Oxytocin and vasopressin receptor distributions in a solitary and a social species of tuco‐tuco ( Ctenomys haigi and Ctenomys sociabilis )
Abstract
The neuropeptides oxytocin and vasopressin and their receptors have been implicated in elements of mammalian social behavior such as attachment to mates and offspring, but their potential role in mediating other types of social relationships remains largely unknown. We performed receptor autoradiography to assess whether forebrain oxytocin receptor (OTR) or vasopressin V1a receptor (V1aR) distributions differed with social structure in two closely related and ecologically similar species of South American rodents, the colonial tuco‐tuco ( Ctenomys sociabilis ) and the Patagonian tuco‐tuco ( Ctenomys haigi ). Long‐term field studies have revealed that C. haigi is solitary, whereas C. sociabilis is social and provides a model of female‐based group living. Our analyses revealed marked differences in OTR and V1aR distributions between these species. For example, only C. sociabilis had OTR binding in the piriform cortex and thalamus and V1aR binding in the olfactory bulbs. In contrast, C. haigi exhibited dramatically higher levels of OTR binding throughout the lateral septum and hippocampus. More generally, the group‐living C. sociabilis exhibited a pattern of nucleus accumbens OTR and ventral pallidum V1aR binding different from that associated with the formation of opposite‐sex pair bonds in microtine rodents. Higher binding in the central nucleus of the amygdala of C. sociabilis was consistent with the hypothesis that formation of social groups in C. sociabilis may be facilitated by reduced social anxiety. Low OTR binding in the lateral septum might also be a permissive factor for group living in C. sociabilis . Future studies will expand on these analyses to explore interspecific differences in ctenomyid receptor binding patterns in a phylogenetic context. J. Comp. Neurol. 507:1847–1859, 2008. © 2008 Wiley‐Liss, Inc.
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OTR binding density in the lateral septum was lower in group-living as opposed to solitary tuco-tucos.
“and was lower in group-living as opposed to solitary tuco-tucos (Beery et al., 2008).”
From Sex-specific modulation of juvenile social play behavior by vasopressin and oxytocin depends on social context (2014) · cites this paper as Beery et al., 2008
Rodent species with known oxytocin receptor and vasopressin receptor 1a distributions include laboratory mice and rats, hamsters, guinea pigs, California mice, deer mice, tuco-tucos, singing mice, naked mole-rats, Cape mole-rats, prairie and pine voles, and montane and meadow voles.
“To our knowledge, rodent species with known OXTR and AVPR1a distributions include laboratory mice and rats, hamsters, guinea pigs, the socially monogamous California mouse and the promiscuous deer mouse, a social and a solitary species of tuco-tuco, two species of Central American singing mice, the eusocial naked mole-rat and the solitary Cape mole-rat, and the socially monogamous prairie and pine”
From Comparative Perspectives on Oxytocin and Vasopressin Receptor Research in Rodents and Primates: Translational Implications (2016) · cites this paper as [17]
These findings were surprising given typically pro-social effects of OT, although recent studies suggest a role for the OTR in the LS in reducing pro-social behaviors and enhancing anxiety in rodents.
“These findings were a bit surprising, given the typically pro-social behavior effects of OT, although recent studies suggest a role for the OTR in the LS in reducing pro-social behaviors and enhancing anxiety in rodents”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Beery et al., 2008
Other rodent studies that did not find sex differences in OTR binding analyzed only a few brain regions.
“other rodent studies that did not find sex differences in OTR binding analyzed only a few brain regions”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Beery et al., 2008
Among rodents, there is pronounced interspecific variation in OTR and V1aR binding in the central nervous system that reflects differential social organization and mating strategies.
“Among rodents, there is pronounced interspecific variation in OTR and V1aR binding in the central nervous system that reflects differential social organization and mating strategies (Barrett et al., 2013; Beery et al., 2008; Insel and Shapiro, 1992; Mooney et al., 2015; Ophir et al., 2012; Young et al., 2011).”
From Neuropeptide diversity and the regulation of social behavior in New World primates (2016) · cites this paper as Beery et al., 2008
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Self-citation
- Authors
- Beery, A. K., Lacey, E. A., & Francis, D. D.
- Affiliations
- University of California, Berkeley (US)
- Museum of Vertebrate Zoology (US)
- Corresponding author
- Beery, Annaliese K.
- Venue
- Journal of Comparative Neurology
- Publisher
- Wiley
- Published
- 2008-02-12
- Volume
- 507
- Issue
- 6
- Pages
- 1847-1859
- ISSN
- 0021-9967 (ISSN-L)
- 1096-9861
- OpenAlex
- W1987667709
- Cited by
- 144
- References
- 69
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 6 · 2023: 2 · 2022: 2 · 2021: 13 · 2020: 3 · 2019: 8 · 2018: 9 · 2017: 4 · 2016: 17 · 2015: 15 · 2014: 13 · 2013: 8 · 2012: 4
- FWCI
- 11.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Comparative Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH 61171, R01MH061171)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
- Keywords
- oxytocin receptor, vasopressin V1a receptor, Ctenomys sociabilis, tuco-tuco, social behavior, group living, lateral septum, hippocampus, nucleus accumbens, ventral pallidum, central amygdala, social anxiety, neuropeptides
- MeSH terms
- Adaptation, Physiological, Animals, Autoradiography, Basal Ganglia, Behavior, Animal, Brain, Female, Ligands, Male, Nucleus Accumbens, Olfactory Bulb, Oxytocin, Phylogeny, Rodentia, Sexual Behavior, Animal, Sex Characteristics, Social Behavior, Vasopressins, Receptors, Vasopressin, Receptors, Oxytocin
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