Cited by 854Regulation of Appetite and ObesityNeuropeptides and Animal PhysiologyEating Disorders and Behaviors

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

Neuropeptide Y chronically injected into the hypothalamus: A powerful neurochemical inducer of hyperphagia and obesity

Glenn Stanley, B., Kyrkouli, Stavroula E., Lampert, Sharon, Leibowitz, Sarah F.·1986·Peptides

Open this paper in CoChat — free account

Abstract

Neuropeptide Y (NPY), a putative neurotransmitter abundant in the brain, has recently been shown to act within the hypothalamus, inducing a powerful eating response and a specific appetite for carbohydrates. In the present study, NPY (235 pmol) injected bilaterally in the paraventricular nucleus three times a day for 10 days caused approximately a two-fold increase in daily food intake, a six-fold increase in the rate of body weight gain and a three-fold increase in the body fat of female rats. Subsequently, the food intake and body weight of these subjects decreased precipitously, reaching control levels 20 days postinjection. These findings, demonstrating that exogenous NPY is capable of overriding mechanisms of satiety and body weight control, suggest that disturbances in NPY function may play a role in some disorders of eating behavior and body weight regulation.

Integrity signals

Registry

Crossref · 10.1016/0196-9781(86)90149-x

Cites

27 of 27 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Neuropeptide Y—a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide
Tatemoto, K., Carlquist, M., & Mutt, V. (1982) · Nature · doi:10.1038/296659a0 · Cited by 2,254
NEUROPEPTIDE Y AND HUMAN PANCREATIC POLYPEPTIDE STIMULATE FEEDING BEHAVIOR IN RATS
Clark, J. T., Kalra, P. S., Crowley, W. R., & Kalra, S. P. (1984) · Endocrinology · doi:10.1210/endo-115-1-427 · Cited by 1,276
Neuropeptide Y Distribution in the Rat Brain
Allen, Y. S., Adrian, T. E., Allen, J. M., Tatemoto, K., Crow, T. J., Bloom, S. R., & Polak, J. M. (1983) · Science · doi:10.1126/science.6136091 · Cited by 1,097
The anatomy of neuropeptide-y-containing neurons in rat brain
Chronwall, B. M., DiMaggio, D. A., Massari, V. J., Pickel, V. M., Ruggiero, D. A., & O’Donohue, T. L. (1985) · Neuroscience · doi:10.1016/0306-4522(85)90260-x · Cited by 1,088
Hypothalamic lesions and adiposity in the rat
Hetherington, A. W., & Ranson, S. W. (1940) · The Anatomical Record · doi:10.1002/ar.1090780203 · Cited by 1,028
Neuropeptide Y injected in the paraventricular hypothalamus: a powerful stimulant of feeding behavior.
Stanley, B. G., & LEIBOWITZ, S. F. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.11.3940 · Cited by 741
Self-citation
Neuropeptide Y distribution in human brain
Adrian, T. E., Allen, J. M., Bloom, S. R., Ghatei, M. A., Rossor, M. N., Roberts, G. W., Crow, T. J., Tatemoto, K., & Polak, J. M. (1983) · Nature · doi:10.1038/306584a0 · Cited by 701
Neuroreptide Y: Stimulation of feeding and drinking by injection into the paraventricular nucleus
Stanley, B. G., & LEIBOWITZ, S. F. (1984) · Life Sciences · doi:10.1016/0024-3205(84)90032-8 · Cited by 665
Self-citation
Colocalization of neuropeptide Y immunoreactivity in brainstem catecholaminergic neurons that project to the paraventricular nucleus of the hypothalamus
Sawchenko, P. E., Swanson, L. W., Grzanna, R., Howe, P. R. C., Bloom, S. R., & Polak, J. M. (1985) · The Journal of Comparative Neurology · doi:10.1002/cne.902410203 · Cited by 663
Paraventricular nucleus: A primary site mediating adrenergic stimulation of feeding and drinking
LEIBOWITZ, S. F. (1978) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(78)90333-7 · Cited by 439
Self-citation

Show all 27 references

Research works printed but not linked: 1

Stanley, 1985, Hyperphagia and obesity induced by neuropeptide Y injected chronically into the paraventricular hypothalamus of the rat, Soc Neurosci Abstr, 11, 36

