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Cited by 930Neural dynamics and brain functionSleep and Wakefulness ResearchMemory and Neural Mechanisms

Communication between neocortex and hippocampus during sleep in rodents

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Sirota, Anton, Csicsvari, Jozsef, Buhl, Derek, Buzsáki, György·2003·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0437938100PMC PMC149959
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Abstract

Both neocortical and hippocampal networks organize the firing patterns of their neurons by prominent oscillations during sleep, but the functional role of these rhythms is not well understood. Here, we show a robust correlation of neuronal discharges between the somatosensory cortex and hippocampus on both slow and fine time scales in the mouse and rat. Neuronal bursts in deep cortical layers, associated with sleep spindles and delta waves/slow rhythm, effectively triggered hippocampal discharges related to fast (ripple) oscillations. We hypothesize that oscillation-mediated temporal links coordinate specific information transfer between neocortical and hippocampal cell assemblies. Such a neocortical–hippocampal interplay may be important for memory consolidation.

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  • Generation of spindles in the thalamus and generation of SW-Rs in the hippocampus are distinctly suppressed during the down-phase of the slow oscillation, followed by a rebound in spindle and SW-R activity during the succeeding depolarizing up-state.

    “Generation of spindles in the thalamus and generation of SW-Rs in the hippocampus are distinctly suppressed during the down-phase of the slow oscillation, and this is followed by a rebound in spindle and SW-R activity during the succeeding depolarizing up-state (66, 215, 597, 829 -832, 925, 1088).”

    From About Sleep's Role in Memory (2013) · cites this paper as [1088]

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  • Fast sleep spindles can reach 18 Hz.

    “Frequencies below 20 Hz were avoided because of the potential overlap with fast sleep spindles, which can reach 18 Hz 65,66 .”

    From The neural correlates of dreaming (2017) · cites this paper as [66]

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Cited by

Sorted by citations

Authors
Sirota, A., Csicsvari, J., Buhl, D., & Buzsáki, G.
Affiliations
Rutgers, The State University of New Jersey (US)
ORCID
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2003-02-07
Volume
100
Issue
4
Pages
2065-2069
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.0437938100
PMC
PMC149959
OpenAlex
W2023924009
Cited by
930
References
6
Citations by year
2026: 31 · 2025: 38 · 2024: 41 · 2023: 49 · 2022: 52 · 2021: 47 · 2020: 60 · 2019: 76 · 2018: 45 · 2017: 57 · 2016: 50 · 2015: 44 · 2014: 33 · 2013: 41 · 2012: 38
FWCI
11.59
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5p41rr009754-09, 1P41RR09754)
  • National Institute of Mental Health (R01MH054671, MH54671)
  • National Institute of Neurological Disorders and Stroke (NS 43157, R01NS043157, R01NS034994, NS-34994)
  • National Center for Research Resources (1P41RR-09754)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
sleep, neural oscillations, sleep spindles, hippocampal ripples, slow-wave sleep, somatosensory cortex, memory consolidation, cell assemblies
MeSH terms
Animals, Hippocampus, Male, Mice, Inbred C57BL, Sleep, Rats, Sprague-Dawley, Mice, Knockout, Neocortex, Mice, Rats

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