The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
The comparative distribution of forebrain receptors for neurohypophyseal peptides in monogamous and polygamous mice
Abstract
Several recent studies have suggested that the neurohypophyseal peptide oxytocin may have a role within the brain to mediate various forms of affiliative behavior. As the regulation of oxytocin function may be largely determined by the number and distribution of its membrane bound receptor, we investigated oxytocin receptor distribution in two Peromyscus species selected for differences in affiliative behavior. Using in vitro receptor autoradiography with the selective oxytocin receptor ligand [125I]d(CH2)5[Tyr(Me)2,Tyr-NH9(2)]OVT ([125I]OTA), we compared Peromyscus maniculatus, a polygamous species, to Peromyscus californicus, a monogamous species. Marked species differences in the distribution of [125I]OTA were apparent in several brain areas, including olfactory pathways, bed nucleus of the stria terminalis, amygdala, dorsal lateral septum, and several cortical regions. In addition, gender differences in the binding pattern were evident in several regions, mostly due to sexually dimorphic patterns in the polygamous species, P. maniculatus. To further compare these species, the binding of a [3H]arginine-vasopressin antagonist was assessed in alternate sections from those used for [125I]OTA. Relative to oxytocin receptors, binding to arginine-vasopressin receptors showed fewer species differences, although the monogamous species appeared to have more arginine-vasopressin receptors in the neocortex and lateral septum. The striking differences in oxytocin receptor distribution are consistent with earlier studies in other rodents, suggesting that oxytocin may have an important role for mediating species-typical patterns of social affiliation.
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In the citing paper
“In Peromyscus (P.) maniculatus and P. californicus mice, no sex differences were found for VP receptor binding in any of the brain regions analyzed, except for higher binding in the centromedial thalamic nucleus in females”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Insel et al., 1991
In the citing paper
“Interestingly, these sex-specific effects seem to be independent of whether sex differences are found in VP and/or V1aR binding (rats; Figs. 1 and 2) or whether no sex differences are found in VP and/or V1aR binding (prairie voles: Insel et al., 1991; Smeltzer et al., 2006; humans: Loup et al., 1991).”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Insel et al., 1991
In the citing paper
“Similar to V1aR, sex differences in OTR binding were found in multiple brain regions in those rodent studies that used a more comprehensive analysis (deer mice: 8 out of 20 brain regions; Insel et al., 1991; rats: 9 out of 15 forebrain regions; Dumais et al., 2013).”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Insel et al., 1991
In the citing paper
“There were no sex differences in OTR expression, consistent with previous reports in other species (53, 54).”
From Oxytocin receptors in the anteromedial bed nucleus of the stria terminalis promote stress-induced social avoidance in female California mice (2018) · cites this paper as [54]
Citations
Cites
Pedersen, C. A., & Prange, A. J. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.12.6661 · Cited by 841
Oxytocin induces maternal behavior in virgin female rats
Pedersen, C. A., Ascher, J. A., Monroe, Y. L., & Prange, A. J. (1982) · Science · doi:10.1126/science.7071605 · Cited by 770
Evolution of spatial cognition: sex-specific patterns of spatial behavior predict hippocampal size.
Jacobs, L. F., Gaulin, S. J. C., Sherry, D. F., & Hoffman, G. E. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.16.6349 · Cited by 370
Possible Role for Endogenous Oxytocin in Estrogen-Facilitated Maternal Behavior in Rats
Fahrbach, S. E., Morrell, J. I., & Pfaff, D. W. (2008) · Neuroendocrinology · doi:10.1159/000124125 · Cited by 322
The biparental care system of the California mouse, Peromyscus californicus.
Gubernick, D. J., & Alberts, J. R. (1987) · Journal of comparative psychology · doi:10.1037/0735-7036.101.2.169 · Cited by 274
Oxytocin facilitates the sexual receptivity of estrogen-treated female rats
Caldwell, J. D., Prange, A. J., & Pedersen, C. A. (1986) · Neuropeptides · doi:10.1016/0143-4179(86)90093-4 · Cited by 229
Sex Differences in Neurotransmitter Systems
Vries, G. J. D. (1990) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1990.tb00385.x · Cited by 226
Gonadal hormone actions on the morphology of the vasopressinergic innervation of the adult rat brain
De Vries, G. J., Buijs, R. M., & Sluiter, A. A. (1984) · Brain Research · doi:10.1016/0006-8993(84)91157-0 · Cited by 224
Tribollet, E., Audigier, S., Dubois-Dauphin, M., & Dreifuss, J. J. (1990) · Brain Research · doi:10.1016/0006-8993(90)90232-z · Cited by 203
Birdsall, D. A., & Nash, D. (1973) · Evolution · doi:10.1111/j.1558-5646.1973.tb05922.x · Cited by 175
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Research works printed but not linked: 4
- Archer, 1974, Chemistry of the neurohypophyseal hormones: an example of molecular evolution, Handbook Physiol., 4, 119
- Dewsbury, 1981, An exercise in the prediction of monogamy in the field from laboratory data on 42 species of muroid rodents, The Biologist, 63, 138
- Insel, 1989, The development of the oxytocin receptor in rat forebrain: chemical neuroanatomy and behavioral correlations, Soc. Neurosci. Abstr., 15, 118.11
- Shapiro, 1990, Oxytocin receptor distribution reflects species-typical patterns of social behavior, Soc. Neurosci. Abstr., 16, 186.6
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A fine line between attack and care
Rigney, N. (2024) · eLife · doi:10.7554/elife.103351
Хрущова, А. М., Vasilieva, N. Y., & Rogovin, K. A. (2024) · Журнал общей биологии · doi:10.31857/s0044459624050014
Hasunuma, K., Horie, K., Yoshida, M., Nishimori, K., Onaka, T., & Sato, N. (2026) · SSRN Electronic Journal · doi:10.2139/ssrn.6336603
Royer, J. (2021) · theses.fr (ABES) · doi:10.70675/9561320dz3197z4755zbb24zf51613d38d02
Oxytocin and social neuroscience - sexually dimorphic OXTR neurons in mouse preoptic area
Teruyama, R., & Govar, A. A. (2026) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2026.102930
Zheng, S., Prounis, G. S., & Ophir, A. G. (2026) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2026.1772423
Hasunuma, K., Horie, K., Yoshida, M., Nishimori, K., Onaka, T., & Sato, N. (2026) · Hormones and Behavior · doi:10.1016/j.yhbeh.2026.105968
Weisenseel, Z., & Glasper, E. R. (2026) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2026.101328
Gould, B. R., & Zingg, H. H. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00283-5 · Cited by 138
Metadata
- Authors
- Insel, T. R., Gelhard, R., & Shapiro, L. E.
- Affiliations
- National Institute of Mental Health (US)
- Corresponding author
- Insel, T.R.
- ORCID
- Insel, T.R.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 1991-01
- Volume
- 43
- Issue
- 2-3
- Pages
- 623-630
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W1992791641
- Cited by
- 209
- References
- 28
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 10 · 2023: 6 · 2022: 7 · 2021: 4 · 2020: 5 · 2019: 9 · 2018: 11 · 2017: 7 · 2016: 6 · 2015: 11 · 2014: 7 · 2013: 14 · 2012: 5
- FWCI
- 20.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- oxytocin receptor, arginine vasopressin receptor, neurohypophyseal peptides, monogamy, polygamy, deer mouse, Peromyscus californicus, affiliative behavior, social behavior, sexual dimorphism, species differences, bed nucleus of the stria terminalis, amygdala, lateral septum, olfactory pathway, neocortex, receptor autoradiography
- MeSH terms
- Animals, Autoradiography, Oxytocin, Peromyscus, Receptors, Angiotensin, Sexual Behavior, Animal, Sex Characteristics, Tissue Distribution, Vasopressins, Prosencephalon, Receptors, Oxytocin, Mice
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