Sorted by citations

Items 301–400 of 854

Hypothalamic neuropeptide Y disturbances in the obese (cp/cp) JCR:LA corpulent rat
Williams, G., Shellard, L., Lewis, D. E., McKibbin, P. E., McCarthy, H. D., Koeslag, D. G., & Russell, J. C. (1992) · Peptides · doi:10.1016/0196-9781(92)90085-h · Cited by 56
Immunohistochemical localization of the neuropeptide Y Y1 receptor in rat central nervous system
Migita, K., Loewy, A. D., Ramabhadran, T. V., Krause, J. E., & Waters, S. M. (2001) · Brain Research · doi:10.1016/s0006-8993(00)03092-4 · Cited by 55
Response of neuropeptide Y-deficient mice to feeding effectors
Hollopeter, G., Erickson, J. C., Seeley, R. J., Marsh, D. J., & Palmiter, R. D. (1998) · Regulatory Peptides · doi:10.1016/s0167-0115(98)00092-5 · Cited by 55
Role of neuropeptide Y in diet-, chemical- and genetic-induced obesity of mice
Hollopeter, G., Erickson, J. C., & Palmiter, R. D. (1998) · International Journal of Obesity · doi:10.1038/sj.ijo.0800615 · Cited by 55
Assessment of Feeding Response of Tumor-Bearing Rats to Hypothalamic Injection and Infusion of Neuropeptide Y
Chance, W. T., Balasubramaniam, A., Thompson, H., Mohapatra, B. N., Ramo, J., & Fischer, J. E. (1996) · Peptides · doi:10.1016/0196-9781(96)00108-8 · Cited by 55
The serotonin (5-HT) antagonist methysergide increases neuropeptide Y (NPY) synthesis and secretion in the hypothalamus of the rat
Dryden, S. D., Wang, Q., Frankish, H. M., Pickavance, L. C., & Williams, G. (1995) · Brain Research · doi:10.1016/0006-8993(95)00841-d · Cited by 55
Integrative role of neuropeptides and cytokines in cancer anorexia–cachexia syndrome
Patra, S. K., & Arora, S. (2012) · Clinica Chimica Acta · doi:10.1016/j.cca.2011.12.008 · Cited by 55
Dihydropyridine Neuropeptide Y Y1 Receptor Antagonists
Poindexter, G. S., Bruce, M. A., LeBoulluec, K. L., Monković, I., Martin, S. W., Parker, E. M., Iben, L., McGovern, R. T., Ortiz, A. A., Stanley, J. A., et al. (2002) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(01)00761-2 · Cited by 54
Influence of diet composition on food intake and hypothalamic neuropeptide Y (NPY) in the rat
Beck, B., Stricker‐Krongrad, A., Burlet, A. J., Nicolas, J. P., & Burlet, C. R. (1990) · Neuropeptides · doi:10.1016/0143-4179(90)90036-x · Cited by 54
Characterisation of the neuropeptide Y receptor that mediates feeding in the rat: a role for the Y5 receptor?
Haynes, A. C., Arch, J. R. S., Wilson, S., Clue, S. M., & Buckingham, R. E. (1998) · Regulatory Peptides · doi:10.1016/s0167-0115(98)00088-3 · Cited by 54
Specificity of Hypothalamic Peptides in the Control of Behavioral and Physiological Processesa
LEIBOWITZ, S. F. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb19804.x · Cited by 54
Self-citation
Feeding and drinking responses to neuropeptide Y injections in the paraventricular hypothalamic nucleus of aged rats
Pich, E. M., Messori, B., Zoli, M., Ferraguti, F., Marrama, P., Biagini, G., Fuxé, K., & Agnati, L. F. (1992) · Brain Research · doi:10.1016/0006-8993(92)90089-r · Cited by 54
A potent neuropeptide Y antagonist, 1229U91, suppressed spontaneous food intake in Zucker fatty rats
Ishihara, A., Tanaka, T., Kanatani, A., Fukami, T., Ihara, M., & Fukuroda, T. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.274.5.r1500 · Cited by 54
Hypothalamic neuropeptide Y receptor characteristics and NPY-induced feeding responses in lean and obese Zucker rats
McCarthy, H. D., McKibbin, P. E., Holloway, B. R., Mayers, R. M., & Williams, G. (1991) · Life Sciences · doi:10.1016/0024-3205(91)90049-h · Cited by 54
Increased feeding in fatty Zucker rats by the thiazolidinedione BRL 49653 (rosiglitazone) and the possible involvement of leptin and hypothalamic neuropeptide Y
Wang, Q., Dryden, S. D., Frankish, H. M., Bing, C., Pickavance, L. C., Hopkins, D., Buckingham, R. E., & Williams, G. (1997) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0701535 · Cited by 53
The effect of norbinaltorphimine, β-funaltrexamine and naltrindole on NPY-induced feeding
Kotz, C. M., Grace, M. K., Billington, C. J., & Levine, A. S. (1993) · Brain Research · doi:10.1016/0006-8993(93)91552-4 · Cited by 53
