Cited by 854Regulation of Appetite and ObesityNeuropeptides and Animal PhysiologyEating Disorders and Behaviors

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Neuropeptide Y chronically injected into the hypothalamus: A powerful neurochemical inducer of hyperphagia and obesity

Glenn Stanley, B., Kyrkouli, Stavroula E., Lampert, Sharon, Leibowitz, Sarah F.·1986·Peptides

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Abstract

Neuropeptide Y (NPY), a putative neurotransmitter abundant in the brain, has recently been shown to act within the hypothalamus, inducing a powerful eating response and a specific appetite for carbohydrates. In the present study, NPY (235 pmol) injected bilaterally in the paraventricular nucleus three times a day for 10 days caused approximately a two-fold increase in daily food intake, a six-fold increase in the rate of body weight gain and a three-fold increase in the body fat of female rats. Subsequently, the food intake and body weight of these subjects decreased precipitously, reaching control levels 20 days postinjection. These findings, demonstrating that exogenous NPY is capable of overriding mechanisms of satiety and body weight control, suggest that disturbances in NPY function may play a role in some disorders of eating behavior and body weight regulation.

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Stanley, 1985, Hyperphagia and obesity induced by neuropeptide Y injected chronically into the paraventricular hypothalamus of the rat, Soc Neurosci Abstr, 11, 36

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Authors: Glenn Stanley, B., Kyrkouli, S. E., Lampert, S., & Leibowitz, S. F.
Affiliations: Rockefeller University (US)
ORCID: Leibowitz, Sarah F.
Venue: Peptides
Publisher: Elsevier BV
Published: 1986-11
Volume: 7
Issue: 6
Pages: 1189-1192
ISSN: 0196-9781 (ISSN-L)
DOI: 10.1016/0196-9781(86)90149-x
OpenAlex: W2033305745
Cited by: 849
References: 27
Citations by year: 2026: 1 · 2025: 8 · 2024: 7 · 2023: 7 · 2022: 3 · 2021: 7 · 2020: 10 · 2019: 9 · 2018: 12 · 2017: 9 · 2016: 14 · 2015: 12 · 2014: 26 · 2013: 24 · 2012: 33
FWCI: 5.69
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Peptides (publishedVersion)
PubMed (publishedVersion)
Funders: Centers for Disease Control and Prevention (MN 22879)
U.S. Public Health Service
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
Keywords: neuropeptide Y, hypothalamus, paraventricular nucleus, hyperphagia, obesity, dietary intake, weight gain, fat mass, satiety, dietary habits, body weight regulation
MeSH terms: Adipose Tissue, Animals, Appetite, Feeding and Eating Disorders, Body Weight, Energy Intake, Female, Hyperphagia, Hypothalamus, Neuropeptide Y, Obesity, Rats, Inbred Strains, Rats

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Neuropeptide Y chronically injected into the hypothalamus: A powerful neurochemical inducer of hyperphagia and obesity

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