Possible Role for Endogenous Oxytocin in Estrogen-Facilitated Maternal Behavior in Rats
Abstract
Intracerebroventricular (i.c.v.) infusions of oxytocin (OXY) induce short-latency maternal behavior in estrogen-primed virgin rats. To investigate if brain OXY might have a role in the onset of maternal behavior at parturition, we have used both antisera to OXY and an analog antagonist of OXY, d(CH2)5–8-ornithine-vasotocin, to reduce the activity of endogenous OXY in a pregnancy-terminated preparation which yields reliable short-latency maternal behavior. Sprague-Dawley rats with lateral ventricle cannulae were ovariectomized and hysterectomized on day 16 of gestation; maternal behavior was stimulated by a s.c. injection of estradiol benzoate (EB). Effects of the i.c.v. infusion of antisera to OXY or of the i.c.v. infusion of d(CH2)5–8-ornithine-vasotocin on the latency to respond to pups were tested by presenting pups 48 h after surgery and EB treatment. Behavioral observations were made for the next 5 h and periodically over the next 5 days. Groups receiving either the antisera to OXY or the analog antagonist had significantly longer latencies to respond to pups than did control groups. In a separate experiment, i.c.v. infusion of d(CH2)5–8-ornithine-vasotocin was shown to have no effect on the performance of maternal behavior in lactating rats 5 days postpartum. These results suggest that OXY may have a role in promoting short-latency maternal behavior in steroid-primed female rats, but that it is probably not involved in sustaining this behavior during lactation.
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OT is released centrally and peripherally during birth; centrally released OT is necessary for rapid onset of maternal behavior in virgin rats and sufficient to induce it.
“OT is released centrally and peripherally during birth, and centrally released OT is both necessary for the rapid onset of maternal behavior in virgin rats, and sufficient to induce it (Pedersen and Prange 1979; Fahrbach et al 1985; van Leengoed et al 1987; Borrow and Cameron 2012).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Fahrbach et al 1985
OT does not appear necessary for maintenance of maternal behavior in experienced females.
“However, OT does not appear to be necessary for the maintenance of maternal behavior in experienced females (Fahrbach et al 1985).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Fahrbach et al 1985
The oxytocin system is important in mammalian social behaviors including social memory, recognition and attachment.
“The importance of the oxytocin system in mammalian social behaviors including social memory, recognition and attachment has been established using a variety of animal models since 1980s.”
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“Support for the role of endogenous OT in regulating maternal behavior has been derived from studies showing that an OT antagonist or OT antisera infused into the brain blocks the onset of maternal behavior in rats that have just given birth [12] [13].”
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- Authors
- Fahrbach, S. E., Morrell, J. I., & Pfaff, D. W.
- Affiliations
- Rockefeller University (US)
- Venue
- Neuroendocrinology
- Publisher
- S. Karger AG
- Published
- 2008-03-28
- Volume
- 40
- Issue
- 6
- Pages
- 526-532
- ISSN
- 0028-3835 (ISSN-L)
- 1423-0194
- OpenAlex
- W1965235291
- Cited by
- 322
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 7 · 2020: 19 · 2019: 6 · 2018: 8 · 2017: 12 · 2016: 7 · 2015: 6 · 2014: 13 · 2013: 6 · 2012: 8
- FWCI
- 14.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- oxytocin, maternal behavior, estrogen, estradiol benzoate, arginine vasotocin, oxytocin antagonist, abortion (veterinary), childbirth, lactation, postpartum behavior, intracerebroventricular infusion
- MeSH terms
- Animals, Estradiol, Female, Immune Sera, Lactation, Maternal Behavior, Oxytocin, Pregnancy, Rats, Inbred Strains, Time Factors, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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