Caloric restriction increases learning consolidation and facilitates synaptic plasticity through mechanisms dependent on NR2B subunits of the NMDA receptor
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One of the main focal points of aging research is the search for treatments that will prevent or ameliorate the learning and memory deficiencies associated with aging. Here we have examined the effects of maintaining mature mice on a long-term intermittent fasting diet (L-IFD). We found that L-IFD enhances learning and consolidation processes. We also assessed the long-term changes in synaptic efficiency in these animals. L-IFD mice showed an increase in low-theta-band oscillations, paired-pulse facilitation, and facilitation of long-term synaptic plasticity in the hippocampus with respect to mice fed ad libitum. In addition, we found an increase in the expression of the NMDA receptor subunit NR2B in some brain areas of L-IFD mice. Specific antagonism of this subunit in the hippocampus reversed the beneficial effects of L-IFD. These data provide a molecular and cellular mechanism by which L-IFD may enhance cognition, ameliorating some aging-associated cognitive deficits.
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Positive lifestyle changes such as aerobic and resistance exercise and/or healthy caloric restriction can favorably affect endocrine and metabolic functions and counter age-related diseases.
“Rather, positive lifestyle modifications such as regular aerobic and resistance exercise programs and/or healthy calorically restricted diet can favorably affect endocrine and metabolic functions and act as countermeasures to various age-related diseases.”
From Hormonal and Metabolic Changes of Aging and the Influence of Lifestyle Modifications (2021) · cites this paper as [18]
Emerging data from multiple studies show beneficial effects of lifestyle changes, especially exercise and caloric restriction, in mitigating many age-related physical and cognitive declines.
“In contrast, the emerging data from multiple studies show the indisputable beneficial effects of lifestyle changes, especially exercise 14, 15 and caloric restriction,16-18 in mitigating many age-related physical and cognitive declines.”
From Hormonal and Metabolic Changes of Aging and the Influence of Lifestyle Modifications (2021) · cites this paper as [18]
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Beneficial effects of dietary restriction in aging brain
Hadem, I. K. H., Majaw, T., Kharbuli, B., & Sharma, R. (2019) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2017.10.001 · Cited by 59 · see citing works
- Authors
- Fontán-Lozano, Á., Sáez-Cassanelli, J. L., Inda, M. C., de los Santos-Arteaga, M., Sierra-Domínguez, S. A., López-Lluch, G., Delgado-García, J. M., & Carrión, Á. M.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2007-09-19
- Volume
- 27
- Issue
- 38
- Pages
- 10185-10195
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6672666
- OpenAlex
- W2143912485
- Cited by
- 195
- References
- 92
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 11 · 2023: 6 · 2022: 10 · 2021: 11 · 2020: 12 · 2019: 8 · 2018: 9 · 2017: 16 · 2016: 10 · 2015: 12 · 2014: 15 · 2013: 6 · 2012: 14
- FWCI
- 4.23
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- caloric restriction, intermittent fasting, learning consolidation, synaptic plasticity, NMDA receptor, NR2B subunit, hippocampus, theta oscillations, paired-pulse facilitation, aging, cognitive impairment, memory
- MeSH terms
- Animals, Conditioning, Psychological, Learning, Male, Neuronal Plasticity, Synapses, Receptors, N-Methyl-D-Aspartate, Caloric Restriction, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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