The cholinergic system and hippocampal plasticity

Drever, Benjamin D.; Riedel, Gernot; Platt, Bettina

doi:10.1016/j.bbr.2010.11.037

Cited by 240Neuroscience and Neuropharmacology ResearchNicotinic Acetylcholine Receptors StudyMemory and Neural Mechanisms

The cholinergic system and hippocampal plasticity

Drever, Benjamin D., Riedel, Gernot, Platt, Bettina·2011·Behavioural Brain Research

DOI 10.1016/j.bbr.2010.11.037

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Abstract

Acetylcholine is an essential excitatory neurotransmitter in the central nervous system and undertakes a vital role in cognitive function. Consequently, there is ample evidence to suggest the involvement of both nicotinic and muscarinic acetylcholine receptors in the modulation of synaptic plasticity, which is believed to be the molecular correlate of learning and memory. In the hippocampus in particular, multiple subtypes of both nicotinic and muscarinic receptors are present at presynaptic and postsynaptic loci of both principal neurons and inhibitory interneurons, where they exert profound bi-directional influences on synaptic transmission. Further evidence points to a role for cholinergic activation in the induction and maintenance of synaptic plasticity, and key influences on hippocampal network oscillations. The present review examines these multiple roles of acetylcholine in hippocampal plasticity.

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Nicotinic and muscarinic acetylcholine receptors on both GABAergic and glutamatergic neurons in the hippocampus can alter the subsequent response to excitatory inputs.
“it is clear that nAChRs and mAChRs on both GABAergic and glutamatergic neurons in the hippocampus can alter the subsequent response to excitatory inputs (Drever et al., 2011).”
From Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior (2012) · cites this paper as Drever et al., 2011
Cholinergic inputs to the hippocampus from the medial septum and the diagonal band of Broca impinge on both glutamatergic and GABAergic neurons throughout the structure.
“Cholinergic inputs to the hippocampus from the medial septum and the diagonal band of Broca impinge on both glutamatergic and GABAergic neurons throughout the structure”
From Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior (2012) · cites this paper as Drever et al., 2011

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Authors: Drever, B. D., Riedel, G., & Platt, B.
Affiliations: University of Aberdeen (GB)
Corresponding author: Platt, Bettina
ORCID: Riedel, Gernot
Platt, Bettina
Venue: Behavioural Brain Research
Publisher: Elsevier BV
Published: 2011-08
Volume: 221
Issue: 2
Pages: 505-514
ISSN: 0166-4328 (ISSN-L)
DOI: 10.1016/j.bbr.2010.11.037
OpenAlex: W2028661968
Cited by: 240
References: 155
Citations by year: 2026: 6 · 2025: 9 · 2024: 17 · 2023: 16 · 2022: 15 · 2021: 20 · 2020: 14 · 2019: 14 · 2018: 19 · 2017: 16 · 2016: 10 · 2015: 16 · 2014: 18 · 2013: 22 · 2012: 16
FWCI: 1.45
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Behavioural Brain Research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: acetylcholine, cholinergic system, hippocampus, synaptic plasticity, nicotinic acetylcholine receptors, muscarinic receptors, learning and memory, hippocampal interneurons, synaptic transmission
MeSH terms: Acetylcholine, Animals, Cholinergic Fibers, Hippocampus, Models, Neurological, Neuronal Plasticity, Neurons, Receptors, Muscarinic, Receptors, Nicotinic, Theta Rhythm

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The cholinergic system and hippocampal plasticity

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