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Neuropeptide Y chronically injected into the hypothalamus: A powerful neurochemical inducer of hyperphagia and obesity
Abstract
Neuropeptide Y (NPY), a putative neurotransmitter abundant in the brain, has recently been shown to act within the hypothalamus, inducing a powerful eating response and a specific appetite for carbohydrates. In the present study, NPY (235 pmol) injected bilaterally in the paraventricular nucleus three times a day for 10 days caused approximately a two-fold increase in daily food intake, a six-fold increase in the rate of body weight gain and a three-fold increase in the body fat of female rats. Subsequently, the food intake and body weight of these subjects decreased precipitously, reaching control levels 20 days postinjection. These findings, demonstrating that exogenous NPY is capable of overriding mechanisms of satiety and body weight control, suggest that disturbances in NPY function may play a role in some disorders of eating behavior and body weight regulation.
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“neuropeptide Y (NPY) directly affects feeding behavior, metabolism and body composition [37, 38]”
From Regulation of obesity and insulin resistance by nitric oxide (2014) · cites this paper as [37]
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Metadata
- Authors
- Glenn Stanley, B., Kyrkouli, S. E., Lampert, S., & Leibowitz, S. F.
- Affiliations
- Rockefeller University (US)
- ORCID
- Leibowitz, Sarah F.
- Venue
- Peptides
- Publisher
- Elsevier BV
- Published
- 1986-11
- Volume
- 7
- Issue
- 6
- Pages
- 1189-1192
- ISSN
- 0196-9781 (ISSN-L)
- OpenAlex
- W2033305745
- Cited by
- 849
- References
- 27
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 7 · 2023: 7 · 2022: 3 · 2021: 7 · 2020: 10 · 2019: 9 · 2018: 12 · 2017: 9 · 2016: 14 · 2015: 12 · 2014: 26 · 2013: 24 · 2012: 33
- FWCI
- 5.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Peptides (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Centers for Disease Control and Prevention (MN 22879)
- U.S. Public Health Service
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Keywords
- neuropeptide Y, hypothalamus, paraventricular nucleus, hyperphagia, obesity, dietary intake, weight gain, fat mass, satiety, dietary habits, body weight regulation
- MeSH terms
- Adipose Tissue, Animals, Appetite, Feeding and Eating Disorders, Body Weight, Energy Intake, Female, Hyperphagia, Hypothalamus, Neuropeptide Y, Obesity, Rats, Inbred Strains, Rats
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