Bivariate genetic analysis of fasting insulin and glucose levels
Snieder, H., Boomsma, D. I., van Doornen, L. J. P., & Neale, M. C. (1999) · Genetic Epidemiology · doi:10.1002/(sici)1098-2272(1999)16:4 · Cited by 56
NPY Y1 and Y5 Receptor Selective Antagonists as Anti-Obesity Drugs
MacNeil, D. (2007) · Current Topics in Medicinal Chemistry · doi:10.2174/156802607782341028 · Cited by 52
Selective Dependence of Intracerebroventricular Neuropeptide Y-Elicited Effects on Central Glucocorticoids
Zakrzewska, K. E., Sainsbury, A., Cusin, I., Rouru, J., Jeanrenaud, B., & Rohner‐Jeanrenaud, F. (1999) · Endocrinology · doi:10.1210/en.140.7.3183 · Cited by 52
Relation of leptin and neuropeptide Y in human blood and cerebrospinal fluid
Dötsch, J., Adelmann, M., Englaro, P., Dötsch, A., Hänze, J., Blum, W. F., Kiess, W., & Rascher, W. (1997) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(97)00116-0 · Cited by 52
Peripheral insulin administration attenuates the increase in neuropeptide Y concentrations in the hypothalamic arcuate nucleus of fasted rats
Malabu, U. H., McCarthy, H. D., McKibbin, P. E., & Williams, G. (1992) · Peptides · doi:10.1016/0196-9781(92)90013-s · Cited by 52
The physiology and brain mechanisms of feeding
Rowland, N. E., Morien, A., & Li, B.-H. (1996) · Nutrition · doi:10.1016/s0899-9007(96)00227-4 · Cited by 52
The regulation of body weight: lessons from the seasonal animal
Morgan, P. J., & Mercer, J. G. (2001) · Proceedings of The Nutrition Society · doi:10.1079/pns200060 · Cited by 52
Intracerebroventricular Glucocorticoid Infusion in Normal Rats: Induction of Parasympathetic‐Mediated Obesity and Insulin Resistance
Cusin, I., Rouru, J., & Rohner‐Jeanrenaud, F. (2001) · Obesity Research · doi:10.1038/oby.2001.52 · Cited by 51
The Suprachiasmatic Nucleus Changes the Daily Activity of the Arcuate Nucleus α-MSH Neurons in Male Rats
Guzmán‐Ruiz, M. A., Saderi, N., Cázarez‐Márquez, F., Guerrero‐Vargas, N. N., Basualdo, M. C., Acosta-Galvan, G., & Buijs, R. M. (2013) · Endocrinology · doi:10.1210/en.2013-1604 · Cited by 52
Cellular Leptin Resistance Impairs the Leptin-Mediated Suppression of Neuropeptide Y Secretion in Hypothalamic Neurons
Dhillon, S. S., McFadden, S. A., Chalmers, J. A., Centeno, M.-L., Kim, G. L., & Belsham, D. D. (2011) · Endocrinology · doi:10.1210/en.2011-0178 · Cited by 52
Characterization of central actions of neuropeptide Y on food and water intake in rabbits
Pau, M.-Y., Pau, K. ‐. F., & Spies, H. G. (1988) · Physiology & Behavior · doi:10.1016/0031-9384(88)90065-0 · Cited by 51
Role of a hydrophobic pocket of the human Y1 neuropeptide Y receptor in ligand binding
Sautel, M., Martínez, R., Miguel, M., Peitsch, M. C., Beck‐Sickinger, A. G., & Walker, P. (1995) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(95)03603-5 · Cited by 51
Electroconvulsive stimuli enhance both neuropeptide Y receptor Y1 and Y2 messenger RNA expression and levels of binding in the rat hippocampus
Madsen, T. M., Greisen, M. H., Nielsen, S. M., Bolwig, T. G., & Mikkelsen, J. D. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00078-6 · Cited by 51
Orexins and the treatment of obesity
Smart, D., Haynes, A. C., Williams, G. H., & Arch, J. R. S. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)01429-2 · Cited by 51
Corticotropin-Releasing Factor, Corticosteroids, Stress, and Sugar
Dallman, M. F., Viau, V., Bhatnagar, S., Gómez-Oliver, F., Laugero, K. D., & Bell, M. E. (2002) · Elsevier eBooks · doi:10.1016/b978-012532104-4/50011-1 · Cited by 52
Feeding responses to perifornical hypothalamic injection of neuropeptide Y in relation to circadian rhythms of eating behavior
Stanley, B. G., & Thomas, W. J. (1993) · Peptides · doi:10.1016/0196-9781(93)90135-4 · Cited by 51
AAV mediated expression of anti-sense neuropeptide Y cRNA in the arcuate nucleus of rats results in decreased weight gain and food intake
Gardiner, J., Kong, W. M., Ward, H., Murphy, K. G., Dhillo, W. S., & Bloom, S. R. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.12.113 · Cited by 50
Ghrelin and gastric acid secretion
Yakabi, K., Kawashima, J., & Kato, S. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.6334 · Cited by 50
The NPY Y1 receptor antagonist BIBP 3226 blocks NPY induced feeding via a non-specific mechanism
Morgan, D. G. A., Small, C. J., Abusnana, S., Turton, M. D., Gunn, I., Heath, M., Rossi, M., Goldstone, A. P., O’Shea, D., Meeran, K. M., et al. (1998) · Regulatory Peptides · doi:10.1016/s0167-0115(98)00091-3 · Cited by 50
The discriminative stimulus effects of neuropeptide Y
Jewett, D. C., Schaal, D. W., Cleary, J. P., Thompson, T. I., & Levine, A. S. (1991) · Brain Research · doi:10.1016/0006-8993(91)90763-l · Cited by 50
Hypothalamic regulation of appetite
Simpson, K. A., Martin, N. M., & Bloom, S. R. (2008) · Expert Review of Endocrinology & Metabolism · doi:10.1586/17446651.3.5.577 · Cited by 49
Neuropeptide Y and alpha-melanocyte-stimulating hormone: interaction in obesity and possible role in the development of hypertension
Baltatzi, M. S., Hatzitolios, A. I., Τζιόμαλος, Κ., Iliadis, F., & Zamboulis, C. (2008) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2008.01823.x · Cited by 49
Chronic Neuropeptide Y Infusion into the Lateral Ventricle Induces Sustained Feeding and Obesity in Mice Lacking Either Npy1r or Npy5r Expression
Raposinho, P., Pedrazzini, T., White, R. B., Palmiter, R. D., & Aubert, M. L. (2003) · Endocrinology · doi:10.1210/en.2003-0914 · Cited by 50
Increased feeding and neuropeptide Y (NPY) but not NPY mRNA levels in the hypothalamus of the rat following central administration of the serotonin synthesis inhibitorp-chlorophenylalanine
Dryden, S. D., Frankish, H. M., Wang, Q., & Williams, G. (1996) · Brain Research · doi:10.1016/0006-8993(96)00329-0 · Cited by 49
Role of hypothalamic neuropeptide Y gene expression in body weight regulation
Davies, L., & Marks, J. L. (1994) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1994.266.5.r1687 · Cited by 49
Rapid changes in hypothalamic neuropeptide Y produced by carbohydrate-rich meals that enhance corticosterone and glucose levels1This manuscript is dedicated to my eminent colleague and dear friend, Dr. Stelios Nicolaidis, who has made so many outstanding contributions and been an enormous inspiration to scientists in the fields of neuroscience and ingestive behavior.1
Wang, J., Dourmashkin, J. T., Yun, R., & LEIBOWITZ, S. F. (1999) · Brain Research · doi:10.1016/s0006-8993(99)02040-5 · Cited by 49
Self-citation
Appetite regulation: The role of peptides and hormones
Morley, J. E. (1989) · Journal of Endocrinological Investigation · doi:10.1007/bf03349944 · Cited by 48
Regulation of feeding behavior, gastric emptying, and sympathetic nerve activity to interscapular brown adipose tissue by galanin and enterostatin: the involvement of vagal-central nervous system interactions
Nagase, H., Nakajima, A., Sekihara, H., York, D. A., & Bray, G. A. (2002) · Journal of Gastroenterology · doi:10.1007/bf03326430 · Cited by 47
Localization of Insulin and Type 1 IGF Receptors in Rat Brain by in Vitro Autoradiography and in Situ Hybridization
Marks, J. L., King, M. G., & Baskin, D. G. (1991) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-5949-4_41 · Cited by 47
Central nervous system and peripheral abnormalities: clues to the understanding of obesity and NIDDM
Jeanrenaud, B. (1994) · Diabetologia · doi:10.1007/bf00400841 · Cited by 47
Hypothalamic neuropeptide expression after food restriction in Zucker rats: evidence of persistent neuropeptide Y gene activation
Pesonen, U., Huupponen, R., Rouru, J., & Koulu, M. (1992) · Molecular Brain Research · doi:10.1016/0169-328x(92)90233-2 · Cited by 47
Bone-specific overexpression of NPY modulates osteogenesis.
Matić, I. S., Matthews, B. G., Kizivat, T., Igwe, J. C., Marijanović, I., Ruohonen, S. T., Savontaus, E., Adams, D. J., & Kalajzić, I. (2012) · PubMed · Cited by 46
The novel, selective, brain-penetrant neuropeptide Y Y2 receptor antagonist, JNJ-31020028, tested in animal models of alcohol consumption, relapse, and anxiety
Cippitelli, A., Rezvani, A. H., Robinson, J. E., Eisenberg, L., Levin, E. D., Bonaventure, P., Motley, S. T., Lovenberg, T. W., Heilig, M. A., & Thorsell, A. (2010) · Alcohol · doi:10.1016/j.alcohol.2010.09.003 · Cited by 46
Design, syntheses, and structure–activity relationships of novel NPY Y5 receptor antagonists: 2-{3-Oxospiro[isobenzofuran-1(3H),4′-piperidin]-1′-yl}benzimidazole derivatives
Ogino, Y., Ohtake, N., Nagae, Y., Matsuda, K., Moriya, M., Suga, T., Ishikawa, M., Kanesaka, M., Mitobe, Y., Itô, J., et al. (2008) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2008.08.018 · Cited by 46
AMP-activated protein kinase activates neuropeptide Y neurons in the hypothalamic arcuate nucleus to increase food intake in rats
Kohno, D., Sone, H., Tanaka, S., Kurita, H., Gantulga, D., & Yada, T. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.05.060 · Cited by 46
Central signalling cross‐talk between insulin and leptin in glucose and energy homeostasis
Boucsein, A., Kamstra, K., & Tups, A. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.12944 · Cited by 48
Role of dorsomedial hypothalamic neuropeptide Y in energy homeostasis
Bi, S. (2006) · Peptides · doi:10.1016/j.peptides.2006.07.030 · Cited by 47
Involvement of neuropeptide Y Y1 receptors in the acute, chronic and withdrawal effects of nicotine on feeding and body weight in rats
Nakhate, K. T., Dandekar, M. P., Kokare, D. M., & Subhedar, N. K. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.03.008 · Cited by 47
Physiology of ghrelin and related peptides
Anderson, L. L., Jeftinija, S., Scanes, C. G., Stromer, M. H., Lee, J.-S., Jeftinija, K., & Glavaski‐Joksimovic, A. (2005) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2005.02.033 · Cited by 46
Leptin signaling pathways in the central nervous system: interactions between neuropeptide Y and melanocortins
Rahmouni, K., & Haynes, W. G. (2001) · BioEssays · doi:10.1002/bies.10018 · Cited by 46
Regional hypothalamic differences in neuropeptide Y-induced feeding and energy substrate utilization
Currie, P. J., & Coscina, D. V. (1996) · Brain Research · doi:10.1016/0006-8993(96)00738-x · Cited by 46
Insulin receptors in the pituitary gland: morphological evidence for influence on opioid peptide-synthesizing cells
Unger, J. W., & Lange, W. (1997) · Cell and Tissue Research · doi:10.1007/s004410050833 · Cited by 45
Ninjin-yoeito activates ghrelin-responsive and unresponsive NPY neurons in the arcuate nucleus and counteracts cisplatin-induced anorexia
Goswami, C., Dezaki, K., Wang, L., Inui, A., Seino, Y., & Yada, T. (2019) · Neuropeptides · doi:10.1016/j.npep.2019.03.001 · Cited by 45
Expression of Melanocortin MC3 and MC4 Receptor mRNAs by Neuropeptide Y Neurons in the Rat Arcuate Nucleus
Mounien, L., Bizet, P., Boutelet, I., Vaudry, H., & Jégou, S. (2005) · Neuroendocrinology · doi:10.1159/000091737 · Cited by 52
Leptin, diabetes, and the brain
Morton, G. J., & Meek, T. H. (2012) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/2230-8210.105568 · Cited by 47
Hypothalamic paraventricular 5-hydroxytryptamine: Receptor-specific inhibition of NPY-stimulated eating and energy metabolism
Currie, P. J., Coiro, C. D., Niyomchai, T., Lira, A., & Farahmand, F. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00671-2 · Cited by 45
Transplantable rat glucagonomas cause acute onset of severe anorexia and adipsia despite highly elevated NPY mRNA levels in the hypothalamic arcuate nucleus.
Jensen, P. B., Blume, N., Mikkelsen, J. D., Larsen, P. J., Jensen, H. I., Holst, J. J., & Madsen, O. D. (1998) · Journal of Clinical Investigation · doi:10.1172/jci275 · Cited by 45
Effects of neuropeptide Y on food-reinforced behavior in satiated rats
Jewett, D. C., Cleary, J. P., Levine, A. S., Schaal, D. W., & Thompson, T. I. (1992) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(92)90517-j · Cited by 46
The Feeding Response to Melanin-Concentrating Hormone Is Attenuated by Antagonism of the NPY Y1-Receptor in the Rat
Chaffer, C. L., & Morris, M. J. (2002) · Endocrinology · doi:10.1210/en.143.1.191 · Cited by 45
Trapped fat: Obesity pathogenesis as an intrinsic disorder in metabolic fuel partitioning
Friedman, M. I., Sørensen, T. I. A., Taubes, G., Lund, J. T., & Ludwig, D. S. (2024) · Obesity Reviews · doi:10.1111/obr.13795 · Cited by 47
Neuropeptide Y is a critical modulator of Leptin's regulation of cortical bone
Wong, I. P. L., Nguyen, A., Khor, E. C., Enriquez, R. F., Eisman, J. A., Sainsbury, A., Herzog, H., & Baldock, P. A. J. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1786 · Cited by 44
Energy Expenditure and Body Composition of Chronically Maintained Decerebrate Rats in the Fed and Fasted Condition
Harris, R. B. S., Kelso, E. W., Flatt, W. P., Bartness, T. J., & Grill, H. J. (2005) · Endocrinology · doi:10.1210/en.2005-1156 · Cited by 44
The forestomach of rats and mice, an effective device supporting digestive metabolism in muridae (review)
Gärtner, K. (2002) · Journal of Experimental Animal Science · doi:10.1016/s0939-8600(02)80002-5 · Cited by 44
NPY antagonism reduces adiposity and attenuates age‐related imbalance of adipose tissue metabolism
Park, S., Fujishita, C., Komatsu, T., Kim, S. E., Chiba, T., Mori, R., & Shimokawa, I. (2014) · The FASEB Journal · doi:10.1096/fj.14-258384 · Cited by 45
Similar feeding patterns are induced by perifornical neuropeptide Y injection and by food deprivation
Bivens, C. L. M., Thomas, W. J., & Stanley, B. G. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01289-4 · Cited by 44
Effect of Uteroplacental Insufficiency upon Brain Neuropeptide Y and Corticotropin-Releasing Factor Gene Expression and Concentrations1
Rajakumar, P. A., He, J., Simmons, R. A., & Devaskar, S. U. (1998) · Pediatric Research · doi:10.1203/00006450-199808000-00005 · Cited by 44
Synthesis and biological evaluation of pNPY fragments
Danho, W., Triscari, J. M., Vincent, G. P., Nakajima, T., Taylor, J. W., & Kaiser, E. T. (1988) · International journal of peptide & protein research · doi:10.1111/j.1399-3011.1988.tb01380.x · Cited by 44
Behavioral effects of neuropeptide Y in F344 rat substrains with a reduced dipeptidyl-peptidase IV activity
Karl, T., Hoffmann, T., Pabst, R., & von Hörsten, S. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(03)00154-0 · Cited by 43
Multiple Neuropeptide Y Receptors Regulate K+and Ca2+Channels in Acutely Isolated Neurons From the Rat Arcuate Nucleus
Sun, L., & Miller, R. J. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.81.3.1391 · Cited by 43
Sequence Variation within the Neuropeptide Y Gene and Obesity in Mexican Americans
Bray, M. S., Boerwinkle, E., & Hanis, C. L. (2000) · Obesity Research · doi:10.1038/oby.2000.25 · Cited by 43
Galanin-Like Peptide Stimulates Food Intake via Activation of Neuropeptide Y Neurons in the Hypothalamic Dorsomedial Nucleus of the Rat
Kuramochi, M., Onaka, T., Kohno, D., Kato, S., & Yada, T. (2006) · Endocrinology · doi:10.1210/en.2005-0907 · Cited by 43
Neuropeptide Y and food intake in fasted rats: effect of naloxone and site of action
Schick, R., SCHUSDZIARRA, V., Nußbaumer, C., & Classen, M. (1991) · Brain Research · doi:10.1016/0006-8993(91)90087-c · Cited by 43
Phenotypic profile of SWR/J and A/J mice compared to control strains: Possible mechanisms underlying resistance to obesity on a high-fat diet
LEIBOWITZ, S. F., Alexander, J. T., Dourmashkin, J. T., Hill, J. O., Gayles, E. C., & Chang, G. (2005) · Brain Research · doi:10.1016/j.brainres.2005.03.047 · Cited by 43
Self-citation
Relationships between hypothalamic neuropeptide Y and food intake in the lactating rat
Pickavance, L. C., Dryden, S. D., Hopkins, D., Bing, C., Frankish, H. M., Wang, Q., Vernon, R. G., & Williams, G. (1996) · Peptides · doi:10.1016/0196-9781(96)00018-6 · Cited by 43
Hypothalamic Neuropeptide Y in Relation to Energy Balancea
LEIBOWITZ, S. F. (1990) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1990.tb48939.x · Cited by 43
Self-citation
Molecular Mechanisms of Migraine: Nitric Oxide Synthase and Neuropeptides
Karsan, N., Gosalia, H., & Goadsby, P. J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241511993 · Cited by 44
Expressions of neuropeptide Y and Y1 receptor in subcutaneous and visceral fat tissues in normal weight and obese humans and their correlations with clinical parameters and peripheral metabolic factors
Sitticharoon, C., Chatree, S., & Churintaraphan, M. (2013) · Regulatory Peptides · doi:10.1016/j.regpep.2013.06.015 · Cited by 43
Can neuropeptides treat obesity? A review of neuropeptides and their potential role in the treatment of obesity
Boughton, C. K., & Murphy, K. G. (2012) · British Journal of Pharmacology · doi:10.1111/bph.12037 · Cited by 45
Obesity: from molecules to man
Jebb, S. A. (1999) · Proceedings of The Nutrition Society · doi:10.1079/pns19990003 · Cited by 42
Altered Hypothalamic Signaling and Responses to Food Deprivation in Rats Fed a Low‐Carbohydrate Diet
Kinzig, K. P., Scott, K. A., Hyun, J., Bi, S., & Moran, T. H. (2005) · Obesity Research · doi:10.1038/oby.2005.205 · Cited by 42
Changes in orexin-A and neuropeptide Y expression in the hypothalamus of the fasted and high-fat diet fed rats
Park, E. S., Yi, S. J., Kim, J. S., Lee, H. S., Lee, I. S., Seong, J. K., Jin, H. K., & Yoon, Y. S. (2004) · Journal of Veterinary Science · doi:10.4142/jvs.2004.5.4.295 · Cited by 44
Determinants of glucose metabolism and the role of NPY in the progression of insulin resistance in chronic migraine
SİVA, Z. O., Uludüz, D., Keskin, F. E., Erenler, F., Balcı, H., Uygunoğlu, U., Saip, S., Göksan, B., & Sıva, A. (2017) · Cephalalgia · doi:10.1177/0333102417748928 · Cited by 43
Photoperiodic effects on body mass, energy balance and hypothalamic gene expression in the bank vole
Peacock, W. L., Król, E., Moar, K. M., McLaren, J. S., Mercer, J. G., & Speakman, J. R. (2003) · Journal of Experimental Biology · doi:10.1242/jeb.00719 · Cited by 42
Reduced hypothalamic neurotensin concentrations in the genetically obese diabetic ( ) mouse: Possible relationship to obesity
Williams, G., Cardoso, H., Lee, Y. C., Ghatei, M. A., Flatt, P. R., Bailey, C. J., & Bloom, S. R. (1991) · Metabolism · doi:10.1016/0026-0495(91)90139-n · Cited by 42
An investigation of tolerance to the actions of leptogenic and anorexigenic drugs in mice
Morley, J. E., & Flood, J. F. (1987) · Life Sciences · doi:10.1016/0024-3205(87)90534-0 · Cited by 42
The Anorexigenic Fatty Acid Synthase Inhibitor, C75, Is a Nonspecific Neuronal Activator
Takahashi, K. A., Smart, J. L., Liu, H., & Cone, R. D. (2003) · Endocrinology · doi:10.1210/en.2003-0337 · Cited by 42
Central effects of neuropeptide Y with emphasis on its role in obesity and diabetes
Turton, M. D., O’Shea, D., & Bloom, S. R. (1997) · Elsevier eBooks · doi:10.1016/b978-012304990-2/50003-2 · Cited by 42
NeuroPred-PLM: an interpretable and robust model for neuropeptide prediction by protein language model
Wang, L., Huang, C., Wang, M., Xue, Z., & Wang, Y. (2023) · Briefings in Bioinformatics · doi:10.1093/bib/bbad077 · Cited by 41
Leptin differentially regulates NPY secretion in hypothalamic cell lines through distinct intracellular signal transduction pathways
Dhillon, S. S., & Belsham, D. D. (2011) · Regulatory Peptides · doi:10.1016/j.regpep.2011.01.005 · Cited by 41
Macronutrient type independently of energy intake modulates hypothalamic neuropeptide y in long-evans rats
Beck, B., Stricker‐Krongrad, A., Burlet, A. J., Max, J., Musse, N., Nicolas, J., & Burlet, C. R. (1994) · Brain Research Bulletin · doi:10.1016/0361-9230(94)90002-7 · Cited by 41
Histamine Mediates the Stimulatory Action of Ghrelin on Acid Secretion in Rat Stomach
Yakabi, K., Ro, S., Onouhi, T., Tanaka, T., Ohno, S., Miura, S., Johno, Y., & Takayama, K. (2006) · Digestive Diseases and Sciences · doi:10.1007/s10620-005-9002-3 · Cited by 41
Overview: neurobiology of OB protein (leptin)
Campfield, L. A., & Smith, F. J. (1998) · Proceedings of The Nutrition Society · doi:10.1079/pns19980062 · Cited by 41
WIdespread increases in regional hypothalamic neuropeptide Y levels in acute cold-exposed rats
McCarthy, H. D., Kilpatrick, A. P., Trayhurn, P., & Williams, G. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90388-v · Cited by 41
NPY-induced feeding: pharmacological characterization using selective opioid antagonists and antisense probes in rats
Israel, Y., Kandov, Y., Khaimova, E., Kest, A., Lewis, S. R., Pasternak, G. W., Pan, Y., Rossi, G. C., & Bodnar, R. J. (2005) · Peptides · doi:10.1016/j.peptides.2005.01.017 · Cited by 41

Authors: Glenn Stanley, B., Kyrkouli, S. E., Lampert, S., & Leibowitz, S. F.
Affiliations: Rockefeller University (US)
ORCID: Leibowitz, Sarah F.
Venue: Peptides
Publisher: Elsevier BV
Published: 1986-11
Volume: 7
Issue: 6
Pages: 1189-1192
ISSN: 0196-9781 (ISSN-L)
DOI: 10.1016/0196-9781(86)90149-x
OpenAlex: W2033305745
Cited by: 849
References: 27
Citations by year: 2026: 1 · 2025: 8 · 2024: 7 · 2023: 7 · 2022: 3 · 2021: 7 · 2020: 10 · 2019: 9 · 2018: 12 · 2017: 9 · 2016: 14 · 2015: 12 · 2014: 26 · 2013: 24 · 2012: 33
FWCI: 5.69
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Peptides (publishedVersion)
PubMed (publishedVersion)
Funders: Centers for Disease Control and Prevention (MN 22879)
U.S. Public Health Service
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
Keywords: neuropeptide Y, hypothalamus, paraventricular nucleus, hyperphagia, obesity, dietary intake, weight gain, fat mass, satiety, dietary habits, body weight regulation
MeSH terms: Adipose Tissue, Animals, Appetite, Feeding and Eating Disorders, Body Weight, Energy Intake, Female, Hyperphagia, Hypothalamus, Neuropeptide Y, Obesity, Rats, Inbred Strains, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Neuropeptide Y chronically injected into the hypothalamus: A powerful neurochemical inducer of hyperphagia and obesity

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks