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Cited by 137Hearing, Cochlea, Tinnitus, GeneticsVestibular and auditory disordersHearing Loss and Rehabilitation

Morphology of labeled afferent fibers in the guinea pig cochlea

Brown, M. Christian·1987·Journal of Comparative Neurology
DOI 10.1002/cne.902600411
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Abstract

Cochlear afferent and efferent fibers in the guinea pig were labeled by focal extracellular injections of horseradish peroxidase into the spiral ganglion of the basal turn. The morphology and pattern of termination of these fibers were studied by light microscopy. Fibers labeled by injections into the peripheral side of the ganglion could be grouped on the basis of their courses and terminations in the cochlea into two classes of afferent fibers, two classes of efferent (olivocochlear) fibers, and other presumably autonomic fibers. This paper describes the characteristics of labeled afferent fibers and their parent ganglion cells. Peripheral afferent fibers were grouped into two major classes: thick (mean diameter 1.7 micron) radial fibers projecting in a primarily radial fashion from the spiral ganglion and terminating on single inner hair cells and thin (mean diameter 0.5 micron) outer spiral fibers that spiral basalward in the organ of Corti to terminate on outer hair cells, usually in one row. For outer spiral fibers, the number of outer hair cells contacted and the length of the terminal region depend on the row of outer hair cells contacted, with third-row fibers forming, on the average, the most extensive region of termination. Within the spiral ganglion, two types of ganglion cells could be distinguished: type-I ganglion cells of large size (mean soma area = 216 microns 2) with a ratio of central process diameter to peripheral process diameter greater than one and type-II ganglion cells of smaller size (mean soma area = 100 microns 2) and a central to peripheral process ratio near one. In three cochleae in which injections were made central to the ganglion, 11 type-I ganglion cells have been traced to radial fibers contacting inner hair cells and eight type-II ganglion cells have been traced to outer spiral fibers contacting outer hair cells. Thus the afferent innervation of the guinea pig cochlea is similar to the pattern described in other mammals, in which there is separate innervation of the inner and outer hair cells by the two types of ganglion cells. The central axons of both types of ganglion cells were traced individually through serial sections of a block of tissue containing the cochlea, the auditory nerve, and the cochlear nucleus. They followed similar courses in the auditory nerve, and the axons followed into the cochlear nucleus bifurcated in similar regions of the interstitial portion.(ABSTRACT TRUNCATED AT 400 WORDS)

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  • Type II cochlear afferents have small caliber, unmyelinated processes that extend hundreds of microns toward the cochlear base, contacting dozens of outer hair cells enroute.

    “Type II cochlear afferents have small caliber, unmyelinated processes that extend hundreds of microns toward the cochlear base, contacting dozens of outer hair cells enroute (27–29).”

    From Damage-evoked signals in cochlear neurons and supporting cells (2024) · cites this paper as [29]

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Authors
Brown, M. C.
Affiliations
Massachusetts Eye and Ear Infirmary (US)
Corresponding author
Brown, M. Christian
ORCID
Brown, M. Christian
Venue
Journal of Comparative Neurology
Publisher
Wiley
Published
1987-06-22
Volume
260
Issue
4
Pages
591-604
ISSN
  • 0021-9967 (ISSN-L)
  • 1096-9861
DOI
10.1002/cne.902600411
OpenAlex
W2037881933
Cited by
137
References
33
Citations by year
2026: 2 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 4 · 2018: 4 · 2017: 2 · 2016: 7 · 2015: 6 · 2014: 3 · 2013: 3 · 2012: 2
FWCI
3.97
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 6319 d)
Locations
  • The Journal of Comparative Neurology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (2t32ns007047-11, 2p01ns013126-12)
  • National Institute of Neurological Disorders and Stroke (P01 NS13126, T32NS07047)
Topics
  • Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
  • Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Hearing Loss and Rehabilitation
Keywords
spiral ganglion, guinea pig cochlea, inner hair cells, outer hair cells, ganglion cell morphology, axon tracing, auditory nerve, cochlear nucleus, horseradish peroxidase labeling
MeSH terms
Vestibulocochlear Nerve, Afferent Pathways, Animals, Cochlea, Efferent Pathways, Guinea Pigs, Horseradish Peroxidase, Neurons, Spiral Ganglion

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