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Cited by 381Microtubule and mitosis dynamicsNeuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanisms

The DOI matches its Crossref record; 58 of the 61 references it cites were found in a registry or an index.

Distribution of microtubule-associated protein 2 in the nervous system of the rat studied by immunofluorescence

De Camilli, P., Miller, P.E., Navone, F., Theurkauf, W.E., Vallee, R.B.·1984·Neuroscience
DOI 10.1016/0306-4522(84)90194-5
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Abstract

It has recently been reported that high molecular weight microtubule-associated proteins are differently distributed in dendrites and axons of neurons [ Matus Bernhardt and Hugh-Jones (1981), Proc. natn Acad. Sci. U.S.A. 78, 3010-3014; Vallee (1982), J. Cell Biol. 92, 435-442]. We have reported earlier in a preliminary form [Miller, Walter, Theurkauf , Vallee and De Camilli (1982), Proc. natn Acad. Sci. U.S.A. 79, 5562-5566] that an antiserum specific for microtubule-associated protein 2, one of the most prominent high molecular weight microtubule-associated proteins in brain and a major brain phosphoprotein, stains specifically neuronal dendrites and perikarya. We have now extended those observations by performing a detailed analysis of the distribution of microtubule-associated protein 2 throughout the nervous system of the rat. We found that microtubule-associated protein 2 is present at high concentrations in the great majority of neurons. Under our conditions of immunostaining microtubule-associated protein 2 was not detected in nonneuronal cells. In all neurons it was compartmentalized in perikarya and dendrites. In most cases, the latter were more heavily stained than perikarya. The pattern of staining (overall intensity, relative intensity in dendrites vs perikarya, and in proximal vs distal segments of the dendritic tree), varied in different classes of neurons but was identical for all neurons with similar geometry in the same brain region. Different patterns of sta…

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Research works printed but not linked: 8

  1. Aamodt, 1983, MAPs mediate association of microtubules and neurofilaments in vitro, Biophys. J., 41, 86a
  2. Golgi, 1883, Sulla fine anatomia degli organi centrali del sistema nervoso. IV. Sulla fine anatomia delle circonvoluzioni cerebellari, Riv. sper. Freniat. Med. leg. Alien. Ment., 9, 1
  3. Kandel, 1977, Neuronal plasticity and the modification of behaviour, Vol. 1, 1137
  4. Papasozomenos, 1972, A monoclonal antibody to microtubule-associated protein (MAP2) localizes with neurofilaments in the b,b′-iminodiproprionitrile (IDPN) model, J. Cell Biol., 95, 341a
  5. Peloquin, 1979, Cell and tissue distribution of the major high molecular weight microtubule-associated protein from brain, J. Cell Biol., 83, 338a
  6. Ramón, 1911, Vol. 1,II
  7. Theurkauf, 1982, Phosphorylation of MAP2 by cAMP-dependent protein kinase, J. Cell Biol., 95, 340a
  8. Vallee, 1982, Identification of MAPs from diverse sources using taxol, J. Cell Biol., 95, 339a

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Metadata

Authors
De Camilli, P., Miller, P. E., Navone, F., Theurkauf, W. E., & Vallee, R. B.
Affiliations
  • Yale University (US)
  • University of Milan (IT)
ORCID
Venue
Neuroscience
Publisher
Elsevier BV
Published
1984-04
Volume
11
Issue
4
Pages
819-846
ISSN
0306-4522 (ISSN-L)
DOI
10.1016/0306-4522(84)90194-5
OpenAlex
W2030804101
Cited by
381
References
61
Citations by year
2026: 1 · 2025: 2 · 2024: 4 · 2022: 4 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 1 · 2014: 4 · 2013: 5 · 2012: 4
FWCI
13.20
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
MAP2, dendrites, perikarya, neuronal localization, dendritic microtubules, axons, axon terminals, primary sensory neurons, dendritic branching, nervous system, rat brain, phosphoproteins, neuronal ultrastructure, dendritic growth, dendritic plasticity
MeSH terms
Animals, Autonomic Nervous System, Brain Stem, Cerebellum, Cerebral Cortex, Fluorescent Antibody Technique, Ganglia, Spinal, Hippocampus, Microtubule-Associated Proteins, Nervous System, Proteins, Rats, Inbred Strains, Retina, Spinal Cord, Rats

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