Description of a short-term Taxol®-induced nociceptive neuropathy in rats

Authier, Nicolas; Gillet, Jean-Pierre; Fialip, Joseph; Eschalier, Alain; Coudore, François

doi:10.1016/s0006-8993(00)02910-3

Cited by 171Cancer Treatment and PharmacologyPain Mechanisms and TreatmentsIon Channels and Receptors

Description of a short-term Taxol®-induced nociceptive neuropathy in rats

Authier, Nicolas, Gillet, Jean-Pierre, Fialip, Joseph, Eschalier, Alain, Coudore, François·2000·Brain Research

DOI 10.1016/s0006-8993(00)02910-3

Open this paper in CoChat — free account

Abstract

This work describes a new animal model of neuropathic pain produced by the single intraperitoneal administration of Taxol (32 mg/kg) to male Sprague-Dawley rats. During the course of the experiment, the clinical status of the rats remained satisfactory and motor function was not altered. A number of classical behavioural tests of nociception as well as histological and electrophysiological investigations were performed. Taxol administration produced an important and rapidly developing mechanical hyperalgesia, a thermal hypoalgesia but no mechanical or thermal allodynia. Degenerative changes were observed in the sciatic nerve, the nerve fibres in the paw subcutaneous tissue and in the lumbar spinal cord. When Taxol or vehicle (a mix of Cremophor and ethanol) were repeatedly injected once a week for 5 weeks, similar nociceptive disorders were observed in addition to a decrease in peripheral nerve conduction velocity. The selective dysfunction of high-diameter myelinated fibres observed after one single administration of Taxol (32 mg/kg) may be attributable to paclitaxel-induced neuropathy, however other mechanisms causing neurochemical dysfunction must also be involved.

Integrity signals

Registry

Crossref · 10.1016/s0006-8993(00)02910-3

Cites

40 of 40 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A single injection of paclitaxel (32 mg/kg, intraperitoneal) in rats produces mechanical and thermal hyperalgesia, but does not elicit mechanical allodynia.
“A single injection of paclitaxel (32 mg/kg, intraperitoneal) in rats produces mechanical and thermal hyperalgesia, but does not elicit mechanical allodynia (Authier et al, 2000).”
From The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain (2018) · cites this paper as Authier et al, 2000

