Cited by 1,056Stress Responses and CortisolMemory and Neural MechanismsNeuropeptides and Animal Physiology

The DOI matches its Crossref record; 92 of the 94 references it cites were found in a registry or an index.

Pattern and time course of immediate early gene expression in rat brain following acute stress

Cullinan, W.E., Herman, J.P., Battaglia, D.F., Akil, H., Watson, S.J.·1995·Neuroscience

Open this paper in CoChat — free account

Abstract

The pattern and time course of brain activation in response to acute swim and restraint stress were examined in the rat by in situ hybridization using complementary RNA probes specific for transcripts encoding the products of the immediate early genes c-fos, c-jun and zif/268. A widespread pattern of c-fos messenger RNA expression was detected in response to these stressors; surprisingly, the expression patterns were substantially similar following both swim and restraint stress. A dramatic induction of c-fos messenger RNA was observed in numerous neo- and allocortical regions, the lateral septal nucleus, the hypothalamic paraventricular and dorsomedial nuclei, the anterior hypothalamic area, the lateral portion of the retrochiasmatic area, the medial and cortical amygdaloid nuclei, the periaqueductal gray, and the locus coeruleus; however, a prominent induction of c-fos was also seen in numerous additional subcortical and brainstem regions. Although not as widely expressed in response to stress as c-fos, induction of zif/268 messenger RNA was also detected throughout many brain areas; these regions were largely similar to those in which c-fos was induced, although in a number of regions zif/268 was expressed in regions devoid of c-fos messenger RNA. Few brain areas showed increased expression of c-jun following stress; these regions also showed induction of c-fos and/or zif/268. The time courses of expression of all three immediate early genes were similar, with peak levels observed at the 30 or 60 min time point, and a markedly reduced signal evident at 120 min post-stress. However, in a number of cases a delayed and/or prolonged induction was noted that may be indicative of secondary neuronal activation. A number of recent studies have attempted to define neural pathways which convey stress-related information to the hypothalamic-pituitary-adrenal axis. The present results reveal a widespread pattern of neuronal activation in response to acute swim or restraint stress. These findings may aid in the identification of stress-specific neural circuits and are thus likely to have important implications for our understanding of neuronal regulation of the stress response.

Integrity signals

Registry

Crossref · 10.1016/0306-4522(94)00355-9

Cites

92 of 92 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
Handbook of Chemical Neuroanatomy
Stern, C. D. (1986) · Neurochemistry International · doi:10.1016/0197-0186(86)90021-5 · Cited by 4,160
Two receptor systems for corticosterone in rat brain: Microdistribution and differential occupation
REUL, J. M. H. M., & KLOET, E. R. D. (1985) · Endocrinology · doi:10.1210/endo-117-6-2505 · Cited by 2,580
The regulation and function of c-fos and other immediate early genes in the nervous system
Sheng, M., & Greenberg, M. E. (1990) · Neuron · doi:10.1016/0896-6273(90)90106-p · Cited by 2,432
Induction of c-fos-like protein in spinal cord neurons following sensory stimulation
Hunt, S. P., Pini, A., & Evan, G. I. (1987) · Nature · doi:10.1038/328632a0 · Cited by 1,986
Expression of c- fos Protein in Brain: Metabolic Mapping at the Cellular Level
Sagar, S. M., Sharp, F. R., & Curran, T. (1988) · Science · doi:10.1126/science.3131879 · Cited by 1,925
Nucleus locus ceruleus: new evidence of anatomical and physiological specificity
Foote, S. L., Bloom, F. E., & Aston-Jones, G. (1983) · Physiological Reviews · doi:10.1152/physrev.1983.63.3.844 · Cited by 1,901
Mapping Patterns of c- fos Expression in the Central Nervous System After Seizure
Morgan, J. I., Cohén, D., Hempstead, J. L., & Curran, T. (1987) · Science · doi:10.1126/science.3037702 · Cited by 1,786
The role of the medial prefrontal cortex (cingulate gyrus) in the regulation of hypothalamic-pituitary-adrenal responses to stress
Diorio, D., Viau, V, & Meaney, M. (1993) · The Journal of Neuroscience · doi:10.1523/jneurosci.13-09-03839.1993 · Cited by 1,151
The melanin‐concentrating hormone system of the rat brain: An immuno‐ and hybridization histochemical characterization
Bittencourt, J. C., Presse, F., Arias, C. M., Peto, C. A., Vaughan, J. M., Nahon, J., Vale, W., & Sawchenko, P. E. (1992) · The Journal of Comparative Neurology · doi:10.1002/cne.903190204 · Cited by 1,075

Show all 94 references

Research works printed but not linked: 2

Baker, 1993, Neurotransmitter-specific neurons that project from the arcuate nucleus to the paraventricular hypothalamic nucleus: effect of adrenalectomy, Soc. Neurosci. Abstr., 19, 762
Ferraguti, 1990, Distribution of glutamic acid decar☐ylase messenger RNA-containing nerve cell populations in the male rat brain, J. chem. Neuroanat., 3, 337

Sorted by citations

Items 801–900 of 1,000

Quinpirole attenuates the striatal Fos expression induced by escape behavior
Struthers, W. M., & Wirtshafter, D. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01378-4 · Cited by 9
Comparison of the Expression of c‐fos, nur77 and egr1 mRNAs in Rat Hypothalamic Magnocellular Neurons and their Putative Afferent Projection Neurons: Cell‐ and Stimulus‐specific Induction
Luckman, S. M. (1997) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1997.tb01661.x · Cited by 9
Effects of Biological Sex and Stress Exposure on Ventromedial Prefrontal Regulation of Mood-Related Behaviors
Wallace, T., & Myers, B. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.737960 · Cited by 8
Peripheral nerve injury attenuates stress-induced Fos-family expression in the Locus Coeruleus of male Sprague-Dawley rats
Boorman, D. C., Kang, J. W. M., & Keay, K. A. (2019) · Brain Research · doi:10.1016/j.brainres.2019.06.007 · Cited by 8
Role of the lateral preoptic area in cardiovascular and neuroendocrine responses to acute restraint stress in rats
Duarte, J. O., Gomes, K. S., Nunes‐de‐Souza, R. L., & Crestani, C. C. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.03.030 · Cited by 8
Behavioral validation of a wireless low-power neurostimulation technology in a conditioned place preference task
Maeng, L. Y., Murillo, M. F., Mu, M., Lo, M.-C., de la Rosa, M., O’Brien, J. M., Freeman, D. K., & Widge, A. S. (2019) · Journal of Neural Engineering · doi:10.1088/1741-2552/aafc72 · Cited by 8
Pathology of Marine Mammals: What It Can Tell Us About Environment and Welfare
Fernández, A., de Quirós, Y. B., Sacchini, S., & Sierra, E. (2017) · Animal welfare · doi:10.1007/978-3-319-46994-2_32 · Cited by 8
Progressive training effects on neuronal hypothalamic activation in the rat
Núñez, P., Perillán, C., Vijande, M., & Argüelles, J. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.04.039 · Cited by 8
Preconditioning-specific reduction of c-fos expression in hippocampal granule and pyramidal but not other forebrain neurons of ischemic brain: a quantitative immunohistochemical study
Nyitrai, G., Puskás, L. G., Antal, K., Takács, V., Sass, M., Juhász, G. D., Kardos, J., & Palkovits, M. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.02.045 · Cited by 8
Mapping of c-Fos Expression in Rat Brain Sub/Regions Following Chronic Social Isolation: Effective Treatments of Olanzapine, Clozapine or Fluoxetine
Stanisavljević, A., & Filipović, D. (2024) · Pharmaceuticals · doi:10.3390/ph17111527 · Cited by 8
Distinct mechanisms of transcriptomic habituation to repeated stress in the mouse hippocampus
Waag, R., von Ziegler, L., Sonder, E., Sturman, O., Leonardi, J., Frei, S., Longster, R., Gapp, K., Germain, P., & Bohacek, J. (2025) · Nature Communications · doi:10.1038/s41467-025-67825-y · Cited by 11
Clozapine impact on c‐Fos expression in mild stress preconditioned male rats exposed to a novelty stressor
Osacká, J., Černáčková, A., Horváthová, Ľ., Majerčíková, Z., Pirník, Z., & Kiss, A. (2018) · Journal of Neuroscience Research · doi:10.1002/jnr.24280 · Cited by 7
Agonistic behaviors and neuronal activation in sexually naïve female Mongolian gerbils
Pan, Y., Zhu, Q., Wang, X., Chen, J., Wen, B., Zhang, Z., & Wang, Z. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112860 · Cited by 7
Both Prelimbic and Infralimbic Noradrenergic Neurotransmissions Modulate Cardiovascular Responses to Restraint Stress in Rats
de Oliveira, L. L., Pollo, T. R. S., Rosa, E. A., Duarte, J. O., Xavier, C. H., & Crestani, C. C. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.700540 · Cited by 7
Elevation of EGR1/zif268, a Neural Activity Marker, in the Auditory Cortex of Patients with Schizophrenia and its Animal Model
Iwakura, Y., Kawahara‐Miki, R., Kida, S., Sotoyama, H., Gabdulkhaev, R., Takahashi, H., Kunii, Y., Hino, M., Nagaoka, A., Izumi, R., et al. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03599-9 · Cited by 8
Expression of CRFR1 and Glu5R mRNA in different brain areas following repeated testing in mice that differ in habituation behaviour
Salomons, A. R., Arndt, S. S., Lavrijsen, M., Kirchhoff, S., & Ohl, F. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.02.023 · Cited by 7
Regional brain c-fos activation associated with penile erection and other symptoms induced by the spider toxin Tx2-6
Troncone, L. R. P., Ravelli, K. G., Magnoli, F. C., Lebrun, I., Hipólide, D. C., Raymond, R., & Nóbrega, J. N. (2011) · Toxicon · doi:10.1016/j.toxicon.2011.05.019 · Cited by 7
Molecular phenotyping of transient postnatal tyrosine hydroxylase neurons in the rat bed nucleus of the stria terminalis
Carter, D. (2017) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2017.04.002 · Cited by 7
Widespread increase in brain protein synthesis following acute immobilization stress in adult rat brain
Baubet, V., Grange, E., Sermet, É., Giaume, M., Gay, N., & Bobillier, P. (1996) · Neuroscience Letters · doi:10.1016/s0304-3940(96)13209-2 · Cited by 7
Morphometric analysis of hypothalamic cells showing c-Fos proteins after movement restriction and EHF-irradiation
Novikova, N. S., Перекрест, С. В., Rogers, V. J., & Korneva, E. A. (2008) · Pathophysiology · doi:10.1016/j.pathophys.2007.11.001 · Cited by 7
Centrally administered bombesin activates COX-containing spinally projecting neurons of the PVN in anesthetized rats
Tanaka, K., Shimizu, T., Lu, L., Nakamura, K., & Yokotani, K. (2012) · Autonomic Neuroscience · doi:10.1016/j.autneu.2012.03.006 · Cited by 6
Honey bee neurogenomic responses to affiliative and agonistic social interactions
Shpigler, H. Y. (2016) · International Congress of Entomology (ICE) · doi:10.1603/ice.2016.115636 · Cited by 6
Chronic physical stress changes gene expression of catecholamine biosynthetic enzymes in the adrenal medulla of adult rats
Gavrilović, L., Stojiljković, V., Kasapović, J., Pejić, S., Todorović, A., Pajović, S. B., & Dronjak, S. (2012) · Acta veterinaria · doi:10.2298/avb1203151g · Cited by 6
Acute Impact of Selected Pyridoindole Derivatives on Fos Expression in Different Structures of the Rat Brain
Koprdová, R., Osacká, J., Mach, M., & Kiss, A. (2017) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-017-0520-2 · Cited by 6
Inactivation of the dorsolateral periaqueductal gray matter impairs the promoting influence of stress on fear memory during retrieval
Giachero, M., Pavesi, E., Calfa, G. D., Motta, S. C., Canteras, N. S., Molina, V. A., & Carobrez, A. P. (2019) · Brain Structure and Function · doi:10.1007/s00429-019-01956-z · Cited by 6
Exposure to 2.45 GHz Radiation Triggers Changes in HSP-70, Glucocorticoid Receptors and GFAP Biomarkers in Rat Brain
Othman, H., López-Furelos, A., Leiro, J. M., Ammari, M., Sakly, M., Abdelmelek, H., Salas-Sanchez, A. A., Ares‐Pena, F., & López-Martín, M. E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105103 · Cited by 6
Modulation of tonic immobility by GABAA and GABAB receptors of the medial amygdala
de Paula, B. B., de Melo, J. R., & Leite‐Panissi, C. R. A. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.01.054 · Cited by 6
Mechanisms of Hypertension in the Central Nervous System
Kubo, T. (2006) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.126.695 · Cited by 6
Chapter 3.2 Neural systems activated in response to predators and partial predator stimuli
Canteras, N. S. (2008) · Handbook of behavioral neuroscience · doi:10.1016/s1569-7339(07)00008-2 · Cited by 6
The relationship between locomotion and heat tolerance in heat exposed rats
Michel, V., Peinnequin, A., Alonso, A., Fidier, N., Maury, R., Drouet, J.-B., Buguet, A., Cespuglio, R., & Canini, F. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.03.006 · Cited by 6
Stimulus-specific induction of an Egr-1 transgene in rat brain
Slade, J. P., Man, P.-S., Wells, T., & Carter, D. (2002) · Neuroreport · doi:10.1097/00001756-200204160-00027 · Cited by 6
Neurocircuit control of the hypothalamo-pituitary-adrenocortical axis during stress
Herman, J. P. (1999) · Current Opinion in Endocrinology & Diabetes · doi:10.1097/00060793-199902000-00002 · Cited by 6
Self-citation
Music-listening regulates human microRNA transcriptomePreprint
Nair, P. S., Raijas, P., Ahvenainen, M., Philips, A. K., Ukkola‐Vuoti, L., & Järvelä, I. E. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/599217 · Cited by 6
Transcriptional characterization of cocaine withdrawal versus extinction within nucleus accumbens in male rats
Martínez-Rivera, F. J., Holt, L. M., Minier-Toribio, A. M., Estill, M. S., Yeh, S.-Y., Tofani, S., Futamura, R., Browne, C. J., Mews, P., Shen, L., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-58151-4 · Cited by 7
Inhibition of hippocampal or thalamic inputs to the nucleus accumbens reverses stress-induced alterations in dopamine system function
Reiley, H. B., McCoy, A. M., Boley, A. M., Yang, O. J., Belle, N. I., & Lodge, D. J. (2025) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyaf034 · Cited by 5
A Group of Descending Glutamatergic Neurons Activated by Stress in Corticolimbic Regions Project to the Nucleus Accumbens
Park, J. Y., Park, S. Y., Kwon, H., Song, Y., Yun, B., Lee, Y., Cho, Y., Joo, A., & Han, P. (2018) · Experimental Neurobiology · doi:10.5607/en.2018.27.5.387 · Cited by 5
Monitoring deep brain stimulation by measuring regional brain oxygen responses in freely moving mice
Bazzu, G., Serra, P. A., Hamelink, R., Feenstra, M. G. P., Willuhn, I., & Denys, D. A. J. P. (2019) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2019.01.012 · Cited by 5
c-Fos expression response to olanzapine, amisulpride, aripiprazole, and quetiapine single administration in the rat forebrain: Effect of a mild stress preconditioning
Kiss, A., Koprdová, R., Osacká, J., & Pečeňák, J. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.03.015 · Cited by 5
Stress‐induced brain histone H3 phosphorylation: contribution of the intensity of stressors and length of exposure
Rotllant, D., Pastor‐Ciurana, J., & Armario, A. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12214 · Cited by 5
Stress-induced alterations in catecholamine enzymes gene expression in the hypothalamic dorsomedial nucleus are modulated by caudal brain and not hypothalamic paraventricular nucleus neurons
Mravec, B., Lukackova, R., Bodnár, I., Kiss, A., Pacák, K., Palkovits, M., & Květňanský, R. (2007) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2007.06.005 · Cited by 5
Stress exposure alters brain mRNA expression of the genes involved in insulin signalling, an effect modified by a high fat/high fructose diet and cinnamon supplement
Canini, F., Qin, B., Marissal‐Arvy, N., Poulet, L., Batandier, C., Roussel, A., & Anderson, R. A. (2018) · PLoS ONE · doi:10.1371/journal.pone.0197094 · Cited by 5
The Effect of Probiotic Intervention in Ameliorating the Altered Central Nervous System Functions in Neurological Disorders: A Review
Sharma, V., & Kaur, S. (2020) · The Open Microbiology Journal · doi:10.2174/1874285802014010018 · Cited by 6
Stress-Related Neuronal Clusters in Sublenticular Extended Amygdala of Basal Forebrain Show Individual Differences of Positions
Kanemoto, M., Nakamura, T., Sasahara, M., & Ichijo, H. (2020) · Frontiers in Neural Circuits · doi:10.3389/fncir.2020.00029 · Cited by 5
Prepubertal and adult male rats differ in the degree and pattern of stress reactive neurons in brain regions that project to the paraventricular nucleus of the hypothalamus
Baker, M. R., Sciortino, R. K., So, V. M., & Romeo, R. D. (2021) · Brain Research · doi:10.1016/j.brainres.2021.147371 · Cited by 5
Angiotensinergic Neurotransmissions in the Medial Amygdala Nucleus Modulate Behavioral Changes in the Forced Swimming Test Evoked by Acute Restraint Stress in Rats
Marchi-Coelho, C., Ferreira, W. C., Reis‐Silva, L. L., & Crestani, C. C. (2021) · Cells · doi:10.3390/cells10051217 · Cited by 5
Prenatal Amphetamine-Induced Dopaminergic Alteration in a Gender- and Estrogen-Dependent Manner
Pennacchio, G. E., Santonja, F. E., Neira, F. J., Bregonzio, C., & Soaje, M. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03531-1 · Cited by 5
c-Fos and Zif268 in Learning and Memory—Studies on Expression and Function
Filipkowski, R. K., Knapska, E., & Kaczmarek, L. (2006) · Springer eBooks · doi:10.1007/978-0-387-33604-6_8 · Cited by 7
Adaptive gene regulation in wild mammals exposed to high predator abundance
Armenta, T. C., Cole, S. W., Wayne, R. K., & Blumstein, D. T. (2019) · Animal Behaviour · doi:10.1016/j.anbehav.2019.04.008 · Cited by 5
Interleukin-2 Gene Expression in Central Nervous System Cells after Stress and Antigen Application
Korneva, E. A., & Kazakova, T. B. (2008) · Neuroimmune biology · doi:10.1016/s1567-7443(07)10017-x · Cited by 5
Vardenafil Enhances Oxytocin Expression in the Paraventricular Nucleus without Sexual Stimulation
Shin, M. S., Ko, I. G., Sung, Y. H., Kim, S. E., Kim, B. K., Kim, C., Lee, S., Kim, D. H., Chang, J. H., & Kim, K. H. (2010) · International Neurourology Journal · doi:10.5213/inj.2010.14.4.213 · Cited by 5
Contusive spinal cord injury evokes localized changes in NADPH‐d activity but extensive changes in Fos‐like immunoreactivity in the rat
Allbutt, H. N., Siddall, P., & Keay, K. A. (2007) · Journal of Anatomy · doi:10.1111/j.1469-7580.2007.00765.x · Cited by 5
Stress Induced Expression of c-fos mRNA in the Brain by Experimental Occlusal Interference in Rats-Relationship with Stress-
Mushimoto, E., Kobayashi, T., Chiba, A., Tanaka, H., Uzuki, M., & Sawai, T. (2004) · Nihon Hotetsu Shika Gakkai Zasshi · doi:10.2186/jjps.48.173 · Cited by 5
NPY up-regulation in the tadpole brain of Euphlyctis cyanophlyctis during osmotic stress
Heigrujam, E., Ali, I., & Bhargava, S. (2017) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2017.01.015 · Cited by 5
Cholinergic stimulation in the lateral septal area activates anterior hypothalamic area neurons via excitatory amino acid receptors in rats
Hagiwara, Y., & Kubo, T. (2005) · Brain Research · doi:10.1016/j.brainres.2005.05.019 · Cited by 5
Odors and pheromones: influences of olfaction on behavior, physiology, and performance to reduce stress in pigs
Krebs, N. (2000) · ThinkTech (Texas Tech University) · Cited by 5
Selective loss of Nkx2.1 -lineage neurons in the lateral septum alters the balance between novelty seeking and threat avoidancePreprint
Garcίa, M. T., Tran, D. N., Peterson, R. E., Ibrahim, L. A., Reid, C. M., Hanson, S. M., Ren, Y., Dale-Huang, F., Xie, Y., Stegmann, S. K., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.24.559205 · Cited by 7
The impact of limited sucrose intake on perineuronal nets of parvalbumin interneurons in the basolateral amygdala: A potential role in stress resilience
Nashawi, H., Foltz, C. T., Smail, M. A., Buesing, D. R., Herman, J. P., & Ulrich‐Lai, Y. M. (2024) · Physiology & Behavior · doi:10.1016/j.physbeh.2024.114774 · Cited by 4
Self-citation
Neighborhood socioeconomic deprivation and individual-level socioeconomic status are associated with dopamine-mediated changes to monocyte subset CCR2 expression via a cAMP-dependent pathway
Baumer, Y., Pita, M. A., Turner, B. S., Baez, A. S., Ortiz-Whittingham, L. R., Gutierrez‐Huerta, C. A., Neally, S. J., Farmer, N. M., Mitchell, V. M., Collins, B. S., et al. (2023) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2023.100640 · Cited by 5
Intermittent environmental enrichment induces behavioral despair, while intermittent social isolation impairs spatial learning in rats
Akkaya, A., Aykan, D., Gencturk, S., & Ünal, G. (2025) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2025.174001 · Cited by 4
Multiplexed detection of nuclear immediate early gene expression reveals hippocampal neuronal subpopulations that engage in the acquisition and updating of spatial experience
Hoang, T., & Manahan‐Vaughan, D. (2025) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2025.1660536 · Cited by 4
Single-dose and chronic corticosterone treatment alters c-Fos or FosB immunoreactivity in the rat cerebral cortex
Szakács, R., Fazekas, I. G., Mihály, A., Krisztin‐Péva, B., Juhász, A., & Janka, Z. (2008) · Acta Histochemica · doi:10.1016/j.acthis.2008.10.001 · Cited by 4
Repeated asenapine treatment does not participate in the mild stress induced FosB/ΔFosB expression in the rat hypothalamic paraventricular nucleus neurons
Kiss, A., & Majerčíková, Z. (2016) · Neuropeptides · doi:10.1016/j.npep.2016.10.003 · Cited by 4
Restraint Stress-Induced Expression of Fos and Several Related Genes in the Hypothalamus of Hypertensive ISIAH Rats
Makovka, Y. V., Fedoseeva, L. A., Oshchepkov, D. Y., Markel, А. L., & Redina, O. E. (2024) · Molecular Biology · doi:10.1134/s0026893324010072 · Cited by 4
Mapping QTL for Multiple Traits
Xu, S. (2012) · Springer eBooks · doi:10.1007/978-0-387-70807-2_14 · Cited by 4
The neural pathway for lacrimal gland tear secretion in New Zealand White rabbits
Wang, J., Zhou, R., & Gao, W. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.04.012 · Cited by 4
Stress-induced brain activation: buffering role of social behavior and neuronal nicotinic receptors
Nosjean, A., de Chaumont, F., Olivo‐Marín, J., & Granon, S. (2018) · Brain Structure and Function · doi:10.1007/s00429-018-1745-7 · Cited by 7
Corticolimbic stress regulatory circuits, hypothalamo–pituitary–adrenocortical adaptation, and resilience
Herman, J. P. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813983-7.00019-7 · Cited by 4
Self-citation
Activation of c-fos expression in the rat inferior olivary nucleus by ghrelin
Zhang, W., Lin, T. R.-Y., Hu, Y., Fan, Y., Zhao, L., & Mulholland, M. W. (2003) · Neuroscience Letters · doi:10.1016/j.neulet.2003.08.083 · Cited by 4
Effects of acute diuresis stress on egr-1 (zif268) mRNA levels in brain regions associated with motivated behavior
Aher, C. V., Duwaerts, C. C., Akama, K. T., & Lucas, L. (2009) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2009.10.004 · Cited by 4
Fos oncoprotein expression in the rat forebrain following muscimol-induced absence seizures
Zhang, X., Salle, G. L. G. L., Ridoux, V., Yu, P. H., & Ju, G. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)12697-5 · Cited by 4
Progesterone's effect on gamete transport in the fallopian tube
Bylander, A. (2014) · Cited by 4
Punishment history biases corticothalamic responses to motivationally-significant stimuliPreprint
Lucantonio, F., Su, Z.-X., Chang, A. J., Bari, B. A., & Cohen, J. Y. (2020) · bioRxiv · doi:10.1101/2020.04.06.027888 · Cited by 5
Assessing adult zebrafish despair-like behaviors in the small vertical cylinder immobility test (VCIT)
Wang, J., Bley, V., Jiang, J., Zhang, Y., Qin, Y., Feng, H., Liu, Y., Li, R., Wang, C., He, S., et al. (2025) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2025.110569 · Cited by 3
Overt physiological responses and atypical behavior evoked in adult zebrafish in the novel tank test by two acute ‘survival’ stressors
Song, Y., Cui, J., Cai, H., Zhang, Y., Qin, Y., Zhou, Z., Feng, H., He, S., He, K., Liu, Y., et al. (2026) · Behavioural Processes · doi:10.1016/j.beproc.2026.105381 · Cited by 3
A projection from the medial prefrontal cortex to the lateral septum modulates coping behavior on the shock-probe test
Liu, J., Tabisola, K. M., & Morilak, D. A. (2025) · Neuropsychopharmacology · doi:10.1038/s41386-025-02074-7 · Cited by 3
Long-lasting expression of FosB/ΔFosB immunoreactivity following acute stress in the paraventricular and supraoptic nuclei of the rat hypothalamus
Uchida, K., Das, G., Talukder, A. H., Kageyama, K., & Itoi, K. (2025) · Neuroscience Research · doi:10.1016/j.neures.2025.104911 · Cited by 4
Pathways transmitter interactions mediating an integrated stress response
(2005) · Techniques in the behavioral and neural sciences · doi:10.1016/s0921-0709(05)80033-1 · Cited by 3
Astrocytes in the spinal cord contributed to acute stress-induced gastric damage via the gap junction protein CX43
Wang, Z., Shen, Y., Huang, C., Wang, Y., Zhang, X., Guo, F., Weng, R., Ma, X., & Sun, H. (2023) · Brain Research · doi:10.1016/j.brainres.2023.148395 · Cited by 3
Beating the Heat: A Lowland Tropical Lizard Expresses Heat Shock Protein Networks in Response to Acute Thermal Stress
Wuthrich, K. L., Chung, A. K. K., Rosso, A. A., McMillan, W. O., Logan, M. L., & Cox, C. L. (2025) · Integrative and Comparative Biology · doi:10.1093/icb/icaf057 · Cited by 3
Stress, Hypertension and Yoga
Wadikar, S. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.88147 · Cited by 3
Recombination Fraction
Xu, S. (2012) · Springer eBooks · doi:10.1007/978-0-387-70807-2_2 · Cited by 3
Early Maternal Separation and Chronic Variable Stress as Adults Differentially Affect Fos Expression in the Anterodorsal Thalami Nuclei
Rivarola, M. A., Dalmasso, C., Valdez, D. J., Vivas, L., & Suárez, M. M. (2008) · International Journal of Neuroscience · doi:10.1080/00207450701750430 · Cited by 3
Neurobiology of Stress and Risk for Relapse
Erb, S. M. (2007) · Elsevier eBooks · doi:10.1016/b978-012370632-4/50010-3 · Cited by 3
Neuroendocrinology of Behavioral Rhythms
Lee, T. M., & Smale, L. (2006) · Springer eBooks · doi:10.1007/978-0-387-30405-2_23 · Cited by 3
Conditioned Aversion and Neuroplasticity Induced by a Superagonist of Extrasynaptic GABAA Receptors: Correlation With Activation of the Oval BNST Neurons and CRF Mechanisms
de Miguel, E., Vekovischeva, O. Y., Elsilä, L. V., Panhelainen, A. E., Kankuri, E. M., Aitta‐aho, T., & Korpi, E. R. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00130 · Cited by 3
Differential expression of 10 genes in the hypothalamus of two generations of rats selected for a reaction to humans
Klimova, N. V., Чадаева, И. В., Shichevich, S. G., & Kozhemyakina, R. V. (2021) · Vavilov Journal of Genetics and Breeding · doi:10.18699/vj21.50-o · Cited by 4
The effect of novel kappa opioid peptide receptor agonists on learning and memory in rats
Welsh, S. A. (2017) · doi:10.26686/wgtn.17065427.v1 · Cited by 3
Distinct molecular mechanisms of stress habituation in the mouse hippocampusPreprint
Waag, R., von Ziegler, L., Sturman, O., Sonder, E., Leonardi, J., Frei, S., Gapp, K., Germain, P., & Bohacek, J. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.04.641433 · Cited by 3
Possible brain regions involved in parturition in mice
Wang, X., Zang, Y., Ma, Y., Li, J., Li, X., Li, Q., Liao, X., Chen, X., Han, J. Z., Zhao, X., et al. (2025) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00430.2024 · Cited by 2
Requisite role of dorsal raphé in contextual cocaine-memory reconsolidation
Ritchie, J. L., Qi, S., Christian, R. J., Greenwood, M. J., Grenz, H. I., Swatzell, S. E., Krych, P. J., & Fuchs, R. A. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109832 · Cited by 2
The Proteomics of Cocaine in the Nucleus Accumbens
Crofton, E. J., Zhang, Y., & Green, T. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803750-8.00018-x · Cited by 2
Chapter 8 Neuroendocrine Aspects of the Aging Brain
Wise, P. M., Herman, J. P., & Landfield, P. W. (1997) · Advances in cell aging and gerontology · doi:10.1016/s1566-3124(08)60058-9 · Cited by 2
Self-citation
ROLE OF LOCUS COERULEUS AND AMYGDALA PROJECTIONS TO VENTRAL SUBICULUM IN STRESS REGULATION
Lipski, W. J. (2011) · D-Scholarship@Pitt (University of Pittsburgh) · Cited by 2
Limbic Forebrain Modulation of Neuroendocrine Responses to Emotional Stress
Radley, J. J., Johnson, S. B., & Sawchenko, P. E. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-802175-0.00002-4 · Cited by 2
Early adolescent adversity alters periaqueductal gray/dorsal raphe threat responding in adult female rats
Moaddab, M., Wright, K. M., & McDannald, M. A. (2020) · Scientific Reports · doi:10.1038/s41598-020-74457-3 · Cited by 2
Social interaction following prepubertal stress alters prefrontal gene expression associated with cell signalling and oligodendrocytes
Moon, A. L., Clifton, N. E., Wellard, N., Thomas, K. L., Hall, J., & Brydges, N. M. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02280-7 · Cited by 2
Perinatal Asphyxia Exerts Lifelong Effects on Neuronal Responsiveness to Stress in Specific Brain Regions in the Rat
Salchner, P., Engidawork, E., Hoeger, H., Lubec, B., & Singewald, N. (2003) · Journal of Investigative Medicine · doi:10.1177/108155890305100516 · Cited by 2
Genome Scanning for Quantitative Trait Loci
Xu, S. (2012) · Springer eBooks · doi:10.1007/978-0-387-70807-2_8 · Cited by 2
The influence of open field exposure on neurons containing nitric oxide synthase in the basolateral complex and paracapsular intercalated nerve cells of the rat amygdala.
Ludkiewicz, B., Klejbor, I., Domaradzka-Pytel, B., Wojcik, S. P., Łuczyńska, A., Badowska‐Szalewska, E., Dziewíatkowski, J., & Moryś, J. (2004) · PubMed · Cited by 2
Glucocorticoids Regulate Kisspeptin Neurons during Stress and Contribute to Infertility and Obesity in Leptin-Deficient Mice
Wang, O. (2012) · Digital Access to Scholarship at Harvard (DASH) (Harvard University) · Cited by 2

Authors: Cullinan, W. E., Herman, J. P., Battaglia, D. F., Akil, H., & Watson, S. J.
Affiliations: University of Michigan (US)
University of Kentucky (US)
Corresponding author: Cullinan, W.E.
ORCID: Herman, J.P.
Akil, H.
Watson, S.J.
Venue: Neuroscience
Publisher: Elsevier BV
Published: 1995-01
Volume: 64
Issue: 2
Pages: 477-505
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/0306-4522(94)00355-9
OpenAlex: W2091497325
Cited by: 1,056
References: 94
Citations by year: 2026: 15 · 2025: 22 · 2024: 11 · 2023: 19 · 2022: 26 · 2021: 27 · 2020: 27 · 2019: 29 · 2018: 33 · 2017: 38 · 2016: 33 · 2015: 39 · 2014: 35 · 2013: 33 · 2012: 61
FWCI: 17.31
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (1k21da000265-01)
National Institute of Mental Health (MH49698)
National Institute on Drug Abuse (DA00265-12, DA 05452)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: acute stress, immediate early genes, c-fos, c-Jun, Zif268, swim stress, restraint stress, brain gene expression, hypothalamic-pituitary-adrenal axis, amygdala, periaqueductal gray, locus coeruleus
MeSH terms: Animals, Brain, Caudate Nucleus, DNA-Binding Proteins, Hippocampus, Male, Raphe Nuclei, Restraint, Physical, RNA, Messenger, Septal Nuclei, Stress, Psychological, Swimming, Time Factors, Transcription Factors, Gene Expression, Genes, jun, Genes, fos, Rats, Sprague-Dawley, Immediate-Early Proteins, Rats, Early Growth Response Protein 1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Pattern and time course of immediate early gene expression in rat brain following acute stress

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks