Mindspan: lessons from rat models of neurocognitive aging
Open accessAbstract
Research on the biology of aging seeks to enhance understanding of basic mechanisms and thus support improvements in outcomes throughout the lifespan, including longevity itself, susceptibility to disease, and life-long adaptive capacities. The focus of this review is the use of rats as an animal model of cognitive change during aging, and specifically lessons learned from aging rats in behavioral studies of cognitive processes mediated by specialized neural circuitry. An advantage of this approach is the ability to compare brain aging across species where functional homology exists for specific neural systems; in this article we focus on behavioral assessments that target the functions of the medial temporal lobe and prefrontal cortex. We also take a critical look at studies using calorie restriction (CR) as a well-defined experimental approach to manipulating biological aging. We conclude that the effects of CR on cognitive aging in rats are less well established than commonly assumed, with much less supportive evidence relative to its benefits on longevity and susceptibility to disease, and that more research in this area is necessary.
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The rat has potential for geroscience research because its aging physiology is closer to humans than mice, especially for onset of certain age-related conditions, and its larger size permits serial sampling and imaging not feasible in mice.
“However, the rat has tremendous potential for use in geroscience research, owning to its aging physiology being closer to humans compared to mice, especially with respect to onset of certain age-related conditions, as well as its larger size, which permits serial sampling and imaging studies not feasible in the mouse [36–41].”
From Reducing Senescent Cell Burden in Aging and Disease (2020) · cites this paper as [37]
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Zebrafish Behavioral Models of Ageing
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- Authors
- Gallagher, M., Stocker, A. M., & Koh, M. T.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Gallagher, M.
- ORCID
- Gallagher, M.
- Venue
- ILAR Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-01-01
- Volume
- 52
- Issue
- 1
- Pages
- 32-40
- ISSN
- 1084-2020 (ISSN-L)
- PMC
- PMC3199952
- OpenAlex
- W1979398121
- Cited by
- 53
- References
- 77
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 1 · 2021: 4 · 2020: 4 · 2019: 3 · 2018: 6 · 2017: 7 · 2016: 2 · 2015: 2 · 2014: 6 · 2013: 3 · 2012: 9
- FWCI
- 2.19
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- ILAR Journal (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Ellison Medical Foundation
- National Institute on Aging (P01AG009973, T32AG027668)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Aging and Gerontology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- cognitive aging, neurocognitive aging, rat model, animal models of aging, medial temporal lobe, prefrontal cortex, caloric restriction, longevity, brain aging, functional homology
- MeSH terms
- Aging, Animals, Breeding, Cognition, Longevity, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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