Pain mechanisms: a new theory.
Melzack, R., & Wall, P. D. (1965) · Science · doi:10.1126/science.150.3699.971 · Cited by 11,108 · see citing works
Ethical guidelines for investigations of experimental pain in conscious animals.
Zimmermann, M. (1983) · Pain · doi:10.1016/0304-3959(83)90201-4 · Cited by 7,762 · see citing works
Quantitative assessment of tactile allodynia in the rat paw
Chaplan, S. R., Bach, F. W., Pogrel, J. W., Chung, J. M., & Yaksh, T. L. (1994) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(94)90144-9 · Cited by 7,740 · see citing works
A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man
Bennett, G. J., & Xie, Y.-K. (1988) · Pain · doi:10.1016/0304-3959(88)90209-6 · Cited by 5,376 · see citing works
A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia
Hargreaves, K., Dubner, R. A., Brown, F. J., Flores, C., & Joris, J. L. (1988) · Pain · doi:10.1016/0304-3959(88)90026-7 · Cited by 5,155 · see citing works
An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat
Ho Kim, S., & Mo Chung, J. (1992) · Pain · doi:10.1016/0304-3959(92)90041-9 · Cited by 3,069 · see citing works
Textbook of pain
Bonica, J. J., Melzack, R., & Wall, P. D. (1999) · Cited by 2,537 · see citing works
A method for measurement of analgesic activity on inflamed tissue.
Randall, L. O., & Selitto, J. J. (1957) · PubMed · Cited by 1,568 · see citing works
THE GATE CONTROL THEORY OF PAIN MECHANISMS
Wall, P. D. (1978) · Brain · doi:10.1093/brain/101.1.1 · Cited by 472 · see citing works
Streptozocin-induced diabetic rats: behavioural evidence for a model of chronic pain
Courteix, C., Eschalier, A., & Lavarenne, J. (1993) · Pain · doi:10.1016/0304-3959(93)90059-x · Cited by 454 · see citing works
Self-citation
A method for the routine assessment of fore- and hindlimb grip strength of rats and mice.
Oa, M., Ha, T., Wc, B., & Mt, R. (1979) · PubMed · Cited by 415 · see citing works
Structure of tubulin at 6.5 Å and location of the taxol-binding site
Nogales, E., Wolf, S. G., KHAN, I. A., Ludueña, R. F., & Downing, K. H. (1995) · Nature · doi:10.1038/375424a0 · Cited by 390 · see citing works
Taxol induces the assembly of free microtubules in living cells and blocks the organizing capacity of the centrosomes and kinetochores.
Brabander, M. D., Geuens, G., Nuydens, R., Willebrords, R., & Mey, J. D. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.9.5608 · Cited by 387 · see citing works
Peripheral neuropathy from taxol and cisplatin combination chemotherapy: Clinical and electrophysiological studies
Chaudhry, V., Rowinsky, E. K., Sartorius, S. E., Donehower, R. C., & Cornblath, D. R. (1994) · Annals of Neurology · doi:10.1002/ana.410350310 · Cited by 362 · see citing works
Taxol produces a predominantly sensory neuropathy
Lipton, R. B., Apfel, S. C., Dutcher, J. P., Rosenberg, R., Kaplan, J., Berger, A., Einzig, A. I., Wiernik, P. H., & Schaumburg, H. H. (1989) · Neurology · doi:10.1212/wnl.39.3.368 · Cited by 317 · see citing works
Intraepidermal nerve fiber density in patients with painful sensory neuropathy
Holland, N. R., Stocks, A., Hauer, P., Cornblath, D. R., Griffin, J. W., & McArthur, J. C. (1997) · Neurology · doi:10.1212/wnl.48.3.708 · Cited by 301 · see citing works
Phase I trial of taxol given as a 24-hour infusion every 21 days: responses observed in metastatic melanoma.
Wiernik, P. H., Schwartz, E. L., Einzig, A. I., Strauman, J. J., Lipton, R. B., & Dutcher, J. P. (1987) · Journal of Clinical Oncology · doi:10.1200/jco.1987.5.8.1232 · Cited by 275 · see citing works
Nerve growth factor prevents toxic neuropathy in mice
Apfel, S. C., Lipton, R. B., Arezzo, J. C., & Kessler, J. A. (1991) · Annals of Neurology · doi:10.1002/ana.410290115 · Cited by 240 · see citing works
Neurotoxicity of Taxol.
Rowinsky, E. K., Chaudhry, V., Cornblath, D. R., & Donehower, R. C. (1993) · PubMed · Cited by 208 · see citing works
Cytotoxicity of the anticancer agents cisplatin and taxol during cell proliferation and the cell cycle
Donaldson, K. L., Goolsby, G. L., & Wahl, A. F. (1994) · International Journal of Cancer · doi:10.1002/ijc.2910570614 · Cited by 195 · see citing works
Epidermal innervation: changes with aging, topographic location, and in sensory neuropathy
Lauria, G., Holland, N. R., Hauer, P. E., Cornblath, D. R., Griffin, J. W., & McArthur, J. C. (1999) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(99)00063-5 · Cited by 187 · see citing works
Experimental Peripheral Neuropathy Induced in Adult Rats by Repeated Intraperitoneal Administration of Taxol
Cavaletti, G., Tredici, G., Braga, M., & Tazzari, S. (1995) · Experimental Neurology · doi:10.1006/exnr.1995.1008 · Cited by 185 · see citing works
Taxol Neuropathy
Sahenk, Z. (1994) · Archives of Neurology · doi:10.1001/archneur.1994.00540190110024 · Cited by 166 · see citing works
Noxious thermal input from the rat tail: Modulation by descending inhibitory influences
Necker, R., & Hellon, R. F. (1977) · Pain · doi:10.1016/0304-3959(77)90135-x · Cited by 160 · see citing works
Physiological characterization of taxol‐induced large‐fiber sensory neuropathy in the rat
Cliffer, K. D., Siuciak, J. A., Carson, S. R., Radley, H. E., Park, J. S., Lewis, D. R., Zlotchenko, E., Nguyen, T. T. T., García, K., Tonra, J. R., et al. (1998) · Annals of Neurology · doi:10.1002/ana.410430111 · Cited by 131 · see citing works
Effect on the peripheral nervous system of the short-term intravenous administration of paclitaxel in the rat.
Cavaletti, G., Cavalletti, E., Montaguti, P., Oggioni, N., Negri, O. D., & Tredici, G. (1997) · PubMed · Cited by 124 · see citing works
Potential neurotoxicity of the solvent vehicle for cyclosporine.
Windebank, A. J., Blexrud, M. D., & de Groen, P. C. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)38962-7 · Cited by 107 · see citing works
Taxol-induced neuropathy: chronic effects of local injection
Röyttä, M., & Raine, C. S. (1986) · Journal of Neurocytology · doi:10.1007/bf01611731 · Cited by 81 · see citing works
Cisplatin induced neuropathy: Central, peripheral and autonomic nerve involvement
Boogerd, W. J., Huinink, W. W. T. B., Dalesio, O., Hoppenbrouwers, W. J. J. F., & van der Sande, J. J. (1990) · Journal of Neuro-Oncology · doi:10.1007/bf02341156 · Cited by 68 · see citing works
Prosaptide prevents paclitaxel neurotoxicity.
Campana, W. M., Eskeland, N. L., Calcutt, N. A., Misasi, R., Myers, R. R., & O′Brien, J. S. (1998) · PubMed · Cited by 61 · see citing works
The ACTH-(4–9) analog, ORG 2766, prevents taxol-induced neuropathy in rats
Hamers, F. P. T., Pette, C., Neijt, J. P., & Gispen, W. H. (1993) · European Journal of Pharmacology · doi:10.1016/0014-2999(93)90367-q · Cited by 55 · see citing works
Rat strain differences in the potentiation of morphine-induced analgesia by stress
Woolfolk, D. R., & Holtzman, S. G. (1995) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)00440-t · Cited by 54 · see citing works
Emulsifier for intravenous cyclosporin inhibits neurite outgrowth, causes deficits in rapid axonal transport and leads to structural abnormalities in differentiating N1E.115 neuroblastoma.
Brat, D. J., Aj, W., & Brimijoin, S. (1992) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)11107-5 · Cited by 38 · see citing works
Sensory neuropathies including painful and toxic neuropathies
Wokke, J. H. J., & van Dijk, G. W. (1997) · Journal of Neurology · doi:10.1007/s004150050075 · Cited by 26 · see citing works
High-performance liquid chromatographic determination of paclitaxel in rat serum: application to a toxicokinetic study
Coudoré, F., Authier, N., Guillaume, D., Béal, A., Duroux, E., & Fialip, J. (1999) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/s0378-4347(98)00465-4 · Cited by 24 · see citing works
Self-citation
Painful Neuropathy
Baron, R., & Maier, C. S. (1995) · Clinical Journal of Pain · doi:10.1097/00002508-199503000-00007 · Cited by 24 · see citing works
Taxol-induced neuropathy after nerve crush: long-term effects on Schwann and endoneurial cells
Vuorinen, V. S., & R�ytt�, M. (1990) · Acta Neuropathologica · doi:10.1007/bf00294244 · Cited by 19 · see citing works
Causes and Diagnosis of Sensory Neuropathies
Mitsumoto, H., & Wilbourn, A. J. (1994) · Journal of Clinical Neurophysiology · doi:10.1097/00004691-199411000-00003 · Cited by 16 · see citing works
Three Decades of Pain Research and its Control
Dubner, R. A. (1997) · Journal of Dental Research · doi:10.1177/00220345970760030401 · Cited by 11 · see citing works
Activity-dependent conduction latency changes in Aβ fibers of neuropathic rats
Shin, H., Oh, S., Jung, S., Choi, Y.-R., Won, C., & Leem, J. W. (1997) · Neuroreport · doi:10.1097/00001756-199708180-00032 · Cited by 8 · see citing works

