The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Cutaneous hypersensitivity following peripheral tissue damage in newborn infants and its reversal with topical anaesthesia
Abstract
The flexion reflex threshold has been used as a measure of sensation in a group of premature infants born at 27-32 weeks postmenstrual age. The threshold in an area of local tissue damage created by routine heel lances was half the threshold on the intact heel on the other side. This indicated a hypersensitivity to tissue damage analogous to tenderness or hyperalgesia reported in adults. In a double-blind study, treatment of the damaged area with the topical anaesthetic cream, EMLA, was found to reverse this hypersensitivity or in other words increase the flexion reflex threshold. Treatment with placebo had no effect. The results show that the newborn infant central nervous system is capable of mounting a chronic pain response to local injury which can be reduced by local anaesthetic.
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Citations
Cites
Evidence for a central component of post-injury pain hypersensitivity
Woolf, C. J. (1983) · Nature · doi:10.1038/306686a0 · Cited by 2,157
Pain and Its Effects in the Human Neonate and Fetus
Anand, K. J. S., & Hickey, P. R. (1987) · New England Journal of Medicine · doi:10.1056/nejm198711193172105 · Cited by 1,703
Pain expression in neonates: facial action and cry
Grunau, R. V. E., & Craig, K. D. (1987) · Pain · doi:10.1016/0304-3959(87)90073-x · Cited by 1,040
Anand, K. J. S., Sippell, W. G., & Green, A. A. (1987) · The Lancet · doi:10.1016/s0140-6736(87)90065-1 · Cited by 481
Prenatal development of neurons in the human prefrontal cortex. II. A quantitative Golgi study
Mrzljak, L., Uylings, H. B. M., Kostovic, I., & van Eden, C. G. (1992) · Journal of Comparative Neurology · doi:10.1002/cne.903160408 · Cited by 315
Development of the Epidermis in the Newborn
Evans, N. J., & Rutter, N. (2009) · Biology of the Neonate · doi:10.1159/000242513 · Cited by 305
Fitzgerald, M., & Koltzenburg, M. (1986) · Developmental Brain Research · doi:10.1016/0165-3806(86)90194-x · Cited by 268
Self-citationMcGrath, P. A. (1987) · Pain · doi:10.1016/0304-3959(87)90033-9 · Cited by 258
FitzgeraId, M., Shaw, A., & MacIntosh, N. (1988) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.1988.tb04779.x · Cited by 254
Acute pain response in infants: a multidimensional description
Johnston, C. C., & Strada, M. E. (1986) · Pain · doi:10.1016/0304-3959(86)90123-5 · Cited by 254
Cited by
Grunau, R. E., Whitfield, M. F., Petrie-Thomas, J., Synnes, A. R., Cepeda, I. L., Keidar, A., Rogers, M., MacKay, M., Hubber-Richard, P., & Johannesen, D. (2009) · Pain · doi:10.1016/j.pain.2009.02.014 · Cited by 502
Long-Term Behavioral Effects of Repetitive Pain in Neonatal Rat Pups
Anand, K. J. S., Coskun, V, Thrivikraman, K. V., Nemeroff, C. B., & Plotsky, P. M. (1999) · Physiology & Behavior · doi:10.1016/s0031-9384(98)00338-2 · Cited by 432
Summary Proceedings From the Neonatal Pain-Control Group
Anand, K. J. S., Aranda, J. V., Berde, C. B., Buckman, S., Capparelli, E. V., Carlo, W., Hummel, P., Johnston, C. C., Lantos, J., Tutag-Lehr, V., et al. (2006) · Pediatrics · doi:10.1542/peds.2005-0620c · Cited by 276
Williams, M. D., & Lascelles, B. D. X. (2020) · Frontiers in Pediatrics · doi:10.3389/fped.2020.00030 · Cited by 269
Iatrogenic skin injury in the neonatal intensive care unit
Sardesai, S. R., Kornacka, M. K., Walas, W., & Ramanathan, R. (2011) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767051003728245 · Cited by 73
Metadata
- Authors
- Fitzgerald, M., Millard, C., & McIntosh, N.
- Venue
- Pain
- Published
- 1989-10
- Volume
- 39
- Issue
- 1
- Pages
- 31-36
- ISSN
- 0304-3959 (ISSN-L)
- OpenAlex
- W1969439040
- Cited by
- 377
- References
- 22
- FWCI
- 4.58
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Cutaneous hypersensitivity following peripheral tissue damage in newborn infants and its reversal with topical anaesthesia. https://app.cochat.ai/papers/10.1016/0304-3959(89)90172-3
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- Fitzgerald, M., Millard, C., & McIntosh, N. (1989). Cutaneous hypersensitivity following peripheral tissue damage in newborn infants and its reversal with topical anaesthesia. Pain. https://doi.org/10.1016/0304-3959(89)90172-3
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
