Cited by 239Parkinson's Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

NACP/α-synuclein immunoreactivity in fibrillary components of neuronal and oligodendroglial cytoplasmic inclusions in the pontine nuclei in multiple system atrophy

Arima, K., Uéda, Kenji, Sunohara, Nobuhiko, Arakawa, Kenji, Hirai, Shigeo, Nakamura, Minako, Tonozuka-Uehara, Haruko, Kawai, Mitsuru·1998·Acta Neuropathologica

Abstract

We examined neuronal cytoplasmic inclusions (NCIs) and oligodendrocytic glial cytoplasmic inclusions (GCIs) in the pontine nuclei in multiple system atrophy (MSA) using antibodies against the non-amyloid beta component of Alzheimer's disease amyloid precursor protein (NACP/alpha-synuclein). Our immunohistochemical study revealed that anti-NACP antibodies labeled both NCIs and GCIs. Immunoelectron microscopy showed that positive reaction products were localized on the 15- to 30-nm-thick filamentous components of NCIs and GCIs. The present study demonstrates that NACP is associated with cytoplasmic inclusions of MSA, and suggests a role of NACP in abnormal filament aggregation in neuronal degeneration.

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Crossref · 10.1007/s004010050917

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Authors
Arima, K., Uéda, K., Sunohara, N., Arakawa, K., Hirai, S., Nakamura, M., Tonozuka-Uehara, H., & Kawai, M.
Affiliations
  • Tokyo Institute of Psychiatry (JP)
  • National Center of Neurology and Psychiatry (JP)
Venue
Acta Neuropathologica
Published
1998-11-01
Volume
96
Issue
5
Pages
439-444
ISSN
  • 0001-6322 (ISSN-L)
  • 1432-0533
OpenAlex
W1986042913
Cited by
239
References
15
Citations by year
2025: 1 · 2024: 4 · 2023: 4 · 2022: 4 · 2021: 6 · 2020: 7 · 2019: 4 · 2018: 6 · 2017: 6 · 2016: 2 · 2015: 5 · 2014: 12 · 2013: 10 · 2012: 8
FWCI
16.41
Type
journal article
Language
en
Open access
closed
Locations
  • Acta Neuropathologica (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
multiple system atrophy, alpha-synuclein, neuronal cytoplasmic inclusions, glial cytoplasmic inclusions, pontine nuclei, amyloid precursor protein, protein aggregation, neurodegeneration, oligodendrocytes
MeSH terms
Adult, Aged, Aged, 80 and over, Animals, Inclusion Bodies, Female, Humans, Immunohistochemistry, Male, Middle Aged, Nerve Tissue Proteins, Neurofibrils, Neurons, Oligodendroglia, Pons, Microscopy, Immunoelectron, Multiple System Atrophy, Rats, Synucleins

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