Flagged first, then by citations

1 of the 41 references couldn’t be matched to a known paper.

Sorted by citations

The biopsychosocial approach to chronic pain: Scientific advances and future directions.
Gatchel, R. J., Peng, Y. B., Peters, M. L., Fuchs, P. N., & Turk, D. C. (2007) · Psychological Bulletin · doi:10.1037/0033-2909.133.4.581 · Cited by 3,392 · see citing works
Phase III Trial of Nanoparticle Albumin-Bound Paclitaxel Compared With Polyethylated Castor Oil–Based Paclitaxel in Women With Breast Cancer
Gradishar, W. J., Tjulandin, S., Davidson, N. G. P., Shaw, H., Desai, N. P., Bhar, P., Hawkins, M., & O’Shaughnessy, J. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.04.937 · Cited by 2,159 · see citing works
Models and Mechanisms of Hyperalgesia and Allodynia
Sandkühler, J. (2009) · Physiological Reviews · doi:10.1152/physrev.00025.2008 · Cited by 1,148 · see citing works
Protein nanoparticles as drug carriers in clinical medicine
Hawkins, M. J., Soon-Shiong, P., & Desai, N. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.08.044 · Cited by 779 · see citing works
Albumin-bound paclitaxel: a next-generation taxane
Gradishar, W. J. (2006) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.7.8.1041 · Cited by 706 · see citing works
Ethosuximide reverses paclitaxel- and vincristine-induced painful peripheral neuropathy
Flatters, S. J. L., & Bennett, G. J. (2004) · Pain · doi:10.1016/j.pain.2004.01.029 · Cited by 576 · see citing works
Studies of peripheral sensory nerves in paclitaxel-induced painful peripheral neuropathy: Evidence for mitochondrial dysfunction
Flatters, S. J. L., & Bennett, G. J. (2006) · Pain · doi:10.1016/j.pain.2006.01.037 · Cited by 536 · see citing works
Structure, enzymatic activities, glycation and therapeutic potential of human serum albumin: A natural cargo
Rabbani, G., & Ahn, S. N. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.11.053 · Cited by 505 · see citing works
A painful peripheral neuropathy in the rat produced by the chemotherapeutic drug, paclitaxel
Polomano, R. C., Mannes, A. J., Clark, U. S., & Bennett, G. J. (2001) · Pain · doi:10.1016/s0304-3959(01)00363-3 · Cited by 476 · see citing works
Animal models of neuropathic pain
Jaggi, A. S., Jain, V., & Singh, N. (2010) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2009.00801.x · Cited by 391 · see citing works
Peripheral Neuropathy Induced by Paclitaxel: Recent Insights and Future Perspectives
Scripture, C. D., Figg, W. D., & Sparreboom, A. (2006) · Current Neuropharmacology · doi:10.2174/157015906776359568 · Cited by 320 · see citing works
Intrathecal interleukin-10 gene therapy attenuates paclitaxel-induced mechanical allodynia and proinflammatory cytokine expression in dorsal root ganglia in rats
Ledeboer, A., Jekich, B. M., Sloane, E. M., Mahoney, J. H., Langer, S. J., Milligan, E. D., Martin, D., Maier, S. F., Johnson, K. W., Leinwand, L. A., et al. (2006) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.10.012 · Cited by 304 · see citing works
Paclitaxel- and vincristine-evoked painful peripheral neuropathies: Loss of epidermal innervation and activation of Langerhans cells
Siau, C., Xiao, W. H., & BENNETT, G. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2006.05.007 · Cited by 302 · see citing works
The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain
Donvito, G., Nass, S. R., Wilkerson, J. L., Curry, Z. A., Schurman, L. D., Kinsey, S. G., & Lichtman, A. H. (2018) · Neuropsychopharmacology · doi:10.1038/npp.2017.204 · Cited by 301 · see citing works
Pathobiology of cancer chemotherapy-induced peripheral neuropathy (CIPN)
Han, F. Y., & Smith, M. T. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00156 · Cited by 273 · see citing works
The paradox of paclitaxel neurotoxicity: Mechanisms and unanswered questions
Gornstein, E. L., & Schwarz, T. L. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.08.016 · Cited by 246 · see citing works
Animal and cellular models of chronic pain
Wang, L. X., & Wang, Z. J. (2003) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(03)00098-x · Cited by 220 · see citing works
Can Controversial Nanotechnology Promise Drug Delivery?
Devadasu, V. R., Bhardwaj, V., & Kumar, M. N. V. R. (2012) · Chemical Reviews · doi:10.1021/cr300047q · Cited by 212 · see citing works
A Mechanistic Understanding of Axon Degeneration in Chemotherapy-Induced Peripheral Neuropathy
Fukuda, Y., Li, Y., & Segal, R. A. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00481 · Cited by 206 · see citing works
Intraepidermal nerve fiber loss corresponds to the development of Taxol-induced hyperalgesia and can be prevented by treatment with minocycline
Boyette-Davis, J. A., Xin, W., Zhang, H., & Dougherty, P. M. (2010) · Pain · doi:10.1016/j.pain.2010.10.030 · Cited by 202 · see citing works
Improving the translation of analgesic drugs to the clinic: animal models of neuropathic pain
du Sert, N. P., & Rice, A. S. C. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12645 · Cited by 188 · see citing works
Enhanced Excitability of Primary Sensory Neurons and Altered Gene Expression of Neuronal Ion Channels in Dorsal Root Ganglion in Paclitaxel-induced Peripheral Neuropathy
Zhang, H., & Dougherty, P. M. (2014) · Anesthesiology · doi:10.1097/aln.0000000000000176 · Cited by 169 · see citing works
Role of protein kinase Cϵ and protein kinase A in a model of paclitaxel-induced painful peripheral neuropathy in the rat
Dina, O. A., Chen, X., Reichling, D. B., & Levine, J. D. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00425-0 · Cited by 167 · see citing works
Calcium Channels As Therapeutic Targets in Neuropathic Pain
Yaksh, T. L. (2006) · Journal of Pain · doi:10.1016/j.jpain.2005.09.007 · Cited by 165 · see citing works
An animal model of nociceptive peripheral neuropathy following repeated cisplatin injections
Authier, N. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(03)00003-7 · Cited by 165 · see citing works
Self-citation
Taxane‐induced neurotoxicity: Pathophysiology and therapeutic perspectives
da Costa, R., Passos, G. F., Quintão, N. L. M., Fernandes, E. S., Maia, J. R., Campos, M. M., & Calixto, J. Β. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15086 · Cited by 162 · see citing works
Overview of neuropathy associated with taxanes for the treatment of metastatic breast cancer
Rivera, E., & Cianfrocca, M. (2015) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-014-2607-5 · Cited by 159 · see citing works
Mitochondrial abnormality in sensory, but not motor, axons in paclitaxel-evoked painful peripheral neuropathy in the rat
