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Cited by 854Regulation of Appetite and ObesityNeuropeptides and Animal PhysiologyEating Disorders and Behaviors

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

Neuropeptide Y chronically injected into the hypothalamus: A powerful neurochemical inducer of hyperphagia and obesity

Glenn Stanley, B., Kyrkouli, Stavroula E., Lampert, Sharon, Leibowitz, Sarah F.·1986·Peptides
DOI 10.1016/0196-9781(86)90149-x
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Abstract

Neuropeptide Y (NPY), a putative neurotransmitter abundant in the brain, has recently been shown to act within the hypothalamus, inducing a powerful eating response and a specific appetite for carbohydrates. In the present study, NPY (235 pmol) injected bilaterally in the paraventricular nucleus three times a day for 10 days caused approximately a two-fold increase in daily food intake, a six-fold increase in the rate of body weight gain and a three-fold increase in the body fat of female rats. Subsequently, the food intake and body weight of these subjects decreased precipitously, reaching control levels 20 days postinjection. These findings, demonstrating that exogenous NPY is capable of overriding mechanisms of satiety and body weight control, suggest that disturbances in NPY function may play a role in some disorders of eating behavior and body weight regulation.

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Crossref · 10.1016/0196-9781(86)90149-x

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Research works printed but not linked: 1

  1. Stanley, 1985, Hyperphagia and obesity induced by neuropeptide Y injected chronically into the paraventricular hypothalamus of the rat, Soc Neurosci Abstr, 11, 36

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Metadata

Authors
Glenn Stanley, B., Kyrkouli, S. E., Lampert, S., & Leibowitz, S. F.
Affiliations
Rockefeller University (US)
ORCID
Leibowitz, Sarah F.
Venue
Peptides
Publisher
Elsevier BV
Published
1986-11
Volume
7
Issue
6
Pages
1189-1192
ISSN
0196-9781 (ISSN-L)
DOI
10.1016/0196-9781(86)90149-x
OpenAlex
W2033305745
Cited by
849
References
27
Citations by year
2026: 1 · 2025: 8 · 2024: 7 · 2023: 7 · 2022: 3 · 2021: 7 · 2020: 10 · 2019: 9 · 2018: 12 · 2017: 9 · 2016: 14 · 2015: 12 · 2014: 26 · 2013: 24 · 2012: 33
FWCI
5.69
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Peptides (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Centers for Disease Control and Prevention (MN 22879)
  • U.S. Public Health Service
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
Keywords
neuropeptide Y, hypothalamus, paraventricular nucleus, hyperphagia, obesity, dietary intake, weight gain, fat mass, satiety, dietary habits, body weight regulation
MeSH terms
Adipose Tissue, Animals, Appetite, Feeding and Eating Disorders, Body Weight, Energy Intake, Female, Hyperphagia, Hypothalamus, Neuropeptide Y, Obesity, Rats, Inbred Strains, Rats

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