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Cited by 456Pain Mechanisms and TreatmentsPain Management and TreatmentAldose Reductase and Taurine

Streptozocin-induced diabetic rats: behavioural evidence for a model of chronic pain

Courteix, C., Eschalier, A., Lavarenne, J.·1993·Pain
DOI 10.1016/0304-3959(93)90059-x
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Abstract

Painful diabetic neuropathy is one of the most common complications of insulin-dependent diabetes in man. Conflicting results have been obtained in experimentally diabetic animals subjected to pain stimuli. This work aimed to systematically study the response of rats made diabetic (hyperglycemia > or = 14 mM) by injection of streptozocin (STZ) (75 mg/kg, i.p.), to various pain stimuli: mechanical, thermal (warm and cold) and chemical. The time course of the scores was followed for 4 weeks simultaneously with the clinical symptoms (weight, body and skin temperature, motility) and hyperglycemia. A decrease in reaction thresholds to noxious heat stimuli (44 degrees C and 46 degrees C) and to non-painful thermal (cold: 10 degrees C, and warm: 38-42 degrees C) and mechanical stimulation (paw pressure) was observed. This can be considered as evidence for hyperalgesia and allodynia, respectively. These troubles appeared gradually and required at least 2 weeks of diabetes to reach statistical significance. Four weeks after the induction of diabetes, the scores obtained in diabetic rats injected with formalin were greater than those in normal rats, indicating hyperalgesia. Variation in sensitivity to pain occurred at the same time as arrested weight increase, fall in skin temperature, some amyotrophy measured in terms of hind-paw volume, and the usual polyuria-polydipsia syndrome. Spontaneous motor activity of the rats was lowered. This model is thus of interest as the observed reactions to noxious and non-noxious stimuli correspond to hyperalgesia and allodynia, symptoms encountered in painful diabetic neuropathy in man. Operating conditions for this model are discussed.

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  • STZ-induced diabetes produces consistent, long-lasting thermal and mechanical hyperalgesia, in addition to cold and mechanical allodynia, associated with hyperexcitability of nociceptive C fibers in response to mechanical stimuli.

    “STZ-induced diabetes produces consistent, long-lasting thermal and mechanical hyperalgesia, in addition to cold and mechanical allodynia (Courteix et al, 1993), associated with hyperexcitability of nociceptive C fibers in response to mechanical stimuli.”

    From The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain (2018) · cites this paper as Courteix et al, 1993

  • STZ injection elicits a time-dependent increase in the intensity of hyperalgesia over a 4-week observation period.

    “Importantly, STZ injection elicits a time-dependent increase in the intensity of hyperalgesia, over a 4-week observation period.”

    From The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain (2018) · cites this paper as Courteix et al, 1993

  • The time course of STZ-induced hyperalgesia might mimic the slow progression of painful neuropathy in individuals with diabetes from the painful stage to the degenerative and painless stage.

    “This time course might mimic the slow progression of painful neuropathy in individuals with diabetes from the painful stage to the degenerative and painless stage (Courteix et al, 1993).”

    From The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain (2018) · cites this paper as Courteix et al, 1993

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Authors
Courteix, C., Eschalier, A., & Lavarenne, J.
Affiliations
Inserm (FR)
Corresponding author
Eschalier, A.
ORCID
Venue
Pain
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1993-04
Volume
53
Issue
1
Pages
81-88
ISSN
0304-3959 (ISSN-L)
DOI
10.1016/0304-3959(93)90059-x
OpenAlex
W2069886558
Cited by
454
References
48
Citations by year
2026: 4 · 2025: 6 · 2024: 7 · 2023: 6 · 2022: 12 · 2021: 13 · 2020: 4 · 2019: 7 · 2018: 7 · 2017: 20 · 2016: 18 · 2015: 19 · 2014: 24 · 2013: 14 · 2012: 28
FWCI
2.89
Type
journal article
Language
en
Open access
closed
Locations
  • Pain (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Aldose Reductase and Taurine
Keywords
streptozotocin-induced diabetes, diabetic neuropathy, hyperalgesia, allodynia, chronic pain model, thermal pain, mechanical pain, formalin test, hyperglycemia, amyotrophy, spontaneous motor activity, skin temperature, type 1 diabetes
MeSH terms
Animals, Behavior, Animal, Blood Glucose, Chronic Disease, Diabetes Mellitus, Experimental, Disease Models, Animal, Formaldehyde, Immersion, Male, Motor Activity, Pain, Pain Measurement, Physical Stimulation, Skin Temperature, Rats, Sprague-Dawley, Rats

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