Xiao, W. H., Zheng, H., Zheng, F. Y., Nuydens, R., Meert, T. F., & Bennett, G. J. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.10.010 · Cited by 154 · see citing works
Prevention of paclitaxel-evoked painful peripheral neuropathy by acetyl-l-carnitine: Effects on axonal mitochondria, sensory nerve fiber terminal arbors, and cutaneous Langerhans cells
Jin, H. W., Flatters, S. J. L., Xiao, W. H., Mulhern, H. L., & Bennett, G. J. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.11.001 · Cited by 154 · see citing works
Global Inhibition of Reactive Oxygen Species (ROS) Inhibits Paclitaxel-Induced Painful Peripheral Neuropathy
Fidanboylu, M., Griffiths, L. A., & Flatters, S. J. L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025212 · Cited by 152 · see citing works
Unilateral hot plate test: a simple and sensitive method for detecting central and peripheral hyperalgesia in mice
Menéndez, L., Lastra, A., Hidalgo, A., & Baamonde, A. (2002) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(01)00483-6 · Cited by 152 · see citing works
Activation of cannabinoid CB<sub>1</sub> and CB<sub>2</sub> receptors suppresses neuropathic nociception evoked by the chemotherapeutic agent vincristine in rats
Rahn, E. J., Makriyannis, A., & Hohmann, A. G. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707333 · Cited by 146 · see citing works
Inhibition of Paclitaxel-Induced A-Fiber Hypersensitization by Gabapentin
Matsumoto, M., Inoue, M., Hald, A., Xie, W., & Ueda, H. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.103614 · Cited by 133 · see citing works
Cannabidiol Prevents the Development of Cold and Mechanical Allodynia in Paclitaxel-Treated Female C57Bl6 Mice
Ward, S. J., Ramirez, M. D., Neelakantan, H., & Walker, E. A. (2011) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e3182283486 · Cited by 133 · see citing works
Morphological and morphometric analysis of paclitaxel and docetaxel-induced peripheral neuropathy in rats
Persohn, E., Canta, A., Schoepfer, S., Traebert, M., Mueller, L., Gilardini, A., Galbiati, S., Nicolini, G., Scuteri, A., Lanzani, F., et al. (2005) · European Journal of Cancer · doi:10.1016/j.ejca.2005.04.006 · Cited by 132 · see citing works
Terminal arbor degeneration - a novel lesion produced by the antineoplastic agent paclitaxel
Bennett, G. J., Liu, G. K., Xiao, W. H., Jin, H. W., & Siau, C. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07652.x · Cited by 121 · see citing works
Olesoxime (TRO19622): A Novel Mitochondrial-Targeted Neuroprotective Compound
Bordet, T., Berna, P. P., Abitbol, J., & Pruss, R. M. (2010) · Pharmaceuticals · doi:10.3390/ph3020345 · Cited by 121 · see citing works
Quercetin ameliorates paclitaxel-induced neuropathic pain by stabilizing mast cells, and subsequently blocking PKCε-dependent activation of TRPV1
Gao, W., Zan, Y., Wang, Z.-J. J., Hu, X.-Y., & Huang, F. (2016) · Acta Pharmacologica Sinica · doi:10.1038/aps.2016.58 · Cited by 120 · see citing works
Animal Models of Chemotherapy-Evoked Painful Peripheral Neuropathies
Authier, N., Balayssac, D., Marchand, F., Ling, B., Zangarelli‌, A., Descoeur, J., Coudoré, F., Bourinet, E., & Eschalier, A. (2009) · Neurotherapeutics · doi:10.1016/j.nurt.2009.07.003 · Cited by 120 · see citing works
Self-citation
Chemotherapy-induced peripheral neuropathies: from clinical relevance to preclinical evidence
Balayssac, D., Ferrier, J., Descoeur, J., Ling, B., Pezet, D., Eschalier, A., & Authier, N. (2011) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2011.543417 · Cited by 119 · see citing works
Self-citation
A cannabinoid agonist, WIN 55,212-2, reduces neuropathic nociception induced by paclitaxel in rats
Pascual, D., Goicoechea, C., Suardíaz, M., & Martín, M. I. (2005) · Pain · doi:10.1016/j.pain.2005.07.008 · Cited by 117 · see citing works
Calpain inhibition protects against Taxol-induced sensory neuropathy
Wang, M. S. (2003) · Brain · doi:10.1093/brain/awh078 · Cited by 116 · see citing works
A New Animal Model of Vincristine-Induced Nociceptive Peripheral Neuropathy
Authier, N., Gillet, J.-P., Fialip, J., Eschalier, A., & Coudoré, F. (2003) · NeuroToxicology · doi:10.1016/s0161-813x(03)00043-3 · Cited by 110 · see citing works
Self-citation
Safety and efficacy of weekly nab®-paclitaxel in combination with carboplatin as first-line therapy in elderly patients with advanced non-small-cell lung cancer
Socinski, M. A., Langer, C. J., Okamoto, I., Hon, J. K., Hirsh, V., Dakhil, S. R., Page, R. D., Orsini, J., Zhang, H., & Renschler, M. F. (2013) · Annals of Oncology · doi:10.1093/annonc/mds461 · Cited by 108 · see citing works
Nanoparticle Albumin Bound Paclitaxel in the Treatment of Human Cancer: Nanodelivery Reaches Prime-Time?
Cucinotto, I., Fiorillo, L., Gualtieri, S., Arbitrio, M., Ciliberto, D., Staropoli, N., Grimaldi, A., Luce, A., Tassone, P., Caraglia, M., et al. (2013) · Journal of Drug Delivery · doi:10.1155/2013/905091 · Cited by 102 · see citing works
Nab-paclitaxel for breast cancer: a new formulation with an improved safety profile and greater efficacy
Henderson, I. C., & Bhatia, V. (2007) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.7.7.919 · Cited by 102 · see citing works
Neurophysiological and neuropathological characterization of new murine models of chemotherapy-induced chronic peripheral neuropathies
Carozzi, V., Canta, A., Oggioni, N., Sala, B., Chiorazzi, A., Meregalli, C., Bossi, M., Marmiroli, P., & Cavaletti, G. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2010.09.004 · Cited by 101 · see citing works
Cannabinoid agonist WIN 55,212-2 prevents the development of paclitaxel-induced peripheral neuropathy in rats. Possible involvement of spinal glial cells
Burgos, E., Gómez‐Nicola, D., Pascual, D., Martı́n, M. I., Nieto‐Sampedro, M., & Goicoechea, C. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.02.008 · Cited by 99 · see citing works
Chemotherapy-Induced Peripheral Neuropathy
Fehrenbacher, J. C. (2015) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2014.12.002 · Cited by 98 · see citing works
Nab-paclitaxel for the treatment of breast cancer: efficacy, safety, and approval
Yamamoto, Y., Kawano, I., & Iwase (2011) · OncoTargets and Therapy · doi:10.2147/ott.s13836 · Cited by 96 · see citing works
Animal Models of Cancer Pain
Wacnik, P. W., Pacharinsak, C., & Beitz, A. J. (2010) · Neuromethods · doi:10.1007/978-1-60761-880-5_8 · Cited by 92 · see citing works
Erythropoietin protects sensory axons against paclitaxel-induced distal degeneration
Melli, G., Jack, C., Lambrinos, G. L., Ringkamp, M., & Höke, A. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.08.014 · Cited by 84 · see citing works
Neuropathic Pain models caused by damage to central or peripheral nervous system
Kumar, A., Kaur, H., & Singh, A. (2017) · Pharmacological Reports · doi:10.1016/j.pharep.2017.09.009 · Cited by 84 · see citing works
Nicotinamide riboside, a form of vitamin B3 and NAD+ precursor, relieves the nociceptive and aversive dimensions of paclitaxel-induced peripheral neuropathy in female rats
Hamity, M. V., White, S. R., Walder, R. Y., Schmidt, M. S., Brenner, C., & Hammond, D. L. (2017) · Pain · doi:10.1097/j.pain.0000000000000862 · Cited by 80 · see citing works
Transplant-mediated enhancement of spinal cord GABAergic inhibition reverses paclitaxel-induced mechanical and heat hypersensitivity
Braz, J. M., Wang, X., Guan, Z., Rubenstein, J. L. R., & Basbaum, A. I. (2015) · Pain · doi:10.1097/j.pain.0000000000000152 · Cited by 71 · see citing works
Herbal medicine Shakuyaku‐kanzo‐to reduces paclitaxel‐induced painful peripheral neuropathy in mice
日高, 隆., Shima, T., Nagira, K., Ieki, M., Nakamura, T., Aono, Y., Kuraishi, Y., Arai, T., & Saito, S. (2008) · European Journal of Pain · doi:10.1016/j.ejpain.2008.03.003 · Cited by 66 · see citing works
Activation of TLR ‐4 to produce tumour necrosis factor‐α in neuropathic pain caused by paclitaxel
Wu, Z., Wang, S., Wu, I., Mata, M. M., & Fink, D. J. (2014) · European Journal of Pain · doi:10.1002/ejp.613 · Cited by 63 · see citing works
Evoked and Ongoing Pain-Like Behaviours in a Rat Model of Paclitaxel-Induced Peripheral Neuropathy
Griffiths, L. A., Duggett, N. A., Pitcher, A., & Flatters, S. J. L. (2018) · Pain Research and Management · doi:10.1155/2018/8217613 · Cited by 62 · see citing works
Methods for in vivo studies in rodents of chemotherapy induced peripheral neuropathy
Bruna, J., Alberti, P., Calls, A., Caillaud, M., Damaj, M. I., & Navarro, X. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.113154 · Cited by 59 · see citing works
Up‐regulation of matrix metalloproteinase‐3 in the dorsal root ganglion of rats with paclitaxel‐induced neuropathy
Nishida, K., Kuchiiwa, S., Oiso, S., Futagawa, T., Masuda, S., Takeda, Y., & Yamada, K. (2008) · Cancer Science · doi:10.1111/j.1349-7006.2008.00877.x · Cited by 57 · see citing works
Peptidergic intraepidermal nerve fibers in the skin contribute to the neuropathic pain in paclitaxel-induced peripheral neuropathy
Ko, M., Hu, M.-E., Hsieh, Y., Lan, C., & Tseng, T.-J. (2014) · Neuropeptides · doi:10.1016/j.npep.2014.02.001 · Cited by 54 · see citing works
Using nanotechnology to improve the characteristics of antineoplastic drugs: Improved characteristics of nab-paclitaxel compared with solvent-based paclitaxel
Foote, M. (2007) · Biotechnology annual review · doi:10.1016/s1387-2656(07)13012-x · Cited by 53 · see citing works
Pharmacological augmentation of nicotinamide phosphoribosyltransferase (NAMPT) protects against paclitaxel-induced peripheral neuropathy
Lococo, P. M., Risinger, A. L., Smith, H. R., Chavera, T. S., Berg, K. A., & Clarke, W. P. (2017) · eLife · doi:10.7554/elife.29626 · Cited by 53 · see citing works
Lithium Attenuates Peripheral Neuropathy Induced by Paclitaxel in Rats
Pourmohammadi, N., Alimoradi, H., Mehr, S. E., Hassanzadeh, G., Hadian, M. R., Sharifzadeh, M. S., Bakhtiarian, A., & Dehpour, A. R. (2011) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2011.00795.x · Cited by 51 · see citing works
Paclitaxel-activated astrocytes produce mechanical allodynia in mice by releasing tumor necrosis factor-α and stromal-derived cell factor 1
Liu, X., Tonello, R., Ling, Y., Gao, Y., & Berta, T. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1619-9 · Cited by 51 · see citing works
Anti-nociceptive effect of a conjugate of substance P and light chain of botulinum neurotoxin type A
Mustafa, G., Anderson, E. M., Bokrand-Donatelli, Y., Neubert, J. K., & Caudle, R. M. (2013) · Pain · doi:10.1016/j.pain.2013.07.041 · Cited by 48 · see citing works
Chemotherapy-induced painful neuropathy
Hopkins, H. L., Duggett, N. A., & Flatters, S. J. L. (2016) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0000000000000204 · Cited by 47 · see citing works
Prevention of paclitaxel-induced neuropathy by formulation approach
Zang, X., Lee, J. B., Deshpande, K., Garbuzenko, O. B., Minko, T., & Kagan, L. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.04.013 · Cited by 47 · see citing works
Effect of Gabapentin and Pregabalin in Rat Model of Taxol Induced Neuropathic Pain
Mangaiarkkarasi, A. (2015) · JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH · doi:10.7860/jcdr/2015/13373.5955 · Cited by 45 · see citing works
Peripheral neuropathy with microtubule inhibitor containing antibody drug conjugates: Challenges and perspectives in translatability from nonclinical toxicology studies to the clinic
Stagg, N. J., Shen, B., Brunstein, F., Li, C., Kamath, A. V., Zhong, F., Schutten, M. M., & Fine, B. M. (2016) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2016.10.012 · Cited by 45 · see citing works
Paclitaxel alters the evoked release of calcitonin gene-related peptide from rat sensory neurons in culture
Pittman, S. K., Gracias, N. G., Vasko, M. R., & Fehrenbacher, J. C. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2013.12.011 · Cited by 44 · see citing works
Paclitaxel Increases High Voltage^|^ndash;Dependent Calcium Channel Current in Dorsal Root Ganglion Neurons of the Rat
Kawakami, K., Chiba, T., Katagiri, N., Saduka, M., Abe, K., Utsunomiya, I., Hama, T., & Taguchi, K. (2012) · Journal of Pharmacological Sciences · doi:10.1254/jphs.12123fp · Cited by 42 · see citing works
Neurotropin reverses paclitaxel-induced neuropathy without affecting anti-tumour efficacy
Kawashiri, T., Egashira, N., Itoh, Y., Shimazoe, T., Ikegami, Y., Yano, T., Yoshimura, M., & Oishi, R. (2008) · European Journal of Cancer · doi:10.1016/j.ejca.2008.10.004 · Cited by 42 · see citing works
Antinociceptive Efficacy of Verticinone in Murine Models of Inflammatory Pain and Paclitaxel Induced Neuropathic Pain
Xu, F., Xu, S., Wang, L., Chen, C., Zhou, X., Lu, Y., & Zhang, H. (2011) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.34.1377 · Cited by 39 · see citing works
Stress enhances muscle nociceptor activity in the rat
Chen, X., Green, P. G., & Levine, J. D. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.04.020 · Cited by 37 · see citing works
Assessment of thermal sensitivity in rats using the thermal place preference test
Balayssac, D., Ling, B., Ferrier, J., Pereira, B., Eschalier, A., & Authier, N. (2014) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000026 · Cited by 37 · see citing works
Self-citation
Nucleolar enlargement, nuclear eccentricity and altered cell body immunostaining characteristics of large-sized sensory neurons following treatment of rats with paclitaxel
Jamieson, S. M. F., Liu, J., Connor, B. J., Dragunow, M., & McKeage, M. J. (2007) · NeuroToxicology · doi:10.1016/j.neuro.2007.04.009 · Cited by 35 · see citing works
Herbal Medicine Goshajinkigan Prevents Paclitaxel-Induced Mechanical Allodynia without Impairing Antitumor Activity of Paclitaxel
Bahar, M. A., Andoh, T., Ogura, K., Hayakawa, Y., Saiki, I., & Kuraishi, Y. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/849754 · Cited by 33 · see citing works
Effect of Particle Size of Nanospheres and Microspheres on the Cellular-Association and Cytotoxicity of Paclitaxel in 4T1 Cells
De, S., Miller, D. W., & Robinson, D. H. (2005) · Pharmaceutical Research · doi:10.1007/s11095-005-2593-8 · Cited by 33 · see citing works
Oxaliplatin-Induced Loss of Phosphorylated Heavy Neurofilament Subunit Neuronal Immunoreactivity in Rat Drg Tissue
Jamieson, S. M. F., Subramaniam, J., Liu, J. J., Jong, N. N., Ip, V., Connor, B. J., & McKeage, M. J. (2009) · Molecular Pain · doi:10.1186/1744-8069-5-66 · Cited by 32 · see citing works
Paclitaxel-induced hyposensitivity to nociceptive chemical stimulation in mice can be prevented by treatment with minocycline
Masocha, W. (2014) · Scientific Reports · doi:10.1038/srep06719 · Cited by 31 · see citing works
Differential effects of paclitaxel treatment on cognitive functioning and mechanical sensitivity
Boyette-Davis, J. A., & Fuchs, P. N. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.02.031 · Cited by 31 · see citing works
Therapeutic efficacy of prosaposin-derived peptide on different models of allodynia
Jolivalt, C. G., Ramos, K. M., Herbetsson, K., Esch, F. S., & Calcutt, N. A. (2006) · Pain · doi:10.1016/j.pain.2005.11.013 · Cited by 31 · see citing works
Mechanisms of experimental neuropathic pain: integration from animal models
Ossipov, M. H., Lai, J. Y., & Porreca, F. (2006) · Elsevier eBooks · doi:10.1016/b0-443-07287-6/50064-3 · Cited by 31 · see citing works
Phosphatidylcholine attenuated docetaxel-induced peripheral neurotoxicity in rats
Kim, S. T., Kyung, E. J., Suh, J. S., Lee, H. S., Lee, J. H., Chae, S. I., Park, E. S., Chung, Y. H., Bae, J., Lee, T. J., et al. (2017) · Drug and Chemical Toxicology · doi:10.1080/01480545.2017.1390580 · Cited by 28 · see citing works
Neuropathy-Inducing Effects of Eribulin Mesylate Versus Paclitaxel in Mice with Preexisting Neuropathy
Wozniak, K. M., Wu, Y., Farah, M. H., Littlefield, B. A., Nomoto, K., & Slusher, B. S. (2013) · Neurotoxicity Research · doi:10.1007/s12640-013-9394-3 · Cited by 27 · see citing works
Etodolac, a Cyclooxygenase-2 Inhibitor, Attenuates Paclitaxel-Induced Peripheral Neuropathy in a Mouse Model of Mechanical Allodynia
Ito, S., Tajima, K., Nogawa, M., Inoue, N., Kyoi, T., Takahashi, Y., Sasagawa, T., Nakamura, A., Kotera, T., Ueda, M., et al. (2012) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.111.187401 · Cited by 27 · see citing works
Paclitaxel induces nucleolar enlargement in dorsal root ganglion neurons in vivo reducing oxaliplatin toxicity
Jamieson, S. M. F., Liu, J., Hsu, T., Baguley, B. C., & McKeage, M. J. (2003) · British Journal of Cancer · doi:10.1038/sj.bjc.6601012 · Cited by 26 · see citing works
Albumin roles in developing anticancer compounds
Ribeiro, A. G., Alves, J. E. F., Soares, J. C. S., dos Santos, K. L., Jacob, Í. T. T., Ferreira, C. J. D. S., dos Santos, J. C., de Azevedo, R. D. S., de Almeida, S. M. V., & de Lima, M. D. C. A. (2021) · Medicinal Chemistry Research · doi:10.1007/s00044-021-02748-z · Cited by 24 · see citing works
Paclitaxel Regulates TRPA1 Function and Expression Through PKA and PKC
Sánchez, J. C., Muñoz, L. V., Galindo-Marquez, M. L., Valencia-Vásquez, A., & García, A. M. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03748-0 · Cited by 24 · see citing works
Vasodilatation in the rat dorsal hindpaw induced by activation of sensory neurons is reduced by paclitaxel
Gracias, N. G., Cummins, T., Kelley, M. R., Basile, D. P., Iqbal, T. R., & Vasko, M. R. (2010) · NeuroToxicology · doi:10.1016/j.neuro.2010.09.006 · Cited by 24 · see citing works
Effects of Taxol on Regeneration in a Rat Sciatic Nerve Transection Model
Hsu, S., Yao, C., Hsu, Y., Lin, J., Chen, Y., & Chen, Y.-S. (2017) · Scientific Reports · doi:10.1038/srep42280 · Cited by 23 · see citing works
Targeting Neuroprotection as an Alternative Approach to Preventing and Treating Neuropathic Pain
Bordet, T., & Pruss, R. M. (2009) · Neurotherapeutics · doi:10.1016/j.nurt.2009.07.001 · Cited by 23 · see citing works
Current Methods for the Assessment and Management of Taxane-Related Neuropathy
Smith, E. (2013) · Clinical journal of oncology nursing · doi:10.1188/13.cjon.s1.22-34 · Cited by 21 · see citing works
Noninvasive Evaluation of Nerve Conduction in Small Diameter Fibers in the Rat
Zotova, E. G., & Arezzo, J. C. (2013) · Physiology Journal · doi:10.1155/2013/254789 · Cited by 20 · see citing works
Nmnat mitigates sensory dysfunction in a Drosophila model of paclitaxel-induced peripheral neuropathy
Brazill, J. M., Cruz, B., Zhu, Y., & Zhai, R. G. (2018) · Disease Models & Mechanisms · doi:10.1242/dmm.032938 · Cited by 20 · see citing works
Signaling pathways and gene co-expression modules associated with cytoskeleton and axon morphology in breast cancer survivors with chronic paclitaxel-induced peripheral neuropathy
Kober, K. M., Schumacher, M. A., Conley, Y. P., Topp, K. S., Mazor, M. B., Hammer, M. J., Paul, S. M., Levine, J. D., & Miaskowski, C. A. (2019) · Molecular Pain · doi:10.1177/1744806919878088 · Cited by 19 · see citing works
Lack of neurotoxicity of the vascular targeting agent ZD6126 following repeated i.v. dosing in the rat
Horner, S., Gould, S., Noakes, J., Rattray, N. J., Allen, S. L., Zotova, E. G., & Arezzo, J. C. (2004) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.783.3.7 · Cited by 18 · see citing works
Survival, quality-adjusted survival, and other clinical end points in older advanced non-small-cell lung cancer patients treated with albumin-bound paclitaxel
Langer, C. J., Hirsh, V., Okamoto, I., Lin, F.-J., Wan, Y., Whiting, S., Ong, T. J., Renschler, M. F., & Botteman, M. F. (2015) · British Journal of Cancer · doi:10.1038/bjc.2015.181 · Cited by 17 · see citing works
Nerve growth factor alters microtubule targeting agent-induced neurotransmitter release but not MTA-induced neurite retraction in sensory neurons
Pittman, S. K., Gracias, N. G., & Fehrenbacher, J. C. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.02.010 · Cited by 16 · see citing works

A painful peripheral neuropathy in the rat produced by the chemotherapeutic drug, paclitaxel
Polomano, R. C., Mannes, A. J., Clark, U. S., & Bennett, G. J. (2001) · Pain · doi:10.1016/s0304-3959(01)00363-3 · Cited by 476 · see citing works
Physiological characterization of taxol‐induced large‐fiber sensory neuropathy in the rat
Cliffer, K. D., Siuciak, J. A., Carson, S. R., Radley, H. E., Park, J. S., Lewis, D. R., Zlotchenko, E., Nguyen, T. T. T., García, K., Tonra, J. R., et al. (1998) · Annals of Neurology · doi:10.1002/ana.410430111 · Cited by 131 · see citing works
Evoked and Ongoing Pain-Like Behaviours in a Rat Model of Paclitaxel-Induced Peripheral Neuropathy
Griffiths, L. A., Duggett, N. A., Pitcher, A., & Flatters, S. J. L. (2018) · Pain Research and Management · doi:10.1155/2018/8217613 · Cited by 62 · see citing works
Behavioral and pharmacological description of oxaliplatin-induced painful neuropathy in rat
Ling, B., Authier, N., Balayssac, D., Eschalier, A., & Coudoré, F. (2006) · Pain · doi:10.1016/j.pain.2006.09.016 · Cited by 158 · see citing works
Self-citation
Animal models of chronic pain
Flatters, S. J. L., & Bennett, G. J. (2004) · Journal of Pain · doi:10.1016/j.jpain.2004.02.023 · Cited by 3 · see citing works

Authors: Authier, N., Gillet, J.-P., Fialip, J., Eschalier, A., & Coudore, F.
Affiliations: Inserm (FR)
ORCID: Authier, Nicolas
Eschalier, Alain
Venue: Brain Research
Publisher: Elsevier BV
Published: 2000-12
Volume: 887
Issue: 2
Pages: 239-249
ISSN: 0006-8993 (ISSN-L)
DOI: 10.1016/s0006-8993(00)02910-3
OpenAlex: W2077039218
Cited by: 171
References: 41
Citations by year: 2026: 4 · 2025: 4 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 6 · 2019: 6 · 2018: 4 · 2017: 14 · 2016: 5 · 2015: 7 · 2014: 14 · 2013: 13 · 2012: 6
FWCI: 1.32
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Brain Research (publishedVersion)
PubMed (publishedVersion)
Funders: Ligue Contre le Cancer
Topics: Health Sciences › Medicine › Oncology › Cancer Treatment and Pharmacology
Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords: paclitaxel, chemotherapy-induced peripheral neuropathy, mechanical hyperalgesia, thermal hypoalgesia, peripheral nerve conduction velocity
MeSH terms: Animals, Hair, Hot Temperature, Hyperalgesia, Male, Motor Activity, Neural Conduction, Neuralgia, Nociceptors, Pain, Sciatic Nerve, Rats, Sprague-Dawley, Paclitaxel, Hand Strength, Somatosensory Disorders, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Description of a short-term Taxol®-induced nociceptive neuropathy in rats

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks