Cited by 466Nerve injury and regenerationNuclear Receptors and SignalingNeurogenesis and neuroplasticity mechanisms

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Function of neurotrophic factors in the adult and aging brain and their possible use in the treatment of neurodegenerative diseases

Hefti, F., Hartikka, J., Knusel, B.·1989·Neurobiology of Aging

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Abstract

This review summarizes the current knowledge of characterized neurotrophic factors, including nerve growth factor (NGF) which serves as paradigmatic example when studying novel molecules. Special consideration is given to the function of neurotrophic factors in the adult and aging brain. Strategies are discussed for the eventual development of pharmacological applications of these molecules in the treatment of neurodegenerative diseases.

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Authors: Hefti, F., Hartikka, J., & Knusel, B.
Affiliations: University of Southern California (US)
ORCID: Hefti, F.
Hartikka, J.
Venue: Neurobiology of Aging
Publisher: Elsevier BV
Published: 1989-09
Volume: 10
Issue: 5
Pages: 515-533
ISSN: 0197-4580 (ISSN-L)
DOI: 10.1016/0197-4580(89)90118-8
OpenAlex: W2020771907
Cited by: 466
References: 325
Citations by year: 2024: 4 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 5 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 3 · 2014: 3 · 2012: 2
FWCI: 5.09
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neurobiology of Aging (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Neurological Disorders and Stroke (NS-22933)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: neurotrophic factors, nerve growth factor, brain aging, adult brain, neurodegenerative diseases, neurotrophic therapy, neuroprotection
MeSH terms: Aging, Alzheimer Disease, Animals, Humans, Nerve Growth Factors, Nervous System, Nervous System Physiological Phenomena, Parkinson Disease

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Function of neurotrophic factors in the adult and aging brain and their possible use in the treatment of neurodegenerative diseases

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