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Organization of the output of the ventral striatopallidal system in the rat: ventral pallidal efferents

Groenewegen, H.J., Berendse, H.W., Haber, S.N.·1993·Neuroscience
DOI 10.1016/0306-4522(93)90115-v
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Abstract

The efferent projections of the ventral pallidum in the rat were studied using anterograde tracing of Phaseolus vulgaris-leucoagglutinin and retrograde tracing of choleratoxin subunit B. The main aim of this study was to determine the degree of topographical organization in the outputs of the ventral pallidum. In the telencephalon, ventral pallidal fibers reach the prefrontal cortex, the ventral striatum, the lateral septum, the basolateral, lateral, and central amygdaloid nuclei, and the lateral entorhinal area. Diencephalic targets of ventral pallidal fibers are the lateral hypothalamus, the reticular nucleus of the thalamus, the mediodorsal thalamic nucleus, the dorsomedial part of the subthalamic nucleus, the medial part of the parafascicular nucleus and the lateral habenula. In the mesencephalon, ventral pallidal fibers terminate in the ventral tegmental area, the substantia nigra, the retrorubral area, the median raphe nucleus, the nucleus raphe magnus, the peribrachial area, the ventromedial part of the central gray substance and the locus coeruleus. The results of the experiments in which retrograde tracers were injected in different nuclei in the mesencephalon allow the distinction of two main areas in the ventral pallidum. Deposits of retrograde tracers in the substantia nigra, pars reticulata result in labeling of cells in the dorsolateral part of the ventral pallidum, located immediately ventral to the anterior limb of the anterior commissure. Retrograde tracer injections in other targets of the ventral mesencephalon, i.e. the dopaminergic cell groups A10, A9 or A8, or nuclei in the peribrachial area result in labeling of neurons in an extensive ventromedial and ventrolateral zone of the ventral pallidum. The medial part of this ventral pallidal zone projects to the ventral tegmental area, whereas ventral and lateral parts connect with more lateral and caudal mesencephalic targets. The projections from the ventral pallidum to the ventral striatum, the subthalamic nucleus and adjacent lateral hypothalamic area, and the mediodorsal thalamic nucleus are distinctly topographically organized. The ventral pallidostriatal projections preserve a medial-to-lateral, a dorsal-to-ventral and, to a lesser degree, a rostral-to-caudal topography. With respect to the subthalamic region, the dorsolateral part of the ventral pallidum projects to the dorsomedial part of the subthalamic nucleus, whereas the ventromedial and ventrolateral parts of the ventral pallidum are topographically connected with the area of the lateral hypothalamus medially adjacent to the subthalamic nucleus.(ABSTRACT TRUNCATED AT 400 WORDS)

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Crossref · 10.1016/0306-4522(93)90115-v

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  • The ventral striatum receives input from the ventral pallidum with mediolateral topography; the medial ventral pallidum projects to the medial shell and medial tubercle, whereas the lateral ventral pallidum projects to the core, lateral shell and lateral tubercle.

    “In addition, the ventral striatum receives input from the ventral pallidum with mediolateral topography. The medial ventral pallidum projects to the medial shell and medial tubercle, whereas the lateral ventral pallidum projects to the core, lateral shell and lateral tubercle (Groenewegen et al., 1993).”

    From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Groenewegen et al., 1993

  • The medial ventral pallidum provides projections to both the posteromedial and lateral VTA, whereas the lateral ventral pallidum provides projections to both the lateral VTA and the medial substantia nigra pars compacta/reticulata.

    “The medial ventral pallidum, which receives its afferents from the medial shell and medial tubercle, provides its projections to both the posteromedial and lateral VTA, whereas the lateral ventral pallidum, which receives its afferents from the core, lateral shell and lateral tubercle, provides its projections to both the lateral VTA and the medial substantia nigra pars compacta/reticulata (Zahm,”

    From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Groenewegen et al., 1993

  • Ventral pallidal neurons, which receive inputs from the medial shell and medial tubercle, project substantially to the lateral hypothalamic area.

    “In addition, ventral pallidal neurons, which receive inputs from the medial shell and medial tubercle, project substantially to the lateral hypothalamic area (Groenewegen et al., 1993).”

    From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Groenewegen et al., 1993

  • The medial ventral pallidum sends its efferents to the medial mediodorsal thalamic nucleus, the lateral hypothalamic area, and the midbrain extrapyramidal area, dorsomedial to the pedunculopontine tegmental nucleus.

    “The medial ventral pallidum sends its efferents to the medial mediodorsal thalamic nucleus, the lateral hypothalamic area (Zahm, 1989; Groenewegen et al., 1993; O’Donnell et al., 1997) and the midbrain extrapyramidal area, dorsomedial to the pedunculopontine tegmental nucleus (Swanson et al., 1984; Rye et al., 1987).”

    From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Groenewegen et al., 1993

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Authors
Groenewegen, H. J., Berendse, H. W., & Haber, S. N.
Affiliations
  • Vrije Universiteit Amsterdam (NL)
  • Neurology, Inc (US)
  • University of Rochester Medicine (US)
Corresponding author
Groenewegen, H.J.
ORCID
Venue
Neuroscience
Publisher
Elsevier BV
Published
1993-11
Volume
57
Issue
1
Pages
113-142
ISSN
0306-4522 (ISSN-L)
DOI
10.1016/0306-4522(93)90115-v
OpenAlex
W2073346596
Cited by
456
References
135
Citations by year
2026: 4 · 2025: 7 · 2024: 9 · 2023: 11 · 2022: 5 · 2021: 12 · 2020: 11 · 2019: 21 · 2018: 6 · 2017: 15 · 2016: 11 · 2015: 17 · 2014: 20 · 2013: 20 · 2012: 16
FWCI
6.21
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
  • Pure Amsterdam UMC (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Funders
National Institute of Mental Health (NIMH MH45573)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Neurology › Neurological disorders and treatments
Keywords
ventral pallidum, topographic organization, subthalamic nucleus, mediodorsal thalamus, substantia nigra, ventral tegmental area, lateral hypothalamus, amygdala, midbrain
MeSH terms
Animals, Brain Mapping, Cholera Toxin, Corpus Striatum, Efferent Pathways, Female, Globus Pallidus, Immunohistochemistry, Phytohemagglutinins, Rats

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