Cited by 195Neuroscience and Neuropharmacology ResearchDietary Effects on HealthMemory and Neural Mechanisms

Caloric restriction increases learning consolidation and facilitates synaptic plasticity through mechanisms dependent on NR2B subunits of the NMDA receptor

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Fontán-Lozano, Ángela, Sáez-Cassanelli, José Luis, Inda, Mari Carmen, de los Santos-Arteaga, Mercedes, Sierra-Domínguez, Sergio Antonio, López-Lluch, Guillermo, Delgado-García, José María, Carrión, Ángel Manuel·2007·The Journal of Neuroscience

Abstract

One of the main focal points of aging research is the search for treatments that will prevent or ameliorate the learning and memory deficiencies associated with aging. Here we have examined the effects of maintaining mature mice on a long-term intermittent fasting diet (L-IFD). We found that L-IFD enhances learning and consolidation processes. We also assessed the long-term changes in synaptic efficiency in these animals. L-IFD mice showed an increase in low-theta-band oscillations, paired-pulse facilitation, and facilitation of long-term synaptic plasticity in the hippocampus with respect to mice fed ad libitum. In addition, we found an increase in the expression of the NMDA receptor subunit NR2B in some brain areas of L-IFD mice. Specific antagonism of this subunit in the hippocampus reversed the beneficial effects of L-IFD. These data provide a molecular and cellular mechanism by which L-IFD may enhance cognition, ameliorating some aging-associated cognitive deficits.

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Crossref · 10.1523/jneurosci.2757-07.2007

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  • Positive lifestyle changes such as aerobic and resistance exercise and/or healthy caloric restriction can favorably affect endocrine and metabolic functions and counter age-related diseases.

    “Rather, positive lifestyle modifications such as regular aerobic and resistance exercise programs and/or healthy calorically restricted diet can favorably affect endocrine and metabolic functions and act as countermeasures to various age-related diseases.”
  • Emerging data from multiple studies show beneficial effects of lifestyle changes, especially exercise and caloric restriction, in mitigating many age-related physical and cognitive declines.

    “In contrast, the emerging data from multiple studies show the indisputable beneficial effects of lifestyle changes, especially exercise 14, 15 and caloric restriction,16-18 in mitigating many age-related physical and cognitive declines.”

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Authors
Fontán-Lozano, Á., Sáez-Cassanelli, J. L., Inda, M. C., de los Santos-Arteaga, M., Sierra-Domínguez, S. A., López-Lluch, G., Delgado-García, J. M., & Carrión, Á. M.
Venue
The Journal of Neuroscience
Published
2007-09-19
Volume
27
Issue
38
Pages
10185-10195
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
OpenAlex
W2143912485
Cited by
195
References
92
Citations by year
2026: 3 · 2025: 5 · 2024: 11 · 2023: 6 · 2022: 10 · 2021: 11 · 2020: 12 · 2019: 8 · 2018: 9 · 2017: 16 · 2016: 10 · 2015: 12 · 2014: 15 · 2013: 6 · 2012: 14
FWCI
4.23
Type
journal article
Language
en
Open access
Locations
  • Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Physiology › Dietary Effects on Health
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
caloric restriction, intermittent fasting, learning consolidation, synaptic plasticity, NMDA receptor, NR2B subunit, hippocampus, theta oscillations, paired-pulse facilitation, aging, cognitive impairment, memory
MeSH terms
Animals, Conditioning, Psychological, Learning, Male, Neuronal Plasticity, Synapses, Receptors, N-Methyl-D-Aspartate, Caloric Restriction, Mice

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