Cited by 466Nerve injury and regenerationNuclear Receptors and SignalingNeurogenesis and neuroplasticity mechanisms

The DOI matches its Crossref record; 321 of the 325 references it cites were found in a registry or an index.

Function of neurotrophic factors in the adult and aging brain and their possible use in the treatment of neurodegenerative diseases

Hefti, F., Hartikka, J., Knusel, B.·1989·Neurobiology of Aging

Open this paper in CoChat — free account

Abstract

This review summarizes the current knowledge of characterized neurotrophic factors, including nerve growth factor (NGF) which serves as paradigmatic example when studying novel molecules. Special consideration is given to the function of neurotrophic factors in the adult and aging brain. Strategies are discussed for the eventual development of pharmacological applications of these molecules in the treatment of neurodegenerative diseases.

Integrity signals

Registry

Crossref · 10.1016/0197-4580(89)90118-8

Cites

321 of 321 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Central cholinergic pathways in the rat: An overview based on an alternative nomenclature (Ch1–Ch6)
Mesulam, M. M., Mufson, E. J., Wainer, B. H., & Levey, A. I. (1983) · Neuroscience · doi:10.1016/0306-4522(83)90108-2 · Cited by 2,329
Growth of a rat neuroblastoma cell line in serum-free supplemented medium.
Bottenstein, J. E., & SATO, G. H. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.1.514 · Cited by 2,268
Identification of a receptor for the morphogen retinoic acid
Giguere, V., Ong, E. S., Segui, P., & Evans, R. M. (1987) · Nature · doi:10.1038/330624a0 · Cited by 1,965
Purification of a new neurotrophic factor from mammalian brain.
Barde, Y. A., Edgar, D., & Thoenen, H. (1982) · The EMBO Journal · doi:10.1002/j.1460-2075.1982.tb01207.x · Cited by 1,822
Physiology of nerve growth factor.
Thoenen, H., & Barde, Y. (1980) · Physiological Reviews · doi:10.1152/physrev.1980.60.4.1284 · Cited by 1,573
Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections
Hefti, F. F. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-08-02155.1986 · Cited by 1,445
The induction of differentiation in teratocarcinoma stem cells by retinoic acid
Strickland, S., & Mahdavi, V. (1978) · Cell · doi:10.1016/0092-8674(78)90008-9 · Cited by 1,420
Actions of Insulin-Like Growth Factors
Froesch, E. R., Schmid, C., Schwander, J., & Zapf, J. (1985) · Annual Review of Physiology · doi:10.1146/annurev.ph.47.030185.002303 · Cited by 1,154
THE ASCENDING CHOLINERGIC RETICULAR SYSTEM: NEOCORTICAL, OLFACTORY AND SUBCORTICAL PROJECTIONS
Shute, C. C. D., & Lewis, P. R. (1967) · Brain · doi:10.1093/brain/90.3.497 · Cited by 1,120
Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease
Tanzi, R. E., McClatchey, A. I., Lamperti, E. D., Villa‐Komaroff, L., Gusella, J. F., & Neve, R. L. (1988) · Nature · doi:10.1038/331528a0 · Cited by 1,093
Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity
Kitaguchi, N., Takahashi, Y., Tokushima, Y., Shiojiri, S., & Ito, H. (1988) · Nature · doi:10.1038/331530a0 · Cited by 1,083
Continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria fornix transection.
Williams, L. R., Varon, S. S., Peterson, G. M., Wictorin, K., Fischer, W., Björklund, A., & Gage, F. H. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.23.9231 · Cited by 1,055
A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors
Ponte, P. A., Gonzalez‐DeWhitt, P. A., Schilling, J., Miller, J., Hsu, D. K., Greenberg, B., Davis, K. L., Wallace, W., Lieberburg, I. M., Fuller, F. H., et al. (1988) · Nature · doi:10.1038/331525a0 · Cited by 1,050
Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor
Fischer, W., Wictorin, K., Björklund, A., Williams, L., Varon, S. S., & Gage, F. H. (1987) · Nature · doi:10.1038/329065a0 · Cited by 1,024
Identification of a second human retinoic acid receptor
Brand, N. J., Petkovich, M. P., Krust, A., Chambon, P., de Thé, H., Marchio, A., Tiollais, P., & Dejean, A. (1988) · Nature · doi:10.1038/332850a0 · Cited by 1,022
Changes of nerve growth factor synthesis in nonneuronal cells in response to sciatic nerve transection.
Heumann, R., Korsching, S. I., Bandtlow, C. E., & Thoenen, H. (1987) · The Journal of Cell Biology · doi:10.1083/jcb.104.6.1623 · Cited by 1,022
Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve
Lindholm, D., Heumann, R., Meyer, M., & Thoenen, H. (1987) · Nature · doi:10.1038/330658a0 · Cited by 994
Nucleotide sequence of a bovine clone encoding the angiogenic protein, basic fibroblast growth factor.
Abraham, J., Mergia, A., Whang, J., Tumolo, A., Friedman, J. M., Hjerrild, K. A., Gospodarowicz, D., & Fiddes, J. (1986) · Science · doi:10.1126/science.2425435 · Cited by 987
Proliferation, differentiation and degeneration in the spinal ganglia of the chick embryo under normal and experimental conditions
Hamburger, V., & Levi‐Montalcini, R. (1949) · Journal of Experimental Zoology · doi:10.1002/jez.1401110308 · Cited by 985
Levels of nerve growth factor and its mRNA in the central nervous system of the rat correlate with cholinergic innervation.
Korsching, S. I., Auburger, G. W. J., Heumann, R., Scott, J., & Thoenen, H. (1985) · The EMBO Journal · doi:10.1002/j.1460-2075.1985.tb03791.x · Cited by 938
Gene transfer and molecular cloning of the rat nerve growth factor receptor
Radeke, M. J., Misko, T. P., Hsu, C., Herzenberg, L. A., & Shooter, E. M. (1987) · Nature · doi:10.1038/325593a0 · Cited by 938
Nerve Growth Factor Treatment After Brain Injury Prevents Neuronal Death
Kromer, L. F. (1987) · Science · doi:10.1126/science.3798108 · Cited by 932
Immunochemical identification of the serine protease inhibitor α1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease
Abraham, C. R., Selkoe, D. J., & Potter, H. (1988) · Cell · doi:10.1016/0092-8674(88)90462-x · Cited by 900
Insulin-like growth factor II receptor as a multifunctional binding protein
Morgan, D. O., Edman, J. C., Standring, D. N., Fried, V. A., Smith, M. C., Roth, R. A., & Rutter, W. J. (1987) · Nature · doi:10.1038/329301a0 · Cited by 848
Interleukin-1 Stimulation of Astroglial Proliferation After Brain Injury
Giulian, D., & Lachman, L. B. (1985) · Science · doi:10.1126/science.3872478 · Cited by 847
Peptide growth factors are multifunctional
Sporn, M. B., & Roberts, A. B. (1988) · Nature · doi:10.1038/332217a0 · Cited by 830
Retinoic acid induces embryonal carcinoma cells to differentiate into neurons and glial cells.
Jones-Villeneuve, E. M., McBurney, M. W., Rogers, K. A., & Kalnins, V. I. (1982) · The Journal of cell biology · doi:10.1083/jcb.94.2.253 · Cited by 781
The Nerve Growth Factor: Biochemistry, Synthesis, and Mechanism of Action
Greene, L. A., & Shooter, E. M. (1980) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.03.030180.002033 · Cited by 734
Fibroblast growth factor promotes survival of dissociated hippocampal neurons and enhances neurite extension.
Walicke, P. A., Cowan, W. M., Ueno, N., Baird, A., & Guillemin, R. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.9.3012 · Cited by 730
The Coupling of Neurotransmitter Receptors to Ion Channels in the Brain
Nicoll, R. A. (1988) · Science · doi:10.1126/science.2456612 · Cited by 729
NGF-Mediated increase of choline acetyltransferase (ChAT) in the neonatal rat forebrain: Evidence for a physiological role of NGF in the brain?
Gnahn, H., Hefti, F. F., Heumann, R., Schwab, M. E., & Thoenen, H. (1983) · Developmental Brain Research · doi:10.1016/0165-3806(83)90107-4 · Cited by 719
Differential regulation of mRNA encoding nerve growth factor and its receptor in rat sciatic nerve during development, degeneration, and regeneration: role of macrophages.
Heumann, R., Lindholm, D., Bandtlow, C. E., Meyer, M., Radeke, M. J., Misko, T. P., Shooter, E. M., & Thoenen, H. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.23.8735 · Cited by 706
A unifying hypothesis for the cause of amyotrophic lateral sclerosis, parkinsonism, and alzheimer disease
Appel, S. H. (1981) · Annals of Neurology · doi:10.1002/ana.410100602 · Cited by 698
Transforming growth factor α
Derynck, R. (1988) · Cell · doi:10.1016/s0092-8674(88)80001-1 · Cited by 692
Basic fibroblast growth factor supports the survival of cerebral cortical neurons in primary culture.
Morrison, R. S., Sharma, A., de Vellis, J., & Bradshaw, R. A. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.19.7537 · Cited by 684
Cholinergic systems in the rat brain: III. Projections from the pontomesencephalic tegmentum to the thalamus, tectum, basal ganglia, and basal forebrain
Woolf, N. J., & Butcher, L. L. (1986) · Brain Research Bulletin · doi:10.1016/0361-9230(86)90134-6 · Cited by 668
Nerve growth factors (NGF, BDNF) enhance axonal regeneration but are not required for survival of adult sensory neurons
Lindsay, R. M. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-07-02394.1988 · Cited by 662
Cell death in the development of the lateral motor column of the chick embryo
Hamburger, V. (1975) · The Journal of Comparative Neurology · doi:10.1002/cne.901600408 · Cited by 660
Decreased expression of N-myc precedes retinoic acid-induced morphological differentiation of human neuroblastoma
Thiele, C. J., Reynolds, C. P., & Israel, M. A. (1985) · Nature · doi:10.1038/313404a0 · Cited by 649
The Nature and Regulation of the Receptors for Insulin-Like Growth Factors
Rechler, M. M., & Nissley, S. P. (1985) · Annual Review of Physiology · doi:10.1146/annurev.ph.47.030185.002233 · Cited by 642
An immunohistochemical study of the nerve growth factor receptor in developing rats
Yan, Q., & Johnson, E. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-09-03481.1988 · Cited by 605
Cholinergic function and intellectual decline in Alzheimer's disease
Collerton, D. (1986) · Neuroscience · doi:10.1016/0306-4522(86)90002-3 · Cited by 601
Human basic fibroblast growth factor: nucleotide sequence and genomic organization.
Abraham, J. A., Whang, J. L., Tumolo, A., Mergia, A., Friedman, J. S., Gospodarowicz, D., & Fiddes, J. C. (1986) · The EMBO Journal · doi:10.1002/j.1460-2075.1986.tb04530.x · Cited by 594
Specific retrograde transport of nerve growth factor (NGF) from neocortex to nucleus basalis in the rat
Seiler, M. J., & Schwab, M. E. (1984) · Brain Research · doi:10.1016/0006-8993(84)91338-6 · Cited by 592
Basic fibroblast growth factor prevents death of lesioned cholinergic neurons in vivo
Anderson, K. J., Dam, D., Lee, S., & Cotman, C. W. (1988) · Nature · doi:10.1038/332360a0 · Cited by 590
Nerve growth factor in sympathetic ganglia and corresponding target organs of the rat: correlation with density of sympathetic innervation.
Korsching, S. I., & Thoenen, H. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.11.3513 · Cited by 554
Neuronal loss in the pedunculopontine tegmental nucleus in Parkinson disease and in progressive supranuclear palsy.
Hirsch, É. C., Graybiel, A. M., Duyckaerts, C. J., & Javoy-Agid, F. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.16.5976 · Cited by 554
The physiological function of nerve growth factor in the central nervous system: Comparison with the periphery
Thoenen, H., Bandtlow, C. E., & Heumann, R. (1987) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/bfb0031026 · Cited by 549
Timing and site of nerve growth factor synthesis in developing skin in relation to innervation and expression of the receptor
Davies, A. M., Bandtlow, C. E., Heumann, R., Korsching, S. I., Rohrer, H., & Thoenen, H. (1987) · Nature · doi:10.1038/326353a0 · Cited by 548
Pedunculopontine tegmental nucleus of the rat: Cytoarchitecture, cytochemistry, and some extrapyramidal connections of the mesopontine tegmentum
Rye, D. B., Saper, C. B., Lee, H. J., & Wainer, B. H. (1987) · The Journal of Comparative Neurology · doi:10.1002/cne.902590403 · Cited by 545
Expression of nerve growth factor receptors by Schwann cells of axotomized peripheral nerves: ultrastructural location, suppression by axonal contact, and binding properties
Taniuchi, M., Clark, H., Schweitzer, J. B., & Johnson, E. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-02-00664.1988 · Cited by 542
Bioerodible polyanhydrides as drug‐carrier matrices. I: Characterization, degradation, and release characteristics
Leong, K. W., Brott, B. C., & Langer, R. (1985) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820190806 · Cited by 541
Studies on the expression of the beta nerve growth factor (NGF) gene in the central nervous system: level and regional distribution of NGF mRNA suggest that NGF functions as a trophic factor for several distinct populations of neurons.
Shelton, D. L., & Reichardt, L. F. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.8.2714 · Cited by 532
Basic and acidic fibroblast growth factors have trophic effects on neurons from multiple CNS regions
Walicke, P. A. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-07-02618.1988 · Cited by 527
Development and regional expression of beta nerve growth factor messenger RNA and protein in the rat central nervous system.
Whittemore, S. R., Ebendal, T., Lärkfors, L., Olson, L., Seiger, Å., Strömberg, I., & Persson, H. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.3.817 · Cited by 522
Brain-derived neurotrophic factor supports the survival of cultured rat retinal ganglion cells
Johnson, J., Barde, Y., Schwab, M. E., & Thoenen, H. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-10-03031.1986 · Cited by 520
Neuronal Chemotaxis: Chick Dorsal-Root Axons Turn Toward High Concentrations of Nerve Growth Factor
Gundersen, R. W., & Barrett, J. N. (1979) · Science · doi:10.1126/science.493992 · Cited by 520
Expression of the beta-nerve growth factor gene correlates with the density of sympathetic innervation in effector organs.
Shelton, D. L., & Reichardt, L. F. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.24.7951 · Cited by 519
Purification of the Chick Eye Ciliary Neuronotrophic Factor
Barbin, G., Manthorpe, M., & Varon, S. S. (1984) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1984.tb05410.x · Cited by 515
Grafting Genetically Modified Cells to the Damaged Brain: Restorative Effects of NGF Expression
Rosenberg, M. B., Friedmann, T., Robertson, R., Tuszynski, M. H., Wolff, J. A., Breakefield, X. O., & Gage, F. H. (1988) · Science · doi:10.1126/science.3201248 · Cited by 505
Thyroid Hormones and Brain Development
Dussault, J. H., & Ruel, J. (1987) · Annual Review of Physiology · doi:10.1146/annurev.ph.49.030187.001541 · Cited by 500
Brain-derived neurotrophic factor prevents neuronal death in vivo
Hofer, M., & Barde, Y. (1988) · Nature · doi:10.1038/331261a0 · Cited by 497
Dorsal Root Ganglion Neurons Are Destroyed by Exposure in Utero to Maternal Antibody to Nerve Growth Factor
Johnson, E. M., Gorin, P. D., Brandeis, L., & Pearson, J. (1980) · Science · doi:10.1126/science.7192014 · Cited by 496
The expression, localization and functional significance of β-nerve growth factor in the central nervous system
Whittemore, S. R., & Seiger, Å. (1987) · Brain Research Reviews · doi:10.1016/0165-0173(87)90008-7 · Cited by 493
Nerve growth factor increases choline acetyl-transferase but not survival or fiber outgrowth of cultured fetal septal cholinergic neurons
Hefti, F. F., Hartikka, J., Eckenstein, F. P., Gnahn, H., Heumann, R., & Schwab, M. E. (1985) · Neuroscience · doi:10.1016/0306-4522(85)90163-0 · Cited by 491
Monomeric insulins obtained by protein engineering and their medical implications
Brange, J., Ribel, U., Hansen, J. F., Dodson, G. G., Hansen, M. T., Havelund, S., Melberg, S., Norris, F., Norris, K. E., Snel, L. I. P., et al. (1988) · Nature · doi:10.1038/333679a0 · Cited by 489
Choline Acetyltransferase Activity in Striatum of Neonatal Rats Increased by Nerve Growth Factor
Mobley, W. C., Rutkowski, J. L., Tennekoon, G. I., Buchanan, K., & Johnston, M. V. (1985) · Science · doi:10.1126/science.2861660 · Cited by 480
Differential expression of insulin-like growth factor genes in rat central nervous system.
Rotwein, P. S., Burgess, S. K., Milbrandt, J., & Krause, J. E. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.1.265 · Cited by 474
Molecular and biological characterization of fibroblast growth factor, an angiogenic factor which also controls the proliferation and differentiation of mesoderm and neuroectoderm derived cells
Gospodarowicz, D., Neufeld, G., & Schweigerer, L. (1986) · Cell Differentiation · doi:10.1016/0045-6039(86)90021-7 · Cited by 471
Gene Transfer and Molecular Cloning of the Human NGF Receptor
Chao, M. V., Bothwell, M. A., Ross, A. H., Koprowski, H., Lanahan, A. A., Buck, C. R., & Sehgal, A. (1986) · Science · doi:10.1126/science.3008331 · Cited by 449
Chronic intraventricular injections of nerve growth factor elevate hippocampal choline acetyltransferase activity in adult rats with partial septo-hippocampal lesions
Hefti, F. F., Dravid, A. R., & Hartikka, J. (1984) · Brain Research · doi:10.1016/0006-8993(84)91237-x · Cited by 447
Nerve Growth Factor Gene Expression in the Developing Rat Brain
Large, T. H., Bodary, S. C., Clegg, D., Weskamp, G., Otten, U., & Reichardt, L. F. (1986) · Science · doi:10.1126/science.3764415 · Cited by 435
Effects of insulin, insulin-like growth factor-II, and nerve growth factor on neurite formation and survival in cultured sympathetic and sensory neurons
Recio‐Pinto, E., Mm, R., & Ishii, D. N. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-05-01211.1986 · Cited by 429
Adhesion molecules and the hierarchy of neural development
Jessell, T. M. (1988) · Neuron · doi:10.1016/0896-6273(88)90204-8 · Cited by 425
Nerve growth factor (NGF) in the rat CNS: Absence of specific retrograde axonal transport and tyrosine hydroxylase induction in locus coeruleus and substantia nigra
Schwab, M. E., Otten, U., Agid, Y., & Thoenen, H. (1979) · Brain Research · doi:10.1016/0006-8993(79)90303-2 · Cited by 416
Autoradiographic localization of insulin receptors in rat brain: Prominence in olfactory and limbic areas
Hill, J. M., Lesniak, M. A., Pert, C. B., & Roth, J. (1986) · Neuroscience · doi:10.1016/0306-4522(86)90082-5 · Cited by 413
In vitro neurite extension by granule neurons is dependent upon astroglial-derived fibroblast growth factor
Hatten, M. E., Lynch, M., Rydel, R. E., Sanchez, J. H., Joseph‐Silverstein, J., Moscatelli, D., & Rifkin, D. B. (1988) · Developmental Biology · doi:10.1016/0012-1606(88)90211-4 · Cited by 408
Distribution of neuronal receptors for nerve growth factor in the rat
Richardson, P., Issa, V. M. K., & Riopelle, R. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-08-02312.1986 · Cited by 393
Insulin-like growth factor I/somatomedin C: a potent inducer of oligodendrocyte development.
McMorris, F. A., Smith, T., DeSalvo, S., & Furlanetto, R. W. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.3.822 · Cited by 386
Nerve growth factor and Alzheimer's disease
Hefti, F. F., & Weiner, W. J. (1986) · Annals of Neurology · doi:10.1002/ana.410200302 · Cited by 383
Nerve growth factor increases choline acetyltransferase activity in developing basal forebrain neurons
Mobley, W. C., Rutkowski, J. L., Tennekoon, G. I., Gemski, J., Buchanan, K., & Johnston, M. V. (1986) · Molecular Brain Research · doi:10.1016/0169-328x(86)90020-3 · Cited by 380
Purification and characterization of a neurite extension factor from bovine brain.
KLIGMAN, D. E., & Marshak, D. R. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.20.7136 · Cited by 379
Increased basic fibroblast growth factor (bFGF) immunoreactivity at the site of focal brain wounds
Finklestein, S. P., Apostolides, P. J., Caday, C. G., Prosser, J. M., Philips, M. F., & Klagsbrun, M. (1988) · Brain Research · doi:10.1016/0006-8993(88)90370-8 · Cited by 379
Retinoic Acid-Induced Growth Inhibition and Morphologic Differentiation of Human Neuroblastoma Cells In Vitro 2
Sidell, N. (1982) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/68.4.589 · Cited by 378
Fibroblast growth factor
Gospodarowicz, D., Neufeld, G., & Schweigerer, L. (1986) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(86)90001-8 · Cited by 373
Relationship between levels of nerve growth factor (NGF) and its messenger RNA in sympathetic ganglia and peripheral target tissues.
Heumann, R., Korsching, S. I., Scott, J., & Thoenen, H. (1984) · The EMBO Journal · doi:10.1002/j.1460-2075.1984.tb02277.x · Cited by 357
Acidic and basic fibroblast growth factors promote stable neurite outgrowth and neuronal differentiation in cultures of PC12 cells
Rydel, R. E., & Greene, L. (1987) · Journal of Neuroscience · doi:10.1523/jneurosci.07-11-03639.1987 · Cited by 356
Expression of the β-Nerve Growth Factor Gene in Hippocampal Neurons
Lièvre, C. A., Olson, L., Ebendal, T., Seiger, Å., & Persson, H. (1988) · Science · doi:10.1126/science.2897715 · Cited by 355
New Perspectives on Alzheimer's Disease
Price, D. L. (1986) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.09.030186.002421 · Cited by 354
Neurochemical Studies of Early-Onset Alzheimer's Disease
Francis, P. T., Palmer, A. M., Sims, N. R., Bowen, D. M., DAVISON, A. N., Esiri, M. M., Neary, D., Snowden, J. S., & Wilcock, G. K. (1985) · New England Journal of Medicine · doi:10.1056/nejm198507043130102 · Cited by 353
Ciliary neurotrophic factor induces type-2 astrocyte differentiation in culture
Hughes, S. M., Lillien, L. E., RAFF, M. C., Rohrer, H., & Sendtner, M. (1988) · Nature · doi:10.1038/335070a0 · Cited by 347
Cellular localization of nerve growth factor synthesis by in situ hybridization.
Bandtlow, C. E., Heumann, R., Schwab, M. E., & Thoenen, H. (1987) · The EMBO Journal · doi:10.1002/j.1460-2075.1987.tb04835.x · Cited by 343
Nerve growth factor mRNA in peripheral and central rat tissues and in the human central nervous system: Lesion effects in the rat brain and levels in Alzheimer's disease
Goedert, M., Fine, A., Hunt, S. P., & Ullrich, A. (1986) · Molecular Brain Research · doi:10.1016/0169-328x(86)90023-9 · Cited by 338
Molecular Characterization of Fibroblast Growth Factor: Distribution and Biological Activities in Various Tissues
Baird, A., Esch, F. S., Mormède, P., Ueno, N., LING, N. C., Böhlen, P., Ying, S., Wehrenberg, W. B., & Guillemin, R. (1986) · Elsevier eBooks · doi:10.1016/b978-0-12-571142-5.50008-2 · Cited by 337
Basic and acidic fibroblast growth factors interact with the same cell surface receptors.
Neufeld, G., & Gospodarowicz, D. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)57261-1 · Cited by 336
Persistence of cholinergic neurons in the basal nucleus in a brain with senile dementia of the Alzheimer's type demonstrated by immunohistochemical staining for choline acetyltransferase
Pearson, R. C. A., Sofroniew, M. V., Cuello, A. C., Powell, T. P. S., Eckenstein, F. P., Esiri, M. M., & Wilcock, G. K. (1983) · Brain Research · doi:10.1016/0006-8993(83)90046-x · Cited by 334
Brain basic fibroblast growth factor stimulates the proliferation of rat neuronal precursor cells in vitro
Gensburger, C., Labourdette, G., & Sensenbrenner, M. (1987) · FEBS Letters · doi:10.1016/0014-5793(87)81230-9 · Cited by 331
Insulin and insulin-like growth factors in the CNS
Baskin, D. G., Wilcox, B. J., Figlewicz, D. P., & Dorsa, D. M. (1988) · Trends in Neurosciences · doi:10.1016/0166-2236(88)90155-5 · Cited by 330
Morphological response of axotomized septal neurons to nerve growth factor
Gage, F. H., Armstrong, D. M., Williams, L. R., & Varon, S. S. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902690112 · Cited by 321
The Biology and Mechanism of Action of Nerve Growth Factor
Yankner, B. A., & Shooter, E. M. (1982) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.51.070182.004213 · Cited by 321
STUDIES OF THE CONNEXIONS OF THE FORNIX SYSTEM
Daitz, H. M., & Powell, T. P. S. (1954) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.17.1.75 · Cited by 320
Receptor- and heparin-binding domains of basic fibroblast growth factor.
Baird, A., Schubert, D., LING, N. C., & Guillemin, R. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.7.2324 · Cited by 320
Development of Septal Cholinergic Neurons in Culture: Plating Density and Glial Cells Modulate Effects of NGF on Survival, Fiber Growth, and Expression of Transmitter-Specific Enzymes
Hartikka, J., & Hefti, F. (1988) · The Journal of Neuroscience · doi:10.1523/jneurosci.08-08-02967.1988 · Cited by 317
Nerve growth factor protects adult sensory neurons from cell death and atrophy caused by nerve injury
Rich, K. M., Luszczynski, J. R., Osborne, P. A., & Johnson, E. M. (1987) · Journal of Neurocytology · doi:10.1007/bf01795309 · Cited by 317
Rat β‐nerve growth factor sequence and site of synthesis in the adult hippocampus
Whittemore, S. R., Friedman, P. L., Larhammar, D., Persson, H., Gonzalez-Carvajal, M., & Holets, V. R. (1988) · Journal of Neuroscience Research · doi:10.1002/jnr.490200402 · Cited by 308
Trophic Stimulation of Cultured Neurons from Neonatal Rat Brain by Epidermal Growth Factor
Morrison, R. S., Kornblum, H. I., Leslie, F. M., & Bradshaw, R. A. (1987) · Science · doi:10.1126/science.3498986 · Cited by 294
Nerve growth factor (NGF) stimulation of cholinergic telencephalic neurons in aggregating cell cultures
Honegger, P., & Lenoir, D. (1982) · Developmental Brain Research · doi:10.1016/0165-3806(82)90023-2 · Cited by 293
A glia-derived neurite promoting factor with protease inhibitory activity belongs to the protease nexins
Gioor, S., Odink, K. G., Guenther, J., Nick, H., & Monard, D. (1986) · Cell · doi:10.1016/0092-8674(86)90511-8 · Cited by 292
Localization of nerve growth factor receptors in cholinergic neurons of the human basal forebrain
Hefti, F. F., Hartikka, J., Salvatierra, A. T., Weiner, W. J., & Mash, D. C. (1986) · Neuroscience Letters · doi:10.1016/0304-3940(86)90410-6 · Cited by 290
Developmental Neurobiology and the Natural History of Nerve Growth Factor
Levi‐Montalcini, R. (1982) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.05.030182.002013 · Cited by 288
Cholinergic systems in mammalian brain identified with antibodies against choline acetyltransferase
Wainer, B. H., Levey, A. I., Mufson, E. J., & Mesulam, M. M. (1984) · Neurochemistry International · doi:10.1016/0197-0186(84)90089-5 · Cited by 287
Pharmacological effects of nerve growth factor and fibroblast growth factor applied to the transectioned sciatic nerve on neuron death in adult rat dorsal root ganglia
OTTO, D., Unsicker, K., & Grothe, C. (1987) · Neuroscience Letters · doi:10.1016/0304-3940(87)90233-3 · Cited by 285
Thyroid Hormones and Brain Development
(1977) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-197711000-00013 · Cited by 277
The brain fibroblast growth factor (FGF) is localized in neurons
Pettmann, B., Labourdette, G., Weibel, M., & Sensenbrenner, M. (1986) · Neuroscience Letters · doi:10.1016/0304-3940(86)90137-0 · Cited by 274
Demonstration of the retrograde transport of nerve growth factor receptor in the peripheral and central nervous system
Johnson, E., Taniuchi, M., Clark, H., Springer, J., Koh, S., Tayrien, M. W., & Loy, R. (1987) · Journal of Neuroscience · doi:10.1523/jneurosci.07-03-00923.1987 · Cited by 268
The effect of fibroblast growth factor on PC12 cells
Togari, A., Dickens, G., Kuzuya, H., & Guroff, G. (1985) · Journal of Neuroscience · doi:10.1523/jneurosci.05-02-00307.1985 · Cited by 266
A glia‐derived neurite‐promoting factor with protease inhibitory activity.
Guenther, J., Nick, H., & Monard, D. (1985) · The EMBO Journal · doi:10.1002/j.1460-2075.1985.tb03878.x · Cited by 262
Epidermal Growth Factor Immunoreactive Material in the Central Nervous System: Location and Development
Fallon, J. H., Seroogy, K. B., Loughlin, S. E., Morrison, R. S., Bradshaw, R. A., Knaver, D. J., & Cunningham, D. D. (1984) · Science · doi:10.1126/science.6144184 · Cited by 262
HYPOTHESES CONCERNED WITH AXONAL REGENERATION IN THE MAMMALIAN NERVOUS SYSTEM
Kiernan, J. A. (1979) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/j.1469-185x.1979.tb00871.x · Cited by 262
Bioerodible polyanhydrides as drug‐carrier matrices. II. Biocompatibility and chemical reactivity
Leong, K. W., D'Amore, P. A., Marletta, M. A., & Langer, R. (1986) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820200106 · Cited by 261
Expression of the insulin-like growth factor II gene in the choroid plexus and the leptomeninges of the adult rat central nervous system.
Stylianopoulou, F., Herbert, J., Soares, M. B., & Efstratiadis, A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.1.141 · Cited by 258
Amyloid Protein Precursor Messenger RNAs: Differential Expression in Alzheimer's Disease
Palmert, M. R., Golde, T. E., Cohen, M. L., Kovacs, D. M., Tanzi, R. E., Gusella, J. F., Usiak, M., Younkin, L. H., & Younkin, S. G. (1988) · Science · doi:10.1126/science.2457949 · Cited by 256
An anatomical study of the development of the septo-hippocampal projection in the rat
Milner, T. A., Loy, R., & Amaral, D. G. (1983) · Developmental Brain Research · doi:10.1016/0165-3806(83)90017-2 · Cited by 254
Purification of adult rat sciatic nerve ciliary neuronotrophic factor
Manthorpe, M., Skaper, S. D., Williams, L. R., & Varon, S. S. (1986) · Brain Research · doi:10.1016/0006-8993(86)91603-3 · Cited by 251
Nerve growth factor receptor and choline acetyltransferase colocalization in neurons within the rat forebrain: Response to fimbria‐fornix transection
Batchelor, P., Armstrong, D. M., Blaker, S. N., & Gage, F. H. (1989) · The Journal of Comparative Neurology · doi:10.1002/cne.902840204 · Cited by 251
Expression of NGF receptor in the developing and adult primate central nervous system
Schatteman, G., Gibbs, L., Lanahan, A. A., Claude, P., & Bothwell, M. A. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-03-00860.1988 · Cited by 251
Basic FGF induces neuronal differentiation, cell division, and NGF dependence in chromaffin cells: A sequence of events in sympathetic development
Stemple, D. L., Mahanthappa, N. K., & Anderson, D. J. (1988) · Neuron · doi:10.1016/0896-6273(88)90182-1 · Cited by 248
The response of chick sensory neurons to brain-derived neurotrophic factor
Davies, A. M., Thoenen, H., & Barde, Y. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-07-01897.1986 · Cited by 247
Type-2 astrocyte development in rat brain cultures is initiated by a CNTF like protein produced by type-1 astrocytes
Lillien, L. E., Sendtner, M., Rohrer, H., Hughes, S. M., & RAFF, M. C. (1988) · Neuron · doi:10.1016/0896-6273(88)90179-1 · Cited by 247
Decreased level of nerve growth factor (NGF) and its messenger RNA in the aged rat brain
Lärkfors, L., Ebendal, T., Whittemore, S. R., Persson, H., Hoffer, B. J., & Olson, L. (1987) · Molecular Brain Research · doi:10.1016/0169-328x(87)90044-1 · Cited by 245
Developmental and regional expression of β-nerve growth factor receptor mRNA in the chick and rat
Ernfors, P., Hallböök, F., Ebendal, T., Shooter, E. M., Radeke, M. J., Misko, T. P., & Persson, H. (1988) · Neuron · doi:10.1016/0896-6273(88)90155-9 · Cited by 243
NGF receptor reexpression and NGF-mediated cholinergic neuronal hypertrophy in the damaged adult neostriatum
Gage, F. H., Batchelor, P., Chen, K. S., Chin, D. E., Higgins, G. A., Koh, S., Deputy, S. R., Rosenberg, M. B., Fischer, W., & Björklund, A. (1989) · Neuron · doi:10.1016/0896-6273(89)90184-0 · Cited by 240
Insulin growth factors regulate the mitotic cycle in cultured rat sympathetic neuroblasts.
DiCicco-Bloom, E. M., & Black, I. B. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.11.4066 · Cited by 240
The role of NGF in sensory neurons in vivo
Johnson, E. M., Rich, K. M., & Yip, H. K.-F. (1986) · Trends in Neurosciences · doi:10.1016/0166-2236(86)90012-3 · Cited by 235
Delayed treatment with nerve growth factor reverses the apparent loss of cholinergic neurons after acute brain damage
Hagg, T., Manthorpe, M., Vahlsing, H. L., & Varon, S. S. (1988) · Experimental Neurology · doi:10.1016/0014-4886(88)90013-1 · Cited by 233
Neurotrophic Factors
Thoenen, H., & Edgar, D. (1985) · Science · doi:10.1126/science.2409599 · Cited by 233
Retrograde cell changes in medial septum and diagonal band following fimbria-fornix transection: Quantitative temporal analysis
Gage, F. H., Wictorin, K., Fischer, W., Williams, L. R., Varon, S. S., & Björklund, A. (1986) · Neuroscience · doi:10.1016/0306-4522(86)90018-7 · Cited by 232
Insulin-like growth factor I (IGF I) stimulates DNA synthesis in fetal rat brain cell cultures
Lenoir, D., & Honegger, P. (1983) · Developmental Brain Research · doi:10.1016/0165-3806(83)90177-3 · Cited by 231
Glia-Induced Morphological Differentiation in Neuroblastoma Cells
Monard, D., Solomon, F., Rentsch, M., & Gysin, R. (1973) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.70.6.1894 · Cited by 229
Nerve growth factor promotes human hemopoietic colony growth and differentiation.
Matsuda, H., Coughlin, M. D., Bienenstock, J., & Denburg, J. A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.17.6508 · Cited by 228
Cholinergic septal grafts into the hippocampal formation improve spatial learning and memory in aged rats by an atropine-sensitive mechanism
Gage, F. H., & Björklund, A. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-10-02837.1986 · Cited by 222
Specificity of retrograde transport of nerve growth factor (NGF) in sensory neurons: A biochemical and morphological study
Stoeckel, K., Schwab, M. E., & Thoenen, H. (1975) · Brain Research · doi:10.1016/0006-8993(75)90129-8 · Cited by 220
Experimental autoimmune model of nerve growth factor deprivation: Effects on developing peripheral sympathetic and sensory neurons
Gorin, P. D., & Johnson, E. M. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.10.5382 · Cited by 220
Rescue of lesioned septal cholinergic neurons by nerve growth factor: specificity and requirement for chronic treatment
Montero‐Menei, C. N., & Hefti, F. F. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-08-02986.1988 · Cited by 211
Reduction of Naturally Occurring Motoneuron Death in Vivo by a Target-Derived Neurotrophic Factor
Oppenheim, R. W., Haverkamp, L. J., Prevette, D. M., McManaman, J. L., & Appel, S. H. (1988) · Science · doi:10.1126/science.3363373 · Cited by 208
Developmental change in the nerve growth factor action from induction of choline acetyltransferase to promotion of cell survival in cultured basal forebrain cholinergic neurons from postnatal rats
Hatanaka, H., Tsukui, H., & Nihonmatsu, I. (1988) · Developmental Brain Research · doi:10.1016/0165-3806(88)90069-7 · Cited by 208
Insulin-like growth factor II (IGF II) in human brain: regional distribution of IGF II and of higher molecular mass forms.
Haselbacher, G. K., Schwab, M. E., Pasi, A., & HUMBEL, R. E. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.7.2153 · Cited by 205
Grafting genetically modified cells to the brain: Possibilities for the future
Gage, F. H., Wolff, J. A., Rosenberg, M. B., Xu, L., Yee, J. K., Shults, C. W., & Friedmann, T. (1987) · Neuroscience · doi:10.1016/0306-4522(87)90159-x · Cited by 204
Nerve growth factor mRNA and protein in the testis and epididymis of mouse and rat.
Lièvre, C. A., Olson, L., Ebendal, T., Hallböök, F., & Persson, H. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.8.2628 · Cited by 201
Association of 125I-nerve growth factor with PC12 pheochromocytoma cells. Evidence for internalization via high-affinity receptors only and for long-term regulation by nerve growth factor of both high- and low-affinity receptors.
Bernd, P., & Greene, L. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42578-6 · Cited by 196
Some characteristics of histamine secretion from rat peritoneal mast cells stimulated with nerve growth factor.
Pearce, F. L., & Thompson, H. L. (1986) · The Journal of Physiology · doi:10.1113/jphysiol.1986.sp016014 · Cited by 196
Retrograde changes in cholinergic neurons in the basal forebrain of the rat following cortical damage
Sofroniew, M. V., Pearson, R. C. A., Eckenstein, F. P., Cuello, A. C., & Powell, T. P. S. (1983) · Brain Research · doi:10.1016/0006-8993(83)90045-8 · Cited by 196
Insulin receptors and insulin modulation of norepinephrine uptake in neuronal cultures from rat brain.
Boyd, F. T., Clarke, D. W., Muther, T. F., & Raizada, M. K. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36340-8 · Cited by 194
Quantitative demonstration of the retrograde axonal transport of endogenous nerve growth factor
Korsching, S. I., & Thoenen, H. (1983) · Neuroscience Letters · doi:10.1016/0304-3940(83)90155-6 · Cited by 193
Innervation of substantia nigra neurons by cholinergic afferents from pedunculopontine nucleus in the rat: neuroanatomical and electrophysiological evidence
Clarke, P. B. S., Hommer, D. W., Pert, A., & Skirboll, L. R. (1987) · Neuroscience · doi:10.1016/0306-4522(87)90176-x · Cited by 191
Cholinergic denervation of the rat hippocampus by fimbrial transection leads to a transient accumulation of nerve growth factor (NGF) without change in mRNANGF content
Korsching, S. I., Heumann, R., Thoenen, H., & Hefti, F. F. (1986) · Neuroscience Letters · doi:10.1016/0304-3940(86)90186-2 · Cited by 189
Localization of cells synthesizing transforming growth factor-alpha mRNA in the mouse brain
Wilcox, J., & Derynck, R. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-06-01901.1988 · Cited by 186
In situ hybridization of nucleus basalis neurons shows increased beta-amyloid mRNA in Alzheimer disease.
Cohen, M. L., Golde, T. E., Usiak, M., Younkin, L. H., & Younkin, S. G. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.4.1227 · Cited by 186
In vivo effect of brain‐derived neurotrophic factor on the survival of developing dorsal root ganglion cells.
Kalcheim, C., Barde, Y., Thoenen, H., & Douarin, N. M. L. (1987) · The EMBO Journal · doi:10.1002/j.1460-2075.1987.tb02589.x · Cited by 183
Insulin-Mediated Regulation of Neuronal Maturation
Puro, D. G., & Agardh, E. (1984) · Science · doi:10.1126/science.6089343 · Cited by 181
Loss of pedunculopontine neurons in progressive supranuclear palsy
Zweig, R. M., Whitehouse, P. J., Casanova, M. F., Walker, L. C., Januarykel, W. R., & Price, D. L. (1987) · Annals of Neurology · doi:10.1002/ana.410220107 · Cited by 180
Is Alzheimer disease caused by lack of nerve growth factor?
Hefti, F. F. (1983) · Annals of Neurology · doi:10.1002/ana.410130127 · Cited by 179
Interleukin‐1‐like activity in rat brain: Sources, targets, and effects of injury
Nieto‐Sampedro, M., & Berman, M. A. (1987) · Journal of Neuroscience Research · doi:10.1002/jnr.490170303 · Cited by 177
Localization of binding sites for insulin-like growth factor-I (IGF-I) in the rat brain by quantitative autoradiography
Bohannon, N. J. V., Wilcox, B. J., Figlewicz, D. P., Dorsa, D. M., & Baskin, D. G. (1988) · Brain Research · doi:10.1016/0006-8993(88)90931-6 · Cited by 177
Insulin, insulin-like growth factor II, and nerve growth factor effects on tubulin mRNA levels and neurite formation.
Mill, J. F., Chao, M. V., & Ishii, D. N. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.20.7126 · Cited by 177
Nerve growth factor receptor immunoreactivity in the nonhuman primate (Cebus apella): Distribution, morphology, and colocalization with cholinergic enzymes
Kordower, J. H., Bartus, R. T., Bothwell, M., Schatteman, G. C., & Gash, D. M. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902770402 · Cited by 174
Characterization of the binding properties and retrograde axonal transport of a monoclonal antibody directed against the rat nerve growth factor receptor.
Taniuchi, M., & Johnson, E. M. (1985) · The Journal of Cell Biology · doi:10.1083/jcb.101.3.1100 · Cited by 173
Potential use of nerve growth factor to treat Alzheimer's disease
Phelps, C. H., Gage, F. H., Growdon, J. H., Hefti, F. F., Harbaugh, R. E., Johnston, M. V., Khachaturian, Z. S., Mobley, W. C., Price, D. L., Raskind, M. A., et al. (1989) · Neurobiology of Aging · doi:10.1016/0197-4580(89)90032-8 · Cited by 172
Behavioural and neurochemical effects of chronic intraventricular injections of nerve growth factor in adult rats with fimbria lesions
Will, B. E., & Hefti, F. F. (1985) · Behavioural Brain Research · doi:10.1016/0166-4328(85)90004-x · Cited by 171
Localization of nerve growth factor receptors in the normal human brain and in Alzheimer's disease
Hefti, F. F., & Mash, D. C. (1989) · Neurobiology of Aging · doi:10.1016/s0197-4580(89)80014-4 · Cited by 168
Effect of exposure to anti-NGF on sensory neurons of adult rats and guinea pigs
Schwartz, J. P., Pearson, J. M., & Johnson, E. M. (1982) · Brain Research · doi:10.1016/0006-8993(82)90102-0 · Cited by 163
Nerve Growth Factor: Biological Significance, Measurement and Distribution
Harper, G., & Thoenen, H. (1980) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1980.tb04615.x · Cited by 163
Senile plaques as aberrant sprout-stimulating structures
Geddes, J. W., Anderson, K. J., & Cotman, C. W. (1986) · Experimental Neurology · doi:10.1016/0014-4886(86)90254-2 · Cited by 162
The cholinergic nuclei of the basal forebrain of the rat: normal structure, development and experimentally induced degeneration
Sofroniew, M. V., Pearson, R. C. A., & Powell, T. P. S. (1987) · Brain Research · doi:10.1016/0006-8993(87)91084-5 · Cited by 161
A single Mr approximately 103,000 125I-beta-nerve growth factor-affinity-labeled species represents both the low and high affinity forms of the nerve growth factor receptor.
Green, S. H., & Greene, L. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)66870-x · Cited by 157
Developmentally regulated expression of the nerve growth factor receptor gene in the periphery and brain.
Buck, C. R., Martínez, H., Black, I. B., & Chao, M. V. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.9.3060 · Cited by 155
Neurotrophic effects of basic and acidic fibroblast growth factors are not mediated through glial cells
Walicke, P. A., & Baird, A. (1988) · Developmental Brain Research · doi:10.1016/0165-3806(88)90009-0 · Cited by 155
Muscle-derived factors that support survival and promote fiber outgrowth from embryonic chick spinal motor neurons in culture
Dohrmann, U., Edgar, D., Sendtner, M., & Thoenen, H. (1986) · Developmental Biology · doi:10.1016/0012-1606(86)90089-8 · Cited by 154
Developmental changes of nerve growth factor and its mRNA in the rat hippocampus: Comparison with choline acetyltransferase
Auburger, G. W. J., Heumann, R., Hellweg, R., Korsching, S. I., & Thoenen, H. (1987) · Developmental Biology · doi:10.1016/0012-1606(87)90235-1 · Cited by 154
Pharmacological Approaches to the Treatment of Brain and Spinal Cord Injury
Stein, D. G., & Sabel, B. A. (1988) · Springer eBooks · doi:10.1007/978-1-4613-0927-7 · Cited by 153
Role of nerve growth factor in the adult dorsal root ganglia neuron and its response to injury
Rich, K. M., Yip, H. K.-F., Osborne, P. A., Schmidt, R. E., & Johnson, E. M. (1984) · The Journal of Comparative Neurology · doi:10.1002/cne.902300110 · Cited by 153
Retrograde transport of nerve growth factor (NGF) in motoneurons of developing rats: Assessment of potential neurotrophic effects
Van, Q., Snider, W. D., Pinzone, J. J., & Johnson, E. M. (1988) · Neuron · doi:10.1016/0896-6273(88)90082-7 · Cited by 152
Stabilizing basic fibroblast growth factor using protein engineering
Seno, M., Sasada, R., Iwane, M., Sudo, K., Kurokawa, T., Ito, K., & Igarashi, K. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(88)80337-1 · Cited by 150
Experimental approaches to age-related cognitive impairments
Gage, F. H., Chen, K. S., Buzsáki, G., & Armstrong, D. L. (1988) · Neurobiology of Aging · doi:10.1016/s0197-4580(88)80129-5 · Cited by 149
Basic fibroblast growth factor and epidermal growth factor exert differential trophic effects on CNS neurons
Morrison, R. S., Keating, R. F., & Moskal, J. R. (1988) · Journal of Neuroscience Research · doi:10.1002/jnr.490210111 · Cited by 147
The effect of platelet-derived growth factor on morphology and motility of human glial cells
Mellstr�m, K., H�glund, A.-S., Nist�r, M., Heldin, C., Westermark, B., & Lindberg, U. (1983) · Journal of Muscle Research and Cell Motility · doi:10.1007/bf00712117 · Cited by 144
Binding characteristics of brain-derived neurotrophic factor to its receptors on neurons from the chick embryo
Rodrı́guez-Tébar, A., & Barde, Y. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-09-03337.1988 · Cited by 142
Choline acetyltransferase activity of spinal cord cell cultures increased by co-culture with muscle and by muscle-conditioned medium
Giller, E. L., Neale, J., Bullock, P. N., Schrier, B. K., & Nelson, P. G. (1977) · The Journal of Cell Biology · doi:10.1083/jcb.74.1.16 · Cited by 140
Insulin‐like growth factor I in cultured rat astrocytes: expression of the gene, and receptor tyrosine kinase.
Ballotti, R., Nielsen, F. C., Pringle, N. P., Kowalski‐Chauvel, A., Richardson, W. D., OBBERGHEN, E. V., & Gammeltoft, S. (1987) · The EMBO Journal · doi:10.1002/j.1460-2075.1987.tb02695.x · Cited by 140
Neurite outgrowth from embryonic chicken spinal neurons is promoted by media conditioned by muscle cells.
Henderson, C. E., Huchet, M., & Changeux, J. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.4.2625 · Cited by 139
Sympathetic sprouting in the central nervous system: a model for studies of axonal growth in the mature mammalian brain
Crutcher, K. A. (1987) · Brain Research Reviews · doi:10.1016/0165-0173(87)90013-0 · Cited by 138
Biologically active synthetic fragments of epidermal growth factor: localization of a major receptor-binding region.
Komoriya, A., Hortsch, M., Meyers, C. A., Smith, M. J., Kanety, H., & Schlessinger, J. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.5.1351 · Cited by 135
Development and survival of neurons in dissociated fetal mesencephalic serum-free cell cultures: I. Effects of cell density and of an adult mammalian striatal-derived neuronotrophic factor (SDNF)
Toso, R. D., Giorgi, O., Soranzo, C., Kirschner, G., Ferrari, G. V. D., Favaron, M., Benvegnú, D. M., Presti, D. L., Vicini, S., & Toffano, G. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-03-00733.1988 · Cited by 134
Extracts of Skeletal Muscle Increase Neurite Outgrowth and Cholinergic Activity of Fetal Rat Spinal Motor Neurons
Smith, R. G., & Appel, S. H. (1983) · Science · doi:10.1126/science.6823568 · Cited by 133
Mr 25,000 heparin-binding protein from guinea pig brain is a high molecular weight form of basic fibroblast growth factor.
Moscatelli, D., Joseph‐Silverstein, J., Manejias, R. E., & Rifkin, D. B. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.16.5778 · Cited by 132
Characterization of a neuronal subtype of insulin-like growth factor I receptor.
Burgess, S. K., Jacobs, S., Cuatrecasas, P., & Sahyoun, N. E. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)75681-6 · Cited by 131
A thyromimetic that decreases plasma cholesterol levels without increasing cardiac activity
Underwood, A. H., Emmett, J. C., Ellis, D. A., Flynn, S. B., Leeson, P. D., Benson, G. M., Novelli, R., Pearce, N. J., & Shah, V. P. (1986) · Nature · doi:10.1038/324425a0 · Cited by 131
Neurite outgrowth induced by an endothelial cell mitogen isolated from retina.
Wagner, J. A., & D'Amore, P. A. (1986) · The Journal of Cell Biology · doi:10.1083/jcb.103.4.1363 · Cited by 131
Transient expression of NGF-receptor-like immunoreactivity in postnatal rat brain and spinal cord
Eckenstein, F. P. (1988) · Brain Research · doi:10.1016/0006-8993(88)91305-4 · Cited by 130
Production of insulin‐like growth factors and their carrier by rat pituitary gland and brain explants in culture
Binoux, M., Hossenlopp, P., LASSARRE, C., & Hardouin, N. (1981) · FEBS Letters · doi:10.1016/0014-5793(81)80131-7 · Cited by 130

Research works printed but not linked: 2

Thoenen, 1985, Neurotrophic factors, Science, 229, 238, 10.1126/science.2409599 · DOI
Thorpe, 1987, Receptors for nerve growth factor on rat spleen mononuclear cells, J. Neurosci. Res., 17, 128, 10.1002/jnr.490170206 · DOI

Sorted by citations

Neurotrophins: Roles in Neuronal Development and Function
Huang, E. J., & Reichardt, L. F. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.677 · Cited by 4,394
Recombinant BDNF Rescues Deficits in Basal Synaptic Transmission and Hippocampal LTP in BDNF Knockout Mice
Patterson, S. L., Abel, T., Deuel, T. A. S., Martin, K. C., Rose, J. C., & Kandel, E. R. (1996) · Neuron · doi:10.1016/s0896-6273(00)80140-3 · Cited by 1,233
Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons
Crowley, C. W., Spencer, S. D., Nishimura, M. C., Chen, K. S., Pitts-Meek, S., Armaninl, M. P., Ling, L. H., McMahon, S. B., Shelton, D. L., Levinson, A. D., et al. (1994) · Cell · doi:10.1016/0092-8674(94)90378-6 · Cited by 1,068
BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease
Phillips, H. S., Hains, J. M., Armanini, M., Laramee, G. R., Johnson, S. A., & Winslow, J. W. (1991) · Neuron · doi:10.1016/0896-6273(91)90273-3 · Cited by 921
Brain-derived neurotrophic factor in the control human brain, and in Alzheimer’s disease and Parkinson’s disease
Murer, M. G., Yan, Q., & Raisman-Vozari, R. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00014-9 · Cited by 874

See all 466

Authors: Hefti, F., Hartikka, J., & Knusel, B.
Affiliations: University of Southern California (US)
ORCID: Hefti, F.
Hartikka, J.
Venue: Neurobiology of Aging
Publisher: Elsevier BV
Published: 1989-09
Volume: 10
Issue: 5
Pages: 515-533
ISSN: 0197-4580 (ISSN-L)
DOI: 10.1016/0197-4580(89)90118-8
OpenAlex: W2020771907
Cited by: 466
References: 325
Citations by year: 2024: 4 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 5 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 3 · 2014: 3 · 2012: 2
FWCI: 5.09
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neurobiology of Aging (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Neurological Disorders and Stroke (NS-22933)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: neurotrophic factors, nerve growth factor, brain aging, adult brain, neurodegenerative diseases, neurotrophic therapy, neuroprotection
MeSH terms: Aging, Alzheimer Disease, Animals, Humans, Nerve Growth Factors, Nervous System, Nervous System Physiological Phenomena, Parkinson Disease

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Function of neurotrophic factors in the adult and aging brain and their possible use in the treatment of neurodegenerative diseases

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks