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Cited by 12Reproductive Health and ContraceptionHypothalamic control of reproductive hormonesRegulation of Appetite and Obesity

The impact of short-term depot-medroxyprogesterone acetate treatment on resting metabolic rate

Steward, Ryan G., Bateman, Lori A., Slentz, Cris, Stanczyk, Frank Z., Price, Thomas M.·2016·Contraception
DOI 10.1016/j.contraception.2016.01.001
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Abstract

Objective This study examines the effect of a progestogen (depot-medroxyprogesterone acetate, DMPA) on resting metabolic rate (RMR) in a cohort of young, normal-weight healthy women. We hypothesize an increase in RMR and nonshivering thermogenesis (NST) resulting in increased body temperature by DMPA.Study design We performed a prospective cohort study in 13 subjects tested at baseline, 3 weeks and 9 weeks after 150 mg intramuscular DMPA administration. RMR was determined with indirect calorimetry. Secondary endpoints included changes in body mass index (BMI), body composition, temperature and serum levels of estradiol (E2), luteinizing hormone (LH), progesterone and MPA.Results The percent change in RMR from baseline to week 3 (9%) was significantly higher than the percent change from baseline to week 9 (1.6%) (p=.045). The greatest percent change from baseline to week 3 compared to baseline to week 9 was seen in women initiating DMPA in the luteal phase of the cycle. Hypothalamic-pituitary-ovarian axis was evident by decreases in E2, LH and progesterone. DMPA resulted in increased body temperature with a significant correlation between the change in body temperature and the change in RMR. No change in body composition was seen.Conclusions RMR and NST increased in young healthy women with normal BMI 3 weeks after receiving the initial dose of 150 mg DMPA for contraception. The effect was augmented when the drug was administered during the luteal phase of the menstrual cycle.Implication DMPA increases RMR and thermogenesis independent of changes in body mass. An increase in weight with chronic DMPA may result from a combination of hyperphagia and abnormal NST in predisposed individuals.

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Authors
Steward, R. G., Bateman, L. A., Slentz, C., Stanczyk, F. Z., & Price, T. M.
Affiliations
  • Duke University (US)
  • University of Southern California (US)
Corresponding author
Price, Thomas M.
ORCID
Venue
Contraception
Publisher
Elsevier BV
Published
2016-04
Volume
93
Issue
4
Pages
317-322
ISSN
0010-7824 (ISSN-L)
DOI
10.1016/j.contraception.2016.01.001
OpenAlex
W2228884237
Cited by
12
References
29
Citations by year
2024: 3 · 2023: 1 · 2022: 3 · 2020: 3 · 2016: 2
FWCI
0.66
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Contraception (publishedVersion)
  • PubMed (publishedVersion)
Funders
Rocky Mountain Research Station
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Health and Contraception
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
depot medroxyprogesterone acetate, resting metabolic rate, non-shivering thermogenesis, body temperature, progestogens, luteal phase, hypothalamic-pituitary-ovarian axis, estradiol, luteinizing hormone, progesterone, body composition, weight gain, hyperphagia
MeSH terms
Adolescent, Adult, Basal Metabolism, Body Composition, Body Temperature, Body Weight, Calorimetry, Indirect, Contraceptive Agents, Female, Delayed-Action Preparations, Female, Humans, Injections, Intramuscular, Luteal Phase, Prospective Studies, Cohort Studies, Body Mass Index, Medroxyprogesterone Acetate, Thermogenesis

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