Effect of Ecdysterone on Glucose Metabolism in vitro
Abstract
The aims of this study was to investigate whether ecdysterone is able to exert glucose-lowering effect on hepatocytes or stimulate the secretion of insulin. HepG2 cell line was used for glucose consumption (GC) studies. At moderate high glucose concentration (11.1 mmol/L), GC of HepG2 cells was increased by 44% to 77% with ecdysterone 1 x 10(-6) to 1 x 10(-4) mol/L, which was comparable to that with 1 x 10(-3) mol/L metformin. The glucose-lowering effect of ecdysterone decreased as the glucose concentration of medium increased. The maximal potency was reached in the presence of 5.5 mmol/L glucose, and the effect was disappeared as the glucose consumption was increased to 22.2 mmol/L. This effect was independent on insulin concentration, which was similar to that of metformin and was different from that of troglitazone, whose glucose-lowering effect was insulin-dependent. Troglitazone had a better antihyperglycemic potency than metformin when insulin was added. Simultaneously, a significant toxicity of troglitazone to HepG2 cells was observed. betaTC3 cells were not stimulated by ecdysterone, that is, no secretogogue effect of ecdysterone was observed. The results indicate that ecdysterone is able to exert the glucose-lowering effect in hepatocytes which is insulin-independent, but has no effect on insulin release.
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In vitro studies associate ecdysterone with endothelial dysfunction prevention, osteoporosis prevention, glucose regulation, cytotoxic effects, antibacterial properties, immunomodulatory effects, and anti-inflammatory activities.
“Moreover, the effects on cell lines are associated with endothelial dysfunction prevention, osteoporosis prevention, glucose regulation, cytotoxic effects, antibacterial properties, immunomodulatory effects, and anti-inflammatory activities [52,53,54,55,56,57,58,60,61,62,63,64,65,66,67,68,69,70,71,72,73].”
From Ecdysterone and Turkesterone—Compounds with Prominent Potential in Sport and Healthy Nutrition (2024) · cites this paper as [60]
Within the in vitro studies of ecdysterone, no serious effects were reported.
“Within these studies, no serious effects were reported [52,53,54,55,56,57,58,60,61,62,63,64,65,66,67,68,69,70,71,72,73].”
From Ecdysterone and Turkesterone—Compounds with Prominent Potential in Sport and Healthy Nutrition (2024) · cites this paper as [60]
20E improves lipid and glucose metabolism in the liver and heart.
“A number of in vitro and in vivo studies have demonstrated the 20E-mediated improvement of lipid and glucose metabolism in the liver and the heart [17,18,19,20,21].”
From 20-Hydroxyecdysone Boosts Energy Production and Biosynthetic Processes in Non-Transformed Mouse Cells (2024) · cites this paper as [21]
Chen and co-authors reported a 20E-dependent increase in glucose uptake in Hep2G hepatoma cell lines.
“which was also reported by Chen and co-authors in Hep2G hepatoma cell lines [21].”
From 20-Hydroxyecdysone Boosts Energy Production and Biosynthetic Processes in Non-Transformed Mouse Cells (2024) · cites this paper as [21]
Phytoecdysteroids have beneficial effects on mammals, including anabolic, adaptogenic, antidiabetic, hypolipidemic, and hepatoprotective effects.
“They are known for their numerous beneficial effects on mammals, which include as anabolic, adaptogenic, antidiabetic, hypolipidemic, and hepatoprotective effects150, 151, 152, 153.”
From The Phytochemical, Biological, and Medicinal Attributes of Phytoecdysteroids: An Updated Review (2021) · cites this paper as [150]
20-HE improves dermal thickness and promotes wound-healing in vivo.
“20-HE has been shown to improve dermal thickness151,158 and promote wound-healing in vivo13,150.”
From The Phytochemical, Biological, and Medicinal Attributes of Phytoecdysteroids: An Updated Review (2021) · cites this paper as [150]
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- Authors
- Chen, Q., Xia, Y., & Qiu, Z.
- Affiliations
- Chongqing Medical University (CN)
- Venue
- Life Sciences
- Publisher
- Elsevier BV
- Published
- 2006-02
- Volume
- 78
- Issue
- 10
- Pages
- 1108-1113
- ISSN
- 0024-3205 (ISSN-L)
- OpenAlex
- W2019374954
- Cited by
- 51
- References
- 31
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 5 · 2022: 2 · 2021: 6 · 2020: 8 · 2019: 4 · 2018: 3 · 2017: 3 · 2014: 2 · 2013: 3
- FWCI
- 1.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Life Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Keywords
- 20-hydroxyecdysone, glucose metabolism, glucose utilization, hepatocytes, insulin secretion, metformin, troglitazone, hypoglycemic effect, HepG2 cells, betaTC3 cells, drug toxicity
- MeSH terms
- Troglitazone, Animals, Chromans, Dose-Response Relationship, Drug, Ecdysterone, Glucose, Humans, Hypoglycemic Agents, Insulin, Liver Neoplasms, Metformin, Mice, Transgenic, Tetrazolium Salts, Thiazoles, Thiazolidinediones, Cell Line, Tumor, Insulin-Secreting Cells, Mice
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