ). Tolerability to idebenone treatment was good and was associated with a statistically significant improvement of memory, attention and behaviour. It is worthwhile noting that these cognitive and behavioral findings were observed after the first month of treatment with enhancement evident in the following period.
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A multicentre, placebo controlled, double-blind trial of idebenone 45 mg twice/day orally in AD patients showed statistically significant improvement of memory, attention and behavior.
“A multicentre, placebo controlled, double-blind trial of idebenone 45 mg twice/day orally, in patients of AD, showed statistically significant improvement of the memory, attention and behavior166.”
From Mitochondrial Approaches for Neuroprotection (2008) · cites this paper as [166]
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- Authors
- Senin, U., Parnetti, L., Barbagallo-Sangiorgi, G., Bartorelli, L., Bocola, V., Capurso, A., Cuzzupoli, M., Denaro, M., Marigliano, V., Tammaro, A. E., & Fioravanti, M.
- Affiliations
- University of Perugia (IT)
- St. Eugenio Hospital (IT)
- University of Bari Aldo Moro (IT)
- Sapienza University of Rome (IT)
- Corresponding author
- Senin, Umberto
- Venue
- Archives of Gerontology and Geriatrics
- Publisher
- Elsevier BV
- Published
- 1992-11
- Volume
- 15
- Issue
- 3
- Pages
- 249-260
- ISSN
- 0167-4943 (ISSN-L)
- OpenAlex
- W2022150546
- Cited by
- 72
- References
- 20
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 4 · 2020: 6 · 2019: 4 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 1 · 2014: 3 · 2013: 3 · 2012: 2
- FWCI
- 0.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Gerontology and Geriatrics (publishedVersion)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
- Keywords
- idebenone, Alzheimer's disease, senile dementia, cognitive impairment, memory, attention, behavior, radical scavengers, mitochondrial protection, lipid peroxidation, tolerability
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