Stress‐induced activation of the immediate early gene Arc (activity‐regulated cytoskeleton‐associated protein) is restricted to telencephalic areas in the rat brain: relationship to c‐fos mRNA

Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites

Lyford, G. L., Yamagata, K., Kaufmann, W. E., Barnes, C. A., Sanders, L. K., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Lanahan, A. A., & Worley, P. F. (1995) · Neuron · doi:10.1016/0896-6273(95)90299-6 · Cited by 1,212 · see citing works

Pattern and time course of immediate early gene expression in rat brain following acute stress

Cullinan, W. E., Herman, J. P., Battaglia, D. F., Akil, H., & Watson, S. J. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00355-9 · Cited by 1,056 · see citing works

Inhibition of activity-dependent arc protein expression in the rat hippocampus impairs the maintenance of long-term potentiation and the consolidation of long-term memory

Guzowski, J. F., Lyford, G. L., Stevenson, G. D., Houston, F. P., McGaugh, J. L., Worley, P. F., & Barnes, C. A. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-11-03993.2000 · Cited by 992 · see citing works

A Complete Protocol for In Situ Hybridization of Messenger RNAs in Brain and Other Tissues With Radio-labeled Single-Stranded RNA Probes

Simmons, D. M., Arriza, J. L., & Swanson, L. W. (1989) · Journal of Histotechnology · doi:10.1179/his.1989.12.3.169 · Cited by 920 · see citing works

The hippocampus—what does it do?

Eichenbaum, H., Otto, T., & Cohen, N. J. (1992) · Behavioral and Neural Biology · doi:10.1016/0163-1047(92)90724-i · Cited by 867 · see citing works

Synaptic activation causes the mRNA for the IEG Arc to localize selectively near activated postsynaptic sites on dendrites.

Steward, O., Wallace, C. S., Lyford, G., & Worley, P. (1998) · Neuron · doi:10.1016/s0896-6273(00)80591-7 · Cited by 845 · see citing works

Invited review c-Fos as a transcription factor: a stressful (re)view from a functional map

Kovács, K. J. (1998) · Neurochemistry International · doi:10.1016/s0197-0186(98)00023-0 · Cited by 740 · see citing works

Somatodendritic expression of an immediate early gene is regulated by synaptic activity.

Link, W., Konietzko, U., Kauselmann, G., Krug, M., Schwanke, B., Frey, U., & Kuhl, D. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5734 · Cited by 706 · see citing works

Experience-Dependent Gene Expression in the Rat Hippocampus after Spatial Learning: A Comparison of the Immediate-Early Genes Arc , c- fos , and zif268

Guzowski, J. F., Setlow, B., Wagner, E. K., & McGaugh, J. L. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-14-05089.2001 · Cited by 700 · see citing works

Selective targeting of newly synthesized Arc mRNA to active synapses requires NMDA receptor activation.

Steward, O., & Worley, P. (2001) · Neuron · doi:10.1016/s0896-6273(01)00275-6 · Cited by 474 · see citing works

Neuroendocrine responses to an emotional stressor: evidence for involvement of the medial but not the central amygdala

Dayas, C. V., Buller, K. M., & Day, T. A. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00645.x · Cited by 303 · see citing works

Stress-induced expression of immediate early genes in the brain and peripheral organs of the rat

Senba, E., & Ueyama, T. (1997) · Neuroscience Research · doi:10.1016/s0168-0102(97)00095-3 · Cited by 249 · see citing works

Emotion: Systems, Cells, Synaptic Plasticity

Rogan, M. T., & LeDoux, J. E. (1996) · Cell · doi:10.1016/s0092-8674(00)81247-7 · Cited by 173 · see citing works

Activation of arc, a Putative “Effector” Immediate Early Gene, by Cocaine in Rat Brain

Fosnaugh, J. S., Bhat, R. V., Yamagata, K., Worley, P. F., & Baraban, J. M. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.64052377.x · Cited by 131 · see citing works

Effects of monoamine oxidase A inhibition on barrel formation in the mouse somatosensory cortex: Determination of a sensitive developmental period

Vitalis, T., Cases, O., Callebert, J., Launay, J., Price, D. J., Seif, I., & Gaspar, P. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19980406)393:2 · Cited by 129 · see citing works

Induction of c-fos mRNA in the brain and anterior pituitary gland by a novel environment.

Handa, R. J., Nunley, K. M., & Bollnow, M. R. (1993) · PubMed · Cited by 120 · see citing works

Evidence that a single exposure to aversive stimuli triggers long-lasting effects in the hypothalamus-pituitary-adrenal axis that consolidate with time

Martı́, O., García, A., Vellès, A., Harbuz, M. S., & Armario, A. (2001) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2001.01355.x · Cited by 114 · see citing works

Acquisition of a novel behavior induces higher levels of Arc mRNA than does overtrained performance

Kelly, M. P., & Deadwyler, S. A. (2002) · Neuroscience · doi:10.1016/s0306-4522(01)00605-4 · Cited by 114 · see citing works

Influence of single or repeated experience of rats with forced swimming on behavioural and physiological responses to the stressor

Dal-Zotto, S., Martı́, O., & Armario, A. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00220-5 · Cited by 113 · see citing works

Changes in c-fos mRNA expression in rat brain during odor discrimination learning: differential involvement of hippocampal subfields CA1 and CA3

Hess, U., LYNCH, G. S., & Gall, C. M. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-07-04786.1995 · Cited by 110 · see citing works

Upregulation of the immediate early gene arc in the brains of rats exposed to environmental enrichment: implications for molecular plasticity

Pinaud, R., Penner, M. R., Robertson, H. A., & Currie, R. W. (2001) · Molecular Brain Research · doi:10.1016/s0169-328x(01)00121-8 · Cited by 108 · see citing works

Distributed changes in c-Fos and c-Jun immunoreactivity in the rat brain associated with arousal and habituation to novelty

Papa, M., Pellicano, M., Welzl, H., & Sadile, A. G. (1993) · Brain Research Bulletin · doi:10.1016/0361-9230(93)90299-q · Cited by 107 · see citing works

Androgens selectively modulate c-Fos messenger RNA induction in the rat hippocampus following novelty

Kerr, J. E., Beck, S. G., & Handa, R. J. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00219-9 · Cited by 60 · see citing works

The ability of amphetamine to evoke arc (Arg 3.1) mRNA expression in the caudate, nucleus accumbens and neocortex is modulated by environmental context

Klebaur, J. E., Ostrander, M. M., Norton, C. S., Watson, S. J., Akil, H., & Robinson, T. E. (2002) · Brain Research · doi:10.1016/s0006-8993(01)03400-x · Cited by 50 · see citing works

Adrenal Stress Responses Following Septal Lesions in the Rat

Seggie, J. A., Uhlir, I., & Brown, G. M. (2008) · Neuroendocrinology · doi:10.1159/000122568 · Cited by 43 · see citing works

Evidence that a single exposure to aversive stimuli triggers long‐lasting effects in the hypothalamus‐pituitary‐adrenal axis that consolidate with time

Martı́, O., García, A., Vellès, A., et al. (2001) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2001.01355.x · Cited by 32 · see citing works

Responses of cells in catʼs area 17 to random dot patterns: influence of stimulus size

Casanova, C. (1993) · Neuroreport · doi:10.1097/00001756-199308000-00004 · Cited by 29 · see citing works

The Effect of Septal Lesions on the Threshold of Adrenal Stress Response

Uhlir, I., Seggie, J. A., & Brown, G. M. (2008) · Neuroendocrinology · doi:10.1159/000122279 · Cited by 22 · see citing works

Untitled work

(1999) · doi:10.1002/(sici)1097-4695(19990205)38:2

Group 1 mGluR-Dependent Synaptic Long-Term Depression: Mechanisms and Implications for Circuitry and Disease

Lüscher, C., & Huber, K. M. (2010) · Neuron · doi:10.1016/j.neuron.2010.01.016 · Cited by 627 · see citing works

Measurement of Immediate‐Early Gene Activation‐ <i>c‐fos</i> and Beyond

Kovács, K. J. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01734.x · Cited by 493 · see citing works

Rapid Translation of Arc/Arg3.1 Selectively Mediates mGluR-Dependent LTD through Persistent Increases in AMPAR Endocytosis Rate

Waung, M. W., Pfeiffer, B. E., Nosyreva, E. D., Ronesi, J. A., & Huber, K. M. (2008) · Neuron · doi:10.1016/j.neuron.2008.05.014 · Cited by 474 · see citing works

Increased Expression of the Immediate-Early Gene Arc/Arg3.1 Reduces AMPA Receptor-Mediated Synaptic Transmission

Verde, E. R., Lee‐Osbourne, J., Worley, P. F., Malinow, R., & Cline, H. T. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.031 · Cited by 403 · see citing works

AMPA receptors regulate transcription of the plasticity-related immediate-early gene Arc

Rao, V. R., Pintchovski, S. A., Chin, J., Peebles, C., Mitra, S. S., & Finkbeiner, S. M. (2006) · Nature Neuroscience · doi:10.1038/nn1708 · Cited by 188 · see citing works

Stress induces region specific alterations in microRNAs expression in mice

Rinaldi, A., Vincenti, S., Vito, F. D., Bozzoni, I., Oliverio, A., Presutti, C., Fragapane, P., & Mele, A. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.11.012 · Cited by 162 · see citing works

Competitive interactions between endogenous LTD and LTP in the hippocampus underlie the storage of emotional memories and stress‐induced amnesia

Diamond, D., Park, C. R., Campbell, A. M., & Woodson, J. C. (2005) · Hippocampus · doi:10.1002/hipo.20107 · Cited by 128 · see citing works

Preferential loss of dorsal-hippocampus synapses underlies memory impairments provoked by short, multimodal stress

Maras, P. M., Molet, J., Chen, Y., Rice, C., Ji, S. G., Solodkin, A., & Baram, T. Z. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.12 · Cited by 118 · see citing works

The role of neurotrophins in major depressive disorder

Jiang, C. S., & Salton, S. R. (2013) · Translational Neuroscience · doi:10.2478/s13380-013-0103-8 · Cited by 112 · see citing works

Cellular and molecular mechanisms of hippocampal activation by acute stress are age-dependent

Chen, Y., Fenoglio, K. A., Dubé, C. M., Grigoriadis, D. E., & Baram, T. Z. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001863 · Cited by 98 · see citing works

Claustrum mediates bidirectional and reversible control of stress-induced anxiety responses

Niu, M., Kasai, A., Tanuma, M., Seiriki, K., Igarashi, H., Kuwaki, T., Nagayasu, K., Miyaji, K., Ueno, H., Tanabe, W., et al. (2022) · Science Advances · doi:10.1126/sciadv.abi6375 · Cited by 93 · see citing works

Postnatal Serotonin Type 2 Receptor Blockade Prevents the Emergence of Anxiety Behavior, Dysregulated Stress-Induced Immediate Early Gene Responses, and Specific Transcriptional Changes that Arise Following Early Life Stress

Benekareddy, M., Vadodaria, K. C., Nair, A. R., & Vaidya, V. A. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.08.005 · Cited by 79 · see citing works

A critical evaluation of the activity-regulated cytoskeleton-associated protein (Arc/Arg3.1)'s putative role in regulating dendritic plasticity, cognitive processes, and mood in animal models of depression

Li, Y., Pehrson, A. L., Waller, J. A., Dale, E., Sánchez, C., & Gulinello, M. E. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00279 · Cited by 78 · see citing works

Regulation of markers of synaptic function in mouse models of depression: chronic mild stress and decreased expression of VGLUT1

Elizalde, N., Pastor, P. M., Garcia‐García, Á. L., Serres, F., Venzala, E., Huarte, J., Ramírez, M. J., Rı́o, J. D., Sharp, T., & Tordera, R. M. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06854.x · Cited by 76 · see citing works

High doses of the histone deacetylase inhibitor sodium butyrate trigger a stress-like response

Gagliano, H., Delgado-Morales, R., Sanz-Garcia, A., & Armario, A. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.10.031 · Cited by 76 · see citing works

The time course of systems consolidation of spatial memory from recent to remote retention: A comparison of the Immediate Early Genes Zif268, c-Fos and Arc

Barry, D. N., Coogan, A. N., & Commins, S. (2015) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2015.12.010 · Cited by 67 · see citing works

ABBA+BraiAn, an integrated suite for whole-brain mapping, reveals brain-wide differences in immediate-early genes induction upon learning

Chiaruttini, N., Castoldi, C., Requie, L. M., Camarena-Delgado, C., Bianco, B. D., Gräff, J., Seitz, A., & Silva, B. A. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115876 · Cited by 66 · see citing works

Chronic Stress Modulates Interneuronal Plasticity: Effects on PSA-NCAM and Perineuronal Nets in Cortical and Extracortical Regions

Pesarico, A. P., Bueno-Fernandez, C., Guirado, R., Gómez-Climent, M. Á., Curto, Y., Carceller, H., & Nacher, J. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00197 · Cited by 62 · see citing works

Social Defeat during Adolescence and Adulthood Differentially Induce BDNF-Regulated Immediate Early Genes

Coppens, C. M., Siripornmongcolchai, T., Wibrand, K., Alme, M. N., Buwalda, B., de Boer, S. F., Koolhaas, J. M., & Bramham, C. R. (2011) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2011.00072 · Cited by 61 · see citing works

Down-regulation of hippocampal BDNF and Arc associated with improvement in aversive spatial memory performance in socially isolated rats

Pisu, M. G., Dore, R., Mostallino, M. C., Loi, M., Pibiri, F., Mameli, R., Cadeddu, R., Secci, P. P., & Serra, M. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.03.021 · Cited by 60 · see citing works

The immediate early gene Arc is associated with behavioral resilience to stress exposure in an animal model of posttraumatic stress disorder

Kozlovsky, N., Matar, M. A., Kaplan, Z., Kotler, M., Zohar, J., & Cohen, H. (2007) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2007.04.009 · Cited by 56 · see citing works

Adaptation of the hypothalamus–pituitary–adrenal axis to daily repeated stress does not follow the rules of habituation: A new perspective

Rabasa, C., Gagliano, H., Pastor‐Ciurana, J., Fuentes, S., Belda, X., Nadal, R. A., & Armario, A. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.06.013 · Cited by 59 · see citing works

Immediate‐early gene response to repeated immobilization: Fos protein and arc mRNA levels appear to be less sensitive than c‐fos mRNA to adaptation

Ons, S., Rotllant, D., Marin‐Blasco, I., & Armario, A. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07242.x · Cited by 53 · see citing works

Neuronal NOS Inhibitor and Conventional Antidepressant Drugs Attenuate Stress-induced Fos Expression in Overlapping Brain Regions

Silva, M., de Aguiar, D. C., Diniz, C. R. A. F., Guimarães, F. S., & Joca, S. R. L. (2011) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-011-9775-1 · Cited by 52 · see citing works

Behavior in the elevated plus maze is differentially affected by testing conditions in rats under and over three weeks of age

Albani, S. H., Andrawis, M. M., Abella, R. J. H., Fulghum, J. T., Vafamand, N., & Dumas, T. C. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00031 · Cited by 50 · see citing works

Post-training disruption of Arc protein expression in the anterior cingulate cortex impairs long-term memory for inhibitory avoidance training

Holloway-Erickson, C. M., & McIntyre, C. K. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.02.002 · Cited by 48 · see citing works

Effects of voluntary ethanol consumption on emotional state and stress responsiveness in socially isolated rats

Pisu, M. G., Mostallino, M. C., Dore, R., Maciocco, E., Secci, P. P., & Serra, M. (2010) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2010.07.006 · Cited by 46 · see citing works

Maternal neglect with reduced depressive-like behavior and blunted c-fos activation in Brattleboro mothers, the role of central vasopressin

Fodor, A., Klausz, B., Pintér, O., Daviu, N., Rabasa, C., Rotllant, D., Balázsfi, D., Kovács, K., Nadal, R. A., & Zelena, D. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.09.003 · Cited by 46 · see citing works

Induction of the plasticity-associated immediate early gene Arc by stress and hallucinogens: role of brain-derived neurotrophic factor

Benekareddy, M., Nair, A. R., Dias, B. G., Suri, D., Autry, A. E., Monteggia, L. M., & Vaidya, V. A. (2012) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145712000168 · Cited by 45 · see citing works

The Yin and Yang of Memory Consolidation: Hippocampal and Neocortical

Genzel, L., Rossato, J. I., Jacobse, J., Grieves, R. M., Spooner, P. A., Battaglia, F. P., Fernández, G., & Morris, R. (2017) · PLoS Biology · doi:10.1371/journal.pbio.2000531 · Cited by 43 · see citing works

Mice lacking adenylyl cyclase‐5 cope badly with repeated restraint stress

Kim, K., & Han, P. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22119 · Cited by 42 · see citing works

Cell-nonautonomous local and systemic responses to cell arrest enable long-bone catch-up growth in developing mice

Roselló‐Díez, A., Madisen, L., Bastide, S., Zeng, H., & Joyner, A. L. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2005086 · Cited by 42 · see citing works

LTP‐ and LTD‐inducing stimulations cause opposite changes in arc/arg3.1 mRNA level in hippocampal area CA1 in vivo

Yilmaz, E., Miyamae, T., Braun, A. E., & Thiels, E. (2010) · Hippocampus · doi:10.1002/hipo.20838 · Cited by 41 · see citing works

Fluorescent Arc/Arg3.1 indicator mice: A versatile tool to study brain activity changes in vitro and in vivo

Grinevich, V., Kolleker, A., Eliava, M., Takada, N., Takuma, H., Fukazawa, Y., Shigemoto, R., Kuhl, D., Waters, J., Seeburg, P. H., et al. (2009) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2009.07.015 · Cited by 39 · see citing works

Effects of stress and adrenalectomy on activity-regulated cytoskeleton protein (Arc) gene expression

Mikkelsen, J. D., & Larsen, M. H. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.04.040 · Cited by 39 · see citing works

Depressive- and anxiety-like behaviors and stress-related neuronal activation in vasopressin-deficient female Brattleboro rats

Fodor, A., Kovács, K., Balázsfi, D., Klausz, B., Pintér, O., Demeter, K., Daviu, N., Rabasa, C., Rotllant, D., Nadal, R. A., et al. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.02.041 · Cited by 38 · see citing works

Activity‐regulated cytoskeleton‐associated protein (Arc/Arg3.1) regulates anxiety‐ and novelty‐related behaviors

Penrod, R. D., Kumar, J., Smith, L. N., McCalley, D. M., Nentwig, T. B., Hughes, B. W., Barry, G. M., Glover, K., Taniguchi, M., & Cowan, C. W. (2019) · Genes Brain & Behavior · doi:10.1111/gbb.12561 · Cited by 37 · see citing works

REM sleep deprivation attenuates actin-binding protein cortactin: A link between sleep and hippocampal plasticity

Davis, C. J., Meighan, P. C., Taishi, P., Krueger, J. M., Harding, J. W., & Wright, J. W. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.02.046 · Cited by 36 · see citing works

TPH2 Deficiency Influences Neuroplastic Mechanisms and Alters the Response to an Acute Stress in a Sex Specific Manner

Brivio, P., Sbrini, G., Peeva, P., Todiraş, M., Bäder, M., Alenina, N. V., & Calabrese, F. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00389 · Cited by 34 · see citing works

Cholinergic involvement in the cortical and hippocampal Fos expression induced in the rat by placement in a novel environment

Wirtshafter, D. (2005) · Brain Research · doi:10.1016/j.brainres.2005.05.052 · Cited by 33 · see citing works

Brain c-fos expression patterns induced by emotional stressors differing in nature and intensity

Úbeda-Contreras, J., Marin‐Blasco, I., Nadal, R. A., & Armario, A. (2018) · Brain Structure and Function · doi:10.1007/s00429-018-1624-2 · Cited by 31 · see citing works

Basal and stress-induced modulation of activity-regulated cytoskeletal associated protein (Arc) in the rat brain following duloxetine treatment

Molteni, R., Calabrese, F., Mancini, M., Racagni, G., & Riva, M. A. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1276-7 · Cited by 31 · see citing works

Long‐term effects of a single exposure to immobilization: A C‐fos mRNA study of the response to the homotypic stressor in the rat brain

Vallès, A., Martı́, O., & Armario, A. (2006) · Journal of Neurobiology · doi:10.1002/neu.20252 · Cited by 31 · see citing works

Differential effects of stress and amphetamine administration on Fos‐like protein expression in corticotropin releasing factor‐neurons of the rat brain

Rotllant, D., Nadal, R. A., & Armario, A. (2007) · Developmental Neurobiology · doi:10.1002/dneu.20345 · Cited by 30 · see citing works

Chronic Stress Alters Behavior in the Forced Swim Test and Underlying Neural Activity in Animals Exposed to Alcohol Prenatally: Sex- and Time-Dependent Effects

Lam, V. Y. Y., Raineki, C., Takeuchi, L. E., Ellis, L. A., Woodward, T. S., & Weinberg, J. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00042 · Cited by 29 · see citing works

Mu opioid receptors in the medial preoptic area govern social play behavior in adolescent male rats

Zhao, C., Chang, L., Auger, A. P., Gammie, S. C., & Riters, L. V. (2020) · Genes Brain & Behavior · doi:10.1111/gbb.12662 · Cited by 28 · see citing works

Memory-enhancing intra-basolateral amygdala infusions of clenbuterol increase Arc and CaMKIIα protein expression in the rostral anterior cingulate cortex

Holloway-Erickson, C. M., McReynolds, J. R., & McIntyre, C. K. (2012) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2012.00017 · Cited by 26 · see citing works

Effects of chronic ethanol consumption on the expression of GLT-1 and neuroplasticity-related proteins in the nucleus accumbens of alcohol-preferring rats

Alhaddad, H., Alasmari, F. F., Alhamadani, B., Wong, W., Bell, R. L., & Sari, Y. (2020) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2020.10.012 · Cited by 24 · see citing works

The activity-regulated cytoskeleton-associated protein, Arc/Arg3.1, influences mouse cocaine self-administration

Penrod, R. D., Thomsen, M., Taniguchi, M., Guo, Y., Cowan, C. W., & Smith, L. N. (2019) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2019.172818 · Cited by 24 · see citing works

Differences in the brain expression of c-fos mRNA after restraint stress in Lewis compared to Sprague–Dawley rats

Trnečková, L., Armario, A., Hynie, S., Šı́da, P., & Klenerová, V. (2006) · Brain Research · doi:10.1016/j.brainres.2006.01.029 · Cited by 24 · see citing works

Enduring Effects of Early Life Stress on Firing Patterns of Hippocampal and Thalamocortical Neurons in Rats: Implications for Limbic Epilepsy

Ali, I. Y., O’Brien, P., Kumar, G., Zheng, T. W., Jones, N. C., Pinault, D., French, C. R., Morris, M. J., Salzberg, M. R., & O'Brien, T. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066962 · Cited by 23 · see citing works

PACAP increases Arc/Arg 3.1 expression within the extended amygdala after fear conditioning in rats

Meloni, E. G., Kaye, K. T., Venkataraman, A., & Carlezon, W. A. (2018) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.11.011 · Cited by 21 · see citing works

Dynamics of immediate early gene and neuropeptide gene response to prolonged immobilization stress: evidence against a critical role of the termination of exposure to the stressor

Trnečková, L., Rotllant, D., Klenerová, V., Hynie, S., & Armario, A. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04278.x · Cited by 22 · see citing works

Peripheral Serotonin Deficiency Affects Anxiety-like Behavior and the Molecular Response to an Acute Challenge in Rats

Sbrini, G., Hanswijk, S. I., Brivio, P., Middelman, A., Bäder, M., Fumagalli, F., Alenina, N. V., Homberg, J. R., & Calabrese, F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094941 · Cited by 20 · see citing works

Changes in NGF/c-Fos double staining in the structures of the limbic system in juvenile and aged rats exposed to forced swim test

Badowska‐Szalewska, E., Klejbor, I., Cecot, T., Spodnik, J. H., & Moryś, J. (2009) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2009-1756 · Cited by 21 · see citing works

Activity-dependent structural plasticity after aversive experiences in amygdala and auditory cortex pyramidal neurons

Gruene, T. M., Flick, K., Rendall, S., Cho, J. H., Gray, J. M., & Shansky, R. M. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.04.045 · Cited by 18 · see citing works

ARC and BDNF expression after cocaine self‐administration or cue‐induced reinstatement of cocaine seeking in adolescent and adult male rats

Li, C., White, A. C., Schochet, T. L., McGinty, J. F., & Frantz, K. J. (2018) · Addiction Biology · doi:10.1111/adb.12689 · Cited by 17 · see citing works

Elucidation of the neural circuits activated by a GABAB receptor positive modulator: Relevance to anxiety

Pizzo, R., O’Leary, O. F., & Cryan, J. F. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.07.021 · Cited by 17 · see citing works

Modulation of neuroplasticity-related targets following stress-induced acute escape deficit

Benatti, C., Radighieri, G., Alboni, S., Blom, J. M. C., Brunello, N., & Tascedda, F. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.02.023 · Cited by 17 · see citing works

Bioluminescence imaging of Arc expression enables detection of activity-dependent and plastic changes in the visual cortex of adult mice

Izumi, H., Ishimoto, T., Yamamoto, H., Nishijo, H., & Mori, H. (2010) · Brain Structure and Function · doi:10.1007/s00429-010-0297-2 · Cited by 17 · see citing works

Acute Chemogenetic Activation of CamKIIα-Positive Forebrain Excitatory Neurons Regulates Anxiety-Like Behaviour in Mice

Salvi, S. S., Pati, S., Chaudhari, P. R., Tiwari, P., Banerjee, T., & Vaidya, V. A. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00249 · Cited by 16 · see citing works

Adaptation of the pituitary-adrenal axis to daily repeated forced swim exposure in rats is dependent on the temperature of water

Rabasa, C., Delgado‐Morales, R., Gómez-Román, A., Nadal, R. A., & Armario, A. (2013) · Stress · doi:10.3109/10253890.2013.824964 · Cited by 16 · see citing works

The Contribution of Immediate Early Genes to the Understanding of Brain Processing of Stressors

Armario, A. (2006) · Springer eBooks · doi:10.1007/978-0-387-33604-6_11 · Cited by 16 · see citing works

Finger release sequence for fastball and curveball pitches.

Stevenson, J. M. (1985) · PubMed · Cited by 16 · see citing works

Transcription Factors as Important Regulators of Changes in Behavior through Domestication of Gray Rats: Quantitative Data from RNA Sequencing

Oshchepkov, D. Y., Витальевна, Ч. И., Kozhemyakina, R. V., Шихевич, С. Г., Sharypova, E. B., Savinkova, L. K., Klimova, N. V., Tsukanov, A. V., Levitsky, V. G., & Markel, А. L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012269 · Cited by 15 · see citing works

The development of compulsive coping behaviour is associated with a downregulation of Arc in a Locus Coeruleus neuronal ensemble

Velázquez-Sánchez, C., Mureşan, L., Martí‐Prats, L., & Belin, D. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-022-01522-y · Cited by 15 · see citing works

Novelty-induced activity-regulated cytoskeletal-associated protein (Arc) expression in frontal cortex requires serotonin 2A receptor activation

Santini, M. A., Klein, A. B., El-Sayed, M., Ratner, C., Knudsen, G. M., Mikkelsen, J. D., & Aznar, S. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.05.048 · Cited by 15 · see citing works

Immediate-early gene expression in the barrel cortex

Staiger, J. F. (2006) · Somatosensory & Motor Research · doi:10.1080/08990220601045411 · Cited by 15 · see citing works

The time course of activity-regulated cytoskeletal (ARC) gene and protein expression in the whisker-barrel circuit using two paradigms of whisker stimulation

Khodadad, A., Adelson, P. D., Lifshitz, J., & Thomas, T. C. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.01.032 · Cited by 14 · see citing works

Microarray profiling of gene expression patterns in adult male rat brain following acute progesterone treatment

Auger, C. J., Jessen, H. M., & Auger, A. P. (2005) · Brain Research · doi:10.1016/j.brainres.2005.10.033 · Cited by 14 · see citing works

Social Fear Affects Limbic System Neuronal Activity and Gene Expression

Hamann, C. S., Bankmann, J., Maza, H. M., Kornhuber, J., Zoicas, I., & Schmitt-Böhrer, A. G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158228 · Cited by 13 · see citing works

Epigallocatechin-3-gallate alleviates gestational stress-induced postpartum anxiety and depression-like behaviors in mice by downregulating semaphorin3A and promoting GSK3β phosphorylation in the hippocampus

Xu, F., Wu, H., Xie, L., Chen, Q., Xu, Q., Sun, L., Li, H., Xie, J., & Chen, X. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.1109458 · Cited by 13 · see citing works

A novel control condition for spatial learning in the Morris water maze

Barry, D. N., & Commins, S. (2019) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2019.02.015 · Cited by 13 · see citing works

SUMOylation and Major Depressive Disorder

Jeoung, S.-W., Park, H.-S., Ryoo, Z. Y., Cho, D., Lee, H., & Ryu, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23148023 · Cited by 14 · see citing works

Enhanced Stress Response in 5-HT1AR Overexpressing Mice: Altered HPA Function and Hippocampal Long-Term Potentiation

Pilar-Cuéllar, F., Vidal, R., Díaz, Á., Garro-Martínez, E., Linge, R., Castro, E., Haberzettl, R., Fink, H., Bert, B., Brosda, J., et al. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00156 · Cited by 13 · see citing works

Sleep Leads to Brain-Wide Neural Changes Independent of Allocentric and Egocentric Spatial Training in Humans and Rats

Samanta, A., van Rongen, L. S., Rossato, J. I., Jacobse, J., Schoenfeld, R., & Genzel, L. (2021) · Cerebral Cortex · doi:10.1093/cercor/bhab135 · Cited by 15 · see citing works

Somatic Arc protein expression in hippocampal granule cells is increased in response to environmental change but independent of task-specific learning

Cleland, J., Willis, E. F., Bartlett, P. F., & Vukovic, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-12583-1 · Cited by 11 · see citing works

Sex Differences in Brain Region-Specific Activation of c-Fos following Kappa Opioid Receptor Stimulation or Acute Stress in Mice

Ma, Q., Wonnacott, S., Bailey, S., & Bailey, C. P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015098 · Cited by 10 · see citing works

The mGluR5‐mediated Arc activation protects against experimental traumatic brain injury in rats

Chen, T., Li, Y.-F., Ren, X., & Wang, Y.-H. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14695 · Cited by 8 · see citing works

Stress and cocaine interact to modulate Arc/Arg3.1 expression in rat brain

Caffino, L., Racagni, G., & Fumagalli, F. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2331-3 · Cited by 9 · see citing works

Critical involvement of the orbitofrontal cortex in hyperlocomotion induced by NMDA receptor blockade in mice

Seiriki, K., Kasai, A., Kuwaki, T., Nakazawa, T., Yamaguchi, S., & Hashimoto, H. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.10.089 · Cited by 9 · see citing works

Activation of immediate early genes by nicotine after chronic neonatal nicotine exposure in brain areas involved in stress and anxiety responses

Halawa, A. A., Damborsky, J. C., Slaton, G. S., & Winzer‐Serhan, U. H. (2018) · Brain Research · doi:10.1016/j.brainres.2018.02.027 · Cited by 9 · see citing works

Neuronal Activation After Prolonged Immobilization: Do the Same or Different Neurons Respond to a Novel Stressor?

Marin‐Blasco, I., Muñoz-Abellán, C., Andero, R., Nadal, R. A., & Armario, A. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx035 · Cited by 8 · see citing works

Combinative Protein Expression of Immediate Early Genes c‐Fos, Arc, and Npas4 Along Aversive and Appetitive Experience‐Related Neural Networks

Arai, M., Osanai, H., Snell, C. C., Gawf, K. E., 北村, 貴., & Ogawa, S. K. (2025) · Hippocampus · doi:10.1002/hipo.70030 · Cited by 7 · see citing works

Structural characterization of two nanobodies targeting the ligand-binding pocket of human Arc

Muñoz, J. M. G., Neset, L., Markússon, S., Weber, S., Krokengen, O. C., Sutinen, A., Christakou, E., López, A. J., Bramham, C. R., & Kursula, P. (2024) · PLoS ONE · doi:10.1371/journal.pone.0300453 · Cited by 7 · see citing works

Blockade of α2-adrenoceptors induces Arc gene expression in rat brain in a glutamate receptor-dependent manner: A combined qPCR, in situ hybridisation and immunocytochemistry study

Serres, F., Rodriguez, M., Rivet, J., Galizzi, J., Lockhart, B. P., Sharp, T., & Millan, M. J. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.06.068 · Cited by 7 · see citing works

Analyses of fear memory in Arc/Arg3.1-deficient mice: intact short-term memory and impaired long-term and remote memory

Yamada, K., Homma, C., Tanemura, K., Ikeda, T., Itohara, S., & Nagaoka, Y. (2011) · World Journal of Neuroscience · doi:10.4236/wjns.2011.11001 · Cited by 7 · see citing works

Rotation and immediate-early gene expression in rats treated with the atypical D1 dopamine agonist SKF 83822

Wirtshafter, D. (2007) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2007.01.011 · Cited by 7 · see citing works

Stress‐induced brain histone H3 phosphorylation: contribution of the intensity of stressors and length of exposure

Rotllant, D., Pastor‐Ciurana, J., & Armario, A. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12214 · Cited by 5 · see citing works

Neuroprotective roles of neurotrophic growth factors in mood disorders

Jiang, C., & Salton, S. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-814037-6.00010-0 · Cited by 5 · see citing works

Characterization of the plasticity‐related gene, Arc, in the frog brain

Mangiamele, L. A., Thomson, C. J., Lebonville, C. L., & Burmeister, S. S. (2010) · Developmental Neurobiology · doi:10.1002/dneu.20817 · Cited by 4 · see citing works

Motor skill learning enhances the expression of activity-regulated cytoskeleton-associated protein in the rat cerebellum

Wang, D., Lin, Y.-Y., Chen, T., & Lin, H. (2014) · Journal of Comparative Physiology A · doi:10.1007/s00359-014-0942-y · Cited by 4 · see citing works

Cyclosomatostatin-induced catalepsy in aged rats: Specific change of brain c-Fos protein expression in the lateral entorhinal cortex

Ionov, I. D., Pushinskaya, I. I., Gorev, N. P., & Frenkel, D. D. (2020) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2020.03.013 · Cited by 4 · see citing works

Cell-nonautonomous local and systemic responses to cell arrest enable long-bone catch-up growth in developing micePreprint

Roselló‐Díez, A., Madisen, L., Bastide, S., Zeng, H., & Joyner, A. L. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/218487 · Cited by 3 · see citing works

Newly Generated Cells in the Dentate Gyrus Differentially Respond to Brief Spatial Exploration and Forced Swim in Adult Female Balb/C Mice

Ramírez-Rodríguez, G. B., Ocaña-Fernández, M. D. Á., & Ortíz‐López, L. (2018) · Neural Plasticity · doi:10.1155/2018/4960869 · Cited by 2 · see citing works

Combinative protein expression of immediate early genes c-Fos, Arc, and Npas4 along aversive- and reward-related neural networksPreprint

Arai, M., Osanai, H., Snell, C. C., 北村, 貴., & Ogawa, S. K. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.21.649441 · Cited by 2 · see citing works

Molecular genetic investigation of dental attrition in mice

Tatsumi, C., & Okamoto, K. (2013) · Pediatric Dental Journal · doi:10.1016/j.pdj.2013.03.004 · Cited by 1 · see citing works

Changes in NGF/c-Fos colocalization in specific limbic structures of juvenile and aged rats after open field stimulation.

Badowska‐Szalewska, E., Klejbor, I., Cecot, T., Domaradzka-Pytel, B., Ludkiewicz, B., & Moryś, J. (2009) · PubMed · Cited by 1 · see citing works

Methods and Approaches to Understand Stress Processing Circuitry

Herman, J. P., & Myers, B. (2015) · Wiley eBooks · doi:10.1002/9781118921692.ch1 · Cited by 1 · see citing works

Consequences of prenatal ethanol exposure and maternal stress on offspring

Staples, M. C. (2013) · UNM’s Digital Repository (University of New Mexico)

Immediate‐early gene response to repeated immobilization: Fos protein and arc mRNA levels appear to be less sensitive than c‐fos mRNA to adaptation

Ons, S., Rotllant, D., Marin‐Blasco, I., & Armario, A. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07242.x · Cited by 53 · see citing works

Pattern and time course of immediate early gene expression in rat brain following acute stress

Cullinan, W. E., Herman, J. P., Battaglia, D. F., Akil, H., & Watson, S. J. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00355-9 · Cited by 1,056 · see citing works

The immediate early gene Arc is associated with behavioral resilience to stress exposure in an animal model of posttraumatic stress disorder

Kozlovsky, N., Matar, M. A., Kaplan, Z., Kotler, M., Zohar, J., & Cohen, H. (2007) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2007.04.009 · Cited by 56 · see citing works

The Contribution of Immediate Early Genes to the Understanding of Brain Processing of Stressors

Armario, A. (2006) · Springer eBooks · doi:10.1007/978-0-387-33604-6_11 · Cited by 16 · see citing works

Effects of stress and adrenalectomy on activity-regulated cytoskeleton protein (Arc) gene expression

Mikkelsen, J. D., & Larsen, M. H. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.04.040 · Cited by 39 · see citing works