Toll-like Receptor 4 and Hepatic Fibrogenesis

Pathogen Recognition and Innate Immunity

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Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in <i>Tlr4</i> Gene

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The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults

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TLR4 enhances TGF-β signaling and hepatic fibrosis

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How dying cells alert the immune system to danger

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Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair

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Regulation of lung injury and repair by Toll-like receptors and hyaluronan

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Oligosaccharides of Hyaluronan Activate Dendritic Cells via Toll-like Receptor 4

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Toll-like receptor 9–dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE

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Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion

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Crystal Structure of the TLR4-MD-2 Complex with Bound Endotoxin Antagonist Eritoran

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Bacterial lipopolysaccharides and innate immunity

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The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion

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TRAM is specifically involved in the Toll-like receptor 4–mediated MyD88-independent signaling pathway

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Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4

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Toll‐like Receptor and RIG‐1‐like Receptor Signaling

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Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease

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Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists

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Hyaluronan in Tissue Injury and Repair

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The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors

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Obesity increases sensitivity to endotoxin liver injury: Implications for the pathogenesis of steatohepatitis

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Primary Prophylaxis of Spontaneous Bacterial Peritonitis Delays Hepatorenal Syndrome and Improves Survival in Cirrhosis

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Toll‐like receptor‐4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non‐alcoholic steatohepatitis

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Antibiotics prevent liver injury in rats following long-term exposure to ethanol

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Bacterial translocation (BT) in cirrhosis†

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CD14 is required for MyD88-independent LPS signaling

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Toll-Like Receptor 4 Mediates Inflammatory Signaling by Bacterial Lipopolysaccharide in Human Hepatic Stellate Cells

Paik, Y.-H., Schwabe, R. F., Bataller, R., Russo, M. P., Jobin, C., & Brenner, D. A. (2003) · Hepatology · doi:10.1053/jhep.2003.50182 · Cited by 651 · see citing works

Increased intestinal permeability to macromolecules and endotoxemia in patients with chronic alcohol abuse in different stages of alcohol-induced liver disease

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Synbiotic modulation of gut flora: Effect on minimal hepatic encephalopathy in patients with cirrhosis

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The grateful dead: damage‐associated molecular pattern molecules and reduction/oxidation regulate immunity

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Drosophila Toll and IL-1 receptor

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The interleukin‐1 receptor/Toll‐like receptor superfamily: 10 years of progress

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High‐mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity

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Toll-Like Receptor 4 Is Involved in the Development of Fructose-Induced Hepatic Steatosis in Mice†

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Inactivation of Kupffer cells prevents early alcohol-induced liver injury

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Bacterial Infections, Sepsis, and Multiorgan Failure in Cirrhosis

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Hyaluronan Fragments Stimulate Endothelial Recognition of Injury through TLR4

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Saturated Fatty Acid Activates but Polyunsaturated Fatty Acid Inhibits Toll-like Receptor 2 Dimerized with Toll-like Receptor 6 or 1

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NADPH oxidase–derived free radicals are key oxidants in alcohol-induced liver disease

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Early enteral supply of lactobacillus and fiber versus selective bowel decontamination: a controlled trial in liver transplant recipients

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Toll–Like Receptor 4 Is Involved in the Mechanism of Early Alcohol–Induced Liver Injury in Mice

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Supply of Pre- and Probiotics Reduces Bacterial Infection Rates After Liver Transplantation—A Randomized, Double-Blind Trial

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Plasma endotoxin concentrations in patients with alcoholic and non-alcoholic liver disease: reevaluation with an improved chromogenic assay

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Beneficial Effects of a Probiotic VSL#3 on Parameters of Liver Dysfunction in Chronic Liver Diseases

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Lactobacillus Feeding Reduces Endotoxemia and Severity of Experimental Alcoholic Liver (Disease)

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CCR1 and CCR5 promote hepatic fibrosis in mice

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The critical role of toll‐like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88†

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HMGB1 Develops Enhanced Proinflammatory Activity by Binding to Cytokines

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Human Kupffer cells secrete IL-10 in response to lipopolysaccharide (LPS) challenge

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A Novel Cyclohexene Derivative, Ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), Selectively Inhibits Toll-Like Receptor 4-Mediated Cytokine Production through Suppression of Intracellular Signaling

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Increased gastrointestinal ethanol production in obese mice: Implications for fatty liver disease pathogenesis

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Endotoxemia in patients with chronic liver diseases: relationship to severity of liver diseases, presence of esophaegeal varices, and hyperdynamic circulation.

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Regulation of Macrophage Chemokine Expression by Lipopolysaccharide In Vitro and In Vivo

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TAK-242 selectively suppresses Toll-like receptor 4-signaling mediated by the intracellular domain

Kawamoto, T., Ii, M., Kitazaki, T., Iizawa, Y., & Kimura, H. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.01.026 · Cited by 311 · see citing works

A 7 gene signature identifies the risk of developing cirrhosis in patients with chronic hepatitis C†

Huang, H., Shiffman, M. L., Friedman, S. L., Venkatesh, R., Bzowej, N. H., Abar, O. T., Rowland, C. M., Catanese, J. J., Leong, D. U., Sninsky, J. J., et al. (2007) · Hepatology · doi:10.1002/hep.21695 · Cited by 300 · see citing works

Exacerbation of Alcoholic Liver Injury by Enteral Endotoxin in Rats

Mathurin, P., Deng, Q.-G., Keshavarzian, A., Choudhary, S., HOLMES, E. W., & Tsukamoto, H. (2000) · Hepatology · doi:10.1053/jhep.2000.19621 · Cited by 297 · see citing works

Inhibition of Endotoxin Response by E5564, a Novel Toll-Like Receptor 4-Directed Endotoxin Antagonist

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High Mobility Group Box 1 Protein Binding to Lipopolysaccharide Facilitates Transfer of Lipopolysaccharide to CD14 and Enhances Lipopolysaccharide-Mediated TNF-α Production in Human Monocytes

Youn, J. H., Oh, Y. J., Kim, E. S., Choi, J. E., & Shin, J.-S. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.7.5067 · Cited by 281 · see citing works

Kupffer cell activation by lipopolysaccharide in rats: Role for lipopolysaccharide binding protein and toll‐like receptor 4

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In liver fibrosis, dendritic cells govern hepatic inflammation in mice via TNF-α

Connolly, M. K., Bedrosian, A. S., Clair, J. M., Mitchell, A. P., Ibrahim, J., Stroud, A., Pachter, H. L., Bar‐Sagi, D., Frey, A. B., & Miller, G. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37581 · Cited by 266 · see citing works

VSL#3 probiotic treatment attenuates fibrosis without changes in steatohepatitis in a diet‐induced nonalcoholic steatohepatitis model in mice†

Velayudham, A., Dolganiuc, A., Ellis, M., Petrášek, J., Kodys, K., Mandrekar, P., & Szabó, G. (2008) · Hepatology · doi:10.1002/hep.22711 · Cited by 263 · see citing works

Apoptotic hepatocyte DNA inhibits hepatic stellate cell chemotaxis via toll-like receptor 9

Watanabe, A., Hashmi, A., Gomes, D. A., Town, T., Badou, A., Flavell, R. A., & Mehal, W. Z. (2007) · Hepatology · doi:10.1002/hep.21867 · Cited by 262 · see citing works

Comparison of Translocation Rates of Various Indigenous Bacteria from the Gastrointestinal Tract to the Mesenteric Lymph Node

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Lipopolysaccharide-Induced IL-18 Secretion from Murine Kupffer Cells Independently of Myeloid Differentiation Factor 88 That Is Critically Involved in Induction of Production of IL-12 and IL-1β

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Multiple TLRs Are Expressed in Human Cholangiocytes and Mediate Host Epithelial Defense Responses to Cryptosporidium parvum via Activation of NF-κB

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Functional Linkage of Cirrhosis-Predictive Single Nucleotide Polymorphisms of Toll-Like Receptor 4 to Hepatic Stellate Cell Responses

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A synthetic TLR4 antagonist has anti-inflammatory effects in two murine models of inflammatory bowel disease

Fort, M. M., Mozaffarian, A., Stöver, A. G., Correia, J. D. S., Johnson, D. A., Crane, R. T., Ulevitch, R. J., Persing, D. H., Bielefeldt-Ohmann, H., Probst, P., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.10.6416 · Cited by 216 · see citing works

Analysis of proinflammatory activity of highly purified eukaryotic recombinant HMGB1 (amphoterin)

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Obesity and Female Gender Increase Breath Ethanol Concentration: Potential Implications for The Pathogenesis of Nonalcoholic Steatohepatitis

Nair, S. P., Cope, K. A., Risby, T. H., & Diehl, A. M. (2001) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2001.03702.x · Cited by 211 · see citing works

Probiotic bacteria prevent hepatic damage and maintain colonic barrier function in a mouse model of sepsis

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Endotoxin and Cytokine Regulation of Toll-like Receptor (TLR) 2 and TLR4 Gene Expression in Murine Liver and Hepatocytes

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Therapeutic effects of TAK-242, a novel selective Toll-like receptor 4 signal transduction inhibitor, in mouse endotoxin shock model

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R‐form LPS, the master key to the activation ofTLR4/MD‐2‐positive cells

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