Horseradish peroxidase injection of physiologically characterized afferent and efferent neurones in the guinea pig spiral ganglion
Abstract
Single afferent and efferent neurones in the guinea pig spiral ganglion were injected with horseradish peroxidase. They could be recovered in subsequent histological processing and traced from the injection site in the ganglion to their final termination in the organ of Corti. All responsive primary afferents innervated the inner hair cells (58 neurones). One outer spiral fibre innervating the outer hair cells was recovered. This cell was non-spiking and unresponsive to acoustic stimulation. Neurones having properties previously attributed to cochlear efferents, terminated on the outer hair cells in regions of the cochlea consistent with their characteristic frequencies.
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The pathogenesis of hyperacusis must involve still other processes, especially considering that acoustically-evoked ear pain can continue for hours to days after sound exposure.
“Undoubtedly the pathogenesis of hyperacusis must involve still other processes.; especially considering that acoustically-evoked ear pain can continue for hours to days after sound exposure2 far beyond the minutes-long phenomena described to date.”
From Damage-evoked signals in cochlear neurons and supporting cells (2024) · cites this paper as [2]
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A non-canonical pathway from cochlea to brain signals tissue-damaging noise
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Wood, M. B., Nowak, N., & Fuchs, P. A. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2024.1361747 · Cited by 7 · see citing works
- Authors
- Robertson, D.
- Affiliations
- The University of Western Australia (AU)
- Corresponding author
- Robertson, Donald
- ORCID
- Robertson, Donald
- Venue
- Hearing Research
- Publisher
- Elsevier BV
- Published
- 1984-08
- Volume
- 15
- Issue
- 2
- Pages
- 113-121
- ISSN
- 0378-5955 (ISSN-L)
- OpenAlex
- W2092235580
- Cited by
- 214
- References
- 15
- Citations by year
- 2026: 1 · 2024: 5 · 2023: 1 · 2022: 3 · 2021: 5 · 2020: 3 · 2019: 8 · 2018: 3 · 2017: 2 · 2016: 7 · 2015: 8 · 2014: 7 · 2013: 4 · 2012: 5
- FWCI
- 6.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hearing Research (publishedVersion)
- PubMed (publishedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
- Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hearing Loss and Rehabilitation
- Keywords
- spiral ganglion, horseradish peroxidase tracing, inner hair cells, outer hair cells, guinea pig cochlea
- MeSH terms
- Animals, Cochlea, Guinea Pigs, Hair Cells, Auditory, Hair Cells, Auditory, Inner, Horseradish Peroxidase, Neurons, Afferent, Neurons, Efferent, Spiral Ganglion
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