Cited by 1,056Stress Responses and CortisolMemory and Neural MechanismsNeuropeptides and Animal Physiology

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Pattern and time course of immediate early gene expression in rat brain following acute stress

Cullinan, W.E., Herman, J.P., Battaglia, D.F., Akil, H., Watson, S.J.·1995·Neuroscience

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Abstract

The pattern and time course of brain activation in response to acute swim and restraint stress were examined in the rat by in situ hybridization using complementary RNA probes specific for transcripts encoding the products of the immediate early genes c-fos, c-jun and zif/268. A widespread pattern of c-fos messenger RNA expression was detected in response to these stressors; surprisingly, the expression patterns were substantially similar following both swim and restraint stress. A dramatic induction of c-fos messenger RNA was observed in numerous neo- and allocortical regions, the lateral septal nucleus, the hypothalamic paraventricular and dorsomedial nuclei, the anterior hypothalamic area, the lateral portion of the retrochiasmatic area, the medial and cortical amygdaloid nuclei, the periaqueductal gray, and the locus coeruleus; however, a prominent induction of c-fos was also seen in numerous additional subcortical and brainstem regions. Although not as widely expressed in response to stress as c-fos, induction of zif/268 messenger RNA was also detected throughout many brain areas; these regions were largely similar to those in which c-fos was induced, although in a number of regions zif/268 was expressed in regions devoid of c-fos messenger RNA. Few brain areas showed increased expression of c-jun following stress; these regions also showed induction of c-fos and/or zif/268. The time courses of expression of all three immediate early genes were similar, with peak levels observed at the 30 or 60 min time point, and a markedly reduced signal evident at 120 min post-stress. However, in a number of cases a delayed and/or prolonged induction was noted that may be indicative of secondary neuronal activation. A number of recent studies have attempted to define neural pathways which convey stress-related information to the hypothalamic-pituitary-adrenal axis. The present results reveal a widespread pattern of neuronal activation in response to acute swim or restraint stress. These findings may aid in the identification of stress-specific neural circuits and are thus likely to have important implications for our understanding of neuronal regulation of the stress response.

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The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
Handbook of Chemical Neuroanatomy
Stern, C. D. (1986) · Neurochemistry International · doi:10.1016/0197-0186(86)90021-5 · Cited by 4,160
Two receptor systems for corticosterone in rat brain: Microdistribution and differential occupation
REUL, J. M. H. M., & KLOET, E. R. D. (1985) · Endocrinology · doi:10.1210/endo-117-6-2505 · Cited by 2,580
The regulation and function of c-fos and other immediate early genes in the nervous system
Sheng, M., & Greenberg, M. E. (1990) · Neuron · doi:10.1016/0896-6273(90)90106-p · Cited by 2,432
Induction of c-fos-like protein in spinal cord neurons following sensory stimulation
Hunt, S. P., Pini, A., & Evan, G. I. (1987) · Nature · doi:10.1038/328632a0 · Cited by 1,986
Expression of c- fos Protein in Brain: Metabolic Mapping at the Cellular Level
Sagar, S. M., Sharp, F. R., & Curran, T. (1988) · Science · doi:10.1126/science.3131879 · Cited by 1,925
Nucleus locus ceruleus: new evidence of anatomical and physiological specificity
Foote, S. L., Bloom, F. E., & Aston-Jones, G. (1983) · Physiological Reviews · doi:10.1152/physrev.1983.63.3.844 · Cited by 1,901
Mapping Patterns of c- fos Expression in the Central Nervous System After Seizure
Morgan, J. I., Cohén, D., Hempstead, J. L., & Curran, T. (1987) · Science · doi:10.1126/science.3037702 · Cited by 1,786
The role of the medial prefrontal cortex (cingulate gyrus) in the regulation of hypothalamic-pituitary-adrenal responses to stress
Diorio, D., Viau, V, & Meaney, M. (1993) · The Journal of Neuroscience · doi:10.1523/jneurosci.13-09-03839.1993 · Cited by 1,151
The melanin‐concentrating hormone system of the rat brain: An immuno‐ and hybridization histochemical characterization
Bittencourt, J. C., Presse, F., Arias, C. M., Peto, C. A., Vaughan, J. M., Nahon, J., Vale, W., & Sawchenko, P. E. (1992) · The Journal of Comparative Neurology · doi:10.1002/cne.903190204 · Cited by 1,075

Show all 94 references

Research works printed but not linked: 2

Baker, 1993, Neurotransmitter-specific neurons that project from the arcuate nucleus to the paraventricular hypothalamic nucleus: effect of adrenalectomy, Soc. Neurosci. Abstr., 19, 762
Ferraguti, 1990, Distribution of glutamic acid decar☐ylase messenger RNA-containing nerve cell populations in the male rat brain, J. chem. Neuroanat., 3, 337

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SHARMA, H. S. (2004) · Elsevier eBooks · doi:10.1016/b978-012639011-7/50019-x · Cited by 55
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Linthorst, A. C. E., Flachskamm, C., & Reul, J. M. H. M. (2008) · Stress · doi:10.1080/10253890701533231 · Cited by 53
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Authors: Cullinan, W. E., Herman, J. P., Battaglia, D. F., Akil, H., & Watson, S. J.
Affiliations: University of Michigan (US)
University of Kentucky (US)
Corresponding author: Cullinan, W.E.
ORCID: Herman, J.P.
Akil, H.
Watson, S.J.
Venue: Neuroscience
Publisher: Elsevier BV
Published: 1995-01
Volume: 64
Issue: 2
Pages: 477-505
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/0306-4522(94)00355-9
OpenAlex: W2091497325
Cited by: 1,056
References: 94
Citations by year: 2026: 15 · 2025: 22 · 2024: 11 · 2023: 19 · 2022: 26 · 2021: 27 · 2020: 27 · 2019: 29 · 2018: 33 · 2017: 38 · 2016: 33 · 2015: 39 · 2014: 35 · 2013: 33 · 2012: 61
FWCI: 17.31
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (1k21da000265-01)
National Institute of Mental Health (MH49698)
National Institute on Drug Abuse (DA00265-12, DA 05452)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: acute stress, immediate early genes, c-fos, c-Jun, Zif268, swim stress, restraint stress, brain gene expression, hypothalamic-pituitary-adrenal axis, amygdala, periaqueductal gray, locus coeruleus
MeSH terms: Animals, Brain, Caudate Nucleus, DNA-Binding Proteins, Hippocampus, Male, Raphe Nuclei, Restraint, Physical, RNA, Messenger, Septal Nuclei, Stress, Psychological, Swimming, Time Factors, Transcription Factors, Gene Expression, Genes, jun, Genes, fos, Rats, Sprague-Dawley, Immediate-Early Proteins, Rats, Early Growth Response Protein 1

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Pattern and time course of immediate early gene expression in rat brain following acute stress

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