The mediodorsal nucleus of the thalamus in rats: II. Behavioral and neurochemical effects of GABA agonists
Abstract
The aim of this study was to determine how GABA receptors in the mediodorsal nucleus of the thalamus in rats might contribute to the regulation of locomotor behavior. Microinjections of the GABAB and GABAA agonists, baclofen and muscimol, into the mediodorsal nucleus produced dose-dependent increases in locomotion that were blocked by co-administration of the GABAB antagonist, 2-hydroxysaclofen. Microinjection of baclofen along the midline, lateral into the ventrolateral thalamus or into the lateral ventricles produced significantly smaller dose-dependent increases in locomotion, indicating that the anatomical locus for baclofen-induced locomotion resides in the mediodorsal nucleus. The motor response elicited by microinjected baclofen was associated with a reduction in dopamine metabolism in the prefrontal cortex and an increase in metabolism in the core of the nucleus accumbens, but not in the accumbal shell or the dorsolateral striatum. These results suggest that GABAergic afferents to the mediodorsal nucleus may oppose a tonic inhibitory tone on locomotor activity. The data also suggest that the motor response produced by baclofen in the mediodorsal thalamus may arise by inhibiting the projections to the prefrontal cortex which modulate mesocorticolimbic dopamine transmission.
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Microinjections of the GABA receptor agonists muscimol or baclofen into the mediodorsal thalamic nucleus elicit locomotion in rats.
“In addition, microinjections of GABA receptor agonists muscimol or baclofen into the mediodorsal thalamic nucleus elicit locomotion in rats (Churchill et al., 1996).”
From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Churchill et al., 1996
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- Authors
- Churchill, L., Zahm, D. S., Duffy, P., & Kalivas, P. W.
- Affiliations
- Washington State University (US)
- Saint Louis University (US)
- Corresponding author
- Churchill, L.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 1996-01
- Volume
- 70
- Issue
- 1
- Pages
- 103-112
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W1991194251
- Cited by
- 50
- References
- 64
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 2 · 2017: 1 · 2016: 2 · 2015: 2 · 2012: 4
- FWCI
- 0.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R01MH040817, MH-40817)
- National Institute on Drug Abuse (DA03906, DA-00158)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- mediodorsal nucleus, thalamus, GABA receptors, baclofen, muscimol, locomotor behavior, GABA-B receptor agonist, GABA-A receptor agonists, 2-hydroxysaclofen, dopamine metabolism, prefrontal cortex, nucleus accumbens, GABAergic afferents, tonic inhibition
- MeSH terms
- Animals, Baclofen, Behavior, Animal, Dose-Response Relationship, Drug, Locomotion, Male, Muscimol, Thalamus, Rats, Sprague-Dawley, Rats
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