Interleukin-6-associated inflammatory processes in Alzheimer's disease: new therapeutic options
Abstract
The cytokine interleukin-6 is consistently detected in the brains of Alzheimer's disease patients but not in the brains of nondemented elderly persons. Until recently it was unclear whether an interleukin-6-associated inflammatory mechanism is an early or late event in the pathological cascade of Alzheimer's disease. We investigated whether interleukin-6 could be detected in plaques of Alzheimer's disease patients prior to the onset of neuritic degeneration. We found interleukin-6 mostly in plaques where neuritic pathology has not yet developed. This indicates that the appearance of interleukin-6 may precede neuritic changes and is not just a consequence of neuritic degeneration. Therefore, one may hypothesize that activation of inflammatory mechanisms may cause neuritic degeneration in plaques. A suppression of interleukin-6 synthesis could, therefore, be of therapeutic value. Upon screening a number of substances, we found that a small number of nonsteroidal antiinflammatory drugs, including tenidap, were able to inhibit interleukin-6 synthesis in cultured human astrocytoma cells. These substances may be therapeutically useful in Alzheimer's disease and should be evaluated in clinical studies.
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IL6 has been linked to diffuse plaques in Alzheimer's disease brains.
“IL6 has been associated with diffuse plaques in the brains of AD patients (Hull, et al., 1996).”
From A potential endophenotype for Alzheimer's disease: cerebrospinal fluid clusterin (2016) · cites this paper as Hull, et al., 1996
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- Authors
- Hüll, M., Fiebich, B. L., Lieb, K., Strauss, S., Berger, M., Volk, B., & Bauer, J.
- Affiliations
- University of Freiburg (DE)
- Corresponding author
- Bauer, J.
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 1996-09
- Volume
- 17
- Issue
- 5
- Pages
- 795-800
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2085981166
- Cited by
- 82
- References
- 56
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 7 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 5 · 2015: 4 · 2014: 2 · 2013: 3 · 2012: 1
- FWCI
- 3.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- interleukin-6, Alzheimer's disease, neuroinflammation, amyloid plaques, nonsteroidal anti-inflammatory drugs, tenidap, astrocytoma cells, therapeutic target
- MeSH terms
- Aged, Alzheimer Disease, Astrocytoma, Brain, Brain Chemistry, Brain Neoplasms, Humans, Inflammation, Nerve Degeneration, Tumor Cells, Cultured, Interleukin-6, Neurites, Neurofibrillary Tangles
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