Long-term potentiation of guinea pig mossy fiber responses is not blocked by N-methyl d-aspartate antagonists
Abstract
Receptors preferentially activated by the excitatory amino acid N-methyl-D-aspartate (NMDA) do not mediate synaptic transmission in the hippocampus but are involved in initiating long-term potentiation (LTP) in hippocampal region CA1. We have examined the role of NMDA receptors in LTP of the commissural/associational and mossy fiber pathways to region CA3 pyramidal neurons. In the commissural/associational pathway, NMDA receptor blockers did not reduce synaptic responses but reversibly blocked the induction of LTP. In contrast, NMDA receptor blockers had no effect on mossy fiber LTP. These results suggest that induction of commissural/associational LTP differs from mossy fiber LTP, although the mechanisms underlying expression of LTP along these pathways could be similar. Kynurenate and L-2-amino-4-phosphonobutyrate, which potently reduce mossy fiber responses, also did not block induction of mossy fiber LTP.
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Mossy fiber LTP is NMDA-independent.
“For example, perforant path and the Schaffer collateral pathway LTP are both dependent on the activation of NMDA receptors (Bliss and Collingridge, 1993), whereas mossy fiber/CA3 LTP is not (Harris and Cotman, 1986;Z alutsky and Nicoll, 1990).”
From Type I Adenylyl Cyclase Mutant Mice Have Impaired Mossy Fiber Long-Term Potentiation (1998) · cites this paper as Harris and Cotman, 1986
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Hippocampal synaptic plasticity and NMDA receptors: a role in information storage?
MORRIS, R. G. M., DAVIS, S., & BUTCHER, S. P. (1991) · Behavioural and Neural Aspects of Learning and Memory · doi:10.1093/acprof:oso/9780198521983.003.0011 · Cited by 15 · see citing works
- Authors
- Harris, E. W., & Cotman, C. W.
- Affiliations
- University of California, Irvine (US)
- Corresponding author
- Harris, Eric W.
- ORCID
- Cotman, Carl W.
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 1986-09
- Volume
- 70
- Issue
- 1
- Pages
- 132-137
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W1995054580
- Cited by
- 540
- References
- 1
- Citations by year
- 2026: 1 · 2025: 3 · 2023: 3 · 2022: 5 · 2021: 5 · 2020: 3 · 2019: 4 · 2018: 13 · 2017: 13 · 2016: 6 · 2015: 9 · 2014: 9 · 2013: 15 · 2012: 13
- FWCI
- 7.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- long-term potentiation, NMDA receptor, mossy fiber pathway, hippocampal CA3 pyramidal neurons, NMDA receptor antagonists, kynurenic acid, synaptic transmission, LTP induction
- MeSH terms
- Aminobutyrates, Animals, Evoked Potentials, Guinea Pigs, Hippocampus, Kynurenic Acid, Neural Pathways, Synaptic Transmission, Receptors, N-Methyl-D-Aspartate, Receptors, Neurotransmitter, In Vitro Techniques
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