NACP/α-synuclein immunoreactivity in fibrillary components of neuronal and oligodendroglial cytoplasmic inclusions in the pontine nuclei in multiple system atrophy
Abstract
We examined neuronal cytoplasmic inclusions (NCIs) and oligodendrocytic glial cytoplasmic inclusions (GCIs) in the pontine nuclei in multiple system atrophy (MSA) using antibodies against the non-amyloid beta component of Alzheimer's disease amyloid precursor protein (NACP/alpha-synuclein). Our immunohistochemical study revealed that anti-NACP antibodies labeled both NCIs and GCIs. Immunoelectron microscopy showed that positive reaction products were localized on the 15- to 30-nm-thick filamentous components of NCIs and GCIs. The present study demonstrates that NACP is associated with cytoplasmic inclusions of MSA, and suggests a role of NACP in abnormal filament aggregation in neuronal degeneration.
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MSA is characterized neuropathologically by α-syn-positive glial cytoplasmic inclusions (GCIs) in oligodendroglia.
“MSA is a synucleinopathy, however, unlike PD and dementia with Lewy bodies, in which α-syn accumulates and aggregates in neurons, MSA is characterized neuropathologically by α-syn-positive glial cytoplasmic inclusions (GCIs) in oligodendroglia [1, 42, 54, 58, 59].”
From Novel oligodendroglial alpha synuclein viral vector models of multiple system atrophy: studies in rodents and nonhuman primates (2017) · cites this paper as [1]
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Self-citation
- Authors
- Arima, K., Uéda, K., Sunohara, N., Arakawa, K., Hirai, S., Nakamura, M., Tonozuka-Uehara, H., & Kawai, M.
- Affiliations
- Tokyo Institute of Psychiatry (JP)
- National Center of Neurology and Psychiatry (JP)
- Venue
- Acta Neuropathologica
- Published
- 1998-11-01
- Volume
- 96
- Issue
- 5
- Pages
- 439-444
- ISSN
- 0001-6322 (ISSN-L)
- 1432-0533
- OpenAlex
- W1986042913
- Cited by
- 239
- References
- 15
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 4 · 2022: 4 · 2021: 6 · 2020: 7 · 2019: 4 · 2018: 6 · 2017: 6 · 2016: 2 · 2015: 5 · 2014: 12 · 2013: 10 · 2012: 8
- FWCI
- 16.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Acta Neuropathologica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- multiple system atrophy, alpha-synuclein, neuronal cytoplasmic inclusions, glial cytoplasmic inclusions, pontine nuclei, amyloid precursor protein, protein aggregation, neurodegeneration, oligodendrocytes
- MeSH terms
- Adult, Aged, Aged, 80 and over, Animals, Inclusion Bodies, Female, Humans, Immunohistochemistry, Male, Middle Aged, Nerve Tissue Proteins, Neurofibrils, Neurons, Oligodendroglia, Pons, Microscopy, Immunoelectron, Multiple System Atrophy, Rats, Synucleins
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