Cited by 1,056Stress Responses and CortisolMemory and Neural MechanismsNeuropeptides and Animal Physiology

The DOI matches its Crossref record; 92 of the 94 references it cites were found in a registry or an index.

Pattern and time course of immediate early gene expression in rat brain following acute stress

Cullinan, W.E., Herman, J.P., Battaglia, D.F., Akil, H., Watson, S.J.·1995·Neuroscience

Open this paper in CoChat — free account

Abstract

The pattern and time course of brain activation in response to acute swim and restraint stress were examined in the rat by in situ hybridization using complementary RNA probes specific for transcripts encoding the products of the immediate early genes c-fos, c-jun and zif/268. A widespread pattern of c-fos messenger RNA expression was detected in response to these stressors; surprisingly, the expression patterns were substantially similar following both swim and restraint stress. A dramatic induction of c-fos messenger RNA was observed in numerous neo- and allocortical regions, the lateral septal nucleus, the hypothalamic paraventricular and dorsomedial nuclei, the anterior hypothalamic area, the lateral portion of the retrochiasmatic area, the medial and cortical amygdaloid nuclei, the periaqueductal gray, and the locus coeruleus; however, a prominent induction of c-fos was also seen in numerous additional subcortical and brainstem regions. Although not as widely expressed in response to stress as c-fos, induction of zif/268 messenger RNA was also detected throughout many brain areas; these regions were largely similar to those in which c-fos was induced, although in a number of regions zif/268 was expressed in regions devoid of c-fos messenger RNA. Few brain areas showed increased expression of c-jun following stress; these regions also showed induction of c-fos and/or zif/268. The time courses of expression of all three immediate early genes were similar, with peak levels observed at the 30 or 60 min time point, and a markedly reduced signal evident at 120 min post-stress. However, in a number of cases a delayed and/or prolonged induction was noted that may be indicative of secondary neuronal activation. A number of recent studies have attempted to define neural pathways which convey stress-related information to the hypothalamic-pituitary-adrenal axis. The present results reveal a widespread pattern of neuronal activation in response to acute swim or restraint stress. These findings may aid in the identification of stress-specific neural circuits and are thus likely to have important implications for our understanding of neuronal regulation of the stress response.

Integrity signals

Registry

Crossref · 10.1016/0306-4522(94)00355-9

Cites

92 of 92 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
Handbook of Chemical Neuroanatomy
Stern, C. D. (1986) · Neurochemistry International · doi:10.1016/0197-0186(86)90021-5 · Cited by 4,160
Two receptor systems for corticosterone in rat brain: Microdistribution and differential occupation
REUL, J. M. H. M., & KLOET, E. R. D. (1985) · Endocrinology · doi:10.1210/endo-117-6-2505 · Cited by 2,580
The regulation and function of c-fos and other immediate early genes in the nervous system
Sheng, M., & Greenberg, M. E. (1990) · Neuron · doi:10.1016/0896-6273(90)90106-p · Cited by 2,432
Induction of c-fos-like protein in spinal cord neurons following sensory stimulation
Hunt, S. P., Pini, A., & Evan, G. I. (1987) · Nature · doi:10.1038/328632a0 · Cited by 1,986
Expression of c- fos Protein in Brain: Metabolic Mapping at the Cellular Level
Sagar, S. M., Sharp, F. R., & Curran, T. (1988) · Science · doi:10.1126/science.3131879 · Cited by 1,925
Nucleus locus ceruleus: new evidence of anatomical and physiological specificity
Foote, S. L., Bloom, F. E., & Aston-Jones, G. (1983) · Physiological Reviews · doi:10.1152/physrev.1983.63.3.844 · Cited by 1,901
Mapping Patterns of c- fos Expression in the Central Nervous System After Seizure
Morgan, J. I., Cohén, D., Hempstead, J. L., & Curran, T. (1987) · Science · doi:10.1126/science.3037702 · Cited by 1,786
The role of the medial prefrontal cortex (cingulate gyrus) in the regulation of hypothalamic-pituitary-adrenal responses to stress
Diorio, D., Viau, V, & Meaney, M. (1993) · The Journal of Neuroscience · doi:10.1523/jneurosci.13-09-03839.1993 · Cited by 1,151
The melanin‐concentrating hormone system of the rat brain: An immuno‐ and hybridization histochemical characterization
Bittencourt, J. C., Presse, F., Arias, C. M., Peto, C. A., Vaughan, J. M., Nahon, J., Vale, W., & Sawchenko, P. E. (1992) · The Journal of Comparative Neurology · doi:10.1002/cne.903190204 · Cited by 1,075

Show all 94 references

Research works printed but not linked: 2

Baker, 1993, Neurotransmitter-specific neurons that project from the arcuate nucleus to the paraventricular hypothalamic nucleus: effect of adrenalectomy, Soc. Neurosci. Abstr., 19, 762
Ferraguti, 1990, Distribution of glutamic acid decar☐ylase messenger RNA-containing nerve cell populations in the male rat brain, J. chem. Neuroanat., 3, 337

Sorted by citations

Items 601–700 of 1,000

Involvement of endocannabinoid neurotransmission in the bed nucleus of stria terminalis in cardiovascular responses to acute restraint stress in rats
Gomes‐de‐Souza, L., de Oliveira, L. L., Benini, R., Rodella, P., Ferreira, W. C., & Crestani, C. C. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13560 · Cited by 26
Learning-induced ribosomal RNA is required for memory consolidation in mice—Evidence of differentially expressed rRNA variants in learning and memory
Allen, K., Regier, M., Hsieh, C., Tsokas, P., Barnard, M., Phatarpekar, S., Wolk, J., Sacktor, T. C., Fenton, A. A., & Hernandez, A. I. (2018) · PLoS ONE · doi:10.1371/journal.pone.0203374 · Cited by 25
Stress-related gene expression in brain and adrenal gland of porcine fetuses and neonates
Schwerin, M., Kanitz, E., Tuchscherer, M., Brüssow, K. ‐., Nürnberg, G., & Otten, W. (2004) · Theriogenology · doi:10.1016/j.theriogenology.2004.06.004 · Cited by 25
PACAP Controls Endocrine and Behavioral Stress Responses via Separate Brain Circuits
Jiang, S. Z., Zhang, H., & Eiden, L. E. (2023) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2023.04.001 · Cited by 24
Hindbrain Adrenergic/Noradrenergic Control of Integrated Endocrine and Autonomic Stress Responses
Pace, S. A., & Myers, B. (2023) · Endocrinology · doi:10.1210/endocr/bqad178 · Cited by 26
Twelve‐hour days in the brain and behavior of split hamsters
Butler, M. P., Rainbow, M. N., Rodriguez, E. R., Lyon, S. M., & Silver, R. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08166.x · Cited by 24
Limbic system development underlies the emergence of classical fear conditioning during the third and fourth weeks of life in the rat.
Deal, A. L., Erickson, K. J., Shiers, S. I., & Burman, M. A. (2016) · Behavioral Neuroscience · doi:10.1037/bne0000130 · Cited by 25
Psychological and physiological stressors
(2005) · Techniques in the behavioral and neural sciences · doi:10.1016/s0921-0709(05)80041-0 · Cited by 24
Differences in the brain expression of c-fos mRNA after restraint stress in Lewis compared to Sprague–Dawley rats
Trnečková, L., Armario, A., Hynie, S., Šída, P., & Klenerová, V. (2006) · Brain Research · doi:10.1016/j.brainres.2006.01.029 · Cited by 25
Modulation of 5‐HT system in mice with a targeted disruption of neuromedin B receptor
Yamano, M., Ogura, H., Okuyama, S., & Ohki‐Hamazaki, H. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10194 · Cited by 24
Stimulatory and inhibitory regulators of the hypothalamo–pituitary–adrenocortical axis
Jessop, D. S. (1999) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1053/beem.1999.0039 · Cited by 24
Corticotropin-releasing hormone messenger RNA distribution and stress-induced activation in the thalamus
Hsu, D. T., Lombardo, K. A., Herringa, R. J., Bakshi, V. P., Roseboom, P. H., & Kalin, N. H. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00239-1 · Cited by 24
Aging impairs the control of prefrontal cortex on the release of corticosterone in response to stress and on memory consolidation
Garrido, P., de Blas, M., Giné, E., Santos, Á., & Mora, F. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.06.011 · Cited by 26
Acute response of hypophysiotropic thyrotropin releasing hormone neurons and thyrotropin release to behavioral paradigms producing varying intensities of stress and physical activity
Gutiérrez-Mariscal, M., Sánchez, E., García-Vázquez, A., Rebolledo-Solleiro, D., Charli, J., & Joseph‐Bravo, P. (2012) · Regulatory Peptides · doi:10.1016/j.regpep.2012.08.010 · Cited by 23
Differential Activation of the Periaqueductal Gray by Mild Anxiogenic Stress at Different Stages of the Estrous Cycle in Female Rats
Devall, A., & Lovick, T. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.222 · Cited by 24
Alcohol consumption increases locomotion in an open field and induces Fos-immunoreactivity in reward and approach/withdrawal-related neurocircuitries
Wscieklica, T., Viana, M. D. B., Sueur, L. D. P. L., Pouza, K. C. P., Spadari, R. C., & Céspedes, I. C. (2015) · Alcohol · doi:10.1016/j.alcohol.2015.11.005 · Cited by 23
Estrogen Receptor-α in the Medial Amygdala Prevents Stress-Induced Elevations in Blood Pressure in Females
Hinton, A. O., Jr., He, Y., Xia, Y., Xu, P., Yang, Y., Saito, K., Wang, C., Yan, X., Shu, G., Henderson, A., et al. (2016) · Hypertension · doi:10.1161/hypertensionaha.116.07175 · Cited by 23
Stress-Induced Stimulation of Pituitary POMC Gene Expression Is Associated with Activation of Transcription Factor AP-1 in Hypothalamus and Pituitary
Autelitano, D. J. (1998) · Brain Research Bulletin · doi:10.1016/s0361-9230(97)00303-1 · Cited by 23
Time-course of immediate early gene expression in hippocampal subregions of adrenalectomized rats after acute corticosterone challenge
Hansson, A. C., & Fuxé, K. (2008) · Brain Research · doi:10.1016/j.brainres.2008.03.080 · Cited by 23
Increased nerve growth factor inducible-A gene and c-fos messenger RNA levels in the rat midbrain and hindbrain associated with the cardiovascular response to electrical stimulation of the mesencephalic cuneiform nucleus
Lam, W. K. W., Gundlach, A. L., & Verberne, A. J. M. (1996) · Neuroscience · doi:10.1016/0306-4522(95)00450-5 · Cited by 23
Space flight affects magnocellular supraoptic neurons of young prepuberal rats: transient and permanent effects
García‐Ovejero, D., Trejo, J. L., Ciriza, I., Walton, K. D., & García‐Segura, L. M. (2001) · Developmental Brain Research · doi:10.1016/s0165-3806(01)00236-x · Cited by 23
Charting of Jun family member proteins in the rat forebrain and midbrain: immunocytochemical evidence for a new Jun-related antigen
Harlan, R. E., & Garcia, M. M. (1995) · Brain Research · doi:10.1016/0006-8993(95)00624-y · Cited by 23
Cognitive and Emotional Symptoms Induced by Chronic Stress Are Regulated by EGR1 in a Subpopulation of Hippocampal Pyramidal Neurons
Sancho‐Balsells, A., Borràs‐Pernas, S., Brito, V., Alberch, J., Girault, J., & Giralt, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043833 · Cited by 22
c-Fos protein expression is increased in cholinergic neurons of the rodent basal forebrain during spontaneous and induced wakefulness
McKenna, J. T., Cordeira, J., Jeffrey, B. A., Ward, C. P., Winston, S. H., McCarley, R. W., & Strecker, R. E. (2009) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2009.08.015 · Cited by 22
Altered expression and modulation of activity-regulated cytoskeletal associated protein (Arc) in serotonin transporter knockout rats
Molteni, R., Calabrese, F., Maj, P. F., Olivier, J. D. A., Racagni, G., Ellenbroek, B. A., & Riva, M. A. (2009) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2009.06.008 · Cited by 22
Neuroanatomical substrates involved in cannabinoid modulation of defensive responses
Moreira, F. A., Aguiar, D., Resstel, L. B. M., Lisboa, S. F. D. S., Campos, A. C., Gomes, F. V., & Guimarães, F. S. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881111400651 · Cited by 24
Digital gene expression analysis of Takifugu rubripes brain after acute hypoxia exposure using next-generation sequencing
Jiang, J.-L., Mao, M., Lü, H.-Q., Wen, S.-H., Sun, M.-L., Liu, R., & Jiang, Z. (2017) · Comparative Biochemistry and Physiology Part D Genomics and Proteomics · doi:10.1016/j.cbd.2017.05.003 · Cited by 22
Neurobiology of Wild and Hatchery-Reared Atlantic Salmon: How Nurture Drives Neuroplasticity
Mes, D., von Krogh, K., Gorissen, M., Mayer, I., & Vindas, M. A. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00210 · Cited by 25
The chemical architecture of the rat's periaqueductal gray based on acetylcholinesterase histochemistry: a quantitative and qualitative study
Ruiz‐Torner, A., Olucha-Bordonau, F. E., Valverde‐Navarro, A. A., & Martı́nez-Soriano, F. (2001) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(01)00119-3 · Cited by 22
Stress-induced changes in c-Fos and corticotropin releasing hormone immunoreactivity in the amygdala of the spontaneously hypertensive rat
Porter, K., & Hayward, L. F. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.08.036 · Cited by 22
Differential hypothalamic tyrosine hydroxylase distribution and activation by light in adult mice reared under different light conditions during the suckling period
Brooks, E., Waters, E., Farrington, L., & Canal, M. M. (2011) · Brain Structure and Function · doi:10.1007/s00429-011-0318-9 · Cited by 22
Deficient hippocampal c-fos expression results in reduced anxiety and altered response to chronic stress in female mice
McQuade, J. M. S., Tamashiro, K. L., Wood, G. E., Herman, J. P., McEwen, B. S., Sakai, R. R., Zhang, J., & Xu, M. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.04.022 · Cited by 22
Self-citation
Dynamics of immediate early gene and neuropeptide gene response to prolonged immobilization stress: evidence against a critical role of the termination of exposure to the stressor
Trnečková, L., Rotllant, D., Klenerová, V., Hynie, S., & Armario, A. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04278.x · Cited by 22
Olfactory modulation of stress-response neural circuits
Shin, M.-G., Bae, Y., Afzal, R., Kondoh, K., & Lee, E. J. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-01048-3 · Cited by 22
Glutamic acid decarboxylase 65 and 67 expression in the lateral septum is up-regulated in association with the postpartum period in mice
Zhao, C., Driessen, T. M., & Gammie, S. C. (2012) · Brain Research · doi:10.1016/j.brainres.2012.06.002 · Cited by 22
Cocaine pre-exposure produces a sensitized and context-specific c-fos mRNA response to footshock stress in the central nucleus of the AMYGDALA
Erb, S. M., Lopak, V., & Smith, C. L. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.08.012 · Cited by 21
Hindbrain Catecholamine Neurons Modulate the Growth Hormone But Not the Feeding Response to Ghrelin
Emanuel, A. J., & Ritter, S. (2010) · Endocrinology · doi:10.1210/en.2010-0219 · Cited by 21
GABAergic mRNA expression is differentially expressed across the prelimbic and orbitofrontal cortices of rats sensitized to methamphetamine: Relevance to psychosis
Wearne, T. A., Parker, L. M., Franklin, J. L., Goodchild, A. K., & Cornish, J. L. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.08.038 · Cited by 21
Acute and chronic restraint stress: effects on [125I]-galanin binding in normotensive and hypertensive rat brain11Published on the World Wide Web on 7 July 2000.
Sweerts, B., Jarrott, B., & Lawrence, A. J. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02558-0 · Cited by 21
Noradrenergic responses of neurones in the mediolateral part of the lateral septum: α1-adrenergic depolarization and rhythmic bursting activities, and α2-adrenergic hyperpolarization from guinea pig brain slices
Carette, B. (1999) · Brain Research Bulletin · doi:10.1016/s0361-9230(98)00168-3 · Cited by 21
Corticosterone and decision-making in male Wistar rats: the effect of corticosterone application in the infralimbic and orbitofrontal cortex
Koot, S., Koukou, M., Baars, A. M., Hesseling, P., Klooster, J. G. L. T., Joëls, M., & van den Bos, R. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00127 · Cited by 23
Chemogenetic activation of CRF neurons as a model of chronic stress produces sex-specific physiological and behavioral effects
Montgomery, K. R., Bridi, M. S., Folts, L. M., Marx-Rattner, R., Zierden, H. C., Wulff, A. B., Kodjo, E., Thompson, S. M., & Bale, T. L. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-023-01739-5 · Cited by 20
The Expression Patterns of c-Fos and c-Jun Induced by Different Frequencies of Electroacupuncture in the Brain
Qiu, Z., Ding, Y., Cui, L.-Y., Hu, M., & Ding, M. (2015) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2015/343682 · Cited by 20
Attenuation of the neuronal stress responsiveness and corticotrophin releasing hormone synthesis after sexual activity in male rats
Waldherr, M., Nyuyki, K. D., Maloumby, R., Bosch, O. J., & Neumann, I. D. (2009) · Hormones and Behavior · doi:10.1016/j.yhbeh.2009.11.006 · Cited by 20
Susceptibility to stress in transgenic mice overexpressing TrkC, a model of panic disorder
Amador‐Arjona, A., Delgado‐Morales, R., Belda, X., Gagliano, H., Gallego, X., Keck, M. E., Armario, A., & Dierssen, M. (2009) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.07.008 · Cited by 20
Chronic stress and moderate physical exercise prompt widespread common activation and limited differential activation in specific brain regions
Kim, T.-K., & Han, P. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.08.007 · Cited by 21
Tachykinin NK1 receptor antagonists enhance stress-induced c-fos in rat locus coeruleus.
Hahn, M., & Bannon, M. J. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00150-2 · Cited by 22
Immobilization stress induces c-fos and c-jun immediate early genes expression in the heart
Ueyama, T., Umemoto, S., & Senba, E. (1996) · Life Sciences · doi:10.1016/0024-3205(96)00303-7 · Cited by 20
Chapter VIII c-Fos in learning: beyond the mapping of neuronal activity
Kaczmarek, L. (2002) · Handbook of chemical neuroanatomy · doi:10.1016/s0924-8196(02)80019-7 · Cited by 20
The histaminergic H1, H2, and H3 receptors of the lateral septum differentially mediate the anxiolytic-like effects of histamine on rats' defensive behaviors in the elevated plus maze and novelty-induced suppression of feeding paradigm
Chee, S. A., & Menard, J. L. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.03.016 · Cited by 19
Social Instability Stress in Adolescence and Social Interaction in Female Rats
Asgari, P., McKinney, G., Hodges, T. E., & McCormick, C. M. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.09.022 · Cited by 19
Phenethylamine is a substrate of monoamine oxidase B in the paraventricular thalamic nucleus
Obata, Y., Kubota‐Sakashita, M., Kasahara, T., Mizuno, M., Nemoto, T., & Kato, T. (2022) · Scientific Reports · doi:10.1038/s41598-021-03885-6 · Cited by 19
Acute stress affects the physiology and behavior of allergic mice
Sutherland, M. A., Shome, G. P., Hulbert, L. E., Krebs, N., Wachtel, M. S., & McGlone, J. J. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.06.003 · Cited by 19
Increased voluntary ethanol consumption and c-Fos expression in selected brain areas induced by fear memory retrieval in ethanol withdrawn rats
Bertotto, M. E., Bussolino, D. F., Molina, V. A., & Martijena, I. D. (2010) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2010.02.014 · Cited by 19
Depression-resistant Phenotype in Mice Overexpressing Regulator of G Protein Signaling 8 (RGS8)
Kobayashi, Y., Takemoto, R., Yamato, S., Okada, T., Iijima, M., Uematsu, Y., Chaki, S., & Saito, Y. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.05.005 · Cited by 20
Transcriptome profiling analysis reveals region‐distinctive changes of gene expression in the CNS in response to different moderate restraint stress
Wang, K., Xiang, X., He, F., Lin, L., Zhang, R., Ping, X., Han, J., Guo, N., Zhang, Q., Cui, C., et al. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06679.x · Cited by 19
Temporal change in NMDA receptor signaling and GABAA receptor exypression in rat caudal vestibular nucleus during motion sickness habituation
Wang, J., Li, H., Chen, X., Mo, F., Qi, R., Guo, J., & Cai, Y. (2012) · Brain Research · doi:10.1016/j.brainres.2012.04.041 · Cited by 19
Effect of acute imipramine administration on the pattern of forced swim-induced c-Fos expression in the mouse brain
Yanagida, S., Motomura, K., Ohashi, A., Hiraoka, K., Miura, T., & Kanba, S. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.06.059 · Cited by 20
Sepsis survivor mice exhibit a behavioral endocrine syndrome with ventral hippocampal dysfunction
Spencer-Segal, J. L., Singer, B. H., Laborc, K. F., Somayaji, K., Watson, S. J., Standiford, T. J., & Akil, H. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.104679 · Cited by 22
Self-citation
Inhibitory Function of the Dorsomedial Hypothalamic Nucleus on the Hypothalamic–Pituitary–Adrenal Axis Response to an Emotional Stressor but not Immune Challenge
Ebner, K., Muigg, P., & Singewald, N. (2013) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02369.x · Cited by 18
Effects of Novelty Stress on Hippocampal Gene Expression, Corticosterone and Motor Activity in Mice
Kurumaji, A., Umino, M., & Nishikawa, T. (2011) · Neuroscience Research · doi:10.1016/j.neures.2011.06.006 · Cited by 18
Pitx3 deficient mice as a genetic animal model of co-morbid depressive disorder and parkinsonism
Kim, K., Kang, Y.-M., Kang, Y. M., Park, T., Park, H., Kim, Y. J., Han, B., Kim, C., Lee, C., Ardayfio, P. A., et al. (2014) · Brain Research · doi:10.1016/j.brainres.2014.01.023 · Cited by 19
Translational reciprocity: Bridging the gap between preclinical studies and clinical treatment of stress effects on the adolescent brain
Neigh, G. N., Ritschel, L. A., Kilpela, L. S., Harrell, C. S., & Bourke, C. H. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.09.075 · Cited by 18
Diagonal band of Broca modulates the cardiac component of the baroreflex in unanesthetized rats
Crestani, C. C., Tavares, R. F., Alves, F. H. F., Resstel, L. B. M., & Corrêa, F. M. D. A. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.10.055 · Cited by 18
Serum Response Factor (SRF) Ablation Interferes with Acute Stress-Associated Immediate and Long-Term Coping Mechanisms
Zimprich, A., Mroz, G., zu Reckendorf, C. M., Anastasiadou, S., Förstner, P., Garrett, L., Hölter, S. M., Becker, L., Rozman, J., Prehn, C. P., et al. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0300-x · Cited by 18
Cholinergic mechanism in the lateral septal area is involved in the stress-induced blood pressure increase in rats
Kubo, T., Okatani, H., Kanaya, T., Hagiwara, Y., Fukumori, R., & Goshima, Y. (2002) · Brain Research Bulletin · doi:10.1016/s0361-9230(02)00928-0 · Cited by 18
Water immersion-restraint stress induces expression of immediate-early genes in gastrointestinal tract of rats
Ueyama, T., Saika, M., Koreeda, C., & Senba, E. (1998) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1998.275.2.g287 · Cited by 18
Evaluation of the posterior insular cortex involvement in anxiogenic response to emotional stress in male rats: Functional topography along the rostrocaudal axis
Vitorio, A. S., Reis‐Silva, L. L., Barretto‐de‐Souza, L., Gomes‐de‐Souza, L., & Crestani, C. C. (2022) · Physiology & Behavior · doi:10.1016/j.physbeh.2022.114006 · Cited by 17
Diurnal effects of enriched environment on immediate early gene expression in the rat brain
Rönnbäck, A., Dahlqvist, P. M., Bergström, S., & Olsson, T. (2005) · Brain Research · doi:10.1016/j.brainres.2005.03.051 · Cited by 17
Immunohistochemical determination of the site of antidepressant-like effects of glucagon-like peptide-2 in ACTH-treated mice
Sasaki‐Hamada, S., Yuri, Y., Hoshi, M., & Oka, J.-I. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.03.010 · Cited by 17
Brain pattern of histone H3 phosphorylation after acute amphetamine administration: Its relationship to brain c-fos induction is strongly dependent on the particular brain area
Rotllant, D., & Armario, A. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.10.019 · Cited by 17
Both N-methyl-D-aspartate and non-N-methyl-D-aspartate glutamate receptors in the bed nucleus of the stria terminalis modulate the cardiovascular responses to acute restraint stress in rats
Adami, M. B., Barretto‐de‐Souza, L., Duarte, J. O., Almeida, J., & Crestani, C. C. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881117691468 · Cited by 17
Repeated exposure to two stressors in sequence demonstrates that corticosterone and paraventricular nucleus of the hypothalamus interleukin‐1β responses habituate independently
Lovelock, D. F., & Deak, T. (2017) · Journal of Neuroendocrinology · doi:10.1111/jne.12514 · Cited by 16
BDNF downregulates β-adrenergic receptor-mediated hypotensive mechanisms in the paraventricular nucleus of the hypothalamus
Thorsdottir, D., Cruickshank, N. C., Einwag, Z., Hennig, G. W., & Erdös, B. (2019) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00478.2019 · Cited by 18
Lesion of the ventral tegmental area amplifies stimulation-induced Fos expression in the rat brain
Majkutewicz, I., Cecot, T., Jerzemowska, G., Myślińska, D., Plucińska, K., Trojniar, W., & Wrona, D. (2010) · Brain Research · doi:10.1016/j.brainres.2010.01.009 · Cited by 17
Prepro-thyrotropin releasing hormone 178-199 immunoreactivity is altered in the hypothalamus of the Wistar–Kyoto strain of rat
Suzuki, S., Solberg, L. C., Redei, E. E., & Handa, R. J. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02853-0 · Cited by 17
Interactions between environmental stimulation and antipsychotic drug effects on forebrain c-fos activation
Murphy, C. A., & Feldon, J. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00110-5 · Cited by 17
Prenatal cocaine exposure enhances responsivity of locus coeruleus norepinephrine neurons: Role of autoreceptors
Elsworth, J. D., Morrow, B. A., Nguyen, V., Mitra, J., Picciotto, M. R., & Roth, R. H. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.04.036 · Cited by 17
Role of protein kinase Cβ in phorbol ester-induced c-fos gene expression in neurons of normotensive and spontaneously hypertensive rat brains
Amemiya, T., Kambe, T., Fukumori, R., & Kubo, T. (2005) · Brain Research · doi:10.1016/j.brainres.2005.01.073 · Cited by 17
c-fos Expression in the Forebrain after Mating in the Female Rat Is Altered by Adrenalectomy
Cameron, N. M., & Erskine, M. S. (2003) · Neuroendocrinology · doi:10.1159/000070283 · Cited by 17
Corticotropin-releasing factor and glucocorticoid receptor (GR) gene expression in the paraventricular nucleus of immune-challenged transgenic mice expressing type II GR antisense ribonucleic acid
Laflamme, N., Barden, N., & Rivest, S. (1997) · Journal of Molecular Neuroscience · doi:10.1007/bf02736831 · Cited by 17
Anaphylactoid reactions activate hypothalamo-pituitary-adrenocortical axis: comparison with endotoxic reactions
Földes, A., Némethy, Z., Szalay, O., & Kovács, K. (2000) · Brain Research Bulletin · doi:10.1016/s0361-9230(00)00299-9 · Cited by 17
Light-induced asymmetries in embryonic retinal gene expression are mediated by the vascular system and extracellular matrix
Versace, E., Sgadó, P., George, J. M., Loveland, J. L., Ward, J., Thorpe, P., Jensen, L. J., Spencer, K. A., Paracchini, S., & Vallortígara, G. (2022) · Scientific Reports · doi:10.1038/s41598-022-14963-8 · Cited by 16
Functional brain‐wide network mapping during acute stress exposure in rats: Interaction between the lateral habenula and cortical, amygdalar, hypothalamic and monoaminergic regions
Durieux, L., Herbeaux, K., Borcuk, C., Hildenbrand, C., Andry, V., Goumon, Y., Barbelivien, A., Mathis, C., Bataglia, D., Majchrzak, M. J., et al. (2022) · European Journal of Neuroscience · doi:10.1111/ejn.15803 · Cited by 15
The medial prefrontal cortex and the cardiac baroreflex activity: physiological and pathological implications
Lagatta, D. C., Fassini, A., Terzian, A. L. B., Corrêa, F. M. D. A., & Resstel, L. B. M. (2023) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-022-02786-5 · Cited by 16
Gene regulation and speciation in a migratory divide between songbirds
Louder, M. I. M., Justen, H. C., Kimmitt, A. A., Lawley, K. S., Turner, L. M., Dickman, J. D., & Delmore, K. E. (2024) · Nature Communications · doi:10.1038/s41467-023-44352-2 · Cited by 16
CRF family peptides are differently altered by acute restraint stress and chronic unpredictable stress
de Andrade, J. S., Viana, M. D. B., Abrão, R. O., Bittencourt, J. C., & Céspedes, I. C. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.06.014 · Cited by 16
Hypothalamo-Pituitary-Adrenocortical Axis, Glucocorticoids, and Neurologic Disease
Doczy, E. J., Seroogy, K. B., Harrison, C. R., & Herman, J. P. (2009) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2009.02.003 · Cited by 16
Self-citation
GABAA but not GABAB receptors in the lateral hypothalamus modulate the tachycardic response to emotional stress in rats
Gomes‐de‐Souza, L., Benini, R., Ferreira, W. C., & Crestani, C. C. (2019) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2019.03.001 · Cited by 16
Early Growth Response Gene Upregulation in Epstein–Barr Virus (EBV)-Associated Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
Kerr, J. R. (2020) · Biomolecules · doi:10.3390/biom10111484 · Cited by 17
Adaptation of the pituitary-adrenal axis to daily repeated forced swim exposure in rats is dependent on the temperature of water
Rabasa, C., Delgado‐Morales, R., Gómez-Román, A., Nadal, R. A., & Armario, A. (2013) · Stress · doi:10.3109/10253890.2013.824964 · Cited by 16
Associations between behavior, hormones, and Fos responses to novelty differ in pre- and post-pubertal grass rats
Novak, C. M., Parfitt, D. B., Sisk, C. L., & Smale, L. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.09.012 · Cited by 16
Chronic restraint stress causes a delayed increase in responding for palatable food cues during forced abstinence via a dopamine D1-like receptor-mediated mechanism
Ball, K. T., Best, O., Luo, J. Z., & Miller, L. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.11.020 · Cited by 16
The Amygdala and Anxiety
Linsambarth, S., Moraga‐Amaro, R., Quintana-Donoso, D., Rojas, S., & Stehberg, J. (2017) · InTech eBooks · doi:10.5772/intechopen.68618 · Cited by 17
The medial amygdaloid area is involved in activation of angiotensin II-sensitive neurons in the anterior hypothalamic area
Hagiwara, Y., Nishigori, Y., Fukumori, R., & Kubo, T. (2005) · Brain Research · doi:10.1016/j.brainres.2004.11.015 · Cited by 16
Ethanol-induced FOS immunoreactivity in the brain of μ-opioid receptor knockout mice
Kolodziejska-Akiyama, K. M., Cha, Y. M., Jiang, Y., Loh, H. H., & Chang, S. L. (2005) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2005.02.006 · Cited by 16
The Contribution of Immediate Early Genes to the Understanding of Brain Processing of Stressors
Armario, A. (2006) · Springer eBooks · doi:10.1007/978-0-387-33604-6_11 · Cited by 16
Recent Evidence of Memory Processing in Sleep
Pavlides, C., & Ribeiro, S. T. G. (2003) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780198574002.003.0017 · Cited by 16
Postnatal Aromatase Blockade Increases c-fos mRNA Responses to Acute Restraint Stress in Adult Male Rats
Bingham, B., Wang, N. X. R., Innala, L., & Viau, V. (2012) · Endocrinology · doi:10.1210/en.2011-1749 · Cited by 17
Site-Specific Regulation of Stress Responses Along the Rostrocaudal Axis of the Insular Cortex in Rats
Tomeo, R. A., Gomes‐de‐Souza, L., Benini, R., Reis‐Silva, L. L., & Crestani, C. C. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.878927 · Cited by 15

Authors: Cullinan, W. E., Herman, J. P., Battaglia, D. F., Akil, H., & Watson, S. J.
Affiliations: University of Michigan (US)
University of Kentucky (US)
Corresponding author: Cullinan, W.E.
ORCID: Herman, J.P.
Akil, H.
Watson, S.J.
Venue: Neuroscience
Publisher: Elsevier BV
Published: 1995-01
Volume: 64
Issue: 2
Pages: 477-505
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/0306-4522(94)00355-9
OpenAlex: W2091497325
Cited by: 1,056
References: 94
Citations by year: 2026: 15 · 2025: 22 · 2024: 11 · 2023: 19 · 2022: 26 · 2021: 27 · 2020: 27 · 2019: 29 · 2018: 33 · 2017: 38 · 2016: 33 · 2015: 39 · 2014: 35 · 2013: 33 · 2012: 61
FWCI: 17.31
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (1k21da000265-01)
National Institute of Mental Health (MH49698)
National Institute on Drug Abuse (DA00265-12, DA 05452)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: acute stress, immediate early genes, c-fos, c-Jun, Zif268, swim stress, restraint stress, brain gene expression, hypothalamic-pituitary-adrenal axis, amygdala, periaqueductal gray, locus coeruleus
MeSH terms: Animals, Brain, Caudate Nucleus, DNA-Binding Proteins, Hippocampus, Male, Raphe Nuclei, Restraint, Physical, RNA, Messenger, Septal Nuclei, Stress, Psychological, Swimming, Time Factors, Transcription Factors, Gene Expression, Genes, jun, Genes, fos, Rats, Sprague-Dawley, Immediate-Early Proteins, Rats, Early Growth Response Protein 1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Pattern and time course of immediate early gene expression in rat brain following acute